LOCUS       NM_007363               2661 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens non-POU domain containing octamer binding (NONO),
            transcript variant 2, mRNA.
ACCESSION   NM_007363
VERSION     NM_007363.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2661)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2661)
  AUTHORS   Trifault,B., Mamontova,V., Cossa,G., Ganskih,S., Wei,Y.,
            Hofstetter,J., Bhandare,P., Baluapuri,A., Nieto,B., Solvie,D.,
            Ade,C.P., Gallant,P., Wolf,E., Larsen,D.H., Munschauer,M. and
            Burger,K.
  TITLE     Nucleolar detention of NONO shields DNA double-strand breaks from
            aberrant transcripts
  JOURNAL   Nucleic Acids Res 52 (6), 3050-3068 (2024)
   PUBMED   38224452
  REMARK    GeneRIF: Nucleolar detention of NONO shields DNA double-strand
            breaks from aberrant transcripts.
REFERENCE   3  (bases 1 to 2661)
  AUTHORS   Yang,Z.Y., Zhao,C., Liu,S.L., Pan,L.J., Zhu,Y.D., Zhao,J.W.,
            Wang,H.K., Ye,Y.Y., Qiang,J., Shi,L.Q., Mei,J.W., Xie,Y., Gong,W.,
            Shu,Y.J., Dong,P. and Xiang,S.S.
  TITLE     NONO promotes gallbladder cancer cell proliferation by enhancing
            oncogenic RNA splicing of DLG1 through interaction with
            IGF2BP3/RBM14
  JOURNAL   Cancer Lett 587, 216703 (2024)
   PUBMED   38341127
  REMARK    GeneRIF: NONO promotes gallbladder cancer cell proliferation by
            enhancing oncogenic RNA splicing of DLG1 through interaction with
            IGF2BP3/RBM14.
REFERENCE   4  (bases 1 to 2661)
  AUTHORS   Weng,N., Zhou,C., Zhou,Y., Zhong,Y., Jia,Z., Rao,X., Qiu,H.,
            Zeng,G., Jin,X., Zhang,J., Zhuang,Z., Liang,Z., Deng,Y., Li,Q.,
            Yang,S., Luo,H., Wang,H. and Wu,X.
  TITLE     IKZF4/NONO-RAB11FIP3 axis promotes immune evasion in gastric cancer
            via facilitating PD-L1 endosome recycling
  JOURNAL   Cancer Lett 584, 216618 (2024)
   PUBMED   38211652
  REMARK    GeneRIF: IKZF4/NONO-RAB11FIP3 axis promotes immune evasion in
            gastric cancer via facilitating PD-L1 endosome recycling.
REFERENCE   5  (bases 1 to 2661)
  AUTHORS   Clark,J., Lu,Y.J., Sidhar,S.K., Parker,C., Gill,S., Smedley,D.,
            Hamoudi,R., Linehan,W.M., Shipley,J. and Cooper,C.S.
  TITLE     Fusion of splicing factor genes PSF and NonO (p54nrb) to the TFE3
            gene in papillary renal cell carcinoma
  JOURNAL   Oncogene 15 (18), 2233-2239 (1997)
   PUBMED   9393982
REFERENCE   6  (bases 1 to 2661)
  AUTHORS   Peters,U., Haberhausen,G., Kostrzewa,M., Nolte,D. and Muller,U.
  TITLE     AFX1 and p54nrb: fine mapping, genomic structure, and exclusion as
            candidate genes of X-linked dystonia parkinsonism
  JOURNAL   Hum Genet 100 (5-6), 569-572 (1997)
   PUBMED   9341872
REFERENCE   7  (bases 1 to 2661)
  AUTHORS   Traish,A.M., Huang,Y.H., Ashba,J., Pronovost,M., Pavao,M.,
            McAneny,D.B. and Moreland,R.B.
  TITLE     Loss of expression of a 55 kDa nuclear protein (nmt55) in estrogen
            receptor-negative human breast cancer
  JOURNAL   Diagn Mol Pathol 6 (4), 209-221 (1997)
   PUBMED   9360842
REFERENCE   8  (bases 1 to 2661)
  AUTHORS   Hallier,M., Tavitian,A. and Moreau-Gachelin,F.
  TITLE     The transcription factor Spi-1/PU.1 binds RNA and interferes with
            the RNA-binding protein p54nrb
  JOURNAL   J Biol Chem 271 (19), 11177-11181 (1996)
   PUBMED   8626664
REFERENCE   9  (bases 1 to 2661)
  AUTHORS   Dong,B., Horowitz,D.S., Kobayashi,R. and Krainer,A.R.
  TITLE     Purification and cDNA cloning of HeLa cell p54nrb, a nuclear
            protein with two RNA recognition motifs and extensive homology to
            human splicing factor PSF and Drosophila NONA/BJ6
  JOURNAL   Nucleic Acids Res 21 (17), 4085-4092 (1993)
   PUBMED   8371983
REFERENCE   10 (bases 1 to 2661)
  AUTHORS   Zhang,W.W., Zhang,L.X., Busch,R.K., Farres,J. and Busch,H.
  TITLE     Purification and characterization of a DNA-binding heterodimer of
            52 and 100 kDa from HeLa cells
  JOURNAL   Biochem J 290 (Pt 1) (Pt 1), 267-272 (1993)
   PUBMED   8439294
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA116840.1, BC028299.1 and
            BC002364.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_007363.4.
            
            Summary: This gene encodes an RNA-binding protein which plays
            various roles in the nucleus, including transcriptional regulation
            and RNA splicing. A rearrangement between this gene and the
            transcription factor E3 gene has been observed in papillary renal
            cell carcinoma. Alternatively spliced transcript variants have been
            described. Pseudogenes exist on Chromosomes 2 and 16. [provided by
            RefSeq, Feb 2009].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein (isoform
            1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.254071.1,
                                           SRR1660809.195848.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000276079.13/ ENSP00000276079.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                DA116840.1         437-470
            35-1817             BC028299.1         1-1783
            1818-2661           BC002364.1         1786-2629
FEATURES             Location/Qualifiers
     source          1..2661
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq13.1"
     gene            1..2661
                     /gene="NONO"
                     /gene_synonym="MRXS34; NMT55; NRB54; P54; P54NRB;
                     PPP1R114"
                     /note="non-POU domain containing octamer binding"
                     /db_xref="GeneID:4841"
                     /db_xref="HGNC:HGNC:7871"
                     /db_xref="MIM:300084"
     exon            1..87
                     /gene="NONO"
                     /gene_synonym="MRXS34; NMT55; NRB54; P54; P54NRB;
                     PPP1R114"
                     /inference="alignment:Splign:2.1.0"
     exon            88..144
                     /gene="NONO"
                     /gene_synonym="MRXS34; NMT55; NRB54; P54; P54NRB;
                     PPP1R114"
                     /inference="alignment:Splign:2.1.0"
     exon            145..307
                     /gene="NONO"
                     /gene_synonym="MRXS34; NMT55; NRB54; P54; P54NRB;
                     PPP1R114"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..1569
                     /gene="NONO"
                     /gene_synonym="MRXS34; NMT55; NRB54; P54; P54NRB;
                     PPP1R114"
                     /note="isoform 1 is encoded by transcript variant 2;
                     non-POU domain-containing octamer (ATGCAAAT) binding
                     protein; 54 kDa nuclear RNA- and DNA-binding protein;
                     p54(nrb); 55 kDa nuclear protein; DNA-binding p52/p100
                     complex, 52 kDa subunit; protein phosphatase 1, regulatory
                     subunit 114"
                     /codon_start=1
                     /product="non-POU domain-containing octamer-binding
                     protein isoform 1"
                     /protein_id="NP_031389.3"
                     /db_xref="CCDS:CCDS14410.1"
                     /db_xref="GeneID:4841"
                     /db_xref="HGNC:HGNC:7871"
                     /db_xref="MIM:300084"
                     /translation="MQSNKTFNLEKQNHTPRKHHQHHHQQQHHQQQQQQPPPPPIPAN
                     GQQASSQNEGLTIDLKNFRKPGEKTFTQRSRLFVGNLPPDITEEEMRKLFEKYGKAGE
                     VFIHKDKGFGFIRLETRTLAEIAKVELDNMPLRGKQLRVRFACHSASLTVRNLPQYVS
                     NELLEEAFSVFGQVERAVVIVDDRGRPSGKGIVEFSGKPAARKALDRCSEGSFLLTTF
                     PRPVTVEPMDQLDDEEGLPEKLVIKNQQFHKEREQPPRFAQPGSFEYEYAMRWKALIE
                     MEKQQQDQVDRNIKEAREKLEMEMEAARHEHQVMLMRQDLMRRQEELRRMEELHNQEV
                     QKRKQLELRQEEERRRREEEMRRQQEEMMRRQQEGFKGTFPDAREQEIRMGQMAMGGA
                     MGINNRGAMPPAPVPAGTPAPPGPATMMPDGTLGLTPPTTERFGQAATMEGIGAIGGT
                     PPAFNRAAPGAEFAPNKRRRY"
     exon            308..501
                     /gene="NONO"
                     /gene_synonym="MRXS34; NMT55; NRB54; P54; P54NRB;
                     PPP1R114"
                     /inference="alignment:Splign:2.1.0"
     exon            502..803
                     /gene="NONO"
                     /gene_synonym="MRXS34; NMT55; NRB54; P54; P54NRB;
                     PPP1R114"
                     /inference="alignment:Splign:2.1.0"
     exon            804..899
                     /gene="NONO"
                     /gene_synonym="MRXS34; NMT55; NRB54; P54; P54NRB;
                     PPP1R114"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1096
                     /gene="NONO"
                     /gene_synonym="MRXS34; NMT55; NRB54; P54; P54NRB;
                     PPP1R114"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1181
                     /gene="NONO"
                     /gene_synonym="MRXS34; NMT55; NRB54; P54; P54NRB;
                     PPP1R114"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1284
                     /gene="NONO"
                     /gene_synonym="MRXS34; NMT55; NRB54; P54; P54NRB;
                     PPP1R114"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1324
                     /gene="NONO"
                     /gene_synonym="MRXS34; NMT55; NRB54; P54; P54NRB;
                     PPP1R114"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1434
                     /gene="NONO"
                     /gene_synonym="MRXS34; NMT55; NRB54; P54; P54NRB;
                     PPP1R114"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..2661
                     /gene="NONO"
                     /gene_synonym="MRXS34; NMT55; NRB54; P54; P54NRB;
                     PPP1R114"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2641..2646
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NONO"
                     /gene_synonym="MRXS34; NMT55; NRB54; P54; P54NRB;
                     PPP1R114"
                     /note="hexamer: AATACA"
     polyA_site      2661
                     /gene="NONO"
                     /gene_synonym="MRXS34; NMT55; NRB54; P54; P54NRB;
                     PPP1R114"
                     /note="major polyA site"
ORIGIN      
        1 gtttccggcg gtcgcgcgct cttttctcgg gacgggagag gccgtgtagc gtcgccgtta
       61 ctccgaggag ataccagtcg gtagaggaga agtcgaggtt agagggaact gggaggcact
      121 ttgctgtctg caatcgaagt tgagggtgca aaaatgcaga gtaataaaac ttttaacttg
      181 gagaagcaaa accatactcc aagaaagcat catcaacatc accaccagca gcagcaccac
      241 cagcagcaac agcagcagcc gccaccaccg ccaatacctg caaatgggca acaggccagc
      301 agccaaaatg aaggcttgac tattgacctg aagaatttta gaaaaccagg agagaagacc
      361 ttcacccaac gaagccgtct ttttgtggga aatcttcctc ccgacatcac tgaggaagaa
      421 atgaggaaac tatttgagaa atatggaaag gcaggcgaag tcttcattca taaggataaa
      481 ggatttggct ttatccgctt ggaaacccga accctagcgg agattgccaa agtggagctg
      541 gacaatatgc cactccgtgg aaagcagctg cgtgtgcgct ttgcctgcca tagtgcatcc
      601 cttacagttc gaaaccttcc tcagtatgtg tccaacgaac tgctggaaga agccttttct
      661 gtgtttggcc aggtagagag ggctgtagtc attgtggatg atcgaggaag gccctcagga
      721 aaaggcattg ttgagttctc agggaagcca gctgctcgga aagctctgga cagatgcagt
      781 gaaggctcct tcctgctaac cacatttcct cgtcctgtga ctgtggagcc catggaccag
      841 ttagatgatg aagagggact tccagagaag ctggttataa aaaaccagca atttcacaag
      901 gaacgagagc agccacccag atttgcacag cctggctcct ttgagtatga atatgccatg
      961 cgctggaagg cactcattga gatggagaag cagcagcagg accaagtgga ccgcaacatc
     1021 aaggaggctc gtgagaagct ggagatggag atggaagctg cacgccatga gcaccaggtc
     1081 atgctaatga gacaggattt gatgaggcgc caagaagaac ttcggaggat ggaagagctg
     1141 cacaaccaag aggtgcaaaa acgaaagcaa ctggagctca ggcaggagga agagcgcagg
     1201 cgccgtgaag aagagatgcg gcggcagcaa gaagaaatga tgcggcgaca gcaggaagga
     1261 ttcaagggaa ccttccctga tgcgagagag caggagattc ggatgggtca gatggctatg
     1321 ggaggtgcta tgggcataaa caacagaggt gccatgcccc ctgctcctgt gccagctggt
     1381 accccagctc ctccaggacc tgccactatg atgccggatg gaactttggg attgacccca
     1441 ccaacaactg aacgctttgg tcaggctgct acaatggaag gaattggggc aattggtgga
     1501 actcctcctg cattcaaccg tgcagctcct ggagctgaat ttgccccaaa caaacgtcgc
     1561 cgatactaat aagttgcagt gtctagtttc tcaaaaccct taaaagaagg accctttttg
     1621 gactagccag aattctaccc tggaaaagtg ttagggattc cttccaatag ttagatctac
     1681 cctgcctgta ctactctagg gagtatgctg gaggcagagg gcaagggagg ggtggtatta
     1741 aacaagtcaa ttctgtgtgg tatattgttt aatcagttct gtgtggtgca ttcctgaagt
     1801 ctctaatgtg actgttgagg gcctggggaa accatggcaa agtggatcca gttagagccc
     1861 attaatcttg atcattccgg tttttttttt ttttgtccat cttgtttcat ttgcttgccc
     1921 cgcccccgag acggagtctt actctgtcgc ccaggctgga gtgtagtggc atgatctcgg
     1981 ctcactgcaa tctctgcctc ccgggttcaa gcttgtccag gttgatcttg aactcctgac
     2041 ctcgtgatct acccacctcg gcctcccaaa atgctgggat tacaggggtg agccaccgtg
     2101 cccaacctca cttgcttctt atccttacac tcccccagcc ccagagaaac tgccacatac
     2161 accacaaaaa ccaaacatcc cccaatgacc ttagccccat tgctccattc actcccaggt
     2221 gagaattcag gcaaacgtcc acaaaggtca caggcagcgt acatacggtt ctgttatacc
     2281 ccatatatta ccccttcatg tcctaaagaa gacattttct cttagagatt ttcattttag
     2341 tgtatcttta aaaaaaaatc ttgtgttaac ttgcctccat ctttttcttg ggtgaggaca
     2401 cccaggaatg acccttttgt gtctatgatg ttgctgttca cagcttttct tgataggcct
     2461 agtacaatct tgggaacagg gttactgtat actgaaggtc tgacagtagc tcttagactc
     2521 gcctatctta ggtagtcatg ctgtgcattt tttttttcat tggtgtactg tgtttgattt
     2581 gtctcatata tttggagttt ttctgaaaaa tggagcagta atgcagcatc aacctattaa
     2641 aatacatttt aagcctttta a
//
