LOCUS       NM_001145410            2441 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens non-POU domain containing octamer binding (NONO),
            transcript variant 4, mRNA.
ACCESSION   NM_001145410
VERSION     NM_001145410.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2441)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2441)
  AUTHORS   Trifault,B., Mamontova,V., Cossa,G., Ganskih,S., Wei,Y.,
            Hofstetter,J., Bhandare,P., Baluapuri,A., Nieto,B., Solvie,D.,
            Ade,C.P., Gallant,P., Wolf,E., Larsen,D.H., Munschauer,M. and
            Burger,K.
  TITLE     Nucleolar detention of NONO shields DNA double-strand breaks from
            aberrant transcripts
  JOURNAL   Nucleic Acids Res 52 (6), 3050-3068 (2024)
   PUBMED   38224452
  REMARK    GeneRIF: Nucleolar detention of NONO shields DNA double-strand
            breaks from aberrant transcripts.
REFERENCE   3  (bases 1 to 2441)
  AUTHORS   Yang,Z.Y., Zhao,C., Liu,S.L., Pan,L.J., Zhu,Y.D., Zhao,J.W.,
            Wang,H.K., Ye,Y.Y., Qiang,J., Shi,L.Q., Mei,J.W., Xie,Y., Gong,W.,
            Shu,Y.J., Dong,P. and Xiang,S.S.
  TITLE     NONO promotes gallbladder cancer cell proliferation by enhancing
            oncogenic RNA splicing of DLG1 through interaction with
            IGF2BP3/RBM14
  JOURNAL   Cancer Lett 587, 216703 (2024)
   PUBMED   38341127
  REMARK    GeneRIF: NONO promotes gallbladder cancer cell proliferation by
            enhancing oncogenic RNA splicing of DLG1 through interaction with
            IGF2BP3/RBM14.
REFERENCE   4  (bases 1 to 2441)
  AUTHORS   Weng,N., Zhou,C., Zhou,Y., Zhong,Y., Jia,Z., Rao,X., Qiu,H.,
            Zeng,G., Jin,X., Zhang,J., Zhuang,Z., Liang,Z., Deng,Y., Li,Q.,
            Yang,S., Luo,H., Wang,H. and Wu,X.
  TITLE     IKZF4/NONO-RAB11FIP3 axis promotes immune evasion in gastric cancer
            via facilitating PD-L1 endosome recycling
  JOURNAL   Cancer Lett 584, 216618 (2024)
   PUBMED   38211652
  REMARK    GeneRIF: IKZF4/NONO-RAB11FIP3 axis promotes immune evasion in
            gastric cancer via facilitating PD-L1 endosome recycling.
REFERENCE   5  (bases 1 to 2441)
  AUTHORS   Clark,J., Lu,Y.J., Sidhar,S.K., Parker,C., Gill,S., Smedley,D.,
            Hamoudi,R., Linehan,W.M., Shipley,J. and Cooper,C.S.
  TITLE     Fusion of splicing factor genes PSF and NonO (p54nrb) to the TFE3
            gene in papillary renal cell carcinoma
  JOURNAL   Oncogene 15 (18), 2233-2239 (1997)
   PUBMED   9393982
REFERENCE   6  (bases 1 to 2441)
  AUTHORS   Peters,U., Haberhausen,G., Kostrzewa,M., Nolte,D. and Muller,U.
  TITLE     AFX1 and p54nrb: fine mapping, genomic structure, and exclusion as
            candidate genes of X-linked dystonia parkinsonism
  JOURNAL   Hum Genet 100 (5-6), 569-572 (1997)
   PUBMED   9341872
REFERENCE   7  (bases 1 to 2441)
  AUTHORS   Traish,A.M., Huang,Y.H., Ashba,J., Pronovost,M., Pavao,M.,
            McAneny,D.B. and Moreland,R.B.
  TITLE     Loss of expression of a 55 kDa nuclear protein (nmt55) in estrogen
            receptor-negative human breast cancer
  JOURNAL   Diagn Mol Pathol 6 (4), 209-221 (1997)
   PUBMED   9360842
REFERENCE   8  (bases 1 to 2441)
  AUTHORS   Hallier,M., Tavitian,A. and Moreau-Gachelin,F.
  TITLE     The transcription factor Spi-1/PU.1 binds RNA and interferes with
            the RNA-binding protein p54nrb
  JOURNAL   J Biol Chem 271 (19), 11177-11181 (1996)
   PUBMED   8626664
REFERENCE   9  (bases 1 to 2441)
  AUTHORS   Dong,B., Horowitz,D.S., Kobayashi,R. and Krainer,A.R.
  TITLE     Purification and cDNA cloning of HeLa cell p54nrb, a nuclear
            protein with two RNA recognition motifs and extensive homology to
            human splicing factor PSF and Drosophila NONA/BJ6
  JOURNAL   Nucleic Acids Res 21 (17), 4085-4092 (1993)
   PUBMED   8371983
REFERENCE   10 (bases 1 to 2441)
  AUTHORS   Zhang,W.W., Zhang,L.X., Busch,R.K., Farres,J. and Busch,H.
  TITLE     Purification and characterization of a DNA-binding heterodimer of
            52 and 100 kDa from HeLa cells
  JOURNAL   Biochem J 290 (Pt 1) (Pt 1), 267-272 (1993)
   PUBMED   8439294
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK297144.1 and BC002364.1.
            
            On Aug 14, 2020 this sequence version replaced NM_001145410.1.
            
            Summary: This gene encodes an RNA-binding protein which plays
            various roles in the nucleus, including transcriptional regulation
            and RNA splicing. A rearrangement between this gene and the
            transcription factor E3 gene has been observed in papillary renal
            cell carcinoma. Alternatively spliced transcript variants have been
            described. Pseudogenes exist on Chromosomes 2 and 16. [provided by
            RefSeq, Feb 2009].
            
            Transcript Variant: This variant (4) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at a
            downstream start codon, compared to variant 1. The encoded isoform
            (2) is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK297144.1, SRR14038193.2101375.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA2144120
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-754               AK297144.1         1-754
            755-2441            BC002364.1         943-2629
FEATURES             Location/Qualifiers
     source          1..2441
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq13.1"
     gene            1..2441
                     /gene="NONO"
                     /gene_synonym="MRXS34; NMT55; NRB54; P54; P54NRB;
                     PPP1R114"
                     /note="non-POU domain containing octamer binding"
                     /db_xref="GeneID:4841"
                     /db_xref="HGNC:HGNC:7871"
                     /db_xref="MIM:300084"
     exon            1..87
                     /gene="NONO"
                     /gene_synonym="MRXS34; NMT55; NRB54; P54; P54NRB;
                     PPP1R114"
                     /inference="alignment:Splign:2.1.0"
     exon            88..281
                     /gene="NONO"
                     /gene_synonym="MRXS34; NMT55; NRB54; P54; P54NRB;
                     PPP1R114"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..1349
                     /gene="NONO"
                     /gene_synonym="MRXS34; NMT55; NRB54; P54; P54NRB;
                     PPP1R114"
                     /note="isoform 2 is encoded by transcript variant 4;
                     non-POU domain-containing octamer (ATGCAAAT) binding
                     protein; 54 kDa nuclear RNA- and DNA-binding protein;
                     p54(nrb); 55 kDa nuclear protein; DNA-binding p52/p100
                     complex, 52 kDa subunit; protein phosphatase 1, regulatory
                     subunit 114"
                     /codon_start=1
                     /product="non-POU domain-containing octamer-binding
                     protein isoform 2"
                     /protein_id="NP_001138882.1"
                     /db_xref="CCDS:CCDS55445.1"
                     /db_xref="GeneID:4841"
                     /db_xref="HGNC:HGNC:7871"
                     /db_xref="MIM:300084"
                     /translation="MRKLFEKYGKAGEVFIHKDKGFGFIRLETRTLAEIAKVELDNMP
                     LRGKQLRVRFACHSASLTVRNLPQYVSNELLEEAFSVFGQVERAVVIVDDRGRPSGKG
                     IVEFSGKPAARKALDRCSEGSFLLTTFPRPVTVEPMDQLDDEEGLPEKLVIKNQQFHK
                     EREQPPRFAQPGSFEYEYAMRWKALIEMEKQQQDQVDRNIKEAREKLEMEMEAARHEH
                     QVMLMRQDLMRRQEELRRMEELHNQEVQKRKQLELRQEEERRRREEEMRRQQEEMMRR
                     QQEGFKGTFPDAREQEIRMGQMAMGGAMGINNRGAMPPAPVPAGTPAPPGPATMMPDG
                     TLGLTPPTTERFGQAATMEGIGAIGGTPPAFNRAAPGAEFAPNKRRRY"
     exon            282..583
                     /gene="NONO"
                     /gene_synonym="MRXS34; NMT55; NRB54; P54; P54NRB;
                     PPP1R114"
                     /inference="alignment:Splign:2.1.0"
     exon            584..679
                     /gene="NONO"
                     /gene_synonym="MRXS34; NMT55; NRB54; P54; P54NRB;
                     PPP1R114"
                     /inference="alignment:Splign:2.1.0"
     exon            680..876
                     /gene="NONO"
                     /gene_synonym="MRXS34; NMT55; NRB54; P54; P54NRB;
                     PPP1R114"
                     /inference="alignment:Splign:2.1.0"
     exon            877..961
                     /gene="NONO"
                     /gene_synonym="MRXS34; NMT55; NRB54; P54; P54NRB;
                     PPP1R114"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1064
                     /gene="NONO"
                     /gene_synonym="MRXS34; NMT55; NRB54; P54; P54NRB;
                     PPP1R114"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1104
                     /gene="NONO"
                     /gene_synonym="MRXS34; NMT55; NRB54; P54; P54NRB;
                     PPP1R114"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1214
                     /gene="NONO"
                     /gene_synonym="MRXS34; NMT55; NRB54; P54; P54NRB;
                     PPP1R114"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..2441
                     /gene="NONO"
                     /gene_synonym="MRXS34; NMT55; NRB54; P54; P54NRB;
                     PPP1R114"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2421..2426
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NONO"
                     /gene_synonym="MRXS34; NMT55; NRB54; P54; P54NRB;
                     PPP1R114"
                     /note="hexamer: AATACA"
     polyA_site      2441
                     /gene="NONO"
                     /gene_synonym="MRXS34; NMT55; NRB54; P54; P54NRB;
                     PPP1R114"
                     /note="major polyA site"
ORIGIN      
        1 gtttccggcg gtcgcgcgct cttttctcgg gacgggagag gccgtgtagc gtcgccgtta
       61 ctccgaggag ataccagtcg gtagaggatg aaggcttgac tattgacctg aagaatttta
      121 gaaaaccagg agagaagacc ttcacccaac gaagccgtct ttttgtggga aatcttcctc
      181 ccgacatcac tgaggaagaa atgaggaaac tatttgagaa atatggaaag gcaggcgaag
      241 tcttcattca taaggataaa ggatttggct ttatccgctt ggaaacccga accctagcgg
      301 agattgccaa agtggagctg gacaatatgc cactccgtgg aaagcagctg cgtgtgcgct
      361 ttgcctgcca tagtgcatcc cttacagttc gaaaccttcc tcagtatgtg tccaacgaac
      421 tgctggaaga agccttttct gtgtttggcc aggtagagag ggctgtagtc attgtggatg
      481 atcgaggaag gccctcagga aaaggcattg ttgagttctc agggaagcca gctgctcgga
      541 aagctctgga cagatgcagt gaaggctcct tcctgctaac cacatttcct cgtcctgtga
      601 ctgtggagcc catggaccag ttagatgatg aagagggact tccagagaag ctggttataa
      661 aaaaccagca atttcacaag gaacgagagc agccacccag atttgcacag cctggctcct
      721 ttgagtatga atatgccatg cgctggaagg cactcattga gatggagaag cagcagcagg
      781 accaagtgga ccgcaacatc aaggaggctc gtgagaagct ggagatggag atggaagctg
      841 cacgccatga gcaccaggtc atgctaatga gacaggattt gatgaggcgc caagaagaac
      901 ttcggaggat ggaagagctg cacaaccaag aggtgcaaaa acgaaagcaa ctggagctca
      961 ggcaggagga agagcgcagg cgccgtgaag aagagatgcg gcggcagcaa gaagaaatga
     1021 tgcggcgaca gcaggaagga ttcaagggaa ccttccctga tgcgagagag caggagattc
     1081 ggatgggtca gatggctatg ggaggtgcta tgggcataaa caacagaggt gccatgcccc
     1141 ctgctcctgt gccagctggt accccagctc ctccaggacc tgccactatg atgccggatg
     1201 gaactttggg attgacccca ccaacaactg aacgctttgg tcaggctgct acaatggaag
     1261 gaattggggc aattggtgga actcctcctg cattcaaccg tgcagctcct ggagctgaat
     1321 ttgccccaaa caaacgtcgc cgatactaat aagttgcagt gtctagtttc tcaaaaccct
     1381 taaaagaagg accctttttg gactagccag aattctaccc tggaaaagtg ttagggattc
     1441 cttccaatag ttagatctac cctgcctgta ctactctagg gagtatgctg gaggcagagg
     1501 gcaagggagg ggtggtatta aacaagtcaa ttctgtgtgg tatattgttt aatcagttct
     1561 gtgtggtgca ttcctgaagt ctctaatgtg actgttgagg gcctggggaa accatggcaa
     1621 agtggatcca gttagagccc attaatcttg atcattccgg tttttttttt ttttgtccat
     1681 cttgtttcat ttgcttgccc cgcccccgag acggagtctt actctgtcgc ccaggctgga
     1741 gtgtagtggc atgatctcgg ctcactgcaa tctctgcctc ccgggttcaa gcttgtccag
     1801 gttgatcttg aactcctgac ctcgtgatct acccacctcg gcctcccaaa atgctgggat
     1861 tacaggggtg agccaccgtg cccaacctca cttgcttctt atccttacac tcccccagcc
     1921 ccagagaaac tgccacatac accacaaaaa ccaaacatcc cccaatgacc ttagccccat
     1981 tgctccattc actcccaggt gagaattcag gcaaacgtcc acaaaggtca caggcagcgt
     2041 acatacggtt ctgttatacc ccatatatta ccccttcatg tcctaaagaa gacattttct
     2101 cttagagatt ttcattttag tgtatcttta aaaaaaaatc ttgtgttaac ttgcctccat
     2161 ctttttcttg ggtgaggaca cccaggaatg acccttttgt gtctatgatg ttgctgttca
     2221 cagcttttct tgataggcct agtacaatct tgggaacagg gttactgtat actgaaggtc
     2281 tgacagtagc tcttagactc gcctatctta ggtagtcatg ctgtgcattt tttttttcat
     2341 tggtgtactg tgtttgattt gtctcatata tttggagttt ttctgaaaaa tggagcagta
     2401 atgcagcatc aacctattaa aatacatttt aagcctttta a
//
