LOCUS       NM_173614               4235 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens NODAL modulator 2 (NOMO2), transcript variant 2, mRNA.
ACCESSION   NM_173614 XM_936703
VERSION     NM_173614.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4235)
  AUTHORS   Sundaram,A., Yamsek,M., Zhong,F., Hooda,Y., Hegde,R.S. and
            Keenan,R.J.
  TITLE     Substrate-driven assembly of a translocon for multipass membrane
            proteins
  JOURNAL   Nature 611 (7934), 167-172 (2022)
   PUBMED   36261522
REFERENCE   2  (bases 1 to 4235)
  AUTHORS   McGilvray,P.T., Anghel,S.A., Sundaram,A., Zhong,F., Trnka,M.J.,
            Fuller,J.R., Hu,H., Burlingame,A.L. and Keenan,R.J.
  TITLE     An ER translocon for multi-pass membrane protein biogenesis
  JOURNAL   Elife 9, e56889 (2020)
   PUBMED   32820719
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4235)
  AUTHORS   Dettmer,U., Kuhn,P.H., Abou-Ajram,C., Lichtenthaler,S.F.,
            Kruger,M., Kremmer,E., Haass,C. and Haffner,C.
  TITLE     Transmembrane protein 147 (TMEM147) is a novel component of the
            Nicalin-NOMO protein complex
  JOURNAL   J Biol Chem 285 (34), 26174-26181 (2010)
   PUBMED   20538592
REFERENCE   4  (bases 1 to 4235)
  AUTHORS   Haffner,C., Dettmer,U., Weiler,T. and Haass,C.
  TITLE     The Nicastrin-like protein Nicalin regulates assembly and stability
            of the Nicalin-nodal modulator (NOMO) membrane protein complex
  JOURNAL   J Biol Chem 282 (14), 10632-10638 (2007)
   PUBMED   17261586
REFERENCE   5  (bases 1 to 4235)
  AUTHORS   Martin,J., Han,C., Gordon,L.A., Terry,A., Prabhakar,S., She,X.,
            Xie,G., Hellsten,U., Chan,Y.M., Altherr,M., Couronne,O., Aerts,A.,
            Bajorek,E., Black,S., Blumer,H., Branscomb,E., Brown,N.C.,
            Bruno,W.J., Buckingham,J.M., Callen,D.F., Campbell,C.S.,
            Campbell,M.L., Campbell,E.W., Caoile,C., Challacombe,J.F.,
            Chasteen,L.A., Chertkov,O., Chi,H.C., Christensen,M., Clark,L.M.,
            Cohn,J.D., Denys,M., Detter,J.C., Dickson,M.,
            Dimitrijevic-Bussod,M., Escobar,J., Fawcett,J.J., Flowers,D.,
            Fotopulos,D., Glavina,T., Gomez,M., Gonzales,E., Goodstein,D.,
            Goodwin,L.A., Grady,D.L., Grigoriev,I., Groza,M., Hammon,N.,
            Hawkins,T., Haydu,L., Hildebrand,C.E., Huang,W., Israni,S.,
            Jett,J., Jewett,P.B., Kadner,K., Kimball,H., Kobayashi,A.,
            Krawczyk,M.C., Leyba,T., Longmire,J.L., Lopez,F., Lou,Y., Lowry,S.,
            Ludeman,T., Manohar,C.F., Mark,G.A., McMurray,K.L., Meincke,L.J.,
            Morgan,J., Moyzis,R.K., Mundt,M.O., Munk,A.C., Nandkeshwar,R.D.,
            Pitluck,S., Pollard,M., Predki,P., Parson-Quintana,B., Ramirez,L.,
            Rash,S., Retterer,J., Ricke,D.O., Robinson,D.L., Rodriguez,A.,
            Salamov,A., Saunders,E.H., Scott,D., Shough,T., Stallings,R.L.,
            Stalvey,M., Sutherland,R.D., Tapia,R., Tesmer,J.G., Thayer,N.,
            Thompson,L.S., Tice,H., Torney,D.C., Tran-Gyamfi,M., Tsai,M.,
            Ulanovsky,L.E., Ustaszewska,A., Vo,N., White,P.S., Williams,A.L.,
            Wills,P.L., Wu,J.R., Wu,K., Yang,J., Dejong,P., Bruce,D.,
            Doggett,N.A., Deaven,L., Schmutz,J., Grimwood,J., Richardson,P.,
            Rokhsar,D.S., Eichler,E.E., Gilna,P., Lucas,S.M., Myers,R.M.,
            Rubin,E.M. and Pennacchio,L.A.
  TITLE     The sequence and analysis of duplication-rich human chromosome 16
  JOURNAL   Nature 432 (7020), 988-994 (2004)
   PUBMED   15616553
REFERENCE   6  (bases 1 to 4235)
  AUTHORS   Haffner,C., Frauli,M., Topp,S., Irmler,M., Hofmann,K., Regula,J.T.,
            Bally-Cuif,L. and Haass,C.
  TITLE     Nicalin and its binding partner Nomo are novel Nodal signaling
            antagonists
  JOURNAL   EMBO J 23 (15), 3041-3050 (2004)
   PUBMED   15257293
REFERENCE   7  (bases 1 to 4235)
  AUTHORS   Loftus,B.J., Kim,U.J., Sneddon,V.P., Kalush,F., Brandon,R.,
            Fuhrmann,J., Mason,T., Crosby,M.L., Barnstead,M., Cronin,L.,
            Deslattes Mays,A., Cao,Y., Xu,R.X., Kang,H.L., Mitchell,S.,
            Eichler,E.E., Harris,P.C., Venter,J.C. and Adams,M.D.
  TITLE     Genome duplications and other features in 12 Mb of DNA sequence
            from human chromosome 16p and 16q
  JOURNAL   Genomics 60 (3), 295-308 (1999)
   PUBMED   10493829
REFERENCE   8  (bases 1 to 4235)
  AUTHORS   van Soest,S., Swart,J., Tijmes,N., Sandkuijl,L.A., Rommers,J. and
            Bergen,A.A.
  TITLE     A locus for autosomal recessive pseudoxanthoma elasticum, with
            penetrance of vascular symptoms in carriers, maps to chromosome
            16p13.1
  JOURNAL   Genome Res 7 (8), 830-834 (1997)
   PUBMED   9267806
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC136618.3.
            
            On Oct 29, 2020 this sequence version replaced NM_173614.3.
            
            Summary: This gene encodes a protein originally thought to be
            related to the collagenase gene family. This gene is one of three
            highly similar genes in a region of duplication located on the p
            arm of chromosome 16. These three genes encode closely related
            proteins that may have the same function. The protein encoded by
            one of these genes has been identified as part of a protein complex
            that participates in the Nodal signaling pathway during vertebrate
            development. Mutations in ABCC6, which is located nearby, rather
            than mutations in this gene are associated with pseudoxanthoma
            elasticum (PXE). Two transcripts encoding different isoforms have
            been described. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) contains  an alternate segment
            in the 3' CDS, compared to variant 1. The resulting protein
            (isoform 2) is shorter and has a distinct C-terminus compared to
            isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853560.10695.1, BC041131.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000622306.5/ ENSP00000478653.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-222               AC136618.3         75390-75611         c
            223-312             AC136618.3         71216-71305         c
            313-358             AC136618.3         68321-68366         c
            359-459             AC136618.3         64953-65053         c
            460-566             AC136618.3         63035-63141         c
            567-639             AC136618.3         60742-60814         c
            640-792             AC136618.3         57131-57283         c
            793-930             AC136618.3         56108-56245         c
            931-1020            AC136618.3         55686-55775         c
            1021-1126           AC136618.3         52373-52478         c
            1127-1277           AC136618.3         52040-52190         c
            1278-1452           AC136618.3         46519-46693         c
            1453-1594           AC136618.3         44980-45121         c
            1595-1726           AC136618.3         44551-44682         c
            1727-1863           AC136618.3         43015-43151         c
            1864-1951           AC136618.3         41051-41138         c
            1952-2015           AC136618.3         38003-38066         c
            2016-2111           AC136618.3         37358-37453         c
            2112-2330           AC136618.3         34279-34497         c
            2331-2413           AC136618.3         34111-34193         c
            2414-2573           AC136618.3         33015-33174         c
            2574-2700           AC136618.3         32743-32869         c
            2701-2814           AC136618.3         30703-30816         c
            2815-2942           AC136618.3         29397-29524         c
            2943-3084           AC136618.3         27856-27997         c
            3085-3168           AC136618.3         26864-26947         c
            3169-3279           AC136618.3         25060-25170         c
            3280-3381           AC136618.3         22680-22781         c
            3382-3501           AC136618.3         20387-20506         c
            3502-3594           AC136618.3         14505-14597         c
            3595-4235           AC136618.3         13441-14081         c
FEATURES             Location/Qualifiers
     source          1..4235
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.3"
     gene            1..4235
                     /gene="NOMO2"
                     /gene_synonym="Nomo; PM5"
                     /note="NODAL modulator 2"
                     /db_xref="GeneID:283820"
                     /db_xref="HGNC:HGNC:22652"
                     /db_xref="MIM:609158"
     exon            1..222
                     /gene="NOMO2"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..3726
                     /gene="NOMO2"
                     /gene_synonym="Nomo; PM5"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; pM5 protein, centromeric copy; pM5 protein 2;
                     BOS complex subunit NOMO2"
                     /codon_start=1
                     /product="BOS complex subunit NOMO2 isoform 2 precursor"
                     /protein_id="NP_775885.1"
                     /db_xref="CCDS:CCDS10570.1"
                     /db_xref="GeneID:283820"
                     /db_xref="HGNC:HGNC:22652"
                     /db_xref="MIM:609158"
                     /translation="MLVGQGAGLLGPAVVTAAVVLLLSGVGPAHGSEDIVVGCGGFVK
                     SDVEINYSLIEIKLYTKHGTLKYQTDCAPNNGYFMIPLYDKGDFILKIEPPLGWSFEP
                     TTVELHVDGVSDICTKGGDINFVFTGFSVNGKVLSKGQPLGPAGVQVSLRNTGTEAKI
                     QSTVTQPGGKFAFFKVLPGDYEILATHPTWALKEASTTVRVTNSNANAASPLIVAGYN
                     VSGSVRSDGEPMKGVKFLLFSSLVTKEDVLGCNVSPVPGFQPQDESLVYLCYTVSRED
                     GSFSFYSLPSGGYTVIPFYRGERITFDVAPSRLDFTVEHDSLKIEPVFHVMGFSVTGR
                     VLNGPEGDGVPEAVVTLNNQIKVKTKADGSFRLENITTGTYTIHAQKEHLYFETVTIK
                     IAPNTPQLADIVATGFSVCGRISIIRFPDTVKQMNKYKVVLSSQDKDKSLVTVETDAH
                     GSFCFKAKPGTYKVQVMVPEAETRAGLTLKPQTFPLTVTDRPVMDVAFVQFLASVSGK
                     VSCLDTCGDLLVTLQSLSRQGEKRSLQLSGKVNAMTFTFDNVLPGKYKISIMHEDWCW
                     KNKSLEVEVLEDDVSAVEFRQTGYMLRCSLSHAITLEFYQDGNGRENVGIYNLSKGVN
                     RFCLSKPGVYKVTPRSCHRFEQAFYTYDTSSPSILTLTAIRHHVLGTITTDKMMDVTV
                     TIKSSIDSEPALVLGPLKSVQELRREQQLAEIEARRQEREKNGNEEGEERMTKPPVQE
                     MVDELQGPFSYDFSYWARSGEKITVTPSSKELLFYPPSMEAVVSGESCPGKLIEIHGK
                     AGLFLEGQIHPELEGVEIVISEKGASSPLITVFTDDKGAYSVGPLHSDLEYTVTSQKE
                     GYVLTAVEGTIGDFKAYALAGVSFEIKAEDDQPLPGVLLSLSGGLFRSNLLTQDNGIL
                     TFSNLSPGQYYFKPMMKEFRFEPSSQMIEVQEGQNLKITITGYRTAYSCYGTVSSLNG
                     EPEQGVAMEAVGQNDCSIYGEDTVTDEEGKFRLRGLLPGCVYHVQLKAEGNDHIERAL
                     PHHRVIEVGNNDIDDVNIIVFRQINQFDLSGNVITSSEYLPTLWVKLYKSENLDNPIQ
                     TVSLGQSLFFHFPPLLRDGENYVVLLDSTLPRSQYDYILPQVSFTAVGYHKHITLIFN
                     PTRKLPEQDIAQGSYIALPLTLLVLLAGYNHDKLIPLLLQLTSRLQGVGALGQAASDN
                     SGPEDAKRQAKKQKTRRT"
     exon            223..312
                     /gene="NOMO2"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            313..358
                     /gene="NOMO2"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            359..459
                     /gene="NOMO2"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            460..566
                     /gene="NOMO2"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            567..639
                     /gene="NOMO2"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            640..792
                     /gene="NOMO2"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            793..930
                     /gene="NOMO2"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1020
                     /gene="NOMO2"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1126
                     /gene="NOMO2"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1277
                     /gene="NOMO2"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1452
                     /gene="NOMO2"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1594
                     /gene="NOMO2"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1726
                     /gene="NOMO2"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1863
                     /gene="NOMO2"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..1951
                     /gene="NOMO2"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2015
                     /gene="NOMO2"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2111
                     /gene="NOMO2"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            2112..2330
                     /gene="NOMO2"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            2331..2413
                     /gene="NOMO2"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            2414..2573
                     /gene="NOMO2"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            2574..2700
                     /gene="NOMO2"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            2701..2814
                     /gene="NOMO2"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            2815..2942
                     /gene="NOMO2"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            2943..3084
                     /gene="NOMO2"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            3085..3168
                     /gene="NOMO2"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            3169..3279
                     /gene="NOMO2"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            3280..3381
                     /gene="NOMO2"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            3382..3501
                     /gene="NOMO2"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            3502..3594
                     /gene="NOMO2"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            3595..4235
                     /gene="NOMO2"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4205..4210
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOMO2"
                     /gene_synonym="Nomo; PM5"
                     /note="hexamer: AATAAA"
     polyA_site      4235
                     /gene="NOMO2"
                     /gene_synonym="Nomo; PM5"
                     /note="major polyA site"
ORIGIN      
        1 agtgtgaggg gcgggacccg gctgccggcg gtgggtctag ctgggggagg tcgggccatg
       61 ctggtgggcc agggcgcggg gctgctgggg cccgcggtgg tcaccgccgc ggtggtgctg
      121 ctgctgagcg gcgtggggcc ggcgcacggc tcggaggaca tcgtggtggg ctgcggtggc
      181 ttcgtcaagt cggacgtgga gatcaactac tcgctcatcg agataaagct gtacaccaag
      241 catgggactt tgaaatacca gacagactgt gcccctaata atggttactt tatgatccct
      301 ttgtatgata agggggattt cattctgaag attgagcctc ccctagggtg gagttttgag
      361 ccgacgaccg tggagctcca tgtggatgga gtcagtgaca tctgcacaaa gggtggggac
      421 atcaactttg tcttcactgg gttctctgtg aatggcaagg tcctcagcaa agggcagccc
      481 ctgggtcctg cgggagttca ggtgtctctg agaaacactg ggaccgaagc aaagatccag
      541 tccacagtta cacagcctgg cggaaagttt gcatttttta aagttctgcc tggagattat
      601 gaaatcctcg caactcatcc aacctgggcg ttgaaagagg caagcaccac agtgcgtgta
      661 accaactcca atgccaatgc ggccagtccc ctcatagttg ctggctacaa tgtgtctggc
      721 tctgtccgaa gtgatgggga gcccatgaaa ggggtgaagt ttcttctctt ttcttcttta
      781 gtaactaaag aggatgtcct gggctgcaat gtctcaccag tgcctgggtt ccagccccaa
      841 gacgagagtc tggtgtattt gtgctacacg gtctccagag aagatggctc gttctctttc
      901 tattccttgc caagtggggg ctacactgtg attccgttct atcgagggga gaggattacc
      961 tttgatgtgg cgccttccag acttgacttc acagtggagc atgacagctt gaaaatcgag
     1021 cccgtgttcc acgtcatggg attctccgtc accgggaggg tcttgaacgg acccgaagga
     1081 gatggtgttc cagaagcagt agtcaccctg aataaccaaa tcaaagttaa aacaaaagct
     1141 gatggctcat tccgccttga gaacataacc acagggacat acaccatcca tgctcagaaa
     1201 gagcacctct actttgaaac ggtcaccatc aaaattgcac cgaacacacc tcagctggct
     1261 gacattgttg caacagggtt cagtgtctgt ggtcggatat caatcattcg cttcccggac
     1321 accgtcaagc agatgaataa atacaaagtt gtcctgtcat ctcaagacaa ggacaagtct
     1381 ttggtcaccg tggagacaga tgctcatgga tcattttgtt ttaaagcaaa accagggact
     1441 tacaaagtgc aggtgatggt tcctgaggca gaaaccagag cagggctgac gttgaaaccc
     1501 cagacatttc ctcttactgt gaccgacagg cccgtgatgg atgtggcctt tgtacagttc
     1561 ttggcatcag tttctgggaa agtctcttgt ttggacacct gtggtgactt gctggtgact
     1621 ctacagtccc tgagccgcca gggtgagaag cggagcctcc agctctccgg caaggtcaac
     1681 gccatgactt tcacctttga caacgtgctc cctggaaaat acaaaataag catcatgcat
     1741 gaggattggt gctggaagaa caagagcctg gaggtggaag tgctggagga tgacgtgtct
     1801 gcagttgagt tcaggcagac gggctacatg ctgagatgtt ccctgtctca cgccatcact
     1861 ctggaatttt atcaggatgg aaatgggcgt gagaatgtgg ggatttataa cctctccaaa
     1921 ggagtcaacc gattctgcct gtccaagcct ggtgtgtaca aagtgacccc tcgctcctgc
     1981 caccggtttg agcaagcgtt ctacacctat gacacgtctt cacctagtat cttgacattg
     2041 acagccattc gccaccatgt ccttggaact atcaccaccg acaaaatgat ggatgtcact
     2101 gtgactatca agtcttccat cgacagtgaa cccgccttgg tcttaggccc tctgaagtct
     2161 gtgcaggagc tgcggaggga gcagcagctg gctgagatcg aggcccgcag gcaggagagg
     2221 gagaaaaacg gcaatgagga aggtgaagaa agaatgacca agcctcccgt gcaggagatg
     2281 gtagatgagt tacaaggccc cttctcgtat gatttctctt actgggcgcg gtctggagag
     2341 aaaatcactg ttacaccgtc atctaaagag ctgctctttt atcccccttc aatggaagcc
     2401 gttgtcagtg gagaaagctg cccagggaag ctgatcgaga tccacgggaa ggcaggcctg
     2461 tttttagaag gccagatcca ccccgagttg gaaggagtcg agattgtcat cagtgaaaag
     2521 ggggcaagtt caccgctgat cacagtcttt actgatgaca aaggtgccta cagtgttggc
     2581 cccctgcaca gtgacctgga gtacacggtg acctcacaga aggagggcta tgttctgact
     2641 gcagtggaag gaaccatcgg agacttcaag gcctatgccc tggcaggcgt aagctttgag
     2701 ataaaagctg aggatgacca gcccctcccg ggagtcctct tatccctgag tggtggcctg
     2761 tttcgttcca acctcttgac ccaggacaac ggcattctga cattctcaaa cctgagccct
     2821 ggccagtatt acttcaaacc catgatgaag gagttccggt ttgagccatc ctcacagatg
     2881 atcgaggtgc aggaaggcca gaacctgaag atcaccatca cggggtaccg aaccgcttac
     2941 agttgctatg gcacagtgtc ttccttaaac ggagagcccg aacaaggggt tgccatggaa
     3001 gcggtgggcc agaacgactg cagcatttac ggagaagaca ccgtgacaga cgaagagggc
     3061 aagttcagat tacgtggatt gctgccggga tgtgtgtacc acgttcagct caaggcagaa
     3121 ggcaacgacc acattgagcg ggcgctcccc caccataggg tgattgaggt tgggaataat
     3181 gacatcgatg atgtaaacat catagttttc cggcagatta atcaatttga tttaagtgga
     3241 aatgtgatca cttcctctga ataccttcct acgttatggg tcaagcttta caaaagcgaa
     3301 aacctcgaca atccaatcca gacagtttcc cttggccagt ccctgttctt ccatttcccc
     3361 ccactgctca gagatggcga gaactatgtt gtgcttctgg actccacact ccccagatcc
     3421 cagtatgact acatcttgcc tcaagtttct ttcaccgcag tgggctacca taaacacatc
     3481 accttgattt ttaatcccac gaggaagctg cctgaacagg acatcgcaca aggatcctac
     3541 attgccctgc cattgacgct gctggttctg ctggccggtt acaaccatga caagctcatt
     3601 cctttgctgc tgcagttgac aagccggcta cagggagtcg gcgcgctcgg ccaggcagcc
     3661 tctgacaata gcggcccaga agatgcaaag agacaagcca agaaacagaa gacaaggcgg
     3721 acgtgaggag gaaggggaca gttgcagtct cacttgggac aggccacagc caggggtccg
     3781 gccactaccc gcccgtggga taaaagccaa aagcatgcgt cagctaactt cagcctgtgc
     3841 tgctgggccc gcaccccatg tcccttgtca ctgtggcatc ctgcacccat cctcacccct
     3901 ccgtagagcc cctcgtgcaa tgcaatgaat ggaccctcct gtcactctgc tgaacagaat
     3961 ttattttctg agtcaaatat aatttattat tatttttgtc aaagaagtat ttaagctgtg
     4021 ctgtggtgtg agaatgtcat tcttgatctt cagccttcgt ttgcaagaag agttccagtt
     4081 gatgtggtgt ttggttccat ggcggggtac cctagggatt catctgtttt cttcacttcc
     4141 ctttgcatct gagatcctgc tggaaaccac ggcaacctgt atccactatt aggaggtaaa
     4201 aatcaataaa atggcccatt catttgtgtt gtagc
//
