LOCUS       NM_014287               4312 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens NODAL modulator 1 (NOMO1), mRNA.
ACCESSION   NM_014287 XM_001716489
VERSION     NM_014287.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4312)
  AUTHORS   Sundaram,A., Yamsek,M., Zhong,F., Hooda,Y., Hegde,R.S. and
            Keenan,R.J.
  TITLE     Substrate-driven assembly of a translocon for multipass membrane
            proteins
  JOURNAL   Nature 611 (7934), 167-172 (2022)
   PUBMED   36261522
REFERENCE   2  (bases 1 to 4312)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4312)
  AUTHORS   McGilvray,P.T., Anghel,S.A., Sundaram,A., Zhong,F., Trnka,M.J.,
            Fuller,J.R., Hu,H., Burlingame,A.L. and Keenan,R.J.
  TITLE     An ER translocon for multi-pass membrane protein biogenesis
  JOURNAL   Elife 9, e56889 (2020)
   PUBMED   32820719
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4312)
  AUTHORS   Perea,J., Garcia,J.L., Perez,J., Rueda,D., Arriba,M., Rodriguez,Y.,
            Urioste,M. and Gonzalez-Sarmiento,R.
  TITLE     NOMO-1 gene is deleted in early-onset colorectal cancer
  JOURNAL   Oncotarget 8 (15), 24429-24436 (2017)
   PUBMED   28416736
  REMARK    GeneRIF: Microsatellite-Stable (MSS) CRC showed a very high
            proportion of homozygous loss of NOMO1 (54 of 59 cases, 91.5%),
            while the deletion was observed in only 7 out of 16 MSI cases.
            Deletion of NOMO1 is a molecular marker predominantly associated
            with CRC, particularly MSS subtypes.
REFERENCE   5  (bases 1 to 4312)
  AUTHORS   Gao,W.L., Liu,M., Yang,Y., Yang,H., Liao,Q., Bai,Y., Li,Y.X.,
            Li,D., Peng,C. and Wang,Y.L.
  TITLE     The imprinted H19 gene regulates human placental trophoblast cell
            proliferation via encoding miR-675 that targets Nodal Modulator 1
            (NOMO1)
  JOURNAL   RNA Biol 9 (7), 1002-1010 (2012)
   PUBMED   22832245
  REMARK    GeneRIF: H19 gene could inhibit human trophoblast cell
            proliferation via encoding miR-675 that targeted NOMO1
            downregulation.
REFERENCE   6  (bases 1 to 4312)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   7  (bases 1 to 4312)
  AUTHORS   Lehner,B. and Sanderson,C.M.
  TITLE     A protein interaction framework for human mRNA degradation
  JOURNAL   Genome Res 14 (7), 1315-1323 (2004)
   PUBMED   15231747
REFERENCE   8  (bases 1 to 4312)
  AUTHORS   Loftus,B.J., Kim,U.J., Sneddon,V.P., Kalush,F., Brandon,R.,
            Fuhrmann,J., Mason,T., Crosby,M.L., Barnstead,M., Cronin,L.,
            Deslattes Mays,A., Cao,Y., Xu,R.X., Kang,H.L., Mitchell,S.,
            Eichler,E.E., Harris,P.C., Venter,J.C. and Adams,M.D.
  TITLE     Genome duplications and other features in 12 Mb of DNA sequence
            from human chromosome 16p and 16q
  JOURNAL   Genomics 60 (3), 295-308 (1999)
   PUBMED   10493829
REFERENCE   9  (bases 1 to 4312)
  AUTHORS   van Soest,S., Swart,J., Tijmes,N., Sandkuijl,L.A., Rommers,J. and
            Bergen,A.A.
  TITLE     A locus for autosomal recessive pseudoxanthoma elasticum, with
            penetrance of vascular symptoms in carriers, maps to chromosome
            16p13.1
  JOURNAL   Genome Res 7 (8), 830-834 (1997)
   PUBMED   9267806
REFERENCE   10 (bases 1 to 4312)
  AUTHORS   Templeton,N.S., Rodgers,L.A., Levy,A.T., Ting,K.L., Krutzsch,H.C.,
            Liotta,L.A. and Stetler-Stevenson,W.G.
  TITLE     Cloning and characterization of a novel human cDNA that has DNA
            similarity to the conserved region of the collagenase gene family
  JOURNAL   Genomics 12 (1), 175-176 (1992)
   PUBMED   1310294
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC136443.3, BI459869.1,
            BC065535.1, X57398.1 and AK125530.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014287.3.
            
            Summary: This gene encodes a protein originally thought to be
            related to the collagenase gene family. This gene is one of three
            highly similar genes in a region of duplication located on the p
            arm of chromosome 16. These three genes encode closely related
            proteins that may have the same function. The protein encoded by
            one of these genes has been identified as part of a protein complex
            that participates in the Nodal signaling pathway during vertebrate
            development. Mutations in ABCC6, which is located nearby, rather
            than mutations in this gene are associated with pseudoxanthoma
            elasticum (PXE). [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065535.1, SRR1803612.166766.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000287667.12/ ENSP00000287667.7
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                AC136443.3         70895-70959         c
            66-156              BI459869.1         72-162
            157-1878            BC065535.1         45-1766
            1879-1983           X57398.1           1652-1756
            1984-3717           BC065535.1         1872-3605
            3718-3889           AK125530.1         1305-1476
            3890-4141           BC065535.1         3778-4029
            4142-4187           X57398.1           3915-3960
            4188-4312           BC065535.1         4076-4200
FEATURES             Location/Qualifiers
     source          1..4312
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.11"
     gene            1..4312
                     /gene="NOMO1"
                     /gene_synonym="Nomo; PM5"
                     /note="NODAL modulator 1"
                     /db_xref="GeneID:23420"
                     /db_xref="HGNC:HGNC:30060"
                     /db_xref="MIM:609157"
     exon            1..296
                     /gene="NOMO1"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..3800
                     /gene="NOMO1"
                     /gene_synonym="Nomo; PM5"
                     /note="pM5 protein, telomeric copy; nodal modulator 3; pM5
                     protein 3"
                     /codon_start=1
                     /product="nodal modulator 1 precursor"
                     /protein_id="NP_055102.3"
                     /db_xref="CCDS:CCDS10556.1"
                     /db_xref="GeneID:23420"
                     /db_xref="HGNC:HGNC:30060"
                     /db_xref="MIM:609157"
                     /translation="MLVGQGAGPLGPAVVTAAVVLLLSGVGPAHGSEDIVVGCGGFVK
                     SDVEINYSLIEIKLYTKHGTLKYQTDCAPNNGYFMIPLYDKGDFILKIEPPLGWSFEP
                     TTVELHVDGVSDICTKGGDINFVFTGFSVNGKVLSKGQPLGPAGVQVSLRNTGTEAKI
                     QSTVTQPGGKFAFFKVLPGDYEILATHPTWALKEASTTVRVTNSNANAASPLIVAGYN
                     VSGSVRSDGEPMKGVKFLLFSSLVTKEDVLGCNVSPVPGFQPQDESLVYLCYTVSRED
                     GSFSFYSLPSGGYTVIPFYRGERITFDVAPSRLDFTVEHDSLKIEPVFHVMGFSVTGR
                     VLNGPEGDGVPEAVVTLNNQIKVKTKADGSFRLENITTGTYTIHAQKEHLYFETVTIK
                     IAPNTPQLADIIATGFSVCGQISIIRFPDTVKQMNKYKVVLSSQDKDKSLVTVETDAH
                     GSFCFKAKPGTYKVQVMVPEAETRAGLTLKPQTFPLTVTNRPMMDVAFVQFLASVSGK
                     VSCLDTCGDLLVTLQSLSRQGEKRSLQLSGKVNAMTFTFDNVLPGKYKISIMHEDWCW
                     KNKSLEVEVLEDDMSAVEFRQTGYMLRCSLSHAITLEFYQDGNGRENVGIYNLSKGVN
                     RFCLSKPGVYKVTPRSCHRFEQAFYTYDTSSPSILTLTAIRHHVLGTITTDKMMDVTV
                     TIKSSIDSEPALVLGPLKSVQELRREQQLAEIEARRQEREKNGNEEGEERMTKPPVQE
                     MVDELQGPFSYDFSYWARSGEKITVTPSSKELLFYPPSMEAVVSGESCPGKLIEIHGK
                     AGLFLEGQIHPELEGVEIVISEKGASSPLITVFTDDKGAYSVGPLHSDLEYTVTSQKE
                     GYVLTAVEGTIGDFKAYALAGVSFEIKAEDDQPLPGVLLSLSGGLFRSNLLTQDNGIL
                     TFSNLSPGQYYFKPMMKEFRFEPSSQMIEVQEGQNLKITITGYRTAYSCYGTVSSLNG
                     EPEQGVAMEAVGQNDCSIYGEDTVTDEEGKFRLRGLLPGCVYHVQLKAEGNDHIERAL
                     PHHRVIEVGNNDIDDVNIIVFRQINQFDLSGNVITSSEYLPTLWVKLYKSENLDNPIQ
                     TVSLGQSLFFHFPPLLRDGENYVVLLDSTLPRSQYDYILPQVSFTAVGYHKHITLIFN
                     PTRKLPEQDIAQGSYIALPLTLLVLLAGYNHDKLIPLLLQLTSRLQGVRALGQAASDN
                     SGPEDAKRQAKKQKTRRT"
     exon            297..386
                     /gene="NOMO1"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            387..432
                     /gene="NOMO1"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            433..533
                     /gene="NOMO1"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            534..640
                     /gene="NOMO1"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            641..713
                     /gene="NOMO1"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            714..866
                     /gene="NOMO1"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1004
                     /gene="NOMO1"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1094
                     /gene="NOMO1"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1200
                     /gene="NOMO1"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1351
                     /gene="NOMO1"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1526
                     /gene="NOMO1"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1668
                     /gene="NOMO1"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1800
                     /gene="NOMO1"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..1937
                     /gene="NOMO1"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2025
                     /gene="NOMO1"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..2089
                     /gene="NOMO1"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2185
                     /gene="NOMO1"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..2404
                     /gene="NOMO1"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            2405..2487
                     /gene="NOMO1"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            2488..2647
                     /gene="NOMO1"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            2648..2774
                     /gene="NOMO1"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            2775..2888
                     /gene="NOMO1"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            2889..3016
                     /gene="NOMO1"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            3017..3158
                     /gene="NOMO1"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            3159..3242
                     /gene="NOMO1"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            3243..3353
                     /gene="NOMO1"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            3354..3455
                     /gene="NOMO1"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            3456..3575
                     /gene="NOMO1"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            3576..3668
                     /gene="NOMO1"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     exon            3669..4312
                     /gene="NOMO1"
                     /gene_synonym="Nomo; PM5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4279..4284
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOMO1"
                     /gene_synonym="Nomo; PM5"
                     /note="hexamer: AATAAA"
     polyA_site      4312
                     /gene="NOMO1"
                     /gene_synonym="Nomo; PM5"
                     /note="major polyA site"
ORIGIN      
        1 ggctctggcg gcggcggtgg ggcggggcct gggctgtcag ccggcctagg aggaggaagg
       61 agcctgcggc gtgcagtgtg aggggcggga cccggctgcc ggcggtgggt ctagctgggg
      121 gaggtcgggc catgctggtg ggccagggcg cggggccgct ggggcccgcg gtggtcaccg
      181 ccgcggtggt gctgctgctg agcggcgtgg ggccggcgca cggctcggag gacatcgtgg
      241 tgggctgcgg tggcttcgtc aagtcggacg tggagatcaa ctactctctc atcgagataa
      301 agctgtacac caagcatggg actttgaaat accagacaga ctgtgcccct aataatggtt
      361 actttatgat ccctttgtat gataaggggg atttcattct gaagattgag cctcccctag
      421 ggtggagttt tgagccgacg accgtggagc tccatgtgga tggagtcagt gacatctgca
      481 caaagggtgg ggacatcaac tttgtcttca ctgggttctc tgtgaatggc aaggtcctca
      541 gcaaagggca gcccctgggt cctgcgggag ttcaggtgtc tctgagaaac actgggaccg
      601 aagcaaagat ccagtccaca gttacacagc ctggcggaaa gtttgcattt tttaaagttc
      661 tgcctggaga ttatgaaatc ctcgcaactc atccaacctg ggcgttgaaa gaggcaagca
      721 ccacagtgcg tgtaaccaac tccaatgcca atgcggccag tcccctcata gttgctggct
      781 acaatgtgtc tggctctgtc cgaagtgatg gggagcccat gaaaggcgtg aagtttcttc
      841 tcttttcttc tttagtaact aaagaggatg tcctgggctg caatgtctca ccagtgcctg
      901 ggttccagcc ccaagacgag agtctggtgt atttgtgcta cacggtctcc agagaagatg
      961 gctcgttctc tttctattcc ttgccaagtg ggggctacac tgtgattccg ttctatcgag
     1021 gggagaggat tacctttgat gtggcgcctt ccagacttga cttcacagtg gagcatgaca
     1081 gcttgaaaat cgagcccgtg ttccacgtca tgggattctc cgtcaccggg agggtcttga
     1141 acggacccga aggagatggt gttccagaag cagtagtcac cctgaataac caaatcaaag
     1201 ttaaaacaaa agctgatggc tcattccgcc ttgagaacat aaccacaggg acatacacca
     1261 tccatgctca gaaagagcac ctctactttg aaacggtcac catcaaaatt gcaccgaaca
     1321 cacctcagct ggctgacatt attgcaacag ggttcagtgt ctgtggtcag atatcaatca
     1381 ttcgcttccc cgacaccgtc aagcagatga ataaatacaa agttgtcctg tcatctcaag
     1441 acaaggacaa gtctttggtc accgtggaga cagatgctca tggatcattt tgttttaaag
     1501 caaaaccagg gacttacaaa gtgcaggtga tggttcctga ggcagaaacc agagcagggc
     1561 tgacgttgaa accccagaca tttcctctta ctgtgaccaa caggcccatg atggatgtgg
     1621 cctttgtaca gttcttggca tcagtttctg ggaaagtctc ttgtttggac acctgtggtg
     1681 acttgctggt gactctacag tccctgagcc gccagggtga gaagcggagc ctccagctct
     1741 ccggcaaggt caacgccatg actttcacct ttgacaacgt gctccctgga aaatacaaaa
     1801 taagcatcat gcatgaggat tggtgctgga agaacaagag cctggaggtg gaagtgctgg
     1861 aggatgacat gtctgcagtt gagttcaggc agacgggcta catgctgaga tgttccctgt
     1921 ctcacgccat cactctggaa ttttatcagg atggaaatgg gcgtgagaat gtggggattt
     1981 ataacctctc caaaggagtc aaccgattct gcctgtccaa gcctggtgtg tacaaagtga
     2041 cccctcgctc ctgccaccgg tttgagcaag cgttctacac ctatgacacg tcttcaccta
     2101 gtatcttgac attgacagcc attcgccacc atgtccttgg aactatcacc accgacaaaa
     2161 tgatggatgt cactgtgact atcaagtctt ccatcgacag tgaacccgcc ttggtcttag
     2221 gccctctgaa gtctgtgcag gagctgcgga gggagcagca gctggctgag atcgaggccc
     2281 gcaggcagga gagggagaaa aacggcaatg aggaaggcga agaaagaatg accaagcctc
     2341 ccgtgcagga gatggtagat gagttacaag gccccttctc gtatgatttc tcttactggg
     2401 cgcggtctgg agagaaaatc actgttacac cgtcatctaa agagctgctc ttttatcccc
     2461 cttcaatgga agccgttgtc agtggagaaa gctgcccagg gaagctgatc gagatccatg
     2521 ggaaggcagg cctgttttta gaaggccaga tccaccccga gttggaagga gtcgagattg
     2581 tcatcagtga aaagggggca agttcaccgc tgatcacagt ctttactgat gacaaaggtg
     2641 cctacagtgt tggccccctg cacagtgacc tggagtacac ggtgacctca cagaaggagg
     2701 gctatgttct gactgcggtg gaaggaacca tcggagactt caaggcctat gccctggcag
     2761 gcgtaagctt tgagataaaa gctgaggatg accagcccct cccgggagtc ctcttatccc
     2821 tgagcggtgg cctgtttcgt tccaacctct tgacccagga caacggcatt ctgacattct
     2881 caaacctgag ccctggccag tattacttca aacccatgat gaaggagttc cggtttgagc
     2941 catcctcaca gatgatcgag gtgcaggaag gccagaacct gaagatcacc atcacggggt
     3001 accgaaccgc ttacagttgc tatggcacag tgtcttcctt aaacggagag cccgaacaag
     3061 gggttgccat ggaagcggtg ggccagaacg actgcagcat ttacggagaa gacaccgtga
     3121 cagacgaaga gggcaagttc agattacgtg gattgctgcc gggatgtgtg taccacgttc
     3181 agctcaaggc agaaggcaac gaccacattg agcgggcgct cccccaccat agggtgattg
     3241 aggttgggaa taatgacatc gatgatgtaa acatcatagt tttccggcag attaatcaat
     3301 ttgatttaag tggaaatgtg atcacttcct ctgaatacct tcctacatta tgggtcaagc
     3361 tttacaaaag cgaaaacctc gacaatccaa tccagacagt ttcccttggc cagtccctgt
     3421 tcttccattt ccccccactg ctcagagacg gcgagaacta tgttgtgctt ctggactcca
     3481 cactccccag atcccagtat gactacatct tgcctcaagt ttctttcacc gcagtgggct
     3541 accataaaca catcaccttg atttttaatc ccacgaggaa gctgcctgaa caggacatcg
     3601 cacaaggatc ctacattgcc ctgccattga cgctgctggt tctgctggcc ggttacaacc
     3661 atgacaagct cattcctttg ctgctgcagt tgacaagccg gctacaggga gtccgcgcgc
     3721 tcggccaggc agcctctgac aatagcggcc cagaagatgc aaagagacaa gccaagaaac
     3781 agaagacaag gcggacttga ggaggaaggg gacagttgca gtctcacttg ggacaggcca
     3841 cagccagggg tccggccact acccgcccgt gggataaaag ccaaaagcat gcgtcagcta
     3901 acttcagcct gtgctgctgg gcccgcaccc catgtccctt gtcactgtgg catcctgcac
     3961 ccatcctcac ccctccgtag agcccctcgt gcaatgcaat gaatggaccc tcctgtcact
     4021 ctgctgaaca gaatttattt tctgagtcaa atataattta ttattatttt tgtcaaagaa
     4081 gtatttaagc tgtgctgtgg tgtgagaatg tcattcttga tcttcagcct tcgtttgcaa
     4141 ggagagttcc agttgacgtg gtgtttggtt ccatggcggg gtaccctagg gattcatctg
     4201 ttttcttcac ttccctttgc atctgagatc ctgctggaaa ccacagcaac ctgtatccac
     4261 tattaggagg taaaaatcaa taaaatggcc cattcatttg tgttgtagct ca
//
