LOCUS       NM_138400               6082 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens nucleolar protein with MIF4G domain 1 (NOM1),
            transcript variant 1, mRNA.
ACCESSION   NM_138400 XM_049384 XM_374590
VERSION     NM_138400.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6082)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 6082)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 6082)
  AUTHORS   Solomon-Zemler,R., Pozniak,Y., Geiger,T. and Werner,H.
  TITLE     Identification of nucleolar protein NOM1 as a novel nuclear
            IGF1R-interacting protein
  JOURNAL   Mol Genet Metab 126 (3), 259-265 (2019)
   PUBMED   30639046
  REMARK    GeneRIF: Results are consistent with a physiologically-relevant
            interplay between the nuclear IGF1 signaling pathway and nucleolar
            protein NOM1.
REFERENCE   4  (bases 1 to 6082)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 6082)
  AUTHORS   Alexandrov,A., Colognori,D. and Steitz,J.A.
  TITLE     Human eIF4AIII interacts with an eIF4G-like partner, NOM1,
            revealing an evolutionarily conserved function outside the exon
            junction complex
  JOURNAL   Genes Dev 25 (10), 1078-1090 (2011)
   PUBMED   21576267
  REMARK    GeneRIF: demonstrate direct physical interactions between yeast
            Sgd1p and Fal1p, and between their human orthologs (NOM1 and
            eIF4AIII) in vitro and in vivo, identifying human NOM1 as a missing
            eIF4G-like interacting partner of eIF4AIII
REFERENCE   6  (bases 1 to 6082)
  AUTHORS   Gunawardena,S.R., Ruis,B.L., Meyer,J.A., Kapoor,M. and Conklin,K.F.
  TITLE     NOM1 targets protein phosphatase I to the nucleolus
  JOURNAL   J Biol Chem 283 (1), 398-404 (2008)
   PUBMED   17965019
  REMARK    GeneRIF: Data demonstrate that NOM1 can target PP1 to the nucleolus
            and show NOM1 nucleolar localization sequence are required for this
            targeting activity and conclude that NOM1 is a PP1 nucleolar
            targeting subunit, the first identified in eukaryotic cells.
REFERENCE   7  (bases 1 to 6082)
  AUTHORS   Simmons,H.M., Ruis,B.L., Kapoor,M., Hudacek,A.W. and Conklin,K.F.
  TITLE     Identification of NOM1, a nucleolar, eIF4A binding protein encoded
            within the chromosome 7q36 breakpoint region targeted in cases of
            pediatric acute myeloid leukemia
  JOURNAL   Gene 347 (1), 137-145 (2005)
   PUBMED   15715967
REFERENCE   8  (bases 1 to 6082)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   9  (bases 1 to 6082)
  AUTHORS   Heus,H.C., Hing,A., van Baren,M.J., Joosse,M., Breedveld,G.J.,
            Wang,J.C., Burgess,A., Donnis-Keller,H., Berglund,C., Zguricas,J.,
            Scherer,S.W., Rommens,J.M., Oostra,B.A. and Heutink,P.
  TITLE     A physical and transcriptional map of the preaxial polydactyly
            locus on chromosome 7q36
  JOURNAL   Genomics 57 (3), 342-351 (1999)
   PUBMED   10329000
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC006357.5 and AY576779.1.
            
            On Nov 22, 2018 this sequence version replaced NM_138400.1.
            
            Summary: Proteins that contain MIF4G (middle of eIF4G (MIM 600495))
            and/or MA3 domains, such as NOM1, function in protein translation.
            These domains include binding sites for members of the EIF4A family
            of ATP-dependent DEAD box RNA helicases (see EIF4A1; MIM 602641)
            (Simmons et al., 2005 [PubMed 15715967]).[supplied by OMIM, Mar
            2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY576779.1, SRR1803612.115891.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000275820.4/ ENSP00000275820.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AC006357.5         77255-77265         c
            12-6082             AY576779.1         1-6071
FEATURES             Location/Qualifiers
     source          1..6082
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.3"
     gene            1..6082
                     /gene="NOM1"
                     /gene_synonym="C7orf3; PPP1R113; SGD1"
                     /note="nucleolar protein with MIF4G domain 1"
                     /db_xref="GeneID:64434"
                     /db_xref="HGNC:HGNC:13244"
                     /db_xref="MIM:611269"
     exon            1..1013
                     /gene="NOM1"
                     /gene_synonym="C7orf3; PPP1R113; SGD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..2609
                     /gene="NOM1"
                     /gene_synonym="C7orf3; PPP1R113; SGD1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nucleolar MIF4G domain-containing protein 1; protein
                     phosphatase 1, regulatory subunit 113; SGD1 homolog"
                     /codon_start=1
                     /product="nucleolar MIF4G domain-containing protein 1
                     isoform 1"
                     /protein_id="NP_612409.1"
                     /db_xref="CCDS:CCDS34787.1"
                     /db_xref="GeneID:64434"
                     /db_xref="HGNC:HGNC:13244"
                     /db_xref="MIM:611269"
                     /translation="MAASRSAGEAGPGGSQGRVVRMKRRGGRGPRRGPAGGGEKALKR
                     LKLAVEEFVHATSEGEAPGGCEGRGAPVSFRPGGRKSRKELRKEKRHLRKARRLQRTA
                     GPEQGPGLGGRSGAEEASGHRQDTEERARPAPSRDPSPPRKPRPSRVKAKATAATAKT
                     RPSAAATAAARKRALLAANEEEDREIRKLERCLGLNKRKKKDGSSSVPLSFARDGLDY
                     ILGALESGKNSGLYDSSGEEEEDAGQTLPESDLESDSQDESEEEEEGDVEKEKKAQEA
                     EAQSEDDDEDTEEEQGEEKEKGAQEKRRGKRVRFAEDEEKSENSSEDGDITDKSLCGS
                     GEKYIPPHVRQAEETVDFKKKEELERLKKHVKGLLNRLSEPNMASISGQLEELYMAHS
                     RKDMNDTLTSALMGACVTASAMPSRLMMEHVLLVSILHHTVGIEVGAHFLEAVVRKFD
                     AIYKYGSEGKECDNLFTVIAHLYNFHVVQSLLIFDILKKLIGTFTEKDIELILLMLKN
                     VGFSLRKDDALSLKELITEAQTKASGAGSEFQDQTRIRFMLETMLALKNNDMRKIPGY
                     DPEPVEKLRKLQRALVRNAGSGSETQLRVSWDSVLSAEQTGRWWIVGSAWSGAPMIDN
                     SHHTHLQKQLVGTVSSKILELARKQRMNTDIRRNIFCTIMTSEDFLDAFEKLLKLGLK
                     DQQEREIIHVLMDCCLQEKTYNPFYAFLASKFCEYERRFQMTFQFSIWDKFRDLENLP
                     ATNFSNLVHLVAHLLKTKSLSLSILKVVEFSELDKPRVRFLRKVLSILLMETEVEDLS
                     LIFTRVSDNPKLGVLREGLKLFISHFLLKNAQAHRSADEANVLREKADLATKCLQGKA
                     SLRM"
     exon            1014..1138
                     /gene="NOM1"
                     /gene_synonym="C7orf3; PPP1R113; SGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1334
                     /gene="NOM1"
                     /gene_synonym="C7orf3; PPP1R113; SGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1658
                     /gene="NOM1"
                     /gene_synonym="C7orf3; PPP1R113; SGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1769
                     /gene="NOM1"
                     /gene_synonym="C7orf3; PPP1R113; SGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1937
                     /gene="NOM1"
                     /gene_synonym="C7orf3; PPP1R113; SGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2059
                     /gene="NOM1"
                     /gene_synonym="C7orf3; PPP1R113; SGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2192
                     /gene="NOM1"
                     /gene_synonym="C7orf3; PPP1R113; SGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2193..2324
                     /gene="NOM1"
                     /gene_synonym="C7orf3; PPP1R113; SGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2325..2434
                     /gene="NOM1"
                     /gene_synonym="C7orf3; PPP1R113; SGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2435..6082
                     /gene="NOM1"
                     /gene_synonym="C7orf3; PPP1R113; SGD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2730..2735
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOM1"
                     /gene_synonym="C7orf3; PPP1R113; SGD1"
                     /note="hexamer: ATTATA"
     polyA_site      2753
                     /gene="NOM1"
                     /gene_synonym="C7orf3; PPP1R113; SGD1"
                     /note="major polyA site"
     regulatory      6058..6063
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOM1"
                     /gene_synonym="C7orf3; PPP1R113; SGD1"
                     /note="hexamer: AATAAA"
     polyA_site      6082
                     /gene="NOM1"
                     /gene_synonym="C7orf3; PPP1R113; SGD1"
                     /note="major polyA site"
ORIGIN      
        1 agtcgtgcgt ccacgcgttt cgaaagatgg cggcgtccag gagcgcggga gaggccggcc
       61 cgggcggctc ccagggacgc gtggtccgca tgaagcgcag aggcgggcgc gggccgcgcc
      121 gcggtcctgc tggcggtggg gagaaggccc tgaagaggct gaagctagcg gtggaggagt
      181 tcgtgcacgc gacttcggaa ggcgaggctc ccgggggttg cgaggggcgc ggcgccccgg
      241 tgagctttcg cccgggaggg agaaaaagcc gtaaggaact gaggaaggag aagcggcacc
      301 tgcggaaagc acgccggctg cagaggacgg cgggccccga acagggtccc ggcctgggag
      361 gccgaagcgg agccgaagaa gccagcggtc accggcagga cacggaggag cgcgcccgcc
      421 cagcccctag tcgggacccc tcgcctccca ggaagccgcg gccgtcccgg gtcaaggcca
      481 aggccacggc cgccaccgca aagaccagac cctccgcagc cgccaccgcc gctgcccgga
      541 aacgggcgct tttagcggcg aacgaggagg aggaccgaga gatccgaaag ctggagcgtt
      601 gcctcggttt gaacaagcgc aaaaagaagg acggcagcag ctccgtgccg ctgagctttg
      661 cacgcgacgg tcttgactat attctgggag ccctggagtc tgggaaaaat agcggcttgt
      721 acgacagcag tggtgaggag gaggaagatg ccggacagac actccccgaa agtgacttag
      781 agagtgactc ccaggacgaa agtgaggagg aggaggaggg agacgtagaa aaggaaaaga
      841 aggcgcagga agcagaagcg cagagcgagg acgacgacga ggatacagaa gaggaacagg
      901 gggaagaaaa ggaaaaggga gcgcaggaga aaaggagggg gaagagagtc cgttttgcag
      961 aagatgaaga aaagagtgaa aattcctcgg aggacggtga cataacggat aagagtcttt
     1021 gtggaagtgg tgaaaagtac atcccacctc atgtgaggca agctgaggag acagtggact
     1081 tcaagaaaaa ggaagaacta gaaaggctga agaaacatgt aaaaggtcta cttaacaggt
     1141 tgagtgaacc caacatggct tccatcagtg ggcagctgga ggaactgtac atggcccaca
     1201 gcagaaagga catgaatgac accctgacct ccgctctcat gggtgcctgc gtcactgcct
     1261 cggccatgcc cagcagactg atgatggagc atgttctctt agtcagcatc cttcaccaca
     1321 cagttggaat cgaggtcggt gcccactttc tggaggcagt ggtgaggaag ttcgatgcca
     1381 tctataaata cggaagcgaa gggaaagagt gtgacaacct gttcaccgtc attgcccatt
     1441 tatacaactt ccacgtggta cagtctctcc tcatcttcga cattttgaaa aaactgattg
     1501 gaactttcac cgaaaaagat attgaactga tcttgttaat gctgaaaaac gtgggttttt
     1561 cattgaggaa agatgatgct ttatcactta aggaattgat cactgaagcc cagaccaaag
     1621 ccagcggggc aggcagcgag tttcaggacc agaccaggat tcggtttatg ctagagacga
     1681 tgttggccct gaagaacaat gacatgcgca aaattccagg ctatgacccc gagcccgtgg
     1741 agaagctgag gaaactgcag agagctttgg tccgcaacgc cggctcaggt tctgagacgc
     1801 agcttcgcgt ctcctgggac agtgtcttga gtgcggagca gacgggtcgc tggtggattg
     1861 tggggtccgc ctggagtggg gccccgatga tcgacaacag tcaccatacg cacctgcaga
     1921 agcagcttgt ggggacggtc agttcaaaga tcctagaact cgcccggaag cagaggatga
     1981 acacagacat ccggagaaac atattctgca caataatgac aagtgaagat tttttggatg
     2041 cttttgaaaa gcttctgaag cttggactta aggatcagca ggagagagaa atcattcacg
     2101 ttctcatgga ttgctgcctt caagagaaaa cttacaatcc cttctatgct ttcctggcta
     2161 gcaaattctg tgaatatgaa aggagatttc agatgacttt ccagttcagc atatgggaca
     2221 aatttcggga cttggaaaac ttgccagcta cgaatttctc taatttggtt catctggtgg
     2281 cccacttgtt gaagacaaaa tcgctttccc tttccatctt aaaggtagtt gaattcagtg
     2341 aattggacaa acccagagtc cgttttttac gaaaagtatt aagtatccta ttaatggaaa
     2401 cagaagttga agacctcagt ttaattttca caagagtatc tgacaaccca aagctggggg
     2461 tgttacgtga gggtttgaag cttttcatca gccacttctt gctaaagaac gcacaggccc
     2521 acagaagcgc cgacgaagcc aacgtgctga gagagaaagc tgaccttgca acgaagtgtc
     2581 tgcaaggaaa agcttccctg agaatgtagt cagggaagga aggagggcag gtggcccttt
     2641 gactgtaaaa tgtccttggt aaacccaaag gcttattctg ttgcctgcgt gtgaatgttt
     2701 ggtagagcta tatcattgtc tgttaatgta ttatattttg agattttttt tgatctaagg
     2761 ttttattgtt tgtatttcaa gccattttca aataactatc ttgggggtga gaggagaagg
     2821 agggagggaa aaggggtcag gcacactgga cagggttctc taagcagtga ggctggtgtg
     2881 tatgattgtc ttaaaatttt ttaatagata tggccgagcg tgatggctca cccctgtaat
     2941 cccagcactt tgtgaggcca aggtgggcgg atcacttgag gccaggaatt tgaaaccagc
     3001 ctgggcaaaa ccctgtctct actaaaaata taaaaattag ccaggcatga tggcacatgc
     3061 tggtaatagc agctactgag gtggctgagg cacaagaatt gcttggaccc tggaggtaga
     3121 ggctgcagtg agccaagatt gtaccactgt actccagcct gggctggaca gtgagacttt
     3181 tgacagtgag actgtcaaaa aaaaaaaaaa aattaataga taaaacaggc cactagaggg
     3241 tgcagttata aagaaattga tgaggttttt acctttttaa aatattggtt agaagttcaa
     3301 aaaccatccc ttaaaggtga ttgttttttt gagacagagt cttgctctgt cacccagagt
     3361 ggagtgcagt gtcctgtaat ctcagctcac tgcaacctct acctcccggg ttcaagcgat
     3421 tctcctgcct cagcctcttt agctgggact acaggcgcac gccaccacgc ccggctaatt
     3481 tttgtatttt agtagagatg ggtttcacca tgttggcaag gctggtcttg aactcctgac
     3541 ctcaggtgat acacccatct cggcctccca aagtgctggg attacaggct tgagccacca
     3601 cgcccagctt aaatgtgatt cttgatactg ttttaagtat ttaggttgca attaactttg
     3661 gcaaagtcag tcgacataag ccctgtggat atggccttat gtacactgta atgcagacag
     3721 gtgcttttca tcattcatgt aacattctca cacagttgag gatattcatc tcctcaccaa
     3781 ttccagattg taaatgtacc atcttaaaca actctgaggt caccaaacag tagttatttg
     3841 actgttaata ggtgctactt gcttgcaagg atttggagat gtaaacatga agaaaatata
     3901 gttactgcct gcaaagaatt aacatccgtc tagtgggaga aacaaacaca ccccactcac
     3961 taagtatgga aaactgattc tgggaggaag cagaaatgtc cctagataac agcatgtatt
     4021 gcagataccc aaatgtttat tgttttctca gcccttcaat tttgcttttc tctctcaaat
     4081 gctacagact caatttaaat cttacctttg attgttgaaa aaagtcacta agatgtgaat
     4141 acagaataga cattgagagg ttatatatgt ccaaaactca tctgtccagc agtcaccgtc
     4201 ctcttcagag tggtcacgtt gggcagatgg gcacaggtgc tggtgatgcc tctcctgggc
     4261 aaaacgcccc atttgtggca ctttcagata ctatttattt actttttaag agagagacag
     4321 gctcactctg tcacccaggc cagagtgcag tggcacgatc atagttaccg cagcatcaaa
     4381 ttcctggact gaagcggtcc ttttgcctca gcctcgcgga tagctaggac cacaagcagt
     4441 agagacaaga tctccgtatg ttatacaggc tggcctcaag tgatcctctt accttggcct
     4501 cccaaacacc gggattatag gcgtgagccc ccgtgcctgg cctcaaattt tattttagct
     4561 cgaccctatg gcagtttgtg tttggaaatc gtgatgtgaa gtcatcagta tctgtgcata
     4621 tccctaaact aatggtttaa gctttgaagc atgcgcaagc aacatgaaca actgaataca
     4681 gaaagtaact gaaagcagca cagagactgt gtcgtcccta cagacttcta accctgcatt
     4741 cagcaacatc attcgacccg aagccagatt caaaccctat gtcttctagc aggttctgaa
     4801 tttagaggac aaataaggtg acaggtacta agagaagagt gaattaagtg aaaatcttcc
     4861 ctttgttaag gagcttttta acaagagtgt ctttgctggg tggtgattgg gatgtaacag
     4921 atcagttcta ctggacttgt agcttgatag tgaaataagg agcttgggct aaggtataaa
     4981 tcaacacact gcttccttcc tccagaaggt cttactgtga aggaaaaaat gtcagttgaa
     5041 ctaaattgtg cttcacgcct cggtagattt gcattctgat gcaagccccc aacctcacgg
     5101 accaagagga tccctggctg cctgtgaatg gcccacattt gagtggtgct aacttgatgt
     5161 gagtaggcat taattatggg tgcggctact aagatgggaa aaactatcac gacagtggca
     5221 ccacctgatt tcatgatgta ccatatgcag taacccatgt ttgaggtaca gaattgaagc
     5281 tgatttttct gcaaaagatg aatttctata aacaatccca tttttatatt ttattattaa
     5341 aacaaaaata cctctctttg ctagagagtt atatgtatga cttaaattat tagctatggt
     5401 ttgcatttag tacatggcag attgcctgta agtctgttca ttttaacaac atacagggct
     5461 gggcacggtg gctcacgcct gtaatcccag cactttggga ggttgcgggt ggatcacttg
     5521 aggtcaggag ttcgagacca gcctggccaa catggcaaaa ccccgtctct atgaaaaata
     5581 taaaaattag ctgggcatgg tggcaggcac ctgtaatccc agctactcgg gaggctgagg
     5641 caggagaatc gcttgaacct gggaggcgga tgttgcagtg agcagagatc gtgccattgc
     5701 actccagcct gggaacaaga gtgaaactct caaaagcaga aacaaaaacc caacatatat
     5761 gggctgttag atagtaattg taatttcgta taaatagtaa atgagtacat cttgattaaa
     5821 agctatgaat tcagaattgc ttttaaatat atagggggtt ttttgaaatt tattacagtg
     5881 caattgaaaa tacacttaaa atactgcagg atgcttagtg ctcagtgtta tgtatgaact
     5941 tgtggacttt acaatgcagg ttgagaactg ctaatgtata gaatgactaa acagctgtct
     6001 ttcagggtat catttttaaa ggtataagga acaaacttta atgtattgaa atgcataaat
     6061 aaaatttatt ttttatattt tg
//
