LOCUS       NM_004741               3723 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens nucleolar and coiled-body phosphoprotein 1 (NOLC1),
            transcript variant 2, mRNA.
ACCESSION   NM_004741
VERSION     NM_004741.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3723)
  AUTHORS   Zhang,M., Zeng,Y., Wang,F., Feng,H., Liu,Q., Li,F., Zhao,S.,
            Zhao,J., Liu,Z., Zheng,F. and Liu,H.
  TITLE     Effects of the Nonstructural Protein-Nucleolar and Coiled-Body
            Phosphoprotein 1 Protein Interaction on rRNA Synthesis Through
            Telomeric Repeat-Binding Factor 2 Regulation Under Nucleolar Stress
  JOURNAL   AIDS Res Hum Retroviruses 40 (6), 408-416 (2024)
   PUBMED   38062753
  REMARK    GeneRIF: Effects of the Nonstructural Protein-Nucleolar and
            Coiled-Body Phosphoprotein 1 Protein Interaction on rRNA Synthesis
            Through Telomeric Repeat-Binding Factor 2 Regulation Under
            Nucleolar Stress.
REFERENCE   2  (bases 1 to 3723)
  AUTHORS   Choi,H., Kim,H.D., Choi,Y.W., Lim,H., Kim,K.W., Kim,K.S., Lee,Y.C.
            and Kim,C.H.
  TITLE     T7 phage display reveals NOLC1 as a GM3 binding partner in human
            breast cancer MCF-7 cells
  JOURNAL   Arch Biochem Biophys 750, 109810 (2023)
   PUBMED   37939867
  REMARK    GeneRIF: T7 phage display reveals NOLC1 as a GM3 binding partner in
            human breast cancer MCF-7 cells.
REFERENCE   3  (bases 1 to 3723)
  AUTHORS   Sun,Z., Zhang,Q., Lv,J., Sun,Y., Feng,Z., Zhang,M., Zhang,F.,
            Xia,C., Gao,Y., Zhang,Z., Zuo,Y.F. and Ren,S.Y.
  TITLE     High expression of NOLC1 as an independent prognostic factor for
            survival in patients with colorectal cancer
  JOURNAL   J Cancer Res Clin Oncol 149 (17), 15697-15712 (2023)
   PUBMED   37670166
  REMARK    GeneRIF: High expression of NOLC1 as an independent prognostic
            factor for survival in patients with colorectal cancer.
REFERENCE   4  (bases 1 to 3723)
  AUTHORS   Zhai,F., Wang,J., Luo,X., Ye,M. and Jin,X.
  TITLE     Roles of NOLC1 in cancers and viral infection
  JOURNAL   J Cancer Res Clin Oncol 149 (12), 10593-10608 (2023)
   PUBMED   37296317
  REMARK    GeneRIF: Roles of NOLC1 in cancers and viral infection.
            Review article
REFERENCE   5  (bases 1 to 3723)
  AUTHORS   Kim,W., Yeo,D.Y., Choi,S.K., Kim,H.Y., Lee,S.W., Ashim,J.,
            Han,J.E., Yu,W., Jeong,H., Park,J.K. and Park,S.
  TITLE     NOLC1 knockdown suppresses prostate cancer progressions by reducing
            AKT phosphorylation and beta-catenin accumulation
  JOURNAL   Biochem Biophys Res Commun 635, 99-107 (2022)
   PUBMED   36265288
  REMARK    GeneRIF: NOLC1 knockdown suppresses prostate cancer progressions by
            reducing AKT phosphorylation and beta-catenin accumulation.
REFERENCE   6  (bases 1 to 3723)
  AUTHORS   Chiu,C.M., Tsay,Y.G., Chang,C.J. and Lee,S.C.
  TITLE     Nopp140 is a mediator of the protein kinase A signaling pathway
            that activates the acute phase response alpha1-acid glycoprotein
            gene
  JOURNAL   J Biol Chem 277 (42), 39102-39111 (2002)
   PUBMED   12167624
  REMARK    GeneRIF: NOPP140 is involved in a PKA signaling pathway that leads
            to agp activation
REFERENCE   7  (bases 1 to 3723)
  AUTHORS   Chen,H.K., Pai,C.Y., Huang,J.Y. and Yeh,N.H.
  TITLE     Human Nopp140, which interacts with RNA polymerase I: implications
            for rRNA gene transcription and nucleolar structural organization
  JOURNAL   Mol Cell Biol 19 (12), 8536-8546 (1999)
   PUBMED   10567578
REFERENCE   8  (bases 1 to 3723)
  AUTHORS   Chen,H.K. and Yeh,N.H.
  TITLE     The nucleolar phosphoprotein P130 is a GTPase/ATPase with intrinsic
            property to form large complexes triggered by F- and Mg2+
  JOURNAL   Biochem Biophys Res Commun 230 (2), 370-375 (1997)
   PUBMED   9016786
REFERENCE   9  (bases 1 to 3723)
  AUTHORS   Pai,C.Y. and Yeh,N.H.
  TITLE     Cell proliferation-dependent expression of two isoforms of the
            nucleolar phosphoprotein p130
  JOURNAL   Biochem Biophys Res Commun 221 (3), 581-587 (1996)
   PUBMED   8630004
REFERENCE   10 (bases 1 to 3723)
  AUTHORS   Pai,C.Y., Chen,H.K., Sheu,H.L. and Yeh,N.H.
  TITLE     Cell-cycle-dependent alterations of a highly phosphorylated
            nucleolar protein p130 are associated with nucleologenesis
  JOURNAL   J Cell Sci 108 (Pt 5), 1911-1920 (1995)
   PUBMED   7657714
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK314363.1, BC006769.2 and AL520884.3.
            
            On Jun 2, 2019 this sequence version replaced NM_004741.4.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 1. This
            results in a shorter protein (isoform 2), compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.170269.1,
                                           SRR1803617.144290.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000605788.6/ ENSP00000474710.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1798              AK314363.1         1-1798
            1799-2991           BC006769.2         1297-2489
            2992-3723           AL520884.3         94-825
FEATURES             Location/Qualifiers
     source          1..3723
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.32"
     gene            1..3723
                     /gene="NOLC1"
                     /gene_synonym="NOPP130; NOPP140; NS5ATP13; P130; Srp40"
                     /note="nucleolar and coiled-body phosphoprotein 1"
                     /db_xref="GeneID:9221"
                     /db_xref="HGNC:HGNC:15608"
                     /db_xref="MIM:602394"
     exon            1..142
                     /gene="NOLC1"
                     /gene_synonym="NOPP130; NOPP140; NS5ATP13; P130; Srp40"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..2122
                     /gene="NOLC1"
                     /gene_synonym="NOPP130; NOPP140; NS5ATP13; P130; Srp40"
                     /note="isoform 2 is encoded by transcript variant 2;
                     nucleolar protein p130; nucleolar and coiled-body
                     phosphprotein 1; nucleolar phosphoprotein p130; HCV NS5A
                     trans-regulated protein 13; nucleolar 130 kDa protein; 140
                     kDa nucleolar phosphoprotein; HCV NS5A-transactivated
                     protein 13; hepatitis C virus NS5A-transactivated protein
                     13"
                     /codon_start=1
                     /product="nucleolar and coiled-body phosphoprotein 1
                     isoform 2"
                     /protein_id="NP_004732.2"
                     /db_xref="CCDS:CCDS7530.1"
                     /db_xref="GeneID:9221"
                     /db_xref="HGNC:HGNC:15608"
                     /db_xref="MIM:602394"
                     /translation="MADAGIRRVVPSDLYPLVLGFLRDNQLSEVANKFAKATGATQQD
                     ANASSLLDIYSFWLKSAKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPA
                     KKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAP
                     PKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSS
                     SSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEE
                     EQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSE
                     EEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPA
                     VTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKAT
                     AKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPAS
                     AKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEE
                     EEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNTFPKRKKGEKRASSP
                     FRRVREEEIEVDSRVADNSFDAKRGAAGDWGERANQVLKFTKGKSFRHEKTKKKRGSY
                     RGGSISVQVNSIKFDSE"
     exon            143..198
                     /gene="NOLC1"
                     /gene_synonym="NOPP130; NOPP140; NS5ATP13; P130; Srp40"
                     /inference="alignment:Splign:2.1.0"
     exon            199..338
                     /gene="NOLC1"
                     /gene_synonym="NOPP130; NOPP140; NS5ATP13; P130; Srp40"
                     /inference="alignment:Splign:2.1.0"
     exon            339..463
                     /gene="NOLC1"
                     /gene_synonym="NOPP130; NOPP140; NS5ATP13; P130; Srp40"
                     /inference="alignment:Splign:2.1.0"
     exon            464..629
                     /gene="NOLC1"
                     /gene_synonym="NOPP130; NOPP140; NS5ATP13; P130; Srp40"
                     /inference="alignment:Splign:2.1.0"
     exon            630..745
                     /gene="NOLC1"
                     /gene_synonym="NOPP130; NOPP140; NS5ATP13; P130; Srp40"
                     /inference="alignment:Splign:2.1.0"
     exon            746..881
                     /gene="NOLC1"
                     /gene_synonym="NOPP130; NOPP140; NS5ATP13; P130; Srp40"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1010
                     /gene="NOLC1"
                     /gene_synonym="NOPP130; NOPP140; NS5ATP13; P130; Srp40"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1121
                     /gene="NOLC1"
                     /gene_synonym="NOPP130; NOPP140; NS5ATP13; P130; Srp40"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1763
                     /gene="NOLC1"
                     /gene_synonym="NOPP130; NOPP140; NS5ATP13; P130; Srp40"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1870
                     /gene="NOLC1"
                     /gene_synonym="NOPP130; NOPP140; NS5ATP13; P130; Srp40"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..1963
                     /gene="NOLC1"
                     /gene_synonym="NOPP130; NOPP140; NS5ATP13; P130; Srp40"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..3723
                     /gene="NOLC1"
                     /gene_synonym="NOPP130; NOPP140; NS5ATP13; P130; Srp40"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3699..3704
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOLC1"
                     /gene_synonym="NOPP130; NOPP140; NS5ATP13; P130; Srp40"
                     /note="hexamer: AATAAA"
     polyA_site      3723
                     /gene="NOLC1"
                     /gene_synonym="NOPP130; NOPP140; NS5ATP13; P130; Srp40"
                     /note="major polyA site"
ORIGIN      
        1 agtgacgcgt attgcctgga ggatggcgga cgccggcatt cgccgcgtgg ttcccagcga
       61 cctgtatccc ctcgtgctcg gcttcctgcg cgataaccaa ctctcagagg tggccaataa
      121 gttcgccaaa gcgacaggag ctacacagca ggatgccaat gcctcttccc tcttagacat
      181 ctatagcttc tggctcaagt ctgccaaggt cccagagcga aagttacagg caaatggacc
      241 agtggctaag aaagctaaga agaaggcctc atccagtgac agtgaggaca gcagcgagga
      301 ggaggaggaa gttcaagggc ctccagcaaa gaaggctgct gtacctgcca agcgagtcgg
      361 tctgcctcct gggaaggctg cagccaaagc atcagagagt agcagcagtg aagagtccag
      421 tgatgatgat gatgaggagg accaaaagaa acagcctgtc cagaagggag ttaagcccca
      481 agccaaggca gccaaagctc ctcctaagaa ggccaagagc tctgattctg attctgactc
      541 aagctccgag gatgagccac caaagaacca gaagccaaag ataacacctg tgacagttaa
      601 agctcagact aaagcccctc ccaaaccagc tcgagcagca cctaaaatag ccaatggtaa
      661 agcagccagt agcagcagta gcagcagcag cagcagtagc agtgatgact cagaggagga
      721 gaaggcagca gccaccccca agaagactgt acctaaaaag caagttgtgg ccaaggcccc
      781 agtgaaagca gctaccaccc ctacccggaa gagttctagc agtgaggatt cctccagtga
      841 cgaggaagag gagcaaaaaa aacccatgaa aaataaacca ggtccctaca gttcagtccc
      901 cccgccttct gctcccccac caaagaagtc tctgggaacc cagcctccca agaaggctgt
      961 ggagaagcag cagcctgtgg aaagcagtga agacagcagt gatgagtctg attcaagttc
     1021 tgaagaagag aagaaacccc caactaaggc agtagtctct aaagcaacca ctaaaccacc
     1081 tccagcaaag aaagcagcag agagctcttc agacagctca gactctgaca gctctgagga
     1141 tgatgaagct ccttctaagc cagctggtac caccaagaat tcttcaaata agccagctgt
     1201 caccaccaag tcacctgcag tgaagccagc tgcagccccc aagcaacctg tgggcggtgg
     1261 ccagaagctt ctgacgagaa aggctgacag cagctccagt gaggaagaga gcagctccag
     1321 tgaggaggag aagacaaaga agatggtggc caccactaag cccaaggcga ctgccaaagc
     1381 agctctatct ctgcctgcca agcaggctcc tcagggtagt agggacagca gctctgattc
     1441 agacagctcc agcagtgagg aggaggaaga gaagacatct aagtctgcag ttaagaagaa
     1501 gccacagaag gtagcaggag gtgcagcccc ttccaagcca gcctctgcaa agaaaggaaa
     1561 ggctgagagc agcaacagtt cttcttctga tgactccagt gaggaagagg aagagaagct
     1621 caagggcaag ggctctccaa gaccacaagc ccccaaggcc aatggcacct ctgcactgac
     1681 tgcccagaat ggaaaagcag ctaagaacag tgaggaggag gaagaagaaa agaaaaaggc
     1741 ggcagtggta gtttccaaat caggttcatt aaagaagcgg aagcagaatg aggctgccaa
     1801 ggaggcagag actcctcagg ccaagaagat aaagcttcag acccctaaca catttccaaa
     1861 aaggaagaaa ggagaaaaaa gggcatcatc cccattccga agggtcaggg aggaggaaat
     1921 tgaggtggat tcacgagttg cggacaactc ctttgatgcc aagcgaggtg cagccggaga
     1981 ctggggagag cgagccaatc aggttttgaa gttcaccaaa ggcaagtcct ttcggcatga
     2041 gaaaaccaag aagaagcggg gcagctaccg gggaggctca atctctgtcc aggtcaattc
     2101 tattaagttt gacagcgagt gacctgaggc catcttcggt gaagcaaggg tgatgatcgg
     2161 agactactta ctttctccag tggacctggg aaccctcagg tctctaggtg agggtcttga
     2221 tgaggacaga agtttagagt aggtcctaag actttacagt gtaacatcct ctctggtcct
     2281 tttctgtgtt cctagttttg tacagacttg tttttgagtg ttgagtagca gggacaaaat
     2341 aagggaatgt tattttttaa gaaaattcat tttcattgtt gtctccttcc ttttctgtga
     2401 aagtcctcat actgagaaat ttgtatattt tatattaaat cacttactat tgatttttgt
     2461 tgtgattttc aaaggtggat tcccacagat aaaatcttgg ctattgccca aaacatagta
     2521 aagggtcacg tgtgactttt tataatagga agaaaattct gcctttgtga gtgcacatgt
     2581 ccacatttca tccctccttc cctcaaaacc ctagagaggg gcattaaaga attgttgatg
     2641 tatatgcaat gtctgttaag catgcactat gtatttcatc ctcatttatt gggtctggga
     2701 ctgaagtttt tagccagcat ggacctaacc tactttttgg gataaaattc tctgttttgt
     2761 tacaggcaaa attctggtat ggcgtgaatg ccatgggtca ttctgaatat atttttttct
     2821 gtaattttat cattacacga tgtttgcaat acgtgctttg ttttttaatt tgaaagcaaa
     2881 cttttctact gttgaaagac attttttgac aacttgaccc ttcctagtat tgagttctaa
     2941 gttgaggact gcatcttctc gttttttaca gtatagagaa caaaatgaca tgagtttgaa
     3001 aaatacatat cacttggtat tgctgtcttg gttgcagtgg tgatacagaa ttggtttcat
     3061 taattcctac atggttgaga atcactgatc aagaaagtgg ggggaaaaaa aacaaacgtt
     3121 aaaacctcaa tcctcagtag gaaggtagat tacattaggt gaaattatag gtaatctatg
     3181 tatgtgctaa tggggttgga aagaacctta cagagcatat tacctgataa actggagtgg
     3241 gtttgggaga acaaactaat aggattattg tgtctcctag ttggtacctg ggagcaattg
     3301 acatgccccc ttcagaacct taactgttag tagcagtggc tgtaacaaca caaaccagtg
     3361 accagagata acagctttta ggccaagctg gcctgacggt atggctgcag gaagtgactg
     3421 agcagtagcg gtactcagcc agaccaagac ggagagggaa gagtccacag ctttctggaa
     3481 gctaaggcat tctggtggta gaaaagtgtg ccccaagcct tcatggacga gttataggtc
     3541 ttaagattag tctcctcttg tttggattcc atacttgcta aataacctga taataacctg
     3601 gttttccatg taactgcctc taggaagaaa atgtactgtt catgctgaca cagatatttc
     3661 agtctgcatg gtaaaagttc taaatcttac tacaaaataa taaactggct ggtttataat
     3721 gtg
//
