LOCUS       NM_017948               4075 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens nucleolar protein 8 (NOL8), transcript variant 1,
            mRNA.
ACCESSION   NM_017948
VERSION     NM_017948.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4075)
  AUTHORS   Gu,S., Hou,P., Liu,K., Niu,X., Wei,B., Mao,F. and Xu,Z.
  TITLE     NOL8, the binding protein for beta-catenin, promoted the growth and
            migration of prostate cancer cells
  JOURNAL   Chem Biol Interact 294, 40-47 (2018)
   PUBMED   30125550
REFERENCE   2  (bases 1 to 4075)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 4075)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 4075)
  AUTHORS   Sekiguchi,T., Hayano,T., Yanagida,M., Takahashi,N. and Nishimoto,T.
  TITLE     NOP132 is required for proper nucleolus localization of DEAD-box
            RNA helicase DDX47
  JOURNAL   Nucleic Acids Res 34 (16), 4593-4608 (2006)
   PUBMED   16963496
REFERENCE   5  (bases 1 to 4075)
  AUTHORS   Jinawath,N., Furukawa,Y. and Nakamura,Y.
  TITLE     Identification of NOL8, a nucleolar protein containing an RNA
            recognition motif (RRM), which was overexpressed in diffuse-type
            gastric cancer
  JOURNAL   Cancer Sci 95 (5), 430-435 (2004)
   PUBMED   15132771
REFERENCE   6  (bases 1 to 4075)
  AUTHORS   Sekiguchi,T., Todaka,Y., Wang,Y., Hirose,E., Nakashima,N. and
            Nishimoto,T.
  TITLE     A novel human nucleolar protein, Nop132, binds to the G proteins,
            RRAG A/C/D
  JOURNAL   J Biol Chem 279 (9), 8343-8350 (2004)
   PUBMED   14660641
  REMARK    GeneRIF: nucleolar protein 132(Nop132) is associated with the GTP
            form, but not the GDP form, of ras-related GTP binding protein RRAG
            A, suggesting that RRAG A might regulate Nop132 function
REFERENCE   7  (bases 1 to 4075)
  AUTHORS   Sekiguchi,T., Hirose,E., Nakashima,N., Ii,M. and Nishimoto,T.
  TITLE     Novel G proteins, Rag C and Rag D, interact with GTP-binding
            proteins, Rag A and Rag B
  JOURNAL   J Biol Chem 276 (10), 7246-7257 (2001)
   PUBMED   11073942
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB105104.1 and AL136097.10.
            
            On Nov 23, 2018 this sequence version replaced NM_017948.5.
            
            Summary: NOL8 binds Ras-related GTP-binding proteins (see MIM
            608267) and plays a role in cell growth (Sekiguchi et al., 2004
            [PubMed 14660641]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB105104.1, SRR1803616.210771.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000442668.7/ ENSP00000401177.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3910              AB105104.1         211-4120
            3911-3925           AL136097.10        132337-132351       c
            3926-4075           AB105104.1         4136-4285
FEATURES             Location/Qualifiers
     source          1..4075
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.31"
     gene            1..4075
                     /gene="NOL8"
                     /gene_synonym="bA62C3.3; bA62C3.4; C9orf34; NOP132"
                     /note="nucleolar protein 8"
                     /db_xref="GeneID:55035"
                     /db_xref="HGNC:HGNC:23387"
                     /db_xref="MIM:611534"
     exon            1..45
                     /gene="NOL8"
                     /gene_synonym="bA62C3.3; bA62C3.4; C9orf34; NOP132"
                     /inference="alignment:Splign:2.1.0"
     exon            46..232
                     /gene="NOL8"
                     /gene_synonym="bA62C3.3; bA62C3.4; C9orf34; NOP132"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..3597
                     /gene="NOL8"
                     /gene_synonym="bA62C3.3; bA62C3.4; C9orf34; NOP132"
                     /note="isoform a is encoded by transcript variant 1;
                     nucleolar protein Nop132"
                     /codon_start=1
                     /product="nucleolar protein 8 isoform a"
                     /protein_id="NP_060418.4"
                     /db_xref="CCDS:CCDS47993.1"
                     /db_xref="GeneID:55035"
                     /db_xref="HGNC:HGNC:23387"
                     /db_xref="MIM:611534"
                     /translation="MKVNRETKRLYVGGLSQDISEADLQNQFSRFGEVSDVEIITRKD
                     DQGNPQKVFAYINISVAEADLKKCMSVLNKTKWKGGTLQIQLAKESFLHRLAQEREAA
                     KAKKEESTTGNANLLEKTGGVDFHMKAVPGTEVPGHKNWVVSKFGRVLPVLHLKNQHK
                     RKIIKYDPSKYCHNLKKIGEDFSNTIPISSLTWELEGGNDPMSKKRRGEFSDFHGPPK
                     KIIKVQKDESSTGSLAMSTRPRRVIERPPLTQQQAAQKRTCDSITPSKSSPVPVSDTQ
                     KLKNLPFKTSGLETAKKRNSISDDDTDSEDELRMMIAKEENLQRTTQPSINESESDPF
                     EVVRDDFKSGVHKLHSLIGLGIKNRVSCHDSDDDIMRNDREYDSGDTDEIIAMKKNVA
                     KVKNSTEFSQMEKSTKKTSFKNRENCELSDHCIKLQKRKSNVESALSHGLKSLNRKSP
                     SHSSSSEDADSASELADSEGGEEYNAMMKNCLRVNLTLADLEQLAGSDLKVPNEDTKS
                     DGPETTTQCKFDRGSKSPKTPTGLRRGRQCIRPAEIVASLLEGEENTCGKQKPKENNL
                     KPKFQAFKGVGCLYEKESMKKSLKDSVASNNKDQNSMKHEDPSIISMEDGSPYVNGSL
                     GEVTPCQHAKKANGPNYIQPQKRQTTFESQDRKAVSPSSSEKRSKNPISRPLEGKKSL
                     SLSAKTHNIGFDKDSCHSTTKTEASQEERSDSSGLTSLKKSPKVSSKDTREIKTDFSL
                     SISNSSDVSAKDKHAEDNEKRLAALEARQKAKEVQKKLVHNALANLDGHPEDKPTHII
                     FGSDSECETEETSTQEQSHPGEEWVKESMGKTSGKLFDSSDDDESDSEDDSNRFKIKP
                     QFEGRAGQKLMDLQSHFGTDDRFRMDSRFLETDSEEEQEEVNEKKTAEEEELAEEKKK
                     ALNVVQSVLQINLSNSTNRGSVAAKKFKDIIHYDPTKQDHATYERKRDDKPKESKAKR
                     KKKREEAEKLPEVSKEMYYNIAMDLKEIFQTTKYTSEKEEGTPWNEDCGKEKPEEIQD
                     PAALTSDAEQPSGFTFSFFDSDTKDIKEETYRVETVKPGKIVWQEDPRLQDSSSEEED
                     VTEETDHRNSSPGEASLLEKETTRFFFFSKNDERLQGSDLFWRGVGSNMSRNSWEART
                     TNLRMDCRKKHKDAKRKMKPK"
     exon            233..295
                     /gene="NOL8"
                     /gene_synonym="bA62C3.3; bA62C3.4; C9orf34; NOP132"
                     /inference="alignment:Splign:2.1.0"
     exon            296..374
                     /gene="NOL8"
                     /gene_synonym="bA62C3.3; bA62C3.4; C9orf34; NOP132"
                     /inference="alignment:Splign:2.1.0"
     exon            375..510
                     /gene="NOL8"
                     /gene_synonym="bA62C3.3; bA62C3.4; C9orf34; NOP132"
                     /inference="alignment:Splign:2.1.0"
     exon            511..579
                     /gene="NOL8"
                     /gene_synonym="bA62C3.3; bA62C3.4; C9orf34; NOP132"
                     /inference="alignment:Splign:2.1.0"
     exon            580..2451
                     /gene="NOL8"
                     /gene_synonym="bA62C3.3; bA62C3.4; C9orf34; NOP132"
                     /inference="alignment:Splign:2.1.0"
     exon            2452..2565
                     /gene="NOL8"
                     /gene_synonym="bA62C3.3; bA62C3.4; C9orf34; NOP132"
                     /inference="alignment:Splign:2.1.0"
     exon            2566..2688
                     /gene="NOL8"
                     /gene_synonym="bA62C3.3; bA62C3.4; C9orf34; NOP132"
                     /inference="alignment:Splign:2.1.0"
     exon            2689..2779
                     /gene="NOL8"
                     /gene_synonym="bA62C3.3; bA62C3.4; C9orf34; NOP132"
                     /inference="alignment:Splign:2.1.0"
     exon            2780..2918
                     /gene="NOL8"
                     /gene_synonym="bA62C3.3; bA62C3.4; C9orf34; NOP132"
                     /inference="alignment:Splign:2.1.0"
     exon            2919..2996
                     /gene="NOL8"
                     /gene_synonym="bA62C3.3; bA62C3.4; C9orf34; NOP132"
                     /inference="alignment:Splign:2.1.0"
     exon            2997..3268
                     /gene="NOL8"
                     /gene_synonym="bA62C3.3; bA62C3.4; C9orf34; NOP132"
                     /inference="alignment:Splign:2.1.0"
     exon            3269..3395
                     /gene="NOL8"
                     /gene_synonym="bA62C3.3; bA62C3.4; C9orf34; NOP132"
                     /inference="alignment:Splign:2.1.0"
     exon            3396..3466
                     /gene="NOL8"
                     /gene_synonym="bA62C3.3; bA62C3.4; C9orf34; NOP132"
                     /inference="alignment:Splign:2.1.0"
     exon            3467..3546
                     /gene="NOL8"
                     /gene_synonym="bA62C3.3; bA62C3.4; C9orf34; NOP132"
                     /inference="alignment:Splign:2.1.0"
     exon            3547..4075
                     /gene="NOL8"
                     /gene_synonym="bA62C3.3; bA62C3.4; C9orf34; NOP132"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3794..3799
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOL8"
                     /gene_synonym="bA62C3.3; bA62C3.4; C9orf34; NOP132"
                     /note="hexamer: ATTAAA"
     polyA_site      3819
                     /gene="NOL8"
                     /gene_synonym="bA62C3.3; bA62C3.4; C9orf34; NOP132"
                     /note="major polyA site"
     regulatory      3926..3931
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOL8"
                     /gene_synonym="bA62C3.3; bA62C3.4; C9orf34; NOP132"
                     /note="hexamer: AATAAA"
     polyA_site      3956
                     /gene="NOL8"
                     /gene_synonym="bA62C3.3; bA62C3.4; C9orf34; NOP132"
                     /note="major polyA site"
     regulatory      4047..4052
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOL8"
                     /gene_synonym="bA62C3.3; bA62C3.4; C9orf34; NOP132"
                     /note="hexamer: GATAAA"
     polyA_site      4075
                     /gene="NOL8"
                     /gene_synonym="bA62C3.3; bA62C3.4; C9orf34; NOP132"
                     /note="major polyA site"
ORIGIN      
        1 agaagttagg ggctgcagcg gcgctggctt taggtgaacg acgtgaaaat tacttttccc
       61 actgaaacac acccaagtat atgcccagcc ttcatgaaag tgaacagaga aacgaagcgc
      121 ctttatgtgg gtggccttag ccaggacatt tctgaggcag acctacaaaa tcagttcagc
      181 agatttggag aagtttcgga tgtggagatc atcacacgga aagatgacca aggaaaccca
      241 cagaaagttt ttgcatatat caacatcagt gtagcagaag cggacctgaa aaaatgtatg
      301 tctgttttaa ataaaacaaa atggaaaggt ggaacattac aaattcaact agcaaaagaa
      361 agctttctgc acagattggc ccaagagaga gaagcagcaa aagctaagaa agaagaatca
      421 acaacaggta acgccaactt gttagaaaag acaggaggag tggatttcca tatgaaagct
      481 gtgccaggga cagaagtgcc agggcataag aattgggttg tgagcaaatt tggaagagtc
      541 ttacctgttc ttcaccttaa aaatcaacat aaacgtaaaa tcatcaaata tgatccctca
      601 aaatactgcc acaacctgaa gaagataggg gaggatttct caaacaccat tcctatatcc
      661 agcctgactt gggaattaga aggagggaat gaccctatga gtaagaaacg gcgaggagag
      721 ttctctgact ttcatggccc tcccaagaag ataataaaag tgcagaagga tgagagttcc
      781 actgggtctc tggccatgag tacaaggccc aggagggtaa tagagagacc acccttaaca
      841 cagcaacagg ctgcacaaaa aagaacttgt gattccatta ctccttctaa atcatctcct
      901 gtacctgttt ctgatactca gaaacttaaa aatctacctt ttaagacttc tggcttggaa
      961 actgccaaga agagaaacag catttctgat gatgatactg attctgaaga tgaattgaga
     1021 atgatgattg cgaaagagga aaacttacag agaactacac aaccctcaat aaatgaatct
     1081 gaaagtgatc cttttgaagt tgtaagggat gatttcaaat caggcgttca caaactgcat
     1141 tctttaatag gtttaggtat caaaaatcgt gtctcttgcc atgatagtga tgatgatatt
     1201 atgagaaatg atcgtgagta tgactcagga gatacagatg aaattattgc gatgaaaaaa
     1261 aatgttgcta aggtcaaaaa cagtacagaa ttttcacaaa tggaaaaatc tacgaagaaa
     1321 acttctttca aaaatagaga aaactgtgag ctttctgatc actgtattaa actacaaaaa
     1381 agaaaaagca atgtagagtc agccctcagt catggattaa agtctcttaa tcgtaaatct
     1441 ccctctcact ccagtagcag tgaagatgct gattctgcat cagaattagc tgactctgaa
     1501 ggaggtgagg agtataatgc catgatgaaa aactgccttc gtgtgaatct cactttagct
     1561 gatttggaac aattggctgg cagtgatctg aaggttccaa atgaagatac taagagtgat
     1621 ggaccagaaa ccaccaccca atgcaagttt gacagaggct ccaagagccc caagactccc
     1681 actggcctcc gcagaggccg acagtgtatt cgtcctgcgg agattgtggc ttccctgtta
     1741 gaaggagagg agaacacctg tggcaaacag aaaccaaagg aaaacaattt aaagccaaaa
     1801 tttcaggctt tcaagggagt aggctgtcta tatgaaaagg agtcaatgaa aaaatccttg
     1861 aaagacagtg ttgcctctaa caataaagat cagaattcca tgaaacatga ggatcccagt
     1921 atcatatcca tggaagatgg gtccccatat gttaatggct cattaggtga agtgactcca
     1981 tgccaacatg caaagaaggc gaatggccca aactatattc agcctcaaaa aagacagacc
     2041 acttttgaaa gccaggatcg caaggcagtg tcccctagca gttctgaaaa gagaagtaag
     2101 aatcctattt ctaggccatt agaaggtaag aagtccttaa gtcttagtgc aaagactcac
     2161 aacataggct ttgacaaaga cagctgccat agtaccacaa agacagaagc ttcacaggaa
     2221 gagcggtctg attcaagcgg cctcacatct ctcaagaaat caccaaaggt ctcatccaag
     2281 gacactcggg aaatcaaaac tgatttctca ctttctatta gtaattcgtc agatgtgagt
     2341 gctaaagata agcatgctga agacaatgag aagcgtttgg cagccttgga agcgaggcaa
     2401 aaagcaaaag aagtgcagaa gaagctggtg cataatgctc tggcaaattt ggatggtcat
     2461 ccagaggata agccaacgca catcatcttc ggttctgaca gtgaatgtga aacagaggag
     2521 acatcgactc aggagcagag ccatccagga gaggaatggg tgaaagagtc tatgggtaaa
     2581 acatcaggga agctgtttga tagcagtgat gatgacgaat ctgattctga agatgacagt
     2641 aataggttca aaattaaacc tcagtttgag ggcagagctg gacagaagct catggattta
     2701 cagtcgcact ttggcaccga tgacagattc cgcatggact ctcgatttct agaaactgac
     2761 agtgaagagg aacaggaaga ggtaaatgaa aagaaaactg ctgaggaaga agagcttgct
     2821 gaagaaaaaa agaaagccct gaatgttgta caaagtgttt tgcaaatcaa cttaagcaat
     2881 tctacaaaca gaggatcagt agctgctaag aaatttaagg acatcataca ttatgatcca
     2941 acgaagcaag accatgccac ttacgaaaga aaaagagatg ataagccaaa agaaagtaaa
     3001 gcaaaacgaa aaaagaaaag ggaggaagct gagaaactac ctgaggtgtc taaagaaatg
     3061 tattataata ttgctatgga tctgaaagaa atattccaaa ctacaaaata taccagtgaa
     3121 aaggaagagg gcacaccctg gaatgaggac tgtggtaaag agaaacctga ggaaatccag
     3181 gaccctgcag ctctgaccag tgacgctgag cagcccagcg ggttcacgtt ctcttttttt
     3241 gattcagaca ctaaagacat aaaggaagag acctacagag ttgaaacagt gaaacctgga
     3301 aagattgtct ggcaggaaga ccctcgttta caagacagca gttcagaaga ggaagatgtt
     3361 actgaagaaa cagatcacag aaactccagt cctggagaag catcattact tgagaaagag
     3421 accactagat ttttcttttt ctctaagaat gatgaacgac ttcaaggttc tgacttattc
     3481 tggagaggag taggaagtaa tatgagcagg aactcttggg aggccagaac aaccaacctg
     3541 cgtatggatt gtcgaaagaa acataaagac gcaaaaagga aaatgaaacc aaaataataa
     3601 atgtcagctg gttttgatac tgaatgtgaa caaggctcac ctaaggaaac tgacccagaa
     3661 aacagtttta gctgacaaag aagaaatttc agagtgaagg aattttaaaa atctggctga
     3721 cggaatatca ttctggttgc catctttttc tgtggaactc ctctgcattt cttcctaagt
     3781 aattacttca aaaattaaat tcaacttctt ataaaggaag aacaagatag tccttgaaaa
     3841 tactttttgt atataatctc tttgccctct atcctgagta actaatggac atcttctcat
     3901 gcaaggttta tatgaagcct ttttaaataa atgagtcaaa gcacttgtat tttccagcct
     3961 aggctttgtg tgaattatag gctatttgaa attttatttc tgattatgtc aaatacacct
     4021 tccattttgt catttttgtt taaactgata aattacaagt caacattgag tttta
//
