LOCUS       NM_016167               1683 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens nucleolar protein 7 (NOL7), transcript variant 1,
            mRNA.
ACCESSION   NM_016167
VERSION     NM_016167.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1683)
  AUTHORS   Yoshioka,Y., Huang,Y., Jin,X., Ngo,K.X., Kumaki,T., Jin,M.,
            Toyoda,S., Takayama,S., Inotsume,M., Fujita,K., Homma,H., Ando,T.,
            Tanaka,H. and Okazawa,H.
  TITLE     PQBP3 prevents senescence by suppressing PSME3-mediated proteasomal
            Lamin B1 degradation
  JOURNAL   EMBO J 43 (18), 3968-3999 (2024)
   PUBMED   39103492
  REMARK    GeneRIF: PQBP3 prevents senescence by suppressing PSME3-mediated
            proteasomal Lamin B1 degradation.
REFERENCE   2  (bases 1 to 1683)
  AUTHORS   McCool,M.A., Bryant,C.J., Huang,H., Ogawa,L.M., Farley-Barnes,K.I.,
            Sondalle,S.B., Abriola,L., Surovtseva,Y.V. and Baserga,S.J.
  TITLE     Human nucleolar protein 7 (NOL7) is required for early pre-rRNA
            accumulation and pre-18S rRNA processing
  JOURNAL   RNA Biol 20 (1), 257-271 (2023)
   PUBMED   37246770
  REMARK    GeneRIF: Human nucleolar protein 7 (NOL7) is required for early
            pre-rRNA accumulation and pre-18S rRNA processing.
REFERENCE   3  (bases 1 to 1683)
  AUTHORS   Li,Y., Zhong,C., Wang,J., Chen,F., Shen,W., Li,B., Zheng,N., Lu,Y.,
            Katanaev,V.L. and Jia,L.
  TITLE     NOL7 facilitates melanoma progression and metastasis
  JOURNAL   Signal Transduct Target Ther 6 (1), 352 (2021)
   PUBMED   34642294
  REMARK    GeneRIF: NOL7 facilitates melanoma progression and metastasis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1683)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   5  (bases 1 to 1683)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1683)
  AUTHORS   Hasina,R., Pontier,A.L., Fekete,M.J., Martin,L.E., Qi,X.M.,
            Brigaudeau,C., Pramanik,R., Cline,E.I., Coignet,L.J. and
            Lingen,M.W.
  TITLE     NOL7 is a nucleolar candidate tumor suppressor gene in cervical
            cancer that modulates the angiogenic phenotype
  JOURNAL   Oncogene 25 (4), 588-598 (2006)
   PUBMED   16205646
REFERENCE   7  (bases 1 to 1683)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   8  (bases 1 to 1683)
  AUTHORS   Scherl,A., Coute,Y., Deon,C., Calle,A., Kindbeiter,K.,
            Sanchez,J.C., Greco,A., Hochstrasser,D. and Diaz,J.J.
  TITLE     Functional proteomic analysis of human nucleolus
  JOURNAL   Mol Biol Cell 13 (11), 4100-4109 (2002)
   PUBMED   12429849
REFERENCE   9  (bases 1 to 1683)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
REFERENCE   10 (bases 1 to 1683)
  AUTHORS   Imafuku,I., Waragai,M., Takeuchi,S., Kanazawa,I., Kawabata,M.,
            Mouradian,M.M. and Okazawa,H.
  TITLE     Polar amino acid-rich sequences bind to polyglutamine tracts
  JOURNAL   Biochem Biophys Res Commun 253 (1), 16-20 (1998)
   PUBMED   9875212
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF172066.3, CX760811.1 and
            BM510944.1.
            
            On Nov 23, 2018 this sequence version replaced NM_016167.4.
            
            Summary: The protein encoded by this gene localizes to the
            nucleolus, where it maintains nucleolar structure and cell growth
            rates. The encoded protein also functions as a tumor suppressor and
            regulator of angiogenesis. The RB tumor suppressor gene recruits
            transcription factors to this gene and positively regulates its
            expression. Two transcript variants encoding the same protein have
            been found for this gene. [provided by RefSeq, Dec 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.97670.1,
                                           SRR1660807.223088.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000451315.7/ ENSP00000405674.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-866               AF172066.3         9-874
            867-1495            CX760811.1         28-656              c
            1496-1683           BM510944.1         15-202              c
FEATURES             Location/Qualifiers
     source          1..1683
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p23"
     gene            1..1683
                     /gene="NOL7"
                     /gene_synonym="C6orf90; dJ223E5.2; PQBP3; RARG-1"
                     /note="nucleolar protein 7"
                     /db_xref="GeneID:51406"
                     /db_xref="HGNC:HGNC:21040"
                     /db_xref="MIM:611533"
     exon            1..290
                     /gene="NOL7"
                     /gene_synonym="C6orf90; dJ223E5.2; PQBP3; RARG-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..798
                     /gene="NOL7"
                     /gene_synonym="C6orf90; dJ223E5.2; PQBP3; RARG-1"
                     /note="retinoic acid repressible protein; polyglutamine
                     binding protein 3; nucleolar protein of 27 kDa; nucleolar
                     protein 7, 27kDa; U3 snoRNA-associated protein NOL7"
                     /codon_start=1
                     /product="U3 small nucleolar RNA-associated protein NOL7"
                     /protein_id="NP_057251.2"
                     /db_xref="CCDS:CCDS4528.1"
                     /db_xref="GeneID:51406"
                     /db_xref="HGNC:HGNC:21040"
                     /db_xref="MIM:611533"
                     /translation="MVQLRPRASRAPASAEAMVDEGQLASEEEEAEHGLLLGQPSSGA
                     AAEPLEEDEEGDDEFDDEAPEELTFASAQAEAREEERRVRETVRRDKTLLKEKRKRRE
                     ELFIEQKKRKLLPDTILEKLTTASQTNIKKSPGKVKEVNLQKKNEDCEKGNDSKKVKV
                     QKVQSVSQNKSYLAVRLKDQDLRDSRQQAAQAFIHNSLYGPGTNRTTVNKFLSLANKR
                     LPVKRAAVQFLNNAWGIQKKQNAKRFKRRWMVRKMKTKK"
     exon            291..351
                     /gene="NOL7"
                     /gene_synonym="C6orf90; dJ223E5.2; PQBP3; RARG-1"
                     /inference="alignment:Splign:2.1.0"
     exon            352..410
                     /gene="NOL7"
                     /gene_synonym="C6orf90; dJ223E5.2; PQBP3; RARG-1"
                     /inference="alignment:Splign:2.1.0"
     exon            411..442
                     /gene="NOL7"
                     /gene_synonym="C6orf90; dJ223E5.2; PQBP3; RARG-1"
                     /inference="alignment:Splign:2.1.0"
     exon            443..524
                     /gene="NOL7"
                     /gene_synonym="C6orf90; dJ223E5.2; PQBP3; RARG-1"
                     /inference="alignment:Splign:2.1.0"
     exon            525..646
                     /gene="NOL7"
                     /gene_synonym="C6orf90; dJ223E5.2; PQBP3; RARG-1"
                     /inference="alignment:Splign:2.1.0"
     exon            647..724
                     /gene="NOL7"
                     /gene_synonym="C6orf90; dJ223E5.2; PQBP3; RARG-1"
                     /inference="alignment:Splign:2.1.0"
     exon            725..1683
                     /gene="NOL7"
                     /gene_synonym="C6orf90; dJ223E5.2; PQBP3; RARG-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      847..852
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOL7"
                     /gene_synonym="C6orf90; dJ223E5.2; PQBP3; RARG-1"
                     /note="hexamer: AATAAA"
     polyA_site      866
                     /gene="NOL7"
                     /gene_synonym="C6orf90; dJ223E5.2; PQBP3; RARG-1"
                     /note="major polyA site"
     regulatory      1151..1156
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOL7"
                     /gene_synonym="C6orf90; dJ223E5.2; PQBP3; RARG-1"
                     /note="hexamer: ATTAAA"
     polyA_site      1176
                     /gene="NOL7"
                     /gene_synonym="C6orf90; dJ223E5.2; PQBP3; RARG-1"
     regulatory      1615..1620
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOL7"
                     /gene_synonym="C6orf90; dJ223E5.2; PQBP3; RARG-1"
                     /note="hexamer: AATAAA"
     polyA_site      1638
                     /gene="NOL7"
                     /gene_synonym="C6orf90; dJ223E5.2; PQBP3; RARG-1"
     regulatory      1657..1662
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOL7"
                     /gene_synonym="C6orf90; dJ223E5.2; PQBP3; RARG-1"
                     /note="hexamer: AATACA"
     polyA_site      1683
                     /gene="NOL7"
                     /gene_synonym="C6orf90; dJ223E5.2; PQBP3; RARG-1"
ORIGIN      
        1 agacggtcta gcgctgcgtg ggccatggtg cagctccgac cgcgagcgtc tcgcgccccg
       61 gcgtcggcgg aggcgatggt ggacgagggc cagctggcct cggaggagga ggaggcggag
      121 cacgggctgt tgctcgggca gcccagcagc ggcgcggccg ccgagcccct ggaggaagac
      181 gaggaagggg acgatgagtt tgacgatgag gccccggagg agctgacttt cgccagcgcc
      241 caggcggaag cgagagaaga ggagcggcga gtgcgggaga ccgtgcgcag ggataaaacg
      301 ctcctgaagg agaagaggaa gcgacgcgag gagctgttca tcgaacagaa gaaaagaaaa
      361 ctccttccag acactatttt ggagaagtta accacagctt cacagactaa catcaagaaa
      421 tcgccaggaa aggtgaaaga agttaatttg caaaagaaaa atgaagactg tgaaaaagga
      481 aatgactcca agaaagttaa agtacaaaaa gtacagtctg tcagccagaa taaaagctac
      541 ttggccgtaa ggctaaaaga ccaagatctg agagattcaa ggcaacaagc agcacaagcc
      601 ttcatacata attcattata tgggccagga accaacagga ctactgtaaa taagttcctg
      661 tctcttgcca acaagaggtt accagtgaaa agagctgctg tccagttttt gaataatgct
      721 tggggaatcc aaaaaaaaca aaatgccaag aggtttaaaa gacggtggat ggtcagaaag
      781 atgaaaacta agaagtaaat caatgctaaa tgaagaatct gtactttgta tgtatagaat
      841 ttatctaata aatcattcat agatcatttt aaaggatcat tataaaaatc ataaacctat
      901 ttgaggaagt gctcaaccac atttcattct tctggagtag aactgtgcct tgcaatccta
      961 gaggaaaaag tggtttaaga aggaattgtt ttctttttaa tatatttaac tgaattcaag
     1021 ccatacccac atcagcaaca gcacctcttc tactctcccc gggttagagg ggtggcaaaa
     1081 atggcacgga ctaaaaggag aaatggatat tccagcaaag tctctaactg cagcctgtag
     1141 acaatttgct attaaagatt cagtgcacaa aatatagcta acagctttta aatttttact
     1201 tttaaccagt ctggggattt gcttgcctgg tgagtctcat atgccatatt atgaatatga
     1261 aaataatgaa gttaatttcc tgttgccttt ctgtgtcagc cacaatatca ggtctaaccc
     1321 taatccaggg atgccagtaa actgaaggca attttaggtt gtagaactca gattaattgt
     1381 agaaaccatt aattttaatt gctctaattt tcatagtaat cataaaaagt atgcaagtac
     1441 ctaatatata aactcaattg acactgtatc tgtagaagta aatttttaat ggctggttaa
     1501 ttatatcact acattttatt gcaatatagt actcatttaa gcacttaaaa atggaaggtg
     1561 tacaaagatt aaattaagac acggtaaatt gactaaatat ttggttttta tataaataaa
     1621 ggtcataacc acaccgttga catgtaatac tgttataata caacagttaa acttgtgagt
     1681 cta
//
