LOCUS       NM_022917               4834 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens nucleolar protein 6 (NOL6), transcript variant alpha,
            mRNA.
ACCESSION   NM_022917
VERSION     NM_022917.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4834)
  AUTHORS   Liang,J., Sun,W., Song,H., Wang,C., Li,Q., Li,C., Wei,D., Zhao,Y.,
            Li,C. and Zhang,H.
  TITLE     NOL6 promotes the proliferation and migration of endometrial cancer
            cells by regulating TWIST1 expression
  JOURNAL   Epigenomics 13 (19), 1571-1585 (2021)
   PUBMED   34607487
  REMARK    GeneRIF: NOL6 promotes the proliferation and migration of
            endometrial cancer cells by regulating TWIST1 expression.
REFERENCE   2  (bases 1 to 4834)
  AUTHORS   Meng,L., Xu,K.X., Zhao,M.X., Li,K., Zhu,K., Yuan,D.W., Wang,H.N.,
            Dai,P.G. and Yan,R.
  TITLE     Nucleolar protein 6 promotes cell proliferation and acts as a
            potential novel prognostic marker for hepatocellular carcinoma
  JOURNAL   Chin Med J (Engl) 134 (21), 2611-2618 (2021)
   PUBMED   34561331
  REMARK    GeneRIF: Nucleolar protein 6 promotes cell proliferation and acts
            as a potential novel prognostic marker for hepatocellular
            carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4834)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   4  (bases 1 to 4834)
  AUTHORS   Farooq,M., Lindbaek,L., Krogh,N., Doganli,C., Keller,C.,
            Monnich,M., Goncalves,A.B., Sakthivel,S., Mang,Y., Fatima,A.,
            Andersen,V.S., Hussain,M.S., Eiberg,H., Hansen,L., Kjaer,K.W.,
            Gopalakrishnan,J., Pedersen,L.B., Mollgard,K., Nielsen,H.,
            Baig,S.M., Tommerup,N., Christensen,S.T. and Larsen,L.A.
  TITLE     RRP7A links primary microcephaly to dysfunction of ribosome
            biogenesis, resorption of primary cilia, and neurogenesis
  JOURNAL   Nat Commun 11 (1), 5816 (2020)
   PUBMED   33199730
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4834)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 4834)
  AUTHORS   Bernstein,K.A., Gallagher,J.E., Mitchell,B.M., Granneman,S. and
            Baserga,S.J.
  TITLE     The small-subunit processome is a ribosome assembly intermediate
  JOURNAL   Eukaryot Cell 3 (6), 1619-1626 (2004)
   PUBMED   15590835
REFERENCE   7  (bases 1 to 4834)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   8  (bases 1 to 4834)
  AUTHORS   Scherl,A., Coute,Y., Deon,C., Calle,A., Kindbeiter,K.,
            Sanchez,J.C., Greco,A., Hochstrasser,D. and Diaz,J.J.
  TITLE     Functional proteomic analysis of human nucleolus
  JOURNAL   Mol Biol Cell 13 (11), 4100-4109 (2002)
   PUBMED   12429849
REFERENCE   9  (bases 1 to 4834)
  AUTHORS   Utama,B., Kennedy,D., Ru,K. and Mattick,J.S.
  TITLE     Isolation and characterization of a new nucleolar protein, Nrap,
            that is conserved from yeast to humans
  JOURNAL   Genes Cells 7 (2), 115-132 (2002)
   PUBMED   11895476
REFERENCE   10 (bases 1 to 4834)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB267269.1, AF361079.2 and
            BC008852.2.
            
            On Nov 22, 2018 this sequence version replaced NM_022917.4.
            
            Summary: The nucleolus is a dense subnuclear membraneless organelle
            that assembles around clusters of rRNA genes and functions in
            ribosome biogenesis. This gene encodes a nucleolar RNA-associated
            protein that is highly conserved between species. RNase treatment
            of permeabilized cells indicates that the nucleolar localization is
            RNA dependent. Further studies suggest that the protein is
            associated with ribosome biogenesis through an interaction with
            pre-rRNA primary transcripts. Alternative splicing has been
            observed at this locus and two splice variants encoding distinct
            isoforms have been identified. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (alpha) encodes the longest
            isoform (alpha), also known as the long isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF361079.2, SRR11853567.30172.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297990.9/ ENSP00000297990.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                CB267269.1         20-70
            52-4001             AF361079.2         1-3950
            4002-4834           BC008852.2         2414-3246
FEATURES             Location/Qualifiers
     source          1..4834
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     gene            1..4834
                     /gene="NOL6"
                     /gene_synonym="bA311H10.1; NRAP; UTP22"
                     /note="nucleolar protein 6"
                     /db_xref="GeneID:65083"
                     /db_xref="HGNC:HGNC:19910"
                     /db_xref="MIM:611532"
     exon            1..136
                     /gene="NOL6"
                     /gene_synonym="bA311H10.1; NRAP; UTP22"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..3523
                     /gene="NOL6"
                     /gene_synonym="bA311H10.1; NRAP; UTP22"
                     /note="isoform alpha is encoded by transcript variant
                     alpha; nucleolar RNA-associated protein; nucleolar protein
                     family 6 (RNA-associated); nucleolar protein 6
                     (RNA-associated)"
                     /codon_start=1
                     /product="nucleolar protein 6 isoform alpha"
                     /protein_id="NP_075068.2"
                     /db_xref="CCDS:CCDS6543.1"
                     /db_xref="GeneID:65083"
                     /db_xref="HGNC:HGNC:19910"
                     /db_xref="MIM:611532"
                     /translation="MGPAPAGEQLRGATGEPEVMEPALEGTGKEGKKASSRKRTLAEP
                     PAKGLLQPVKLSRAELYKEPTNEELNRLRETEILFHSSLLRLQVEELLKEVRLSEKKK
                     DRIDAFLREVNQRVVRVPSVPETELTDQAWLPAGVRVPLHQVPYAVKGCFRFLPPAQV
                     TVVGSYLLGTCIRPDINVDVALTMPREILQDKDGLNQRYFRKRALYLAHLAHHLAQDP
                     LFGSVCFSYTNGCHLKPSLLLRPRGKDERLVTVRLHPCPPPDFFRPCRLLPTKNNVRS
                     AWYRGQSPAGDGSPEPPTPRYNTWVLQDTVLESHLQLLSTILSSAQGLKDGVALLKVW
                     LRQRELDKGQGGFTGFLVSMLVVFLVSTRKIHTTMSGYQVLRSVLQFLATTDLTVNGI
                     SLCLSSDPSLPALADFHQAFSVVFLDSSGHLNLCADVTASTYHQVQHEARLSMMLLDS
                     RADDGFHLLLMTPKPMIRAFDHVLHLRPLSRLQAACHRLKLWPELQDNGGDYVSAALG
                     PLTTLLEQGLGARLNLLAHSRPPVPEWDISQDPPKHKDSGTLTLGLLLRPEGLTSVLE
                     LGPEADQPEAAKFRQFWGSRSELRRFQDGAIREAVVWEAASMSQKRLIPHQVVTHLLA
                     LHADIPETCVHYVGGPLDALIQGLKETSSTGEEALVAAVRCYDDLSRLLWGLEGLPLT
                     VSAVQGAHPVLRYTEVFPPTPVRPAFSFYETLRERSSLLPRLDKPCPAYVEPMTVVCH
                     LEGSGQWPQDAEAVQRVRAAFQLRLAELLTQQHGLQCRATATHTDVLKDGFVFRIRVA
                     YQREPQILKEVQSPEGMISLRDTAASLRLERDTRQLPLLTSALHGLQQQHPAFSGVAR
                     LAKRWVRAQLLGEGFADESLDLVAAALFLHPEPFTPPSSPQVGFLRFLFLVSTFDWKN
                     NPLFVNLNNELTVEEQVEIRSGFLAARAQLPVMVIVTPQDRKNSVWTQDGPSAQILQQ
                     LVVLAAEALPMLEKQLMDPRGPGDIRTVFRPPLDIYDVLIRLSPRHIPRHRQAVDSPA
                     ASFCRGLLSQPGPSSLMPVLGYDPPQLYLTQLREAFGDLALFFYDQHGGEVIGVLWKP
                     TSFQPQPFKASSTKGRMVMSRGGELVMVPNVEAILEDFAVLGEGLVQTVEARSERWTV
                     "
     exon            137..343
                     /gene="NOL6"
                     /gene_synonym="bA311H10.1; NRAP; UTP22"
                     /inference="alignment:Splign:2.1.0"
     exon            344..460
                     /gene="NOL6"
                     /gene_synonym="bA311H10.1; NRAP; UTP22"
                     /inference="alignment:Splign:2.1.0"
     exon            461..640
                     /gene="NOL6"
                     /gene_synonym="bA311H10.1; NRAP; UTP22"
                     /inference="alignment:Splign:2.1.0"
     exon            641..809
                     /gene="NOL6"
                     /gene_synonym="bA311H10.1; NRAP; UTP22"
                     /inference="alignment:Splign:2.1.0"
     exon            810..944
                     /gene="NOL6"
                     /gene_synonym="bA311H10.1; NRAP; UTP22"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1108
                     /gene="NOL6"
                     /gene_synonym="bA311H10.1; NRAP; UTP22"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1229
                     /gene="NOL6"
                     /gene_synonym="bA311H10.1; NRAP; UTP22"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1288
                     /gene="NOL6"
                     /gene_synonym="bA311H10.1; NRAP; UTP22"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1390
                     /gene="NOL6"
                     /gene_synonym="bA311H10.1; NRAP; UTP22"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1506
                     /gene="NOL6"
                     /gene_synonym="bA311H10.1; NRAP; UTP22"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1684
                     /gene="NOL6"
                     /gene_synonym="bA311H10.1; NRAP; UTP22"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1807
                     /gene="NOL6"
                     /gene_synonym="bA311H10.1; NRAP; UTP22"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..1956
                     /gene="NOL6"
                     /gene_synonym="bA311H10.1; NRAP; UTP22"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2032
                     /gene="NOL6"
                     /gene_synonym="bA311H10.1; NRAP; UTP22"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2173
                     /gene="NOL6"
                     /gene_synonym="bA311H10.1; NRAP; UTP22"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2291
                     /gene="NOL6"
                     /gene_synonym="bA311H10.1; NRAP; UTP22"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2446
                     /gene="NOL6"
                     /gene_synonym="bA311H10.1; NRAP; UTP22"
                     /inference="alignment:Splign:2.1.0"
     exon            2447..2610
                     /gene="NOL6"
                     /gene_synonym="bA311H10.1; NRAP; UTP22"
                     /inference="alignment:Splign:2.1.0"
     exon            2611..2763
                     /gene="NOL6"
                     /gene_synonym="bA311H10.1; NRAP; UTP22"
                     /inference="alignment:Splign:2.1.0"
     exon            2764..2861
                     /gene="NOL6"
                     /gene_synonym="bA311H10.1; NRAP; UTP22"
                     /inference="alignment:Splign:2.1.0"
     exon            2862..2986
                     /gene="NOL6"
                     /gene_synonym="bA311H10.1; NRAP; UTP22"
                     /inference="alignment:Splign:2.1.0"
     exon            2987..3076
                     /gene="NOL6"
                     /gene_synonym="bA311H10.1; NRAP; UTP22"
                     /inference="alignment:Splign:2.1.0"
     exon            3077..3271
                     /gene="NOL6"
                     /gene_synonym="bA311H10.1; NRAP; UTP22"
                     /inference="alignment:Splign:2.1.0"
     exon            3272..3373
                     /gene="NOL6"
                     /gene_synonym="bA311H10.1; NRAP; UTP22"
                     /inference="alignment:Splign:2.1.0"
     exon            3374..4834
                     /gene="NOL6"
                     /gene_synonym="bA311H10.1; NRAP; UTP22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4714..4719
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOL6"
                     /gene_synonym="bA311H10.1; NRAP; UTP22"
                     /note="hexamer: AATAAA"
     polyA_site      4735
                     /gene="NOL6"
                     /gene_synonym="bA311H10.1; NRAP; UTP22"
                     /note="major polyA site"
     polyA_site      4834
                     /gene="NOL6"
                     /gene_synonym="bA311H10.1; NRAP; UTP22"
ORIGIN      
        1 aggcatttcc gcccacgtgg gaagctatga ggtatagacc cggctagaat ctgaagtgcg
       61 ggagagtgct ggaccctgag tgatggggcc ggcgccagct ggagagcagc ttcgcggagc
      121 gactggagag ccagaggtga tggaaccagc cctggaaggc acaggcaaag aggggaagaa
      181 agcatcctcc aggaagcgta cattggctga acctccagcg aagggcctcc tgcagccagt
      241 gaagctcagc agggcagaac tgtacaagga gcctaccaat gaggagctta atcgccttcg
      301 ggagactgag atcttgttcc actccagctt gcttcgttta caggtagagg agctactaaa
      361 ggaagtaagg ctgtcagaga agaagaagga tcggattgat gccttcctac gggaggtcaa
      421 ccagcgggtt gtgagggtgc cctcagtccc tgagacagag ctcactgacc aggcatggct
      481 cccagctggg gttcgagtgc ccctccacca agtgccctat gccgtgaagg gctgtttccg
      541 cttcctgccc ccagcccagg ttactgttgt gggcagctac cttctgggca cctgcatccg
      601 accagacatc aatgtggatg tggcactgac catgcccagg gaaatcctac aggacaagga
      661 cgggctgaac cagcgctact tccgcaagcg tgccctctac ctggcccact tggctcacca
      721 cctggcccag gaccccctct ttggcagtgt ttgcttctcc tacacaaatg gctgccacct
      781 gaaaccctca ctgttgctgc ggccgcgtgg aaaggatgag cgcctggtca ctgtacgtct
      841 gcatccgtgc cctccacctg acttcttccg cccgtgccgc ttgctgccaa ccaagaacaa
      901 tgtgcgctct gcctggtacc gagggcagag tcctgcaggg gatggtagcc cagagcctcc
      961 taccccccgc tataacacat gggtcctgca agatacagtt ctcgagtccc atttgcagct
     1021 gctgtcaacc attctgagtt cagcccaggg cctgaaggat ggcgtggcac ttctgaaggt
     1081 ctggctgcgg cagcgggagc tggacaaggg ccagggtggg tttactgggt tccttgtctc
     1141 catgctggtt gtcttccttg tgtctacacg caagatccat accaccatga gtggctacca
     1201 ggtcctgaga agtgtcttgc agtttctggc cactacagac ctgacagtca acgggatcag
     1261 tttatgtctc agctcagatc cctctttgcc ggccctggct gacttccacc aggccttctc
     1321 cgttgtcttc ctggattcct caggccatct caacctctgt gctgatgtca ctgcctctac
     1381 ttaccaccag gtacagcatg aggcacggct gtctatgatg ttgctggaca gcagagctga
     1441 cgacgggttc cacctgctgt tgatgactcc caaacccatg atccgggctt ttgaccatgt
     1501 cctgcatctc cgtccactga gtcgcctgca ggcagcgtgc caccggctga agctctggcc
     1561 agagctgcag gacaatggtg gggactatgt ctcagctgct ttgggccccc tgaccaccct
     1621 cctggagcag ggcctggggg ctcggctgaa cctgctggct cactctcgac ccccagtccc
     1681 agagtgggac atcagccaag atccaccaaa gcacaaagac tctgggaccc tgaccctggg
     1741 actccttctc cggcctgagg gactgaccag cgtccttgag ctgggtccag aggcagacca
     1801 gcctgaggct gctaaattcc gccagttctg gggatcccgc tcggagcttc ggcgtttcca
     1861 ggacggagcc attcgggaag ctgtggtctg ggaggcagcc tctatgtccc agaagcgcct
     1921 tattccccac caggtggtca cccacctctt ggcactccat gctgacatcc cagaaacctg
     1981 tgtccactat gtggggggcc ccctggatgc acttatccaa ggcctgaaag agacctccag
     2041 cacaggtgag gaggccctgg tagcggcggt acgttgctac gacgacctca gtcgcctact
     2101 gtgggggcta gagggtctcc cactgaccgt gtctgctgtt cagggagctc acccagtgct
     2161 gcgctacaca gaggtgttcc caccaactcc agtccgtcca gccttctcct tctatgagac
     2221 tctgcgggag cggtcctcac tgctgccccg gctcgataag ccctgtccgg cctacgtgga
     2281 gcccatgacc gtggtttgtc acctggaggg cagtggccag tggccacagg acgctgaggc
     2341 cgtgcagcgg gtccgagctg ccttccagct gcgcctggca gagctgttga cacaacagca
     2401 tggtctgcag tgccgtgcca ctgccacgca cacggatgtc cttaaggatg gatttgtgtt
     2461 tcggattcgc gtggcctatc agcgggagcc ccagatcctg aaggaggtgc agagcccaga
     2521 ggggatgatc tcgctgaggg acacagctgc ctccctccgc cttgagagag acacaaggca
     2581 gttgccactg ctcaccagtg ccctgcacgg actgcagcag cagcacccag ccttctctgg
     2641 tgtggcacgg ctggccaagc ggtgggtgcg tgcccagctt cttggtgagg gtttcgctga
     2701 tgagagcctg gatctggtgg ccgctgccct tttcctgcac cctgagccct tcacccctcc
     2761 gagttccccc caggttggct tccttcgatt ccttttcttg gtatcaacgt ttgattggaa
     2821 gaacaacccc ctctttgtca acctcaataa tgagctcact gtggaggagc aggtggagat
     2881 ccgcagtggc ttcctggcag ctcgggcaca gctccccgtc atggtcattg ttacccccca
     2941 agaccgcaaa aactctgtgt ggacacagga tggaccctca gcccagatcc tgcagcagct
     3001 tgtggtcctg gcagctgaag ccctgcccat gttagagaag cagctcatgg atccccgggg
     3061 acctggggac atcaggacag tgttccggcc gcccttggac atttacgacg tgctgattcg
     3121 cctgtctcct cgccatatcc cgcggcaccg ccaggctgtg gactcgccag ctgcctcctt
     3181 ctgccggggc ctgctcagcc agccggggcc ctcatccctg atgcccgtgc tgggctatga
     3241 tcctcctcag ctctatctga cgcagctcag ggaggccttt ggggatctgg cccttttctt
     3301 ctatgaccag catggtggag aggtgattgg tgtcctctgg aagcccacca gcttccagcc
     3361 gcagcccttc aaggcctcca gcacaaaggg gcgcatggtg atgtctcgag gtggggagct
     3421 agtaatggtg cccaatgttg aagcaatcct ggaggacttt gctgtgctgg gtgaaggcct
     3481 ggtgcagact gtggaggccc gaagtgagag gtggactgtg tgatcccagc tctggagcaa
     3541 gctgtagacg gacagcagga cattggacct ctagagcaag atgtcagtag gatgacctcc
     3601 accctccttg gacatgaatc ctccatggag ggcctgctgg ctgaacatgc tgaatcatct
     3661 ccaacaaaac ccagccccaa ctttctctct gatgctccag cattggggca ggggcatggt
     3721 ggcccatgta gtctcctggg cctcaccatc ccagaagagg agtgggagcc agctcagaga
     3781 aggaactgaa cccaggagat ccatccacct attagccctg ggcctggacc tccctgcgat
     3841 ttcccactcc tttcttagtc ttcttccaga aacagagaag gggatgtgtg cctgggagag
     3901 gctctgtctc cttcctgctg ccaggacctg tgcctagact tagcatgccc ttcactgcag
     3961 tgtcaggcct ttagatggga cccagcgaaa atgtggccct tctgagtcac atcaccgaca
     4021 ctgagcagtg gaaaggggct atatgtgtat gaatagacca cattgaagga gcacaatgcc
     4081 ctcctgtgtt gatgccactt cccagggtgg agacagtgga aaagaaccga ggacaggaaa
     4141 ggattgggta ggtgaagggg tcaggggact ggtagtcacc caatcttgga gaggtgcaaa
     4201 aagcactggg ggctacccgt tagctgcatc tgccctggct gtttgcccgt tcatgtcaca
     4261 aactgccact actatgtacc tgcagtgggg ttgcagagat gggggagact caagtcttac
     4321 tccccaggag ctcccagggc ccaaggagga gaatgctgcc tcctttcagt ctggtctaca
     4381 cccactttct ggtagcctct ctgcttcctg taattctggc tgtttttcca gactcagctc
     4441 aaatagtgcc cctccttaag cccatccctc gcccccagcc tgaggtgatc tttccctcct
     4501 ctgaactatt agagcagtta ctgtctgttc agttcgtttg gcaggcacac acagtggcat
     4561 aaattctatt gttttgaact ctgatttaaa attaaattgc agctgggcgt ggtggcttat
     4621 gcttgtaatc ccaacactta gggagtcagg agaatcactt gagctcagga gttctagacc
     4681 aatctgggca acagagagac cccatctctt ttaaataaaa agttaaattg cttaatttcc
     4741 cccgtattcc tggcctgtct gcccctttca cataatttta acctggtttc ttgtatgtaa
     4801 actccttgag ggcaagaaca tgtttgaaca taga
//
