LOCUS       NM_001276309            1355 bp    mRNA    linear   PRI 29-MAY-2023
DEFINITION  Homo sapiens nucleolar protein 3 (NOL3), transcript variant 5,
            mRNA.
ACCESSION   NM_001276309
VERSION     NM_001276309.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1355)
  AUTHORS   Roser C, Toth C, Renner M, Herpel E and Schirmacher P.
  TITLE     Expression of apoptosis repressor with caspase recruitment domain
            (ARC) in familial adenomatous polyposis (FAP) adenomas and its
            correlation with DNA mismatch repair proteins, p53, Bcl-2, COX-2
            and beta-catenin
  JOURNAL   Cell Commun Signal 19 (1), 15 (2021)
   PUBMED   33579312
  REMARK    GeneRIF: Expression of apoptosis repressor with caspase recruitment
            domain (ARC) in familial adenomatous polyposis (FAP) adenomas and
            its correlation with DNA mismatch repair proteins, p53, Bcl-2,
            COX-2 and beta-catenin.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1355)
  AUTHORS   Wang Q, Zhang T, Chang X, Lim DY, Wang K, Bai R, Wang T, Ryu J,
            Chen H, Yao K, Ma WY, Boardman LA, Bode AM and Dong Z.
  TITLE     ARC Is a Critical Protector against Inflammatory Bowel Disease
            (IBD) and IBD-Associated Colorectal Tumorigenesis
  JOURNAL   Cancer Res 80 (19), 4158-4171 (2020)
   PUBMED   32816906
  REMARK    GeneRIF: ARC Is a Critical Protector against Inflammatory Bowel
            Disease (IBD) and IBD-Associated Colorectal Tumorigenesis.
REFERENCE   3  (bases 1 to 1355)
  AUTHORS   Liu M, Yu T, Li M, Fang X, Hou B, Liu G and Wang J.
  TITLE     Apoptosis repressor with caspase recruitment domain promotes cell
            proliferation and phenotypic modulation through 14-3-3epsilon/YAP
            signaling in vascular smooth muscle cells
  JOURNAL   J Mol Cell Cardiol 147, 35-48 (2020)
   PUBMED   32771410
  REMARK    GeneRIF: Apoptosis repressor with caspase recruitment domain
            promotes cell proliferation and phenotypic modulation through
            14-3-3epsilon/YAP signaling in vascular smooth muscle cells.
REFERENCE   4  (bases 1 to 1355)
  AUTHORS   Haenig C, Atias N, Taylor AK, Mazza A, Schaefer MH, Russ J,
            Riechers SP, Jain S, Coughlin M, Fontaine JF, Freibaum BD,
            Brusendorf L, Zenkner M, Porras P, Stroedicke M, Schnoegl S,
            Arnsburg K, Boeddrich A, Pigazzini L, Heutink P, Taylor JP,
            Kirstein J, Andrade-Navarro MA, Sharan R and Wanker EE.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1355)
  AUTHORS   Nam YJ, Mani K, Ashton AW, Peng CF, Krishnamurthy B, Hayakawa Y,
            Lee P, Korsmeyer SJ and Kitsis RN.
  TITLE     Inhibition of both the extrinsic and intrinsic death pathways
            through nonhomotypic death-fold interactions
  JOURNAL   Mol Cell 15 (6), 901-912 (2004)
   PUBMED   15383280
  REMARK    GeneRIF: ARC is recruited to the Fas DISC. By interacting with Fas
            and FADD through CARD-DD and CARD-DED interactions, ARC prevents
            DISC assembly and procaspase-8 activation.
            GeneRIF: The CARD of ARC binds the Bax C-terminus, preventing Bax
            activation and activation of the intrinsic mitochondrial pathway
            GeneRIF: ARC holds multiple death pathways in check by
            non-homotypic death-fold interactions. Loss of ARC disinhibits
            these, leading to accelerated DISC assembly and Bax activation and
            may be an apoptotic trigger in heart failure and
            ischemia-reperfusion.
REFERENCE   6  (bases 1 to 1355)
  AUTHORS   Gustafsson AB, Tsai JG, Logue SE, Crow MT and Gottlieb RA.
  TITLE     Apoptosis repressor with caspase recruitment domain protects
            against cell death by interfering with Bax activation
  JOURNAL   J Biol Chem 279 (20), 21233-21238 (2004)
   PUBMED   15004034
REFERENCE   7  (bases 1 to 1355)
  AUTHORS   Ekhterae D, Platoshyn O, Zhang S, Remillard CV and Yuan JX.
  TITLE     Apoptosis repressor with caspase domain inhibits cardiomyocyte
            apoptosis by reducing K+ currents
  JOURNAL   Am J Physiol Cell Physiol 284 (6), C1405-C1410 (2003)
   PUBMED   12734105
  REMARK    GeneRIF: These results suggest that the antiapoptotic effect of
            apoptotic repressor with caspase recruitment domain is, in part,
            due to inhibition of voltage-gated potassium channels in
            cardiomyocytes.
REFERENCE   8  (bases 1 to 1355)
  AUTHORS   Li PF, Li J, Muller EC, Otto A, Dietz R and von Harsdorf R.
  TITLE     Phosphorylation by protein kinase CK2: a signaling switch for the
            caspase-inhibiting protein ARC
  JOURNAL   Mol Cell 10 (2), 247-258 (2002)
   PUBMED   12191471
REFERENCE   9  (bases 1 to 1355)
  AUTHORS   Stoss O, Schwaiger FW, Cooper TA and Stamm S.
  TITLE     Alternative splicing determines the intracellular localization of
            the novel nuclear protein Nop30 and its interaction with the
            splicing factor SRp30c
  JOURNAL   J Biol Chem 274 (16), 10951-10962 (1999)
   PUBMED   10196175
REFERENCE   10 (bases 1 to 1355)
  AUTHORS   Koseki T, Inohara N, Chen S and Nunez G.
  TITLE     ARC, an inhibitor of apoptosis expressed in skeletal muscle and
            heart that interacts selectively with caspases
  JOURNAL   Proc Natl Acad Sci U S A 95 (9), 5156-5160 (1998)
   PUBMED   9560245
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC074143.5.
            
            On May 13, 2021 this sequence version replaced NM_001276309.2.
            
            Summary: This gene encodes an anti-apoptotic protein that has been
            shown to down-regulate the enzyme activities of caspase 2, caspase
            8 and tumor protein p53. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jun 2010].
            
            Transcript Variant: This variant (5) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 4, and 5 encode the same protein
            (isoform MYP).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB988736.1, DRR138513.50528.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000564992.2/ ENSP00000457720.2
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                AC074143.5         139174-139210
            38-340              AC074143.5         142798-143100
            341-664             AC074143.5         143257-143580
            665-1355            AC074143.5         143683-144373
FEATURES             Location/Qualifiers
     source          1..1355
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..1355
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYOCL1; MYP; NOP; NOP30"
                     /note="nucleolar protein 3"
                     /db_xref="GeneID:8996"
                     /db_xref="HGNC:HGNC:7869"
                     /db_xref="MIM:605235"
     exon            1..37
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYOCL1; MYP; NOP; NOP30"
                     /inference="alignment:Splign:2.1.0"
     exon            38..340
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYOCL1; MYP; NOP; NOP30"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..672
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYOCL1; MYP; NOP; NOP30"
                     /note="isoform MYP is encoded by transcript variant 5;
                     nucleolar protein of 30 kDa; muscle-enriched cytoplasmic
                     protein; nucleolar protein 3 (apoptosis repressor with
                     CARD domain)"
                     /codon_start=1
                     /product="nucleolar protein 3 isoform MYP"
                     /protein_id="NP_001263238.1"
                     /db_xref="CCDS:CCDS42176.1"
                     /db_xref="GeneID:8996"
                     /db_xref="HGNC:HGNC:7869"
                     /db_xref="MIM:605235"
                     /translation="MGNAQERPSETIDRERKRLVETLQADSGLLLDALLARGVLTGPE
                     YEALDALPDAERRVRRLLLLVQGKGEAACQELLRCAQRTAGAPDPAWDWQHVGPGYRD
                     RSYDPPCPGHWTPEAPGSGTTCPGLPRASDPDEAGGPEGSEAVQSGTPEEPEPELEAE
                     ASKEAEPEPEPEPELEPEAEAEPEPELEPEPDPEPEPDFEERDESEDS"
     exon            341..664
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYOCL1; MYP; NOP; NOP30"
                     /inference="alignment:Splign:2.1.0"
     exon            665..1355
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYOCL1; MYP; NOP; NOP30"
                     /inference="alignment:Splign:2.1.0"
     regulatory      786..791
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYOCL1; MYP; NOP; NOP30"
                     /note="hexamer: AATAAA"
     polyA_site      811
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYOCL1; MYP; NOP; NOP30"
     regulatory      1319..1324
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYOCL1; MYP; NOP; NOP30"
                     /note="hexamer: AATATA"
     regulatory      1336..1341
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYOCL1; MYP; NOP; NOP30"
                     /note="hexamer: AATGAA"
     polyA_site      1341
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYOCL1; MYP; NOP; NOP30"
                     /note="major polyA site"
     polyA_site      1355
                     /gene="NOL3"
                     /gene_synonym="ARC; FCM; MYOCL1; MYP; NOP; NOP30"
ORIGIN      
        1 ctgcaccgtc atctcctgcc ccgccgaggc ttgacccccc cgacaatggg caacgcgcag
       61 gagcggccgt cagagactat cgaccgcgag cggaaacgcc tggtcgagac gctgcaggcg
      121 gactcgggac tgctgttgga cgcgctgctg gcgcggggcg tgctcaccgg gccagagtac
      181 gaggcattgg atgcactgcc tgatgccgag cgcagggtgc gccgcctact gctgctggtg
      241 cagggcaagg gcgaggccgc ctgccaggag ctgctacgct gtgcccagcg taccgcgggc
      301 gcgccggacc ccgcttggga ctggcagcac gtgggtccgg gctaccggga ccgcagctat
      361 gaccctccat gcccaggcca ctggacgccg gaggcacccg gctcggggac cacatgcccc
      421 gggttgccca gagcttcaga ccctgacgag gccgggggcc ctgagggctc cgaggcggtg
      481 caatccggga ccccggagga gccagagcca gagctggaag ctgaggcctc taaagaggct
      541 gaaccggagc cggagccaga gccagagctg gaacccgagg ctgaagcaga accagagccg
      601 gaactggagc cagaaccgga cccagagccc gagcccgact tcgaggaaag ggacgagtcc
      661 gaagattcct gaaggccaga gctctgacag gcggtgcccc gcccatgctg gataggacct
      721 gggatgctgc tggagctgaa tcggatgcca ccaaggctcg gtccagccca gtaccgctgg
      781 aagtgaataa actccggagg gtcggacggg acctgggctc tctccacgat tctggctgtt
      841 tgcccaggaa cttagggtgg gtacctctga gtcccaggga cctgggcagg cccaagccca
      901 ccacgagcat catccagtcc tcagccctaa tctgccctta ggagtccagg ctgcaccctg
      961 gagatcccaa acctagcccc ctagtgggac aaggacctga ccctcctgcc cgcatacaca
     1021 acccatttcc cctggtgagc cacttggcag catatgtagg taccagctca accccacgca
     1081 agttcctgag ctgaacatgg agcaagggga gggtgacttc tctccacata gggagggctt
     1141 agagctcaca gccttgggaa gtgagactag aagaggggag cagaaaggga ccttgagtag
     1201 acaaaggcca cacacatcat tgtcattact gttttaattg tctggcttct ctctggactg
     1261 ggagctcagt gaggattctg accagtgact tacacaaaag gcgctctata catattataa
     1321 tatattcgct tactaaatga ataaggactt tccaa
//
