LOCUS       NM_024313               2830 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens nucleolar protein 12 (NOL12), mRNA.
ACCESSION   NM_024313
VERSION     NM_024313.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2830)
  AUTHORS   Zgheib,S., Taha,N., Zeiger,M., Glushonkov,O., Lequeu,T., Anton,H.,
            Didier,P., Boutant,E., Mely,Y. and Real,E.
  TITLE     The human cellular protein NoL12 is a specific partner of the HIV-1
            nucleocapsid protein NCp7
  JOURNAL   J Virol 97 (9), e0004023 (2023)
   PUBMED   37695057
  REMARK    GeneRIF: The human cellular protein NoL12 is a specific partner of
            the HIV-1 nucleocapsid protein NCp7.
REFERENCE   2  (bases 1 to 2830)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2830)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2830)
  AUTHORS   Pinho,M., Macedo,J.C., Logarinho,E. and Pereira,P.S.
  TITLE     NOL12 Repression Induces Nucleolar Stress-Driven Cellular
            Senescence and Is Associated with Normative Aging
  JOURNAL   Mol Cell Biol 39 (12), e00099-19 (2019)
   PUBMED   30988155
  REMARK    GeneRIF: Results show that NOL12 is important for nucleolar
            homeostasis, regulating its structure and the nucleolar levels of
            the multifunctional fibrillarin and nucleolin proteins. Moreover,
            NOL12 depletion to induce strong p53 activation leading to cell
            senescence suggesting an important role for NOL12 in replicative
            and chronological aging and its potential as aging biomarker.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2830)
  AUTHORS   Scott,D.D., Trahan,C., Zindy,P.J., Aguilar,L.C., Delubac,M.Y., Van
            Nostrand,E.L., Adivarahan,S., Wei,K.E., Yeo,G.W., Zenklusen,D. and
            Oeffinger,M.
  TITLE     Nol12 is a multifunctional RNA binding protein at the nexus of RNA
            and DNA metabolism
  JOURNAL   Nucleic Acids Res 45 (21), 12509-12528 (2017)
   PUBMED   29069457
  REMARK    GeneRIF: Nol12 is an RNA binding protein required for both ribosome
            maturation and genome integrity
REFERENCE   6  (bases 1 to 2830)
  AUTHORS   Nousiainen,M., Sillje,H.H., Sauer,G., Nigg,E.A. and Korner,R.
  TITLE     Phosphoproteome analysis of the human mitotic spindle
  JOURNAL   Proc Natl Acad Sci U S A 103 (14), 5391-5396 (2006)
   PUBMED   16565220
REFERENCE   7  (bases 1 to 2830)
  AUTHORS   Shahin,H., Walsh,T., Sobe,T., Abu Sa'ed,J., Abu Rayan,A.,
            Lynch,E.D., Lee,M.K., Avraham,K.B., King,M.C. and Kanaan,M.
  TITLE     Mutations in a novel isoform of TRIOBP that encodes a
            filamentous-actin binding protein are responsible for DFNB28
            recessive nonsyndromic hearing loss
  JOURNAL   Am J Hum Genet 78 (1), 144-152 (2006)
   PUBMED   16385458
REFERENCE   8  (bases 1 to 2830)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
REFERENCE   9  (bases 1 to 2830)
  AUTHORS   Collins,J.E., Goward,M.E., Cole,C.G., Smink,L.J., Huckle,E.J.,
            Knowles,S., Bye,J.M., Beare,D.M. and Dunham,I.
  TITLE     Reevaluating human gene annotation: a second-generation analysis of
            chromosome 22
  JOURNAL   Genome Res 13 (1), 27-36 (2003)
   PUBMED   12529303
REFERENCE   10 (bases 1 to 2830)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BE241845.1, BC002808.1 and Z83844.5.
            
            On Nov 23, 2018 this sequence version replaced NM_024313.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.169032.1,
                                           SRR1803613.194870.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359114.9/ ENSP00000352021.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BE241845.1         8-24
            18-780              BC002808.1         1-763
            781-2830            Z83844.5           65375-67424
FEATURES             Location/Qualifiers
     source          1..2830
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..2830
                     /gene="NOL12"
                     /gene_synonym="dJ37E16.7; Nop25"
                     /note="nucleolar protein 12"
                     /db_xref="GeneID:79159"
                     /db_xref="HGNC:HGNC:28585"
     exon            1..133
                     /gene="NOL12"
                     /gene_synonym="dJ37E16.7; Nop25"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..692
                     /gene="NOL12"
                     /gene_synonym="dJ37E16.7; Nop25"
                     /codon_start=1
                     /product="nucleolar protein 12"
                     /protein_id="NP_077289.1"
                     /db_xref="CCDS:CCDS13955.1"
                     /db_xref="GeneID:79159"
                     /db_xref="HGNC:HGNC:28585"
                     /translation="MGRNKKKKRDGDDRRPRLVLSFDEEKRREYLTGFHKRKVERKKA
                     AIEEIKQRLKEEQRKLREERHQEYLKMLAEREEALEEADELDRLVTAKTESVQYDHPN
                     HTVTVTTISDLDLSGARLLGLTPPEGGAGDRSEEEASSTEKPTKALPRKSRDPLLSQR
                     ISSLTASLHAHSRKKVKRKHPRRAQDSKKPPRAPRTSKAQRRRLTGKARHSGE"
     exon            134..239
                     /gene="NOL12"
                     /gene_synonym="dJ37E16.7; Nop25"
                     /inference="alignment:Splign:2.1.0"
     exon            240..288
                     /gene="NOL12"
                     /gene_synonym="dJ37E16.7; Nop25"
                     /inference="alignment:Splign:2.1.0"
     exon            289..431
                     /gene="NOL12"
                     /gene_synonym="dJ37E16.7; Nop25"
                     /inference="alignment:Splign:2.1.0"
     exon            432..529
                     /gene="NOL12"
                     /gene_synonym="dJ37E16.7; Nop25"
                     /inference="alignment:Splign:2.1.0"
     exon            530..2830
                     /gene="NOL12"
                     /gene_synonym="dJ37E16.7; Nop25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2809..2814
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOL12"
                     /gene_synonym="dJ37E16.7; Nop25"
                     /note="hexamer: ATTAAA"
     polyA_site      2830
                     /gene="NOL12"
                     /gene_synonym="dJ37E16.7; Nop25"
                     /note="major polyA site"
ORIGIN      
        1 gctacacccg gaagtgtctt cagggagagg aagccggcgg cctcactgct atgggccgca
       61 acaagaagaa gaagcgagat ggtgacgacc ggcggccgag gctcgttctt agcttcgacg
      121 aggagaagag gcgggagtac ctgacaggct tccacaagcg gaaggtcgag cgaaagaagg
      181 cagccattga ggagattaag cagcggctga aagaggagca gaggaagctt cgggaggagc
      241 gccaccagga atacttgaag atgctggcag agagagaaga ggctctggag gaggcagatg
      301 agctggaccg gttggtgaca gcaaagacgg agtcggtgca gtatgaccac cccaaccaca
      361 cagtcaccgt gaccaccatc agtgacctgg acctctcggg ggcccggctg ctcgggctga
      421 ccccacctga gggaggggct ggagacaggt ctgaggagga ggcgtcatcc acggagaaac
      481 caaccaaagc cttgcccagg aagtccagag accccctgct ctctcagcgg atctcctccc
      541 tcacagcatc actacatgca cacagccgca aaaaggtcaa gaggaaacat ccccgacggg
      601 cccaggactc caaaaagccc ccaagggccc ctcgtaccag caaggcccag cgccgccgtc
      661 tcacaggcaa agcacggcac agcggggagt gagaccgaga acgaagcggt gccccagtct
      721 aggctgcggg gacctgtcct tgctcagctt ggctgtccct gtagcccagc ctgcacctag
      781 gtaatgactg cacagctcaa ggttgggaag ccaggacctc tctggcctgg ggccagctgc
      841 ctttgcctgg ggtcagctgc ctttgcctgg ggtttgaatt cccgaaggag caggcagctg
      901 agagcaggcc tcccccagga agagccttca gagccacgtg ggggcatctt cccaaatgtg
      961 caccccacct ggcactcatc agatttgtgc gcttgtgatt tgtttgtcct tgataccacg
     1021 cacaagggca ggtttttggg gtggtggaaa tggccagggc ccatgggtct gtctccagca
     1081 gttagccctg tggctgcaat aaagtacagt tctccctgtg ttaagatcct aaccagggtt
     1141 aaggatcagt gtgtccgttg ctagaatcca gagcccacct gctgctctga aaagcaggct
     1201 cctgaggcca gtgggggagc agtgcccccc atgcccttca ccgaggagcc tctgtgcctg
     1261 tcccttgtcc tcggccccag gagtctcctc aactgacact gaagtggtgg aagcagttga
     1321 gtgccaggtc atcccccatc accacactgg ggcagcgtcc ccaggcttcc agcagctccc
     1381 aggtgggtcc caacgtggaa ggattaatta attctttcta aagcagttgc agccgggctt
     1441 ggtggctcac gcctgtaatc ccagcacttt gggaggccca ggcgggcaga tcacttaagg
     1501 tcgggagctc gagaccagcc tggccaacat ggtgaaaccc tgtctctact aaaaatgcaa
     1561 aaattagcca ggtgtggtgg cacacgcgtg taatcccagc tacttgggag gctgaggtgg
     1621 aagaatcact tgaaccctgg aggcggaggc tgcagtgagc cgagatcacg ccattgcact
     1681 ccagcctggg caacgttgtg accttgtctc aaaaaaaaac taaaaaataa agcagttgca
     1741 tcttgactcg tacaaaagta gcccccacca gagtagaccc tgcgggtgcc agctagaact
     1801 ccacaagggg ccatgtcttc acactccttc cagatggatg agttgatgga aaccctgtcc
     1861 cttccttgtc ccagcttgtc agtcctgggc aggagagaat ttcaggttgt gccttggtta
     1921 gaggagctgt gttgggtcct aaacactagg accacaaagg ggagtgaact gtgttcccag
     1981 ggcttgctga cgcccgtgga ctatggagtc aggatgacag gacagtgcgg tgaggggcat
     2041 ctgcgacagg actgcgggct ctacccgccc tgatgtggga gctcctggag tgggggtgag
     2101 cagtgagcca gggtctgcag ggctgtcctc tctccacagc caacagccag gccttacagt
     2161 ggggcaggct tagtgactgt gcctcagtta tgctgtacct gggagtgggc aggccctctc
     2221 ccatgtcacc atcaaaaccc actgatgaag gctggtggga gtctgagggc tgcacccggg
     2281 tatggtgagt tcccctcagg gattgtgctg agcgccttgg cctggcttct tggctccgcc
     2341 cacctgctct ccctgccacc aagttgtctt ccccgggtgg catgtgccac ttggctgcct
     2401 cgtgcctggg cacagtggtg cctattatgg gccctccagg tggctctggt gctcagcctg
     2461 ctgtgagcag gaacagctga gtcccagggg ttcttgcaca cagcagggct cgggtttgaa
     2521 tccaggctct gctgcttggt cgctgcatga gcttctgctg tgctgacctc tctggtttgt
     2581 ctcgtcatgt gtaaggtgac accagatacc tacctcttag ggctgccccg agactaaaat
     2641 aagaccatgt gcatgaacca cttaccaaag tgcctgttgc tctccaggtg tgcctaccgc
     2701 atgttgccgc tgctgtttct gctgggacgt ctgactccag ttccttctcc cctctccagt
     2761 gacaaggtca tttacaactt acatttacaa tttatagtgt ttaccagtat taaattctca
     2821 gccactcctt
//
