LOCUS       NM_015462               2844 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens nucleolar protein 11 (NOL11), transcript variant 1,
            mRNA.
ACCESSION   NM_015462
VERSION     NM_015462.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2844)
  AUTHORS   McCool,M.A., Bryant,C.J., Huang,H., Ogawa,L.M., Farley-Barnes,K.I.,
            Sondalle,S.B., Abriola,L., Surovtseva,Y.V. and Baserga,S.J.
  TITLE     Human nucleolar protein 7 (NOL7) is required for early pre-rRNA
            accumulation and pre-18S rRNA processing
  JOURNAL   RNA Biol 20 (1), 257-271 (2023)
   PUBMED   37246770
REFERENCE   2  (bases 1 to 2844)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 2844)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2844)
  AUTHORS   Fujimura,A., Hayashi,Y., Kato,K., Kogure,Y., Kameyama,M.,
            Shimamoto,H., Daitoku,H., Fukamizu,A., Hirota,T. and Kimura,K.
  TITLE     Identification of a novel nucleolar protein complex required for
            mitotic chromosome segregation through centromeric accumulation of
            Aurora B
  JOURNAL   Nucleic Acids Res 48 (12), 6583-6596 (2020)
   PUBMED   32479628
  REMARK    GeneRIF: Identification of a novel nucleolar protein complex
            required for mitotic chromosome segregation through centromeric
            accumulation of Aurora B.
REFERENCE   5  (bases 1 to 2844)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 2844)
  AUTHORS   Carvill,G.L., Weckhuysen,S., McMahon,J.M., Hartmann,C.,
            Moller,R.S., Hjalgrim,H., Cook,J., Geraghty,E., O'Roak,B.J.,
            Petrou,S., Clarke,A., Gill,D., Sadleir,L.G., Muhle,H., von
            Spiczak,S., Nikanorova,M., Hodgson,B.L., Gazina,E.V., Suls,A.,
            Shendure,J., Dibbens,L.M., De Jonghe,P., Helbig,I., Berkovic,S.F.,
            Scheffer,I.E. and Mefford,H.C.
  TITLE     GABRA1 and STXBP1: novel genetic causes of Dravet syndrome
  JOURNAL   Neurology 82 (14), 1245-1253 (2014)
   PUBMED   24623842
REFERENCE   7  (bases 1 to 2844)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   8  (bases 1 to 2844)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   9  (bases 1 to 2844)
  AUTHORS   Freed,E.F., Prieto,J.L., McCann,K.L., McStay,B. and Baserga,S.J.
  TITLE     NOL11, implicated in the pathogenesis of North American Indian
            childhood cirrhosis, is required for pre-rRNA transcription and
            processing
  JOURNAL   PLoS Genet 8 (8), e1002892 (2012)
   PUBMED   22916032
  REMARK    GeneRIF: NOL11 is a novel protein required for the early stages of
            ribosome biogenesis in humans and is implicated in the pathogenesis
            of North American Indian childhood cirrhosis.
REFERENCE   10 (bases 1 to 2844)
  AUTHORS   Scherl,A., Coute,Y., Deon,C., Calle,A., Kindbeiter,K.,
            Sanchez,J.C., Greco,A., Hochstrasser,D. and Diaz,J.J.
  TITLE     Functional proteomic analysis of human nucleolus
  JOURNAL   Mol Biol Cell 13 (11), 4100-4109 (2002)
   PUBMED   12429849
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA772356.1, AK023702.1, AK299483.1, AW273123.1 and AC006534.10.
            
            On Nov 23, 2018 this sequence version replaced NM_015462.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.20070.1,
                                           SRR1803613.1671.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000253247.9/ ENSP00000253247.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 DA772356.1         104-112
            10-1979             AK023702.1         3-1972
            1980-2515           AK299483.1         1915-2450
            2516-2521           AW273123.1         26-31               c
            2522-2844           AC006534.10        107662-107984
FEATURES             Location/Qualifiers
     source          1..2844
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q24.2"
     gene            1..2844
                     /gene="NOL11"
                     /note="nucleolar protein 11"
                     /db_xref="GeneID:25926"
                     /db_xref="HGNC:HGNC:24557"
                     /db_xref="MIM:615366"
     exon            1..153
                     /gene="NOL11"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..2172
                     /gene="NOL11"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="nucleolar protein 11 isoform 1"
                     /protein_id="NP_056277.2"
                     /db_xref="CCDS:CCDS11671.1"
                     /db_xref="GeneID:25926"
                     /db_xref="HGNC:HGNC:24557"
                     /db_xref="MIM:615366"
                     /translation="MAALEEEFTLSSVVLSAGPEGLLGVEQSDKTDQFLVTDSGRTVI
                     LYKVSDQKPLGSWSVKQGQIITCPAVCNFQTGEYVVVHDNKVLRIWNNEDVNLDKVFK
                     ATLSAEVYRILSVQGTEPLVLFKEGAVRGLEALLADPQQKIETVISDEEVIKWTKFFV
                     VFRHPVLIFITEKHGNYFAYVQMFNSRILTKYTLLLGQDENSVIKSFTASVDRKFISL
                     MSLSSDGCIYETLIPIRPADPEKNQSLVKSLLLKAVVSGNARNGVALTALDQDHVAVL
                     GSPLAASKECLSVWNIKFQTLQTSKELPQGTSGQLWYYGEHLFMLHGKSLTVIPYKCE
                     VSSLAGALGKLKHSQDPGTHVVSHFVNWETPQGCGLGFQNSEQSRRILRRRKIEVSLQ
                     PEVPPSKQLLSTIMKDSEKHIEVEVRKFLALKQTPDFHTVIGDTVTGLLERCKAEPSF
                     YPRNCLMQLIQTHVLSYSLCPDLMEIALKKKDVQLLQLCLQQFPDIPESVTCACLKIF
                     LSIGDDSLQETDVNMESVFDYSINSVHDEKMEEQTEILQNGFNPEEDKCNNCDQELNK
                     KPQDETKESTSCPVVQKRAALLNAILHSAYSETFLLPHLKDIPAQHITLFLKYLYFLY
                     LKCSENATMTLPGIHPPTLNQIMDWICLLLDANFTVVVMMPEAKRLLINLYKLVKSQI
                     SVYSELNKIEVSFRELQKLNQEKNNRGLYSIEVLELF"
     exon            154..267
                     /gene="NOL11"
                     /inference="alignment:Splign:2.1.0"
     exon            268..324
                     /gene="NOL11"
                     /inference="alignment:Splign:2.1.0"
     exon            325..473
                     /gene="NOL11"
                     /inference="alignment:Splign:2.1.0"
     exon            474..531
                     /gene="NOL11"
                     /inference="alignment:Splign:2.1.0"
     exon            532..676
                     /gene="NOL11"
                     /inference="alignment:Splign:2.1.0"
     exon            677..865
                     /gene="NOL11"
                     /inference="alignment:Splign:2.1.0"
     exon            866..942
                     /gene="NOL11"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1066
                     /gene="NOL11"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1155
                     /gene="NOL11"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1230
                     /gene="NOL11"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1415
                     /gene="NOL11"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1541
                     /gene="NOL11"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1775
                     /gene="NOL11"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1854
                     /gene="NOL11"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..1947
                     /gene="NOL11"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2055
                     /gene="NOL11"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2844
                     /gene="NOL11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2490..2495
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOL11"
                     /note="hexamer: AATAAA"
     polyA_site      2516
                     /gene="NOL11"
                     /note="major polyA site"
     regulatory      2825..2830
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOL11"
                     /note="hexamer: AATAAA"
     polyA_site      2844
                     /gene="NOL11"
ORIGIN      
        1 ggtttgctca aaatggcagc gctggaggaa gaattcacgt tgtcttcggt agtcctgagc
       61 gccgggcctg aaggactcct aggcgtggag cagagcgaca aaacagacca gtttctagtg
      121 acagacagcg gcaggacagt catcctctat aaggtttctg atcagaaacc cttggggagc
      181 tggtcagtga aacaaggtca aattataaca tgtccagctg tgtgcaactt tcaaactgga
      241 gagtatgttg ttgtacacga taataaggtt ttaagaatat ggaataatga agatgtaaac
      301 ctggataaag tatttaaagc tacattgtca gcagaagtat ataggatact ttcagtgcaa
      361 gggacagaac ccttggtgct cttcaaggaa ggtgctgttc gtggtttaga ggccttgctt
      421 gcagaccccc agcagaaaat tgaaactgtt atctctgatg aagaagtgat taaatggaca
      481 aagtttttcg tagtattcag acatcctgtt ttaattttta ttactgaaaa acatggaaat
      541 tactttgctt acgtgcaaat gtttaactca cgtatcttaa ccaaatatac actcttactt
      601 ggacaagacg aaaactctgt tataaagagt tttactgcat ctgtagatcg gaaattcatc
      661 tctttgatgt cattaagctc tgatggttgt atatatgaaa ccttgatacc aatacgtcca
      721 gctgacccag aaaaaaatca gagcttagtt aaatcactgc tgctcaaggc tgttgtatct
      781 ggtaacgctc gaaatggagt tgcactcact gccctggatc aggatcacgt cgcagtccta
      841 ggaagtccac tagcagcttc taaggaatgc ctctctgtat ggaacataaa atttcaaaca
      901 ctacagactt caaaagagtt accacaaggg accagtggtc aactctggta ttatggagaa
      961 catttgttta tgctacatgg aaaatctcta actgtgattc catacaagtg tgaagtgtca
     1021 tcattagcag gtgctcttgg aaaactcaag catagtcaag atccaggaac tcatgtcgtg
     1081 tcccattttg taaactggga gacacctcaa ggatgtggac ttgggttcca gaactcagag
     1141 cagtcaagaa gaattttaag gagacgaaaa attgaagtga gtttacagcc agaggttcca
     1201 ccatccaaac aacttttgtc aaccataatg aaagattcag aaaaacacat tgaagtagaa
     1261 gtacggaaat ttttggctct gaagcagaca cctgactttc atactgtcat tggggacaca
     1321 gtaacaggac ttctggaaag gtgtaaagca gaaccatcat tttatccccg gaactgtctg
     1381 atgcagctta tccaaacgca tgtgctttct tacagtttgt gccccgactt aatggagatt
     1441 gccttaaaaa agaaagatgt acagttgtta caactctgtc tacagcagtt ccctgacatt
     1501 cctgaatcag tcacctgtgc ttgcttaaaa attttcttga gcattggtga tgacagtctt
     1561 caagaaacag atgttaatat ggagtcagtt tttgactata gtataaattc tgtacatgat
     1621 gagaaaatgg aagagcaaac tgaaattctt caaaatggct tcaatcctga agaagataaa
     1681 tgcaataact gtgatcaaga gttaaataaa aagccccagg acgaaacaaa ggagagcact
     1741 tcatgccctg tggtacaaaa aagagcagct ctacttaatg caattcttca ttcagcatat
     1801 agcgagacat ttcttctgcc tcatttgaaa gacatcccag cacagcatat cacgctgttt
     1861 cttaagtatt tgtatttcct gtacctgaag tgtagcgaaa atgctactat gactcttcct
     1921 ggaatacacc cacctacctt gaaccagatt atggattgga tatgtctact tctggatgca
     1981 aattttactg ttgttgtaat gatgccagaa gcaaagaggc tactgataaa tctttacaag
     2041 cttgtaaaat ctcagatatc tgtttattct gagctcaaca agattgaagt aagttttcgg
     2101 gagctacaga aattaaatca agaaaagaat aatagaggat tatattcaat tgaagtgctg
     2161 gagctcttct gatattatca attctccttc atagacattt tataaagctc ttttatgtga
     2221 actcttgctt catccaggca agaacggtgt tttgtttgcg accatctcag tgtcaagaga
     2281 aacgtgtcag tgagtacctg gaccatcact taactgatgc tccggggtag gactgcaggt
     2341 ttcacatgaa cctgttctag gctgtggaca ttggtgtgga gaggttctgc aattttttaa
     2401 aaatatgtaa ctgggttgat tttaagtaaa attatttgtg tattgataaa agtctaattt
     2461 cttatcatgt gttttgaatt ttttctttta ataaaaaatg accattgaag cagtgattct
     2521 aggaagaatg taattttatc agagtcagaa gctgcccctg ctcatttgtt ccacagctca
     2581 cctttatttc acacatttgc agtgtgtctt ctgccacaag cagggcagag aggggccctc
     2641 acacaggcac gtgattgcct cctgcggtct cccctgtcct ttaggacaaa tgaaaagttc
     2701 aagtgtgatt ctacagccca gctttacaga aagaatcctg atggctgaat ttaccttgca
     2761 gtagtgaaaa gctgcgtttt aggtcaggca ctgtatgtaa actttagtca cacatgtggc
     2821 cgttaataaa caggttctcc tcca
//
