LOCUS       NM_024894               3498 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens nucleolar protein 10 (NOL10), transcript variant 1,
            mRNA.
ACCESSION   NM_024894
VERSION     NM_024894.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3498)
  AUTHORS   Jin,X., Tanaka,H., Jin,M., Fujita,K., Homma,H., Inotsume,M.,
            Yong,H., Umeda,K., Kodera,N., Ando,T. and Okazawa,H.
  TITLE     PQBP5/NOL10 maintains and anchors the nucleolus under physiological
            and osmotic stress conditions
  JOURNAL   Nat Commun 14 (1), 9 (2023)
   PUBMED   36599853
  REMARK    GeneRIF: PQBP5/NOL10 maintains and anchors the nucleolus under
            physiological and osmotic stress conditions.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3498)
  AUTHORS   Bammert,L., Jonas,S., Ungricht,R. and Kutay,U.
  TITLE     Human AATF/Che-1 forms a nucleolar protein complex with NGDN and
            NOL10 required for 40S ribosomal subunit synthesis
  JOURNAL   Nucleic Acids Res 44 (20), 9803-9820 (2016)
   PUBMED   27599843
REFERENCE   3  (bases 1 to 3498)
  AUTHORS   Al Olama,A.A., Kote-Jarai,Z., Berndt,S.I., Conti,D.V.,
            Schumacher,F., Han,Y., Benlloch,S., Hazelett,D.J., Wang,Z.,
            Saunders,E., Leongamornlert,D., Lindstrom,S., Jugurnauth-Little,S.,
            Dadaev,T., Tymrakiewicz,M., Stram,D.O., Rand,K., Wan,P., Stram,A.,
            Sheng,X., Pooler,L.C., Park,K., Xia,L., Tyrer,J., Kolonel,L.N., Le
            Marchand,L., Hoover,R.N., Machiela,M.J., Yeager,M., Burdette,L.,
            Chung,C.C., Hutchinson,A., Yu,K., Goh,C., Ahmed,M., Govindasami,K.,
            Guy,M., Tammela,T.L., Auvinen,A., Wahlfors,T., Schleutker,J.,
            Visakorpi,T., Leinonen,K.A., Xu,J., Aly,M., Donovan,J.,
            Travis,R.C., Key,T.J., Siddiq,A., Canzian,F., Khaw,K.T.,
            Takahashi,A., Kubo,M., Pharoah,P., Pashayan,N., Weischer,M.,
            Nordestgaard,B.G., Nielsen,S.F., Klarskov,P., Roder,M.A.,
            Iversen,P., Thibodeau,S.N., McDonnell,S.K., Schaid,D.J.,
            Stanford,J.L., Kolb,S., Holt,S., Knudsen,B., Coll,A.H.,
            Gapstur,S.M., Diver,W.R., Stevens,V.L., Maier,C., Luedeke,M.,
            Herkommer,K., Rinckleb,A.E., Strom,S.S., Pettaway,C., Yeboah,E.D.,
            Tettey,Y., Biritwum,R.B., Adjei,A.A., Tay,E., Truelove,A., Niwa,S.,
            Chokkalingam,A.P., Cannon-Albright,L., Cybulski,C., Wokolorczyk,D.,
            Kluzniak,W., Park,J., Sellers,T., Lin,H.Y., Isaacs,W.B.,
            Partin,A.W., Brenner,H., Dieffenbach,A.K., Stegmaier,C., Chen,C.,
            Giovannucci,E.L., Ma,J., Stampfer,M., Penney,K.L., Mucci,L.,
            John,E.M., Ingles,S.A., Kittles,R.A., Murphy,A.B., Pandha,H.,
            Michael,A., Kierzek,A.M., Blot,W., Signorello,L.B., Zheng,W.,
            Albanes,D., Virtamo,J., Weinstein,S., Nemesure,B., Carpten,J.,
            Leske,C., Wu,S.Y., Hennis,A., Kibel,A.S., Rybicki,B.A.,
            Neslund-Dudas,C., Hsing,A.W., Chu,L., Goodman,P.J., Klein,E.A.,
            Zheng,S.L., Batra,J., Clements,J., Spurdle,A., Teixeira,M.R.,
            Paulo,P., Maia,S., Slavov,C., Kaneva,R., Mitev,V., Witte,J.S.,
            Casey,G., Gillanders,E.M., Seminara,D., Riboli,E., Hamdy,F.C.,
            Coetzee,G.A., Li,Q., Freedman,M.L., Hunter,D.J., Muir,K.,
            Gronberg,H., Neal,D.E., Southey,M., Giles,G.G., Severi,G.,
            Cook,M.B., Nakagawa,H., Wiklund,F., Kraft,P., Chanock,S.J.,
            Henderson,B.E., Easton,D.F., Eeles,R.A. and Haiman,C.A.
  CONSRTM   Breast and Prostate Cancer Cohort Consortium (BPC3); PRACTICAL
            (Prostate Cancer Association Group to Investigate Cancer-Associated
            Alterations in the Genome) Consortium; COGS (Collaborative
            Oncological Gene-environment Study) Consortium; GAME-ON/ELLIPSE
            Consortium
  TITLE     A meta-analysis of 87,040 individuals identifies 23 new
            susceptibility loci for prostate cancer
  JOURNAL   Nat Genet 46 (10), 1103-1109 (2014)
   PUBMED   25217961
REFERENCE   4  (bases 1 to 3498)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 3498)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 3498)
  AUTHORS   Scherl,A., Coute,Y., Deon,C., Calle,A., Kindbeiter,K.,
            Sanchez,J.C., Greco,A., Hochstrasser,D. and Diaz,J.J.
  TITLE     Functional proteomic analysis of human nucleolus
  JOURNAL   Mol Biol Cell 13 (11), 4100-4109 (2002)
   PUBMED   12429849
REFERENCE   7  (bases 1 to 3498)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
REFERENCE   8  (bases 1 to 3498)
  AUTHORS   Imafuku,I., Waragai,M., Takeuchi,S., Kanazawa,I., Kawabata,M.,
            Mouradian,M.M. and Okazawa,H.
  TITLE     Polar amino acid-rich sequences bind to polyglutamine tracts
  JOURNAL   Biochem Biophys Res Commun 253 (1), 16-20 (1998)
   PUBMED   9875212
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092687.3 and AC007314.3.
            
            On Nov 23, 2018 this sequence version replaced NM_024894.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest protein (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.33585.1,
                                           SRR1803614.103701.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381685.10/ ENSP00000371101.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               AC092687.3         16844-17023         c
            181-226             AC092687.3         11615-11660         c
            227-325             AC092687.3         9019-9117           c
            326-403             AC092687.3         2842-2919           c
            404-441             AC092687.3         568-605             c
            442-578             AC007314.3         135651-135787       c
            579-644             AC007314.3         132755-132820       c
            645-705             AC007314.3         131315-131375       c
            706-791             AC007314.3         127056-127141       c
            792-870             AC007314.3         123269-123347       c
            871-1020            AC007314.3         121839-121988       c
            1021-1087           AC007314.3         118578-118644       c
            1088-1140           AC007314.3         108417-108469       c
            1141-1267           AC007314.3         71282-71408         c
            1268-1347           AC007314.3         67175-67254         c
            1348-1446           AC007314.3         66873-66971         c
            1447-1536           AC007314.3         64950-65039         c
            1537-1710           AC007314.3         53675-53848         c
            1711-1958           AC007314.3         53140-53387         c
            1959-2061           AC007314.3         41733-41835         c
            2062-3498           AC007314.3         34851-36287         c
FEATURES             Location/Qualifiers
     source          1..3498
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p25.1"
     gene            1..3498
                     /gene="NOL10"
                     /gene_synonym="PQBP5"
                     /note="nucleolar protein 10"
                     /db_xref="GeneID:79954"
                     /db_xref="HGNC:HGNC:25862"
                     /db_xref="MIM:616197"
     exon            1..180
                     /gene="NOL10"
                     /gene_synonym="PQBP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..2181
                     /gene="NOL10"
                     /gene_synonym="PQBP5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     polyglutamine binding protein 5; H_NH0074G24.1"
                     /codon_start=1
                     /product="nucleolar protein 10 isoform 1"
                     /protein_id="NP_079170.2"
                     /db_xref="CCDS:CCDS1673.2"
                     /db_xref="GeneID:79954"
                     /db_xref="HGNC:HGNC:25862"
                     /db_xref="MIM:616197"
                     /translation="MQVSSLNEVKIYSLSCGKSLPEWLSDRKKRALQKKDVDVRRRIE
                     LIQDFEMPTVCTTIKVSKDGQYILATGTYKPRVRCYDTYQLSLKFERCLDSEVVTFEI
                     LSDDYSKIVFLHNDRYIEFHSQSGFYYKTRIPKFGRDFSYHYPSCDLYFVGASSEVYR
                     LNLEQGRYLNPLQTDAAENNVCDINSVHGLFATGTIEGRVECWDPRTRNRVGLLDCAL
                     NSVTADSEINSLPTISALKFNGALTMAVGTTTGQVLLYDLRSDKPLLVKDHQYGLPIK
                     SVHFQDSLDLILSADSRIVKMWNKNSGKIFTSLEPEHDLNDVCLYPNSGMLLTANETP
                     KMGIYYIPVLGPAPRWCSFLDNLTEELEENPESTVYDDYKFVTKKDLENLGLTHLIGS
                     PFLRAYMHGFFMDIRLYHKVKLMVNPFAYEEYRKDKIRQKIEETRAQRVQLKKLPKVN
                     KELALKLIEEEEEKQKSTWKKKVKSLPNILTDDRFKVMFENPDFQVDEESEEFRLLNP
                     LVSKISEKRKKKLRLLEQQELREKEEEEEPEGKPSDAESSESSDDEKAWVEEVRKQRR
                     LLQQEEKVKRQERLKEDQQTVLKPQFYEIKAGEEFRSFKDSATKQKLMNKTLEDRLKI
                     EAKNGTLSVSDTTVGSKQLTFTLKRSEQQKKQQEAEKLHRQERKRLRRSAGHLKSRHK
                     RGRSFH"
     exon            181..226
                     /gene="NOL10"
                     /gene_synonym="PQBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            227..325
                     /gene="NOL10"
                     /gene_synonym="PQBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            326..403
                     /gene="NOL10"
                     /gene_synonym="PQBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            404..441
                     /gene="NOL10"
                     /gene_synonym="PQBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            442..578
                     /gene="NOL10"
                     /gene_synonym="PQBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            579..644
                     /gene="NOL10"
                     /gene_synonym="PQBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            645..705
                     /gene="NOL10"
                     /gene_synonym="PQBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            706..791
                     /gene="NOL10"
                     /gene_synonym="PQBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            792..870
                     /gene="NOL10"
                     /gene_synonym="PQBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1020
                     /gene="NOL10"
                     /gene_synonym="PQBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1087
                     /gene="NOL10"
                     /gene_synonym="PQBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1140
                     /gene="NOL10"
                     /gene_synonym="PQBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1267
                     /gene="NOL10"
                     /gene_synonym="PQBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1347
                     /gene="NOL10"
                     /gene_synonym="PQBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1446
                     /gene="NOL10"
                     /gene_synonym="PQBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1536
                     /gene="NOL10"
                     /gene_synonym="PQBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1710
                     /gene="NOL10"
                     /gene_synonym="PQBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1958
                     /gene="NOL10"
                     /gene_synonym="PQBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2061
                     /gene="NOL10"
                     /gene_synonym="PQBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..3498
                     /gene="NOL10"
                     /gene_synonym="PQBP5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2576..2581
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOL10"
                     /gene_synonym="PQBP5"
                     /note="hexamer: ATTAAA"
     polyA_site      2597
                     /gene="NOL10"
                     /gene_synonym="PQBP5"
                     /note="major polyA site"
     regulatory      3469..3474
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOL10"
                     /gene_synonym="PQBP5"
                     /note="hexamer: AATATA"
     polyA_site      3498
                     /gene="NOL10"
                     /gene_synonym="PQBP5"
ORIGIN      
        1 agtcggcgcc agcggccgca cgccgcggag caggggctcg gaggtcccgg gattacggtg
       61 ctcgagcacg ctggtgggaa aggacccggg acttgaacag tgttgtgcgg cgccatgcag
      121 gtctccagcc tcaatgaggt gaagatttac agcctcagct gcggcaagtc ccttcctgag
      181 tggctttctg ataggaagaa gagagcgcta cagaagaaag atgtagatgt ccgtaggaga
      241 attgaactta ttcaggactt tgaaatgcct actgtgtgta ccactattaa ggtgtcaaaa
      301 gatggacagt acattttagc aactggaaca tataaacctc gggttcgatg ttatgacacc
      361 tatcaattat ccttgaagtt tgaaaggtgt ttagattcag aagttgtcac ctttgaaatt
      421 ttgtctgatg actactcaaa gattgtcttc ttacataatg atagatacat tgaatttcat
      481 tcgcaatcag gtttttacta caaaaccaga ataccaaagt ttgggagaga tttctcttac
      541 cactatccat cctgtgactt gtactttgtt ggtgcaagtt ctgaagttta taggttaaac
      601 ttagaacaag gacgatacct gaatcctcta caaactgatg ctgcggagaa taatgtttgt
      661 gacataaatt cagtgcatgg cttgtttgcc acaggaacca tagagggtag agtggagtgc
      721 tgggacccaa gaactcgaaa cagagttggc ctgttagact gcgccttaaa cagtgtcaca
      781 gcagattcag agataaacag tttaccaaca atctctgctt tgaaatttaa tggtgccttg
      841 accatggcag ttggaacaac cacagggcag gttttattat atgaccttcg atctgataag
      901 ccattgctag ttaaagatca ccagtatggg ctgcccatta agtccgttca tttccaggat
      961 tcattagatc tgattttgtc tgctgactct cgaattgtca agatgtggaa taagaactcc
     1021 ggaaaaatat ttacttcctt ggagccagag catgacctta atgatgtttg tctctacccc
     1081 aactcaggca tgcttctgac ggccaatgaa acccccaaga tgggcatcta ttacattcca
     1141 gttttgggtc ctgctcctcg gtggtgttcc ttcttagaca acttgaccga agaattagaa
     1201 gagaatccag aaagcacagt ctatgatgat tataaatttg tcaccaagaa agaccttgaa
     1261 aatttagggc tcacccacct cattggatct cctttcctcc gggcatatat gcatgggttt
     1321 ttcatggata taagactcta tcacaaggtg aaactgatgg taaatccatt tgcttatgaa
     1381 gaatatagga aagataaaat acgacagaaa atagaagaaa cacgtgcaca gagagtccag
     1441 ttaaagaaat tgccaaaagt taacaaagag ctggcactta aattaattga ggaagaagag
     1501 gagaagcaga aatctacatg gaaaaagaaa gttaagagtc ttcctaatat tctcaccgat
     1561 gatcgattta aagttatgtt tgagaaccct gacttccaag tagatgaaga gagtgaagaa
     1621 tttaggcttc tgaatccact tgtttcaaaa attagtgaaa aaaggaagaa gaaactaaga
     1681 ctcttagagc aacaagaact tcgtgaaaaa gaagaggagg aagagccgga aggaaaacca
     1741 agtgatgcag aaagttcgga gagttcagat gatgaaaaag cctgggttga agaggtcagg
     1801 aagcaacgca gactcctcca gcaggaggaa aaagtgaagc ggcaggaacg actcaaggag
     1861 gaccagcaga cagtcctaaa gccccagttt tatgagatca aagcaggaga agaatttaga
     1921 agcttcaaag attctgccac aaagcagaaa ctgatgaaca aaacccttga agatcgtttg
     1981 aaaattgaag caaaaaatgg gacattgagt gtatccgaca ccaccgttgg cagcaaacaa
     2041 ttgacattca cgttaaagag gtctgaacag cagaagaagc aacaggaggc tgagaaactg
     2101 catcgacaag aaaggaaaag actccgtcgt tcggccggac acctgaagtc aagacacaaa
     2161 agaggacggt cgtttcattg atttgggaag tggtcctacc tgtgattagg gaggggtacg
     2221 tctcccccaa actgatcatc gttagggtgt taaacacaga cgaggaaaca cacgttttta
     2281 aagttcatgt acgttcttgt acacagaggt aaagatttga aaacctgtgc cttgtgggtt
     2341 ggactttgaa gctggccccg ccgacggcca ccgcacagcc ccaggggtgt gcttgcgagt
     2401 cgttgctccc tggaaacatt gtcctttccc cacggcgtta atcatgaaaa ccaggctggg
     2461 gtttttttaa tattgtgaaa tgtacaccat gaaatgaaag gtttatcctg tgccagaaac
     2521 caaggtttat catgctctag gaactttttt cttacactgc ctaccgccat tcatgattaa
     2581 accatccaga aataccatcc ctgttttacc tggtgtctgt gtattgcctg tgtttgtgtt
     2641 tataagttta tgctgatagg tttgttcggc ttgtttatgt attagtttgg gatttgtttt
     2701 taaataattt ataccaagag agtataatct aatggtgcag gttgagagca tcccaaatcc
     2761 gaaaatctaa aactgtttga gcactgtatt tatctgttct tgcactgcta taaagaacta
     2821 cctgaaactg ggtaatttat aagtaaagaa aagaggttta attgactcac agttctacag
     2881 gtggtacagg aagcatggct gtggaggccc tgggaagctt acaatcgtgg cagaaggtga
     2941 agcggaagca ggtatgtcct gcgtggctag agccagagga ggagggcaaa ggggcagatg
     3001 ctgcacactt tcaaacacca gatctccaag aactcactaa cacagaatag caagggggaa
     3061 gtctgccccc atgtttcagt cacctccctc caggcccctc ctccaacacc gaagattaca
     3121 atttgacatg agatttgtgt ggggacacag agcaaaacca tatcaagcac tgacatgaca
     3181 ttggaggaaa atgctcatta gagcttttca ggttttggat tttcagattt gggatacttg
     3241 actagtaaat ataatacaga tattccaaaa cacacaaaaa aaccaaagtc taaaagactt
     3301 ctggtcccaa gcatttcaga taagggatac ccaacctgta ataatgggaa acaagcagta
     3361 gaggctgttg gttaatcttg gcacaagttt aattacaggt tttttttttt tcctgtttct
     3421 taagtacagt caaacataaa cttactggag gaaacattta taaaaataaa tatactttca
     3481 tttgaatagc ttctttga
//
