LOCUS       NM_005450               1913 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens noggin (NOG), mRNA.
ACCESSION   NM_005450
VERSION     NM_005450.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1913)
  AUTHORS   Truchan,K. and Osyczka,A.M.
  TITLE     Noggin promotes osteogenesis in human adipose-derived mesenchymal
            stem cells via FGFR2/Src/Akt and ERK signaling pathway
  JOURNAL   Sci Rep 14 (1), 6724 (2024)
   PUBMED   38509118
  REMARK    GeneRIF: Noggin promotes osteogenesis in human adipose-derived
            mesenchymal stem cells via FGFR2/Src/Akt and ERK signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1913)
  AUTHORS   Lee,J., Shin,J.A., Lee,E.M., Nam,M. and Park,E.M.
  TITLE     Noggin-mediated effects on metabolite profiles of microglia and
            oligodendrocytes after ischemic insult
  JOURNAL   J Pharm Biomed Anal 224, 115196 (2023)
   PUBMED   36529041
  REMARK    GeneRIF: Noggin-mediated effects on metabolite profiles of
            microglia and oligodendrocytes after ischemic insult.
REFERENCE   3  (bases 1 to 1913)
  AUTHORS   Robert,C., Kerff,F., Bouillenne,F., Gavage,M., Vandevenne,M.,
            Filee,P. and Matagne,A.
  TITLE     Structural analysis of the interaction between human cytokine BMP-2
            and the antagonist Noggin reveals molecular details of cell
            chondrogenesis inhibition
  JOURNAL   J Biol Chem 299 (2), 102892 (2023)
   PUBMED   36642181
  REMARK    GeneRIF: Structural analysis of the interaction between human
            cytokine BMP-2 and the antagonist Noggin reveals molecular details
            of cell chondrogenesis inhibition.
REFERENCE   4  (bases 1 to 1913)
  AUTHORS   Phan-Everson,T., Etoc,F., Li,S., Khodursky,S., Yoney,A.,
            Brivanlou,A.H. and Siggia,E.D.
  TITLE     Differential compartmentalization of BMP4/NOGGIN requires NOGGIN
            trans-epithelial transport
  JOURNAL   Dev Cell 56 (13), 1930-1944 (2021)
   PUBMED   34051144
  REMARK    GeneRIF: Differential compartmentalization of BMP4/NOGGIN requires
            NOGGIN trans-epithelial transport.
REFERENCE   5  (bases 1 to 1913)
  AUTHORS   Chun,S.H., Kim,E.Y., Yoon,J.S., Won,H.S., Yim,K., Hwang,H.W.,
            Hong,S.A., Lee,M., Lee,S.L., Kim,S.S., Sun,S. and Ko,Y.H.
  TITLE     Prognostic value of noggin protein expression in patients with
            resected gastric cancer
  JOURNAL   BMC Cancer 21 (1), 558 (2021)
   PUBMED   34001012
  REMARK    GeneRIF: Prognostic value of noggin protein expression in patients
            with resected gastric cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1913)
  AUTHORS   McMahon,J.A., Takada,S., Zimmerman,L.B., Fan,C.M., Harland,R.M. and
            McMahon,A.P.
  TITLE     Noggin-mediated antagonism of BMP signaling is required for growth
            and patterning of the neural tube and somite
  JOURNAL   Genes Dev 12 (10), 1438-1452 (1998)
   PUBMED   9585504
REFERENCE   7  (bases 1 to 1913)
  AUTHORS   Zimmerman,L.B., De Jesus-Escobar,J.M. and Harland,R.M.
  TITLE     The Spemann organizer signal noggin binds and inactivates bone
            morphogenetic protein 4
  JOURNAL   Cell 86 (4), 599-606 (1996)
   PUBMED   8752214
REFERENCE   8  (bases 1 to 1913)
  AUTHORS   Lamb,T.M. and Harland,R.M.
  TITLE     Fibroblast growth factor is a direct neural inducer, which combined
            with noggin generates anterior-posterior neural pattern
  JOURNAL   Development 121 (11), 3627-3636 (1995)
   PUBMED   8582276
REFERENCE   9  (bases 1 to 1913)
  AUTHORS   Valenzuela,D.M., Economides,A.N., Rojas,E., Lamb,T.M., Nunez,L.,
            Jones,P., Lp,N.Y., Espinosa,R. 3rd, Brannan,C.I., Gilbert,D.J. et
            al.
  TITLE     Identification of mammalian noggin and its expression in the adult
            nervous system
  JOURNAL   J Neurosci 15 (9), 6077-6084 (1995)
   PUBMED   7666191
REFERENCE   10 (bases 1 to 1913)
  AUTHORS   Polymeropoulos,M.H., Poush,J., Rubenstein,J.R. and Francomano,C.A.
  TITLE     Localization of the gene (SYM1) for proximal symphalangism to human
            chromosome 17q21-q22
  JOURNAL   Genomics 27 (2), 225-229 (1995)
   PUBMED   7557985
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC015724.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 31, 2019 this sequence version replaced NM_005450.5.
            
            Summary: The secreted polypeptide, encoded by this gene, binds and
            inactivates members of the transforming growth factor-beta
            (TGF-beta) superfamily signaling proteins, such as bone
            morphogenetic protein-4 (BMP4). By diffusing through extracellular
            matrices more efficiently than members of the TGF-beta superfamily,
            this protein may have a principal role in creating morphogenic
            gradients. The protein appears to have pleiotropic effect, both
            early in development as well as in later stages. It was originally
            isolated from Xenopus based on its ability to restore normal
            dorsal-ventral body axis in embryos that had been artificially
            ventralized by UV treatment. The results of the mouse knockout of
            the ortholog suggest that it is involved in numerous developmental
            processes, such as neural tube fusion and joint formation.
            Recently, several dominant human NOG mutations in unrelated
            families with proximal symphalangism (SYM1) and multiple synostoses
            syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple
            joint fusion as their principal feature, and map to the same region
            (17q22) as this gene. All of these mutations altered evolutionarily
            conserved amino acid residues. The amino acid sequence of this
            human gene is highly homologous to that of Xenopus, rat and mouse.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK314080.1, BC034027.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332822.6/ ENSP00000328181.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1892              AC015724.9         60213-62104         c
            1893-1913           AC015724.9         60192-60212         c
FEATURES             Location/Qualifiers
     source          1..1913
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q22"
     gene            1..1913
                     /gene="NOG"
                     /gene_synonym="SYM1; SYNS1; SYNS1A"
                     /note="noggin"
                     /db_xref="GeneID:9241"
                     /db_xref="HGNC:HGNC:7866"
                     /db_xref="MIM:602991"
     exon            1..1913
                     /gene="NOG"
                     /gene_synonym="SYM1; SYNS1; SYNS1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             526..1224
                     /gene="NOG"
                     /gene_synonym="SYM1; SYNS1; SYNS1A"
                     /note="symphalangism 1 (proximal)"
                     /codon_start=1
                     /product="noggin precursor"
                     /protein_id="NP_005441.1"
                     /db_xref="CCDS:CCDS11589.1"
                     /db_xref="GeneID:9241"
                     /db_xref="HGNC:HGNC:7866"
                     /db_xref="MIM:602991"
                     /translation="MERCPSLGVTLYALVVVLGLRATPAGGQHYLHIRPAPSDNLPLV
                     DLIEHPDPIFDPKEKDLNETLLRSLLGGHYDPGFMATSPPEDRPGGGGGAAGGAEDLA
                     ELDQLLRQRPSGAMPSEIKGLEFSEGLAQGKKQRLSKKLRRKLQMWLWSQTFCPVLYA
                     WNDLGSRFWPRYVKVGSCFSKRSCSVPEGMVCKPSKSVHLTVLRWRCQRRGGQRCGWI
                     PIQYPIISECKCSC"
     regulatory      1890..1895
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOG"
                     /gene_synonym="SYM1; SYNS1; SYNS1A"
                     /note="hexamer: ATTAAA"
     polyA_site      1913
                     /gene="NOG"
                     /gene_synonym="SYM1; SYNS1; SYNS1A"
                     /note="major polyA site"
ORIGIN      
        1 aaaccggtgc caacgtgcgc ggacgccgcc gccgccgccg ccgctggagt ccgccgggca
       61 gagccggccg cggagcccgg agcaggcgga gggaagtgcc cctagaacca gctcagccag
      121 cggcgcttgc acagagcggc cggacgaaga gcagcgagag gaggagggga gagcggctcg
      181 tccacgcgcc ctgcgccgcc gccggcccgg gaaggcagcg aggagccggc gcctcccgcg
      241 ccccgcggtc gccctggagt aatttcggat gcccagccgc ggccgccttc cccagtagac
      301 ccgggagagg agttgcggcc aacttgtgtg cctttcttcc gccccggtgg gagccggcgc
      361 tgcgcgaagg gctctcccgg cggctcatgc tgccggccct gcgcctgccc agcctcgggt
      421 gagccgcctc cggagagacg ggggagcgcg gcggcgccgc gggctcggcg tgctctcctc
      481 cggggacgcg ggacgaagca gcagccccgg gcgcgcgcca gaggcatgga gcgctgcccc
      541 agcctagggg tcaccctcta cgccctggtg gtggtcctgg ggctgcgggc gacaccggcc
      601 ggcggccagc actatctcca catccgcccg gcacccagcg acaacctgcc cctggtggac
      661 ctcatcgaac acccagaccc tatctttgac cccaaggaaa aggatctgaa cgagacgctg
      721 ctgcgctcgc tgctcggggg ccactacgac ccaggcttca tggccacctc gccccccgag
      781 gaccggcccg gcgggggcgg gggtgcagct gggggcgcgg aggacctggc ggagctggac
      841 cagctgctgc ggcagcggcc gtcgggggcc atgccgagcg agatcaaagg gctagagttc
      901 tccgagggct tggcccaggg caagaagcag cgcctaagca agaagctgcg gaggaagtta
      961 cagatgtggc tgtggtcgca gacattctgc cccgtgctgt acgcgtggaa cgacctgggc
     1021 agccgctttt ggccgcgcta cgtgaaggtg ggcagctgct tcagtaagcg ctcgtgctcc
     1081 gtgcccgagg gcatggtgtg caagccgtcc aagtccgtgc acctcacggt gctgcggtgg
     1141 cgctgtcagc ggcgcggggg ccagcgctgc ggctggattc ccatccagta ccccatcatt
     1201 tccgagtgca agtgctcgtg ctagaactcg ggggccccct gcccgcaccc ggacacttga
     1261 tcgatcccca ccgacgcccc ctgcaccgcc tccaaccagt tccaccaccc tctagcgagg
     1321 gttttcaatg aacttttttt tttttttttt tttttttttc tgggctacag agacctagct
     1381 ttctggttcc tgtaatgcac tgtttaactg tgtaggaatg tatatgtgtg tgtatatacg
     1441 gtcccagttt taatttactt attaaaaggt cagtattata cgttaaaagt taccggcttc
     1501 tactgtattt ttaaaaaaaa gtaagcaaaa gaaaaaaaaa agaacagaga aaagagagac
     1561 ttattctggt tgttgctaat aatgttaacc tgctatttat attccagtgc ccttcgcatg
     1621 gcgaagcagg ggggaaaagt tatttttttc ttgaagtaca aagagacggg ggaacttttg
     1681 tagaggactt tttaaaagct attttccatt cttcggaaag tgttttggtt ttccttggac
     1741 ctcgaagaag ctatagagtt caatgttatt ttacagttat tgtaaatata gagaacaaat
     1801 ggaatgacta atcattgtaa attaagagta tctgctattt attctttata atatcccgtg
     1861 tagtaaatga gaaagaagtg cagagcagga ttaaagaaaa ccactaaaac cga
//
