LOCUS       NM_001370466            4363 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens nucleotide binding oligomerization domain containing 2
            (NOD2), transcript variant 3, mRNA.
ACCESSION   NM_001370466 XM_005256084
VERSION     NM_001370466.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4363)
  AUTHORS   Antony,B.S., Nagarajan,C., Devaraj,D.V. and Subbaraj,G.K.
  TITLE     A Systemic Review and Meta-analysis on Natural
            Resistance-associated Macrophage Protein 1 (3'-Untranslated Region)
            and Nucleotide-binding Oligomerization Domain-2 (rs8057341)
            Polymorphisms and Leprosy Susceptibility in Asian and Caucasian
            Populations
  JOURNAL   Int J Mycobacteriol 13 (2), 115-125 (2024)
   PUBMED   38916380
  REMARK    GeneRIF: A Systemic Review and Meta-analysis on Natural
            Resistance-associated Macrophage Protein 1 (3'-Untranslated Region)
            and Nucleotide-binding Oligomerization Domain-2 (rs8057341)
            Polymorphisms and Leprosy Susceptibility in Asian and Caucasian
            Populations.
            Review article
REFERENCE   2  (bases 1 to 4363)
  AUTHORS   Zhang,J., Luo,Y., Wu,B., Huang,X., Zhao,M., Wu,N., Miao,J., Li,J.,
            Zhu,L., Wu,D. and Shen,M.
  TITLE     Identifying functional dysregulation of NOD2 variant Q902K in
            patients with Yao syndrome
  JOURNAL   Arthritis Res Ther 26 (1), 58 (2024)
   PUBMED   38395960
  REMARK    GeneRIF: Identifying functional dysregulation of NOD2 variant Q902K
            in patients with Yao syndrome.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4363)
  AUTHORS   Karamanakos,A., Vougiouka,O., Sapountzi,E., Venetsanopoulou,A.I.,
            Tektonidou,M.G., Germenis,A.E., Sfikakis,P.P. and Laskari,K.
  TITLE     The expanding clinical spectrum of autoinflammatory diseases with
            NOD2 variants: a case series and literature review
  JOURNAL   Front Immunol 15, 1342668 (2024)
   PUBMED   38348033
  REMARK    GeneRIF: The expanding clinical spectrum of autoinflammatory
            diseases with NOD2 variants: a case series and literature review.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4363)
  AUTHORS   Rosenstiel,P., Huse,K., Franke,A., Hampe,J., Reichwald,K.,
            Platzer,C., Roberts,R.G., Mathew,C.G., Platzer,M. and Schreiber,S.
  TITLE     Functional characterization of two novel 5' untranslated exons
            reveals a complex regulation of NOD2 protein expression
  JOURNAL   BMC Genomics 8, 472 (2007)
   PUBMED   18096043
  REMARK    GeneRIF: The results suggest complex parallel control mechanisms
            that independently regulate NOD2 expression in the context of
            inflammatory signaling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4363)
  AUTHORS   Kanazawa,N., Okafuji,I., Kambe,N., Nishikomori,R.,
            Nakata-Hizume,M., Nagai,S., Fuji,A., Yuasa,T., Manki,A.,
            Sakurai,Y., Nakajima,M., Kobayashi,H., Fujiwara,I., Tsutsumi,H.,
            Utani,A., Nishigori,C., Heike,T., Nakahata,T. and Miyachi,Y.
  TITLE     Early-onset sarcoidosis and CARD15 mutations with constitutive
            nuclear factor-kappaB activation: common genetic etiology with Blau
            syndrome
  JOURNAL   Blood 105 (3), 1195-1197 (2005)
   PUBMED   15459013
  REMARK    GeneRIF: In early-onset sarcoidosis and Blau syndrome share the
            common genetic etiology of CARD15 mutations that cause constitutive
            NF-kappaB activation.
REFERENCE   6  (bases 1 to 4363)
  AUTHORS   Miceli-Richard,C., Lesage,S., Rybojad,M., Prieur,A.M.,
            Manouvrier-Hanu,S., Hafner,R., Chamaillard,M., Zouali,H., Thomas,G.
            and Hugot,J.P.
  TITLE     CARD15 mutations in Blau syndrome
  JOURNAL   Nat Genet 29 (1), 19-20 (2001)
   PUBMED   11528384
REFERENCE   7  (bases 1 to 4363)
  AUTHORS   Hugot,J.P., Chamaillard,M., Zouali,H., Lesage,S., Cezard,J.P.,
            Belaiche,J., Almer,S., Tysk,C., O'Morain,C.A., Gassull,M.,
            Binder,V., Finkel,Y., Cortot,A., Modigliani,R., Laurent-Puig,P.,
            Gower-Rousseau,C., Macry,J., Colombel,J.F., Sahbatou,M. and
            Thomas,G.
  TITLE     Association of NOD2 leucine-rich repeat variants with
            susceptibility to Crohn's disease
  JOURNAL   Nature 411 (6837), 599-603 (2001)
   PUBMED   11385576
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 4363)
  AUTHORS   Ohmen,J.D., Yang,H.Y., Yamamoto,K.K., Zhao,H.Y., Ma,Y.,
            Bentley,L.G., Huang,Z., Gerwehr,S., Pressman,S., McElree,C.,
            Targan,S., Rotter,J.I. and Fischel-Ghodsian,N.
  TITLE     Susceptibility locus for inflammatory bowel disease on chromosome
            16 has a role in Crohn's disease, but not in ulcerative colitis
  JOURNAL   Hum Mol Genet 5 (10), 1679-1683 (1996)
   PUBMED   8894707
REFERENCE   9  (bases 1 to 4363)
  AUTHORS   Hugot,J.P., Laurent-Puig,P., Gower-Rousseau,C., Olson,J.M.,
            Lee,J.C., Beaugerie,L., Naom,I., Dupas,J.L., Van Gossum,A.,
            Orholm,M., Bonaiti-Pellie,C., Weissenbach,J., Mathew,C.G.,
            Lennard-Jones,J.E., Cortot,A., Colombel,J.F. and Thomas,G.
  TITLE     Mapping of a susceptibility locus for Crohn's disease on chromosome
            16
  JOURNAL   Nature 379 (6568), 821-823 (1996)
   PUBMED   8587604
REFERENCE   10 (bases 1 to 4363)
  AUTHORS   Gilberts,E.C., Greenstein,A.J., Katsel,P., Harpaz,N. and
            Greenstein,R.J.
  TITLE     Molecular evidence for two forms of Crohn disease
  JOURNAL   Proc Natl Acad Sci U S A 91 (26), 12721-12724 (1994)
   PUBMED   7809109
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007608.7 and AC007728.4.
            
            On May 8, 2019 this sequence version replaced XM_005256084.4.
            
            Summary: This gene is a member of the Nod1/Apaf-1 family and
            encodes a protein with two caspase recruitment (CARD) domains and
            six leucine-rich repeats (LRRs). The protein is primarily expressed
            in the peripheral blood leukocytes. It plays a role in the immune
            response to intracellular bacterial lipopolysaccharides (LPS) by
            recognizing the muramyl dipeptide (MDP) derived from them and
            activating the NFKB protein. Mutations in this gene have been
            associated with Crohn disease and Blau syndrome. Alternatively
            spliced transcript variants encoding distinct isoforms have been
            found for this gene. [provided by RefSeq, Jun 2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853561.11315.1,
                                           SRR14038196.2829038.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000647318.2/ ENSP00000495993.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AC007608.7         18053-18109         c
            58-524              AC007608.7         11761-12227         c
            525-630             AC007608.7         3755-3860           c
            631-1787            AC007608.7         1-1157              c
            1788-2446           AC007728.4         138633-139291       c
            2447-2530           AC007728.4         134336-134419       c
            2531-2614           AC007728.4         134032-134115       c
            2615-2698           AC007728.4         130998-131081       c
            2699-2782           AC007728.4         128301-128384       c
            2783-2866           AC007728.4         127622-127705       c
            2867-2950           AC007728.4         125434-125517       c
            2951-3034           AC007728.4         121105-121188       c
            3035-4363           AC007728.4         117931-119259       c
FEATURES             Location/Qualifiers
     source          1..4363
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q12.1"
     gene            1..4363
                     /gene="NOD2"
                     /gene_synonym="ACUG; BLAU; BLAUS; CARD15; CD; CLR16.3;
                     IBD1; NLRC2; NOD2B; PSORAS1; YAOS"
                     /note="nucleotide binding oligomerization domain
                     containing 2"
                     /db_xref="GeneID:64127"
                     /db_xref="HGNC:HGNC:5331"
                     /db_xref="MIM:605956"
     exon            1..57
                     /gene="NOD2"
                     /gene_synonym="ACUG; BLAU; BLAUS; CARD15; CD; CLR16.3;
                     IBD1; NLRC2; NOD2B; PSORAS1; YAOS"
                     /inference="alignment:Splign:2.1.0"
     exon            58..524
                     /gene="NOD2"
                     /gene_synonym="ACUG; BLAU; BLAUS; CARD15; CD; CLR16.3;
                     IBD1; NLRC2; NOD2B; PSORAS1; YAOS"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..3107
                     /gene="NOD2"
                     /gene_synonym="ACUG; BLAU; BLAUS; CARD15; CD; CLR16.3;
                     IBD1; NLRC2; NOD2B; PSORAS1; YAOS"
                     /note="isoform 2 is encoded by transcript variant 3;
                     caspase recruitment domain family, member 15; NOD-like
                     receptor C2; NLR family, CARD domain containing 2;
                     nucleotide-binding oligomerization domain, leucine rich
                     repeat and CARD domain containing 2; inflammatory bowel
                     disease protein 1; nucleotide-binding oligomerization
                     domain 2; caspase recruitment domain protein 15;
                     nucleotide-binding oligomerization domain-containing
                     protein 2; caspase recruitment domain-containing protein
                     15"
                     /codon_start=1
                     /product="nucleotide-binding oligomerization
                     domain-containing protein 2 isoform 2"
                     /protein_id="NP_001357395.1"
                     /db_xref="CCDS:CCDS86525.1"
                     /db_xref="GeneID:64127"
                     /db_xref="HGNC:HGNC:5331"
                     /db_xref="MIM:605956"
                     /translation="MCSQEAFQAQRSQLVELLVSGSLEGFESVLDWLLSWEVLSWEDY
                     EGFHLLGQPLSHLARRLLDTVWNKGTWACQKLIAAAQEAQADSQSPKLHGCWDPHSLH
                     PARDLQSHRPAIVRRLHSHVENMLDLAWERGFVSQYECDEIRLPIFTPSQRARRLLDL
                     ATVKANGLAAFLLQHVQELPVPLALPLEAATCKKYMAKLRTTVSAQSRFLSTYDGAET
                     LCLEDIYTENVLEVWADVGMAGPPQKSPATLGLEELFSTPGHLNDDADTVLVVGEAGS
                     GKSTLLQRLHLLWAAGQDFQEFLFVFPFSCRQLQCMAKPLSVRTLLFEHCCWPDVGQE
                     DIFQLLLDHPDRVLLTFDGFDEFKFRFTDRERHCSPTDPTSVQTLLFNLLQGNLLKNA
                     RKVVTSRPAAVSAFLRKYIRTEFNLKGFSEQGIELYLRKRHHEPGVADRLIRLLQETS
                     ALHGLCHLPVFSWMVSKCHQELLLQEGGSPKTTTDMYLLILQHFLLHATPPDSASQGL
                     GPSLLRGRLPTLLHLGRLALWGLGMCCYVFSAQQLQAAQVSPDDISLGFLVRAKGVVP
                     GSTAPLEFLHITFQCFFAAFYLALSADVPPALLRHLFNCGRPGNSPMARLLPTMCIQA
                     SEGKDSSVAALLQKAEPHNLQITAAFLAGLLSREHWGLLAECQTSEKALLRRQACARW
                     CLARSLRKHFHSIPPAAPGEAKSVHAMPGFIWLIRSLYEMQEERLARKAARGLNVGHL
                     KLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPCLGVCKALYLRDN
                     NISDRGICKLIECALHCEQLQKLALFNNKLTDGCAHSMAKLLACRQNFLALRLGNNYI
                     TAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSLVGNNIGS
                     VGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNSSLKILKLSNNCITYLG
                     AEALLQALERNDTILEVWLRGNTFSLEEVDKLGCRDTRLLL"
     exon            525..630
                     /gene="NOD2"
                     /gene_synonym="ACUG; BLAU; BLAUS; CARD15; CD; CLR16.3;
                     IBD1; NLRC2; NOD2B; PSORAS1; YAOS"
                     /inference="alignment:Splign:2.1.0"
     exon            631..2446
                     /gene="NOD2"
                     /gene_synonym="ACUG; BLAU; BLAUS; CARD15; CD; CLR16.3;
                     IBD1; NLRC2; NOD2B; PSORAS1; YAOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2447..2530
                     /gene="NOD2"
                     /gene_synonym="ACUG; BLAU; BLAUS; CARD15; CD; CLR16.3;
                     IBD1; NLRC2; NOD2B; PSORAS1; YAOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2531..2614
                     /gene="NOD2"
                     /gene_synonym="ACUG; BLAU; BLAUS; CARD15; CD; CLR16.3;
                     IBD1; NLRC2; NOD2B; PSORAS1; YAOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..2698
                     /gene="NOD2"
                     /gene_synonym="ACUG; BLAU; BLAUS; CARD15; CD; CLR16.3;
                     IBD1; NLRC2; NOD2B; PSORAS1; YAOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2699..2782
                     /gene="NOD2"
                     /gene_synonym="ACUG; BLAU; BLAUS; CARD15; CD; CLR16.3;
                     IBD1; NLRC2; NOD2B; PSORAS1; YAOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2783..2866
                     /gene="NOD2"
                     /gene_synonym="ACUG; BLAU; BLAUS; CARD15; CD; CLR16.3;
                     IBD1; NLRC2; NOD2B; PSORAS1; YAOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2867..2950
                     /gene="NOD2"
                     /gene_synonym="ACUG; BLAU; BLAUS; CARD15; CD; CLR16.3;
                     IBD1; NLRC2; NOD2B; PSORAS1; YAOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2951..3034
                     /gene="NOD2"
                     /gene_synonym="ACUG; BLAU; BLAUS; CARD15; CD; CLR16.3;
                     IBD1; NLRC2; NOD2B; PSORAS1; YAOS"
                     /inference="alignment:Splign:2.1.0"
     exon            3035..4363
                     /gene="NOD2"
                     /gene_synonym="ACUG; BLAU; BLAUS; CARD15; CD; CLR16.3;
                     IBD1; NLRC2; NOD2B; PSORAS1; YAOS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4344..4349
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOD2"
                     /gene_synonym="ACUG; BLAU; BLAUS; CARD15; CD; CLR16.3;
                     IBD1; NLRC2; NOD2B; PSORAS1; YAOS"
                     /note="hexamer: AATAAA"
     polyA_site      4363
                     /gene="NOD2"
                     /gene_synonym="ACUG; BLAU; BLAUS; CARD15; CD; CLR16.3;
                     IBD1; NLRC2; NOD2B; PSORAS1; YAOS"
                     /note="major polyA site"
ORIGIN      
        1 ggagccggga gtcgtggccc ggagtgggcc ttggagtcgg cgcgcaggcg gctcgcggtt
       61 gtgaaatgtg ctcgcaggag gcttttcagg cacagaggag ccagctggtc gagctgctgg
      121 tctcagggtc cctggaaggc ttcgagagtg tcctggactg gctgctgtcc tgggaggtcc
      181 tctcctggga ggactacgag ggcttccacc tcctgggcca gcctctctcc cacttggcca
      241 ggcgccttct ggacaccgtc tggaataagg gtacttgggc ctgtcagaag ctcatcgcgg
      301 ctgcccaaga agcccaggcc gacagccagt cccccaagct gcatggctgc tgggaccccc
      361 actcgctcca cccagcccga gacctgcaga gtcaccggcc agccattgtc aggaggctcc
      421 acagccatgt ggagaacatg ctggacctgg catgggagcg gggtttcgtc agccagtatg
      481 aatgtgatga aatcaggttg ccgatcttca caccgtccca gagggcaaga aggctgcttg
      541 atcttgccac ggtgaaagcg aatggattgg ctgccttcct tctacaacat gttcaggaat
      601 taccagtccc attggccctg cctttggaag ctgccacatg caagaagtat atggccaagc
      661 tgaggaccac ggtgtctgct cagtctcgct tcctcagtac ctatgatgga gcagagacgc
      721 tctgcctgga ggacatatac acagagaatg tcctggaggt ctgggcagat gtgggcatgg
      781 ctggaccccc gcagaagagc ccagccaccc tgggcctgga ggagctcttc agcacccctg
      841 gccacctcaa tgacgatgcg gacactgtgc tggtggtggg tgaggcgggc agtggcaaga
      901 gcacgctcct gcagcggctg cacttgctgt gggctgcagg gcaagacttc caggaatttc
      961 tctttgtctt cccattcagc tgccggcagc tgcagtgcat ggccaaacca ctctctgtgc
     1021 ggactctact ctttgagcac tgctgttggc ctgatgttgg tcaagaagac atcttccagt
     1081 tactccttga ccaccctgac cgtgtcctgt taacctttga tggctttgac gagttcaagt
     1141 tcaggttcac ggatcgtgaa cgccactgct ccccgaccga ccccacctct gtccagaccc
     1201 tgctcttcaa ccttctgcag ggcaacctgc tgaagaatgc ccgcaaggtg gtgaccagcc
     1261 gtccggccgc tgtgtcggcg ttcctcagga agtacatccg caccgagttc aacctcaagg
     1321 gcttctctga acagggcatc gagctgtacc tgaggaagcg ccatcatgag cccggggtgg
     1381 cggaccgcct catccgcctg ctccaagaga cctcagccct gcacggtttg tgccacctgc
     1441 ctgtcttctc atggatggtg tccaaatgcc accaggaact gttgctgcag gagggggggt
     1501 ccccaaagac cactacagat atgtacctgc tgattctgca gcattttctg ctgcatgcca
     1561 cccccccaga ctcagcttcc caaggtctgg gacccagtct tcttcggggc cgcctcccca
     1621 ccctcctgca cctgggcaga ctggctctgt ggggcctggg catgtgctgc tacgtgttct
     1681 cagcccagca gctccaggca gcacaggtca gccctgatga catttctctt ggcttcctgg
     1741 tgcgtgccaa aggtgtcgtg ccagggagta cggcgcccct ggaattcctt cacatcactt
     1801 tccagtgctt ctttgccgcg ttctacctgg cactcagtgc tgatgtgcca ccagctttgc
     1861 tcagacacct cttcaattgt ggcaggccag gcaactcacc aatggccagg ctcctgccca
     1921 cgatgtgcat ccaggcctcg gagggaaagg acagcagcgt ggcagctttg ctgcagaagg
     1981 ccgagccgca caaccttcag atcacagcag ccttcctggc agggctgttg tcccgggagc
     2041 actggggcct gctggctgag tgccagacat ctgagaaggc cctgctccgg cgccaggcct
     2101 gtgcccgctg gtgtctggcc cgcagcctcc gcaagcactt ccactccatc ccgccagctg
     2161 caccgggtga ggccaagagc gtgcatgcca tgcccgggtt catctggctc atccggagcc
     2221 tgtacgagat gcaggaggag cggctggctc ggaaggctgc acgtggcctg aatgttgggc
     2281 acctcaagtt gacattttgc agtgtgggcc ccactgagtg tgctgccctg gcctttgtgc
     2341 tgcagcacct ccggcggccc gtggccctgc agctggacta caactctgtg ggtgacattg
     2401 gcgtggagca gctgctgcct tgccttggtg tctgcaaggc tctgtatttg cgcgataaca
     2461 atatctcaga ccgaggcatc tgcaagctca ttgaatgtgc tcttcactgc gagcaattgc
     2521 agaagttagc tctattcaac aacaaattga ctgacggctg tgcacactcc atggctaagc
     2581 tccttgcatg caggcagaac ttcttggcat tgaggctggg gaataactac atcactgccg
     2641 cgggagccca agtgctggcc gaggggctcc gaggcaacac ctccttgcag ttcctgggat
     2701 tctggggcaa cagagtgggt gacgaggggg cccaggccct ggctgaagcc ttgggtgatc
     2761 accagagctt gaggtggctc agcctggtgg ggaacaacat tggcagtgtg ggtgcccaag
     2821 ccttggcact gatgctggca aagaacgtca tgctagaaga actctgcctg gaggagaacc
     2881 atctccagga tgaaggtgta tgttctctcg cagaaggact gaagaaaaat tcaagtttga
     2941 aaatcctgaa gttgtccaat aactgcatca cctacctagg ggcagaagcc ctcctgcagg
     3001 cccttgaaag gaatgacacc atcctggaag tctggctccg agggaacact ttctctctag
     3061 aggaggttga caagctcggc tgcagggaca ccagactctt gctttgaagt ctccgggagg
     3121 atgttcgtct cagtttgttt gtgagcaggc tgtgagtttg ggccccagag gctgggtgac
     3181 atgtgttggc agcctcttca aaatgagccc tgtcctgcct aaggctgaac ttgttttctg
     3241 ggaacaccat aggtcacctt tattctggca gaggagggag catcagtgcc ctccaggata
     3301 gacttttccc aagcctactt ttgccattga cttcttccca agattcaatc ccaggatgta
     3361 caaggacagc ccctcctcca tagtatggga ctggcctctg ctgatcctcc caggcttccg
     3421 tgtgggtcag tggggcccat ggatgtgctt gttaactgag tgccttttgg tggagaggcc
     3481 cggcctctca caaaagaccc cttaccactg ctctgatgaa gaggagtaca cagaacacat
     3541 aattcaggaa gcagctttcc ccatgtctcg actcatccat ccaggccatt ccccgtctct
     3601 ggttcctccc ctcctcctgg actcctgcac acgctccttc ctctgaggct gaaattcaga
     3661 atattagtga cctcagcttt gatatttcac ttacagcacc cccaaccctg gcacccaggg
     3721 tgggaagggc tacaccttag cctgccctcc tttccggtgt ttaagacatt tttggaaggg
     3781 gacacgtgac agccgtttgt tccccaagac attctaggtt tgcaagaaaa atatgaccac
     3841 actccagctg ggatcacatg tggactttta tttccagtga aatcagttac tcttcagtta
     3901 agcctttgga aacagctcga ctttaaaaag ctccaaatgc agctttaaaa aattaatctg
     3961 ggccagaatt tcaaacggcc tcactaggct tctggttgat gcctgtgaac tgaactctga
     4021 caacagactt ctgaaataga cccacaagag gcagttccat ttcatttgtg ccagaatgct
     4081 ttaggatgta cagttatgga ttgaaagttt acaggaaaaa aaattaggcc gttccttcaa
     4141 agcaaatgtc ttcctggatt attcaaaatg atgtatgttg aagcctttgt aaattgtcag
     4201 atgctgtgca aatgttatta ttttaaacat tatgatgtgt gaaaactggt taatatttat
     4261 aggtcacttt gttttactgt cttaagttta tactcttata gacaacatgg ccgtgaactt
     4321 tatgctgtaa ataatcagag gggaataaac tgttgagtca aaa
//
