LOCUS       NM_006092               4503 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens nucleotide binding oligomerization domain containing 1
            (NOD1), transcript variant 1, mRNA.
ACCESSION   NM_006092
VERSION     NM_006092.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4503)
  AUTHORS   Li,K., Yang,B., Du,Y., Ding,Y., Shen,S., Sun,Z., Liu,Y., Wang,Y.,
            Cao,S., Ren,W., Wang,X., Li,M., Zhang,Y., Wu,J., Zheng,W., Yan,W.
            and Li,L.
  TITLE     The HOXC10/NOD1/ERK axis drives osteolytic bone metastasis of
            pan-KRAS-mutant lung cancer
  JOURNAL   Bone Res 12 (1), 47 (2024)
   PUBMED   39191757
  REMARK    GeneRIF: The HOXC10/NOD1/ERK axis drives osteolytic bone metastasis
            of pan-KRAS-mutant lung cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4503)
  AUTHORS   Cheng,X., Barakat,R., Pavani,G., Usha,M.K., Calderon,R., Snella,E.,
            Gorden,A., Zhang,Y., Gadue,P., French,D.L., Dorman,K.S.,
            Fidanza,A., Campbell,C.A. and Espin-Palazon,R.
  TITLE     Nod1-dependent NF-kB activation initiates hematopoietic stem cell
            specification in response to small Rho GTPases
  JOURNAL   Nat Commun 14 (1), 7668 (2023)
   PUBMED   37996457
  REMARK    GeneRIF: Nod1-dependent NF-kB activation initiates hematopoietic
            stem cell specification in response to small Rho GTPases.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4503)
  AUTHORS   Hezinger,L., Bauer,S., Ellwanger,K., Piotrowsky,A., Biber,F.,
            Venturelli,S. and Kufer,T.A.
  TITLE     NOD1 cooperates with HAX-1 to promote cell migration in a RIPK2-
            and NF-kB-independent manner
  JOURNAL   FEBS J 290 (22), 5295-5312 (2023)
   PUBMED   37488967
  REMARK    GeneRIF: NOD1 cooperates with HAX-1 to promote cell migration in a
            RIPK2- and NF-kB-independent manner.
REFERENCE   4  (bases 1 to 4503)
  AUTHORS   Barreyro,F.J., Maiorana,F., Caronia,M.V., Elizondo,K., Schneider,A.
            and Zapata,P.D.
  TITLE     Association between genetic polymorphisms of NOD1, Interleukin-1B,
            and cagA strain with low-grade duodenal eosinophilia in
            Helicobacter pylori-related dyspepsia
  JOURNAL   Helicobacter 28 (5), e13002 (2023)
   PUBMED   37350445
  REMARK    GeneRIF: Association between genetic polymorphisms of NOD1,
            Interleukin-1B, and cagA strain with low-grade duodenal
            eosinophilia in Helicobacter pylori-related dyspepsia.
REFERENCE   5  (bases 1 to 4503)
  AUTHORS   Trepte,P., Secker,C., Kostova,S., Maseko,S.B., Choi,S.G.,
            Blavier,J., Minia,I., Ramos,E.S., Cassonnet,P., Golusik,S.,
            Zenkner,M., Beetz,S., Liebich,M.J., Scharek,N., Schutz,A.,
            Sperling,M., Lisurek,M., Wang,Y., Spirohn,K., Hao,T.,
            Calderwood,M.A., Hill,D.E., Landthaler,M., Olivet,J., Twizere,J.C.,
            Vidal,M. and Wanker,E.E.
  TITLE     AI-guided pipeline for protein-protein interaction drug discovery
            identifies a SARS-CoV-2 inhibitor
  JOURNAL   bioRxiv (2023)
   PUBMED   37398436
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4503)
  AUTHORS   Keestra-Gounder,A.M. and Tsolis,R.M.
  TITLE     NOD1 and NOD2: Beyond Peptidoglycan Sensing
  JOURNAL   Trends Immunol 38 (10), 758-767 (2017)
   PUBMED   28823510
  REMARK    Review article
REFERENCE   7  (bases 1 to 4503)
  AUTHORS   Inohara,N., Ogura,Y., Chen,F.F., Muto,A. and Nunez,G.
  TITLE     Human Nod1 confers responsiveness to bacterial lipopolysaccharides
  JOURNAL   J Biol Chem 276 (4), 2551-2554 (2001)
   PUBMED   11058605
REFERENCE   8  (bases 1 to 4503)
  AUTHORS   Inohara,N., Koseki,T., Lin,J., del Peso,L., Lucas,P.C., Chen,F.F.,
            Ogura,Y. and Nunez,G.
  TITLE     An induced proximity model for NF-kappa B activation in the
            Nod1/RICK and RIP signaling pathways
  JOURNAL   J Biol Chem 275 (36), 27823-27831 (2000)
   PUBMED   10880512
REFERENCE   9  (bases 1 to 4503)
  AUTHORS   Inohara,N., Koseki,T., del Peso,L., Hu,Y., Yee,C., Chen,S.,
            Carrio,R., Merino,J., Liu,D., Ni,J. and Nunez,G.
  TITLE     Nod1, an Apaf-1-like activator of caspase-9 and nuclear
            factor-kappaB
  JOURNAL   J Biol Chem 274 (21), 14560-14567 (1999)
   PUBMED   10329646
REFERENCE   10 (bases 1 to 4503)
  AUTHORS   Bertin,J., Nir,W.J., Fischer,C.M., Tayber,O.V., Errada,P.R.,
            Grant,J.R., Keilty,J.J., Gosselin,M.L., Robison,K.E., Wong,G.H.,
            Glucksmann,M.A. and DiStefano,P.S.
  TITLE     Human CARD4 protein is a novel CED-4/Apaf-1 cell death family
            member that activates NF-kappaB
  JOURNAL   J Biol Chem 274 (19), 12955-12958 (1999)
   PUBMED   10224040
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005154.1, CV569884.1,
            BC040339.1, AF113925.1 and AA845215.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_006092.3.
            
            Summary: This gene encodes a member of the nucleotide-binding
            oligomerization domain (NOD)-like receptor (NLR) family of
            proteins. The encoded protein plays a role in innate immunity by
            acting as a pattern-recognition receptor (PRR) that binds bacterial
            peptidoglycans and initiates inflammation. This protein has also
            been implicated in the immune response to viral and parasitic
            infection. Major structural features of this protein include an
            N-terminal caspase recruitment domain (CARD), a centrally located
            nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats
            (LRRs) in its C terminus. The CARD is involved in apoptotic
            signaling, LRRs participate in protein-protein interactions, and
            mutations in the NBD may affect the process of oligomerization and
            subsequent function of the LRR domain. Mutations in this gene are
            associated with asthma, inflammatory bowel disease, Behcet disease
            and sarcoidosis in human patients. [provided by RefSeq, Aug 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040339.1, AF126484.2 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000222823.9/ ENSP00000222823.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AC005154.1         21377-21383         c
            8-628               CV569884.1         1-621
            629-1420            BC040339.1         537-1328
            1421-4467           AF113925.1         1315-4361
            4468-4503           AA845215.1         11-46               c
FEATURES             Location/Qualifiers
     source          1..4503
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p14.3"
     gene            1..4503
                     /gene="NOD1"
                     /gene_synonym="CARD4; CLR7.1; hNod1; NLRC1"
                     /note="nucleotide binding oligomerization domain
                     containing 1"
                     /db_xref="GeneID:10392"
                     /db_xref="HGNC:HGNC:16390"
                     /db_xref="MIM:605980"
     exon            1..179
                     /gene="NOD1"
                     /gene_synonym="CARD4; CLR7.1; hNod1; NLRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            180..320
                     /gene="NOD1"
                     /gene_synonym="CARD4; CLR7.1; hNod1; NLRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            321..409
                     /gene="NOD1"
                     /gene_synonym="CARD4; CLR7.1; hNod1; NLRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            410..731
                     /gene="NOD1"
                     /gene_synonym="CARD4; CLR7.1; hNod1; NLRC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             531..3392
                     /gene="NOD1"
                     /gene_synonym="CARD4; CLR7.1; hNod1; NLRC1"
                     /note="isoform 1 is encoded by transcript variant 1; NLR
                     family, CARD domain containing 1; nucleotide-binding
                     oligomerization domain, leucine rich repeat and CARD
                     domain containing 1; caspase recruitment domain family,
                     member 4; nucleotide-binding oligomerization
                     domain-containing protein 1; caspase recruitment
                     domain-containing protein 4"
                     /codon_start=1
                     /product="nucleotide-binding oligomerization
                     domain-containing protein 1 isoform 1"
                     /protein_id="NP_006083.1"
                     /db_xref="CCDS:CCDS5427.1"
                     /db_xref="GeneID:10392"
                     /db_xref="HGNC:HGNC:16390"
                     /db_xref="MIM:605980"
                     /translation="MEEQGHSEMEIIPSESHPHIQLLKSNRELLVTHIRNTQCLVDNL
                     LKNDYFSAEDAEIVCACPTQPDKVRKILDLVQSKGEEVSEFFLYLLQQLADAYVDLRP
                     WLLEIGFSPSLLTQSKVVVNTDPVSRYTQQLRHHLGRDSKFVLCYAQKEELLLEEIYM
                     DTIMELVGFSNESLGSLNSLACLLDHTTGILNEQGETIFILGDAGVGKSMLLQRLQSL
                     WATGRLDAGVKFFFHFRCRMFSCFKESDRLCLQDLLFKHYCYPERDPEEVFAFLLRFP
                     HVALFTFDGLDELHSDLDLSRVPDSSCPWEPAHPLVLLANLLSGKLLKGASKLLTART
                     GIEVPRQFLRKKVLLRGFSPSHLRAYARRMFPERALQDRLLSQLEANPNLCSLCSVPL
                     FCWIIFRCFQHFRAAFEGSPQLPDCTMTLTDVFLLVTEVHLNRMQPSSLVQRNTRSPV
                     ETLHAGRDTLCSLGQVAHRGMEKSLFVFTQEEVQASGLQERDMQLGFLRALPELGPGG
                     DQQSYEFFHLTLQAFFTAFFLVLDDRVGTQELLRFFQEWMPPAGAATTSCYPPFLPFQ
                     CLQGSGPAREDLFKNKDHFQFTNLFLCGLLSKAKQKLLRHLVPAAALRRKRKALWAHL
                     FSSLRGYLKSLPRVQVESFNQVQAMPTFIWMLRCIYETQSQKVGQLAARGICANYLKL
                     TYCNACSADCSALSFVLHHFPKRLALDLDNNNLNDYGVRELQPCFSRLTVLRLSVNQI
                     TDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTKILDECKGLTHLKLGKNKITS
                     EGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHPSLTTLSLASNGISTEG
                     GKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLKVNQTLKHLWLIQNQITAKGTA
                     QLADALQSNTGITEICLNGNLIKPEEAKVYEDEKRIICF"
     exon            732..906
                     /gene="NOD1"
                     /gene_synonym="CARD4; CLR7.1; hNod1; NLRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            907..2731
                     /gene="NOD1"
                     /gene_synonym="CARD4; CLR7.1; hNod1; NLRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2732..2815
                     /gene="NOD1"
                     /gene_synonym="CARD4; CLR7.1; hNod1; NLRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2816..2899
                     /gene="NOD1"
                     /gene_synonym="CARD4; CLR7.1; hNod1; NLRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2900..2983
                     /gene="NOD1"
                     /gene_synonym="CARD4; CLR7.1; hNod1; NLRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2984..3067
                     /gene="NOD1"
                     /gene_synonym="CARD4; CLR7.1; hNod1; NLRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3068..3151
                     /gene="NOD1"
                     /gene_synonym="CARD4; CLR7.1; hNod1; NLRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3152..3235
                     /gene="NOD1"
                     /gene_synonym="CARD4; CLR7.1; hNod1; NLRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3236..3319
                     /gene="NOD1"
                     /gene_synonym="CARD4; CLR7.1; hNod1; NLRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3320..4503
                     /gene="NOD1"
                     /gene_synonym="CARD4; CLR7.1; hNod1; NLRC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4480..4485
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOD1"
                     /gene_synonym="CARD4; CLR7.1; hNod1; NLRC1"
                     /note="hexamer: AATAAA"
     polyA_site      4503
                     /gene="NOD1"
                     /gene_synonym="CARD4; CLR7.1; hNod1; NLRC1"
                     /note="major polyA site"
ORIGIN      
        1 agttcccgtt ccgggcccgc gaggcagccg ccccggtcct gcccctccct cgcgctactg
       61 cgggagcagc gtcctcccgg gccacggcgc ttcccggccc cggcgtcccc ggaccatggc
      121 gctctccggg ctcttctcta gctctcagcg gctgcgaagt ctgtaaacct ggtggccaag
      181 tgattgtaag tcaggagact ttccttcggt ttctgccttt gatggcaaga ggtggagatt
      241 gtggcggcga ttacagaaaa catctgggaa gacaagttgc tgtttttatg ggaatcgcag
      301 gcttggaaga gacagaagca attccagaaa taaattggaa attgaagatt taaacaatgt
      361 tgttttaaaa tattctaact tcaaagaatg atgccagaaa cttaaaaagg ggctgcgcag
      421 agtagcaggg gccctggagg gcgcggcctg aatcctgatt gcccttctgc tgagaggaca
      481 cacgcagctg aagatgaatt tgggaaaagt agccgcttgc tactttaact atggaagagc
      541 agggccacag tgagatggaa ataatcccat cagagtctca cccccacatt caattactga
      601 aaagcaatcg ggaacttctg gtcactcaca tccgcaatac tcagtgtctg gtggacaact
      661 tgctgaagaa tgactacttc tcggccgaag atgcggagat tgtgtgtgcc tgccccaccc
      721 agcctgacaa ggtccgcaaa attctggacc tggtacagag caagggcgag gaggtgtccg
      781 agttcttcct ctacttgctc cagcaactcg cagatgccta cgtggacctc aggccttggc
      841 tgctggagat cggcttctcc ccttccctgc tcactcagag caaagtcgtg gtcaacactg
      901 acccagtgag caggtatacc cagcagctgc gacaccatct gggccgtgac tccaagttcg
      961 tgctgtgcta tgcccagaag gaggagctgc tgctggagga gatctacatg gacaccatca
     1021 tggagctggt tggcttcagc aatgagagcc tgggcagcct gaacagcctg gcctgcctcc
     1081 tggaccacac caccggcatc ctcaatgagc agggtgagac catcttcatc ctgggtgatg
     1141 ctggggtggg caagtccatg ctgctacagc ggctgcagag cctctgggcc acgggccggc
     1201 tagacgcagg ggtcaaattc ttcttccact ttcgctgccg catgttcagc tgcttcaagg
     1261 aaagtgacag gctgtgtctg caggacctgc tcttcaagca ctactgctac ccagagcggg
     1321 accccgagga ggtgtttgcc ttcctgctgc gcttccccca cgtggccctc ttcaccttcg
     1381 atggcctgga cgagctgcac tcggacttgg acctgagccg cgtgcctgac agctcctgcc
     1441 cctgggagcc tgcccacccc ctggtcttgc tggccaacct gctcagtggg aagctgctca
     1501 agggggctag caagctgctc acagcccgca caggcatcga ggtcccgcgc cagttcctgc
     1561 ggaagaaggt gcttctccgg ggcttctccc ccagccacct gcgcgcctat gccaggagga
     1621 tgttccccga gcgggccctg caggaccgcc tgctgagcca gctggaggcc aaccccaacc
     1681 tctgcagcct gtgctctgtg cccctcttct gctggatcat cttccggtgc ttccagcact
     1741 tccgtgctgc ctttgaaggc tcaccacagc tgcccgactg cacgatgacc ctgacagatg
     1801 tcttcctcct ggtcactgag gtccatctga acaggatgca gcccagcagc ctggtgcagc
     1861 ggaacacacg cagcccagtg gagaccctcc acgccggccg ggacactctg tgctcgctgg
     1921 ggcaggtggc ccaccggggc atggagaaga gcctctttgt cttcacccag gaggaggtgc
     1981 aggcctccgg gctgcaggag agagacatgc agctgggctt cctgcgggct ttgccggagc
     2041 tgggccccgg gggtgaccag cagtcctatg agtttttcca cctcaccctc caggccttct
     2101 ttacagcctt cttcctcgtg ctggacgaca gggtgggcac tcaggagctg ctcaggttct
     2161 tccaggagtg gatgccccct gcgggggcag cgaccacgtc ctgctatcct cccttcctcc
     2221 cgttccagtg cctgcagggc agtggtccgg cgcgggaaga cctcttcaag aacaaggatc
     2281 acttccagtt caccaacctc ttcctgtgcg ggctgttgtc caaagccaaa cagaaactcc
     2341 tgcggcatct ggtgcccgcg gcagccctga ggagaaagcg caaggccctg tgggcacacc
     2401 tgttttccag cctgcggggc tacctgaaga gcctgccccg cgttcaggtc gaaagcttca
     2461 accaggtgca ggccatgccc acgttcatct ggatgctgcg ctgcatctac gagacacaga
     2521 gccagaaggt ggggcagctg gcggccaggg gcatctgcgc caactacctc aagctgacct
     2581 actgcaacgc ctgctcggcc gactgcagcg ccctctcctt cgtcctgcat cacttcccca
     2641 agcggctggc cctagaccta gacaacaaca atctcaacga ctacggcgtg cgggagctgc
     2701 agccctgctt cagccgcctc actgttctca gactcagcgt aaaccagatc actgacggtg
     2761 gggtaaaggt gctaagcgaa gagctgacca aatacaaaat tgtgacctat ttgggtttat
     2821 acaacaacca gatcaccgat gtcggagcca ggtacgtcac caaaatcctg gatgaatgca
     2881 aaggcctcac gcatcttaaa ctgggaaaaa acaaaataac aagtgaagga gggaagtatc
     2941 tcgccctggc tgtgaagaac agcaaatcaa tctctgaggt tgggatgtgg ggcaatcaag
     3001 ttggggatga aggagcaaaa gccttcgcag aggctctgcg gaaccacccc agcttgacca
     3061 ccctgagtct tgcgtccaac ggcatctcca cagaaggagg aaagagcctt gcgagggccc
     3121 tgcagcagaa cacgtctcta gaaatactgt ggctgaccca aaatgaactc aacgatgaag
     3181 tggcagagag tttggcagaa atgttgaaag tcaaccagac gttaaagcat ttatggctta
     3241 tccagaatca gatcacagct aaggggactg cccagctggc agatgcgtta cagagcaaca
     3301 ctggcataac agagatttgc ctaaatggaa acctgataaa accagaggag gccaaagtct
     3361 atgaagatga gaagcggatt atctgtttct gagaggatgc tttcctgttc atggggtttt
     3421 tgccctggag cctcagcagc aaatgccact ctgggcagtc ttttgtgtca gtgtcttaaa
     3481 ggggcctgcg caggcgggac tatcaggagt ccactgcctc catgatgcaa gccagcttcc
     3541 tgtgcagaag gtctggtcgg caaactccct aagtacccgc tacaattctg cagaaaaaga
     3601 atgtgtcttg cgagctgttg tagttacagt aaatacactg tgaagagact ttattgccta
     3661 ttataattat ttttatctga agctagagga ataaagctgt gagcaaacag aggaggccag
     3721 cctcacctca ttccaacacc tgccataggg accaacggga gcgagttggt caccgctctt
     3781 ttcattgaag agttgaggat gtggcacaaa gttggtgcca agcttcttga ataaaacgtg
     3841 tttgatggat tagtattata cctgaaatat tttcttcctt ctcagcactt tcccatgtat
     3901 tgatactggt cccacttcac agctggagac accggagtat gtgcagtgtg ggatttgact
     3961 cctccaaggt tttgtggaaa gttaatgtca aggaaaggat gcaccacggg cttttaattt
     4021 taatcctgga gtctcactgt ctgctggcaa agatagagaa tgccctcagc tcttagctgg
     4081 tctaagaatg acgatgcctt caaaatgctg cttccactca gggcttctcc tctgctaggc
     4141 taccctcctc tagaaggctg agtaccatgg gctacagtgt ctggccttgg gaagaagtga
     4201 ttctgtccct ccaaagaaat agggcatggc ttgcccctgt ggccctggca tccaaatggc
     4261 tgcttttgtc tcccttacct cgtgaagagg ggaagtctct tcctgcctcc caagcagctg
     4321 aagggtgact aaacgggcgc caagactcag gggatcggct gggaactggg ccagcagagc
     4381 atgttggaca ccccccacca tggtgggctt gtggtggctg ctccatgagg gtgggggtga
     4441 tactactaga tcacttgtcc tcttgccagc tcatttgtta ataaaatact gaaaacactc
     4501 tta
//
