LOCUS       NM_012118               1962 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens nocturnin (NOCT), mRNA.
ACCESSION   NM_012118
VERSION     NM_012118.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1962)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1962)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1962)
  AUTHORS   Abshire,E.T., Hughes,K.L., Diao,R., Pearce,S., Gopalakrishna,S.,
            Trievel,R.C., Rorbach,J., Freddolino,P.L. and Goldstrohm,A.C.
  TITLE     Differential processing and localization of human Nocturnin
            controls metabolism of mRNA and nicotinamide adenine dinucleotide
            cofactors
  JOURNAL   J Biol Chem 295 (44), 15112-15133 (2020)
   PUBMED   32839274
  REMARK    GeneRIF: Differential processing and localization of human
            Nocturnin controls metabolism of mRNA and nicotinamide adenine
            dinucleotide cofactors.
REFERENCE   4  (bases 1 to 1962)
  AUTHORS   Bracci,M., Copertaro,A., Ciarapica,V., Barbaresi,M., Esposito,S.,
            Albanesi,A., Valentino,M., Ledda,C., Rapisarda,V. and Santarelli,L.
  TITLE     NOCTURNIN Gene Diurnal Variation in Healthy Volunteers and
            Expression Levels in Shift Workers
  JOURNAL   Biomed Res Int 2019, 7582734 (2019)
   PUBMED   31467910
  REMARK    GeneRIF: Measuring NOCTURNIN expression levels in human peripheral
            blood lymphocytes can improve investigations on the relationship
            between changes in circadian rhythm and metabolic disorders. Shift
            workers show higher NOCTURNIN levels than daytime worker
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1962)
  AUTHORS   Estrella,M.A., Du,J., Chen,L., Rath,S., Prangley,E., Chitrakar,A.,
            Aoki,T., Schedl,P., Rabinowitz,J. and Korennykh,A.
  TITLE     The metabolites NADP+ and NADPH are the targets of the circadian
            protein Nocturnin (Curled)
  JOURNAL   Nat Commun 10 (1), 2367 (2019)
   PUBMED   31147539
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1962)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 1962)
  AUTHORS   Li,R., Yue,J., Zhang,Y., Zhou,L., Hao,W., Yuan,J., Qiang,B.,
            Ding,J.M., Peng,X. and Cao,J.M.
  TITLE     CLOCK/BMAL1 regulates human nocturnin transcription through binding
            to the E-box of nocturnin promoter
  JOURNAL   Mol Cell Biochem 317 (1-2), 169-177 (2008)
   PUBMED   18587630
  REMARK    GeneRIF: The transcription of human nocturnin gene displayed
            circadian oscillations in Huh7 cells (a human hepatoma cell line)
            and was regulated by CLOCK/BMAL1 heterodimer via the E-box of
            nocturnin promoter.
REFERENCE   8  (bases 1 to 1962)
  AUTHORS   Nakamura,E.S., Koizumi,K., Kobayashi,M., Saitoh,Y., Arita,Y.,
            Nakayama,T., Sakurai,H., Yoshie,O. and Saiki,I.
  TITLE     RANKL-induced CCL22/macrophage-derived chemokine produced from
            osteoclasts potentially promotes the bone metastasis of lung cancer
            expressing its receptor CCR4
  JOURNAL   Clin Exp Metastasis 23 (1), 9-18 (2006)
   PUBMED   16821125
  REMARK    GeneRIF: A human lung cancer cell line SBC-5 that efficiently
            metastasized to bone when intravenously injected into SCID mice was
            found to express CCR4.
REFERENCE   9  (bases 1 to 1962)
  AUTHORS   Wang,Y., Osterbur,D.L., Megaw,P.L., Tosini,G., Fukuhara,C.,
            Green,C.B. and Besharse,J.C.
  TITLE     Rhythmic expression of Nocturnin mRNA in multiple tissues of the
            mouse
  JOURNAL   BMC Dev Biol 1, 9 (2001)
   PUBMED   11394964
REFERENCE   10 (bases 1 to 1962)
  AUTHORS   Dupressoir,A., Barbot,W., Loireau,M.P. and Heidmann,T.
  TITLE     Characterization of a mammalian gene related to the yeast CCR4
            general transcription factor and revealed by transposon insertion
  JOURNAL   J Biol Chem 274 (43), 31068-31075 (1999)
   PUBMED   10521507
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY067201.1, BC113494.1 and
            AC093602.5.
            
            On Nov 22, 2018 this sequence version replaced NM_012118.3.
            
            Summary: The protein encoded by this gene is highly similar to
            Nocturnin, a gene identified as a circadian clock regulated gene in
            Xenopus laevis. This protein and Nocturnin protein share similarity
            with the C-terminal domain of a yeast transcription factor, carbon
            catabolite repression 4 (CCR4). The mRNA abundance of a similar
            gene in mouse has been shown to exhibit circadian rhythmicity,
            which suggests a role for this protein in clock function or as a
            circadian clock effector. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.329239.1, AF183961.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000280614.4/ ENSP00000280614.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               HY067201.1         24-137
            115-1557            BC113494.1         1-1443
            1558-1962           AC093602.5         45491-45895
FEATURES             Location/Qualifiers
     source          1..1962
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.1"
     gene            1..1962
                     /gene="NOCT"
                     /gene_synonym="Ccr4c; CCR4L; CCRN4L; NOC"
                     /note="nocturnin"
                     /db_xref="GeneID:25819"
                     /db_xref="HGNC:HGNC:14254"
                     /db_xref="MIM:608468"
     exon            1..391
                     /gene="NOCT"
                     /gene_synonym="Ccr4c; CCR4L; CCRN4L; NOC"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..1497
                     /gene="NOCT"
                     /gene_synonym="Ccr4c; CCR4L; CCRN4L; NOC"
                     /EC_number="3.1.3.108"
                     /note="CCR4-like (carbon catabolite repression 4,
                     S.cerevisiae); CCR4 protein homolog; circadian deadenylase
                     NOC; carbon catabolite repression 4-like protein; CCR4
                     carbon catabolite repression 4-like"
                     /codon_start=1
                     /product="nocturnin"
                     /protein_id="NP_036250.2"
                     /db_xref="CCDS:CCDS3743.1"
                     /db_xref="GeneID:25819"
                     /db_xref="HGNC:HGNC:14254"
                     /db_xref="MIM:608468"
                     /translation="MFHSPRRLCSALLQRDAPGLRRLPAPGLRRPLSPPAAVPRPASP
                     RLLAAASAASGAARSCSRTVCSMGTGTSRLYSALAKTLNSSAASQHPEYLVSPDPEHL
                     EPIDPKELLEECRAVLHTRPPRFQRDFVDLRTDCPSTHPPIRVMQWNILAQALGEGKD
                     NFVQCPVEALKWEERKCLILEEILAYQPDILCLQEVDHYFDTFQPLLSRLGYQGTFFP
                     KPWSPCLDVEHNNGPDGCALFFLQNRFKLVNSANIRLTAMTLKTNQVAIAQTLECKES
                     GRQFCIAVTHLKARTGWERFRSAQGCDLLQNLQNITQGAKIPLIVCGDFNAEPTEEVY
                     KHFASSSLNLNSAYKLLSADGQSEPPYTTWKIRTSGECRHTLDYIWYSKHALNVRSAL
                     DLLTEEQIGPNRLPSFNYPSDHLSLVCDFSFTEESDGLS"
     exon            392..661
                     /gene="NOCT"
                     /gene_synonym="Ccr4c; CCR4L; CCRN4L; NOC"
                     /inference="alignment:Splign:2.1.0"
     exon            662..1962
                     /gene="NOCT"
                     /gene_synonym="Ccr4c; CCR4L; CCRN4L; NOC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1926..1931
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOCT"
                     /gene_synonym="Ccr4c; CCR4L; CCRN4L; NOC"
                     /note="hexamer: ATTAAA"
     polyA_site      1962
                     /gene="NOCT"
                     /gene_synonym="Ccr4c; CCR4L; CCRN4L; NOC"
                     /note="major polyA site"
ORIGIN      
        1 agacggtgcc gacgcagcgg tgttgcacct ccctctccgg ctctgctgcc cgggatttcc
       61 ccagaacctg cgccgcgcga gaaggagcct gggagcatcc gcccacactg cccggacagt
      121 cggctcgact cggtgccctc ggccccagcc gggctccgct cctcgggcgc gcgaggggcc
      181 gtggtggcgg cggcgcccgg catgtttcat agtccgcggc ggctctgctc ggccctgctg
      241 cagagggacg cgcccggcct gcgccgcctg cccgccccag ggctgcgccg cccgttgtcc
      301 ccgccggctg ctgttcccag gcccgcatcc ccccggctgc tggcggcggc ctcggcggcc
      361 tcgggcgccg cgaggtcgtg ttcccgaaca gtgtgttcca tgggaaccgg tacaagcaga
      421 ctctatagtg ctctcgccaa gacactgaac agcagcgctg cctcccagca cccagagtat
      481 ttggtgtcac ctgacccaga gcatctggag cccattgatc ctaaagagct tcttgaggaa
      541 tgcagggccg tcctgcacac ccgacctccc cggttccaga gggattttgt ggatctgagg
      601 acagattgcc ctagtaccca cccacctatc agggttatgc aatggaacat cctcgcccaa
      661 gctcttggag aaggcaaaga caactttgta cagtgccctg ttgaagcact caaatgggaa
      721 gaaaggaaat gtctcatcct ggaagaaatc ctggcctacc agcctgatat attgtgcctc
      781 caagaggtgg accactattt tgacaccttc cagccactcc tcagtagact aggctatcaa
      841 ggcacgtttt tccccaaacc ctggtcacct tgtctagatg tagaacacaa caatggacca
      901 gatggttgtg ccttattttt tcttcaaaac cgattcaagc tagtcaacag tgccaatatt
      961 aggctgacag ccatgacatt gaaaaccaac caggtggcca ttgcacagac cctggagtgc
     1021 aaggagtcag gccgacagtt ctgcatcgct gttacccatc taaaagcacg cactggctgg
     1081 gagcggtttc gatcagctca aggctgtgac ctccttcaga acctgcaaaa catcacccaa
     1141 ggagccaaga ttccccttat tgtgtgtggg gacttcaatg cagagccaac agaagaggtc
     1201 tacaaacact ttgcttcctc cagcctcaac ctgaacagcg cctacaagct gctgagtgct
     1261 gatgggcagt cagaaccccc atacactacc tggaagatcc ggacctcagg ggagtgcagg
     1321 cacaccctgg attacatctg gtattctaaa catgctctaa atgtaaggtc agctctcgat
     1381 ctgctcactg aagaacagat tggacccaac aggttacctt ccttcaatta tccttcagac
     1441 cacctgtctc tagtgtgtga cttcagcttt actgaggaat ctgatggact ttcataaata
     1501 cttgcttttg tctttttaat cacaggagtc tatttttttt tttttttttt tttttttgag
     1561 acagagtctc gctctgttgc ctaggctgga gtacagtggc ctgatctcgg ctcactgcaa
     1621 gatccgcctc ccgggttcat ggcattctcc tgcctcagcc tccagagcaa ctgggacaac
     1681 aggcgcccgt caccacgccc agctaatttt ttgtattttt agtagagacg gggtttcacc
     1741 gtgttagcca ggatggtctc gatctcctga ccttgaatca caagagtctt aacagggaat
     1801 gtttcaggaa acaaatagga taagacaatg ccagaggaag gatagaaaca tgggaagttt
     1861 ctatcatttc attttctgcg tttccagcat gcccttggaa aagactccct ttagtccctt
     1921 tttcaattaa aacctatggt gaaaaaggcg tttgcactcc aa
//
