LOCUS       NM_024078               1650 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens nucleolar complex associated 4 homolog (NOC4L),
            transcript variant 1, mRNA.
ACCESSION   NM_024078 XM_942717 XM_946334
VERSION     NM_024078.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1650)
  AUTHORS   Talebi,A., Shahidsales,S., Aliakbarian,M., Pezeshki Rad,M. and
            Kerachian,M.A.
  TITLE     Oncogenic fusion transcript analysis identified ADAP1-NOC4L,
            potentially associated with metastatic colorectal cancer
  JOURNAL   Cancer Med 12 (1), 525-540 (2023)
   PUBMED   35702822
  REMARK    GeneRIF: Oncogenic fusion transcript analysis identified
            ADAP1-NOC4L, potentially associated with metastatic colorectal
            cancer.
REFERENCE   2  (bases 1 to 1650)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1650)
  AUTHORS   Qin,Y., Li,H., Jia,L., Yan,J., Gao,G.F. and Li,X.
  TITLE     Targeted disruption of Noc4l leads to preimplantation embryonic
            lethality in mice
  JOURNAL   Protein Cell 8 (3), 230-235 (2017)
   PUBMED   28012024
  REMARK    GeneRIF: The results provide the first in vivo genetic evidence
            that Noc4l plays important roles in early embryogenesis in mice.
REFERENCE   4  (bases 1 to 1650)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 1650)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   6  (bases 1 to 1650)
  AUTHORS   Bernstein,K.A., Gallagher,J.E., Mitchell,B.M., Granneman,S. and
            Baserga,S.J.
  TITLE     The small-subunit processome is a ribosome assembly intermediate
  JOURNAL   Eukaryot Cell 3 (6), 1619-1626 (2004)
   PUBMED   15590835
REFERENCE   7  (bases 1 to 1650)
  AUTHORS   Milkereit,P., Strauss,D., Bassler,J., Gadal,O., Kuhn,H., Schutz,S.,
            Gas,N., Lechner,J., Hurt,E. and Tschochner,H.
  TITLE     A Noc complex specifically involved in the formation and nuclear
            export of ribosomal 40 S subunits
  JOURNAL   J Biol Chem 278 (6), 4072-4081 (2003)
   PUBMED   12446671
REFERENCE   8  (bases 1 to 1650)
  AUTHORS   Scherl,A., Coute,Y., Deon,C., Calle,A., Kindbeiter,K.,
            Sanchez,J.C., Greco,A., Hochstrasser,D. and Diaz,J.J.
  TITLE     Functional proteomic analysis of human nucleolus
  JOURNAL   Mol Biol Cell 13 (11), 4100-4109 (2002)
   PUBMED   12429849
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY051629.1 and BC071958.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024078.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.247707.1,
                                           SRR3476690.778572.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330579.6/ ENSP00000328854.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                HY051629.1         32-58
            28-1650             BC071958.1         1-1623
FEATURES             Location/Qualifiers
     source          1..1650
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.33"
     gene            1..1650
                     /gene="NOC4L"
                     /gene_synonym="NET49; NOC4; UTP19"
                     /note="nucleolar complex associated 4 homolog"
                     /db_xref="GeneID:79050"
                     /db_xref="HGNC:HGNC:28461"
                     /db_xref="MIM:612819"
     exon            1..149
                     /gene="NOC4L"
                     /gene_synonym="NET49; NOC4; UTP19"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..1583
                     /gene="NOC4L"
                     /gene_synonym="NET49; NOC4; UTP19"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nucleolar complex protein 4 homolog; NOC4-like protein;
                     NOC4 protein homolog; nucleolar complex-associated protein
                     4-like protein"
                     /codon_start=1
                     /product="nucleolar complex protein 4 homolog isoform 1"
                     /protein_id="NP_076983.1"
                     /db_xref="CCDS:CCDS9277.1"
                     /db_xref="GeneID:79050"
                     /db_xref="HGNC:HGNC:28461"
                     /db_xref="MIM:612819"
                     /translation="MEREPGAAGVRRALGRRLEAVLASRSEANAVFDILAVLQSEDQE
                     EIQEAVRTCSRLFGALLERGELFVGQLPSEEMVMTGSQGATRKYKVWMRHRYHSCCNR
                     LGELLGHPSFQVKELALSALLKFVQLEGAHPLEKSKWEGNYLFPRELFKLVVGGLLSP
                     EEDQSLLLSQFREYLDYDDTRYHTMQAAVDAVARVTGQHPEVPPAFWNNAFTLLSAVS
                     LPRREPTVSSFYVKRAELWDTWKVAHLKEHRRVFQAMWLSFLKHKLPLSLYKKVLLIV
                     HDAILPQLAQPTLMIDFLTRACDLGGALSLLALNGLFILIHKHNLEYPDFYRKLYGLL
                     DPSVFHVKYRARFFHLADLFLSSSHLPAYLVAAFAKRLARLALTAPPEALLMVLPFIC
                     NLLRRHPACRVLVHRPHGPELDADPYDPGEEDPAQSRALESSLWELQALQRHYHPEVS
                     KAASVINQALSMPEVSIAPLLELTAYEIFERDLKKKGPEPVPLEFIPAQGLLGRPGEL
                     CAQHFTLS"
     exon            150..270
                     /gene="NOC4L"
                     /gene_synonym="NET49; NOC4; UTP19"
                     /inference="alignment:Splign:2.1.0"
     exon            271..377
                     /gene="NOC4L"
                     /gene_synonym="NET49; NOC4; UTP19"
                     /inference="alignment:Splign:2.1.0"
     exon            378..485
                     /gene="NOC4L"
                     /gene_synonym="NET49; NOC4; UTP19"
                     /inference="alignment:Splign:2.1.0"
     exon            486..635
                     /gene="NOC4L"
                     /gene_synonym="NET49; NOC4; UTP19"
                     /inference="alignment:Splign:2.1.0"
     exon            636..735
                     /gene="NOC4L"
                     /gene_synonym="NET49; NOC4; UTP19"
                     /inference="alignment:Splign:2.1.0"
     exon            736..770
                     /gene="NOC4L"
                     /gene_synonym="NET49; NOC4; UTP19"
                     /inference="alignment:Splign:2.1.0"
     exon            771..821
                     /gene="NOC4L"
                     /gene_synonym="NET49; NOC4; UTP19"
                     /inference="alignment:Splign:2.1.0"
     exon            822..933
                     /gene="NOC4L"
                     /gene_synonym="NET49; NOC4; UTP19"
                     /inference="alignment:Splign:2.1.0"
     exon            934..994
                     /gene="NOC4L"
                     /gene_synonym="NET49; NOC4; UTP19"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1105
                     /gene="NOC4L"
                     /gene_synonym="NET49; NOC4; UTP19"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1266
                     /gene="NOC4L"
                     /gene_synonym="NET49; NOC4; UTP19"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1349
                     /gene="NOC4L"
                     /gene_synonym="NET49; NOC4; UTP19"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1463
                     /gene="NOC4L"
                     /gene_synonym="NET49; NOC4; UTP19"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1650
                     /gene="NOC4L"
                     /gene_synonym="NET49; NOC4; UTP19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1600..1605
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOC4L"
                     /gene_synonym="NET49; NOC4; UTP19"
                     /note="hexamer: AATAAA"
     polyA_site      1650
                     /gene="NOC4L"
                     /gene_synonym="NET49; NOC4; UTP19"
                     /note="major polyA site"
ORIGIN      
        1 gagaatccgc gttgttccgt gttgggggcg gcatggagcg ggagccgggc gccgcgggag
       61 ttcgccgggc tctgggccgc cggctggagg cggtgctggc gagccgcagt gaggccaacg
      121 ccgtgttcga catcctggcc gtgctgcagt ctgaggacca ggaggagatc caggaagcag
      181 tccgcacgtg cagccgtctt ttcggggcct tgctggagcg gggagagctg tttgtgggcc
      241 agctgccctc tgaggagatg gtcatgacag ggtcccaggg agccacacgg aagtacaagg
      301 tgtggatgag acaccgctat cacagctgct gcaatcgctt gggagagctc ctgggccacc
      361 cctcctttca ggtcaaggag ctggccctca gcgcactcct gaagttcgtg cagctggaag
      421 gagcgcaccc cctggagaag tccaagtggg aaggcaacta cctgttcccc cgagagctct
      481 tcaagttggt ggtgggaggc ctgctgtctc ctgaggagga ccagagcctg ctcctgtccc
      541 agttccggga gtacctggac tacgacgaca cccgctacca caccatgcag gcagccgtgg
      601 atgccgtggc ccgggtcact ggccagcacc ccgaggtgcc ccccgccttt tggaacaatg
      661 ccttcacgct gctgtctgcc gtgagcctgc cccgccggga gcccaccgtc tccagcttct
      721 atgtgaagcg ggcggagctg tgggacacct ggaaggttgc tcacctgaag gagcacagga
      781 gggttttcca ggccatgtgg ctcagcttcc tcaagcacaa gctgcccctc agcctctaca
      841 agaaggtgct gctgattgtg catgacgcca tcctgccgca gctggcgcag cccacgctca
      901 tgatcgactt cctcacccgc gcctgcgacc tcgggggggc cctcagcctc ttggccttga
      961 acgggctgtt catcttgatt cacaaacaca acctggagta ccctgacttc taccggaagc
     1021 tctacggcct cttggacccc tctgtctttc acgtcaagta ccgcgcccgc ttcttccacc
     1081 tggctgacct cttcctgtcc tcctcccacc tccccgccta cctggtggcc gccttcgcca
     1141 agcggctggc ccgcctggcc ctgacggctc cccctgaggc cctgctcatg gtcctgcctt
     1201 tcatctgtaa cctgctgcgc cggcaccctg cctgccgggt cctcgtgcac cgtccacacg
     1261 gccctgagtt ggacgccgac ccctacgacc ctggagagga ggacccagcc cagagccggg
     1321 ccttggagag ctccctgtgg gagcttcagg ccctccagcg ccactaccac cctgaggtgt
     1381 ccaaagccgc cagcgtcatc aaccaggccc tgtccatgcc tgaggtcagc atcgcgccac
     1441 tgctggagct cacggcctac gagatctttg agcgggacct gaagaagaag gggcccgagc
     1501 cggtgccact ggagtttatc ccagcccagg gcctgctggg acggccgggt gaactctgtg
     1561 cccagcactt cacgctcagc tgaccctggc ccacctgtga ataaatctca gctgacccca
     1621 gcccacctgt gaataaatgt ttttgcagga
//
