LOCUS       NP_076983                516 aa            linear   PRI 27-APR-2025
DEFINITION  nucleolar complex protein 4 homolog isoform 1 [Homo sapiens].
ACCESSION   NP_076983 XP_947810 XP_951427
VERSION     NP_076983.1
DBSOURCE    REFSEQ: accession NM_024078.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 516)
  AUTHORS   Talebi,A., Shahidsales,S., Aliakbarian,M., Pezeshki Rad,M. and
            Kerachian,M.A.
  TITLE     Oncogenic fusion transcript analysis identified ADAP1-NOC4L,
            potentially associated with metastatic colorectal cancer
  JOURNAL   Cancer Med 12 (1), 525-540 (2023)
   PUBMED   35702822
  REMARK    GeneRIF: Oncogenic fusion transcript analysis identified
            ADAP1-NOC4L, potentially associated with metastatic colorectal
            cancer.
REFERENCE   2  (residues 1 to 516)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (residues 1 to 516)
  AUTHORS   Qin,Y., Li,H., Jia,L., Yan,J., Gao,G.F. and Li,X.
  TITLE     Targeted disruption of Noc4l leads to preimplantation embryonic
            lethality in mice
  JOURNAL   Protein Cell 8 (3), 230-235 (2017)
   PUBMED   28012024
  REMARK    GeneRIF: The results provide the first in vivo genetic evidence
            that Noc4l plays important roles in early embryogenesis in mice.
REFERENCE   4  (residues 1 to 516)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (residues 1 to 516)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   6  (residues 1 to 516)
  AUTHORS   Bernstein,K.A., Gallagher,J.E., Mitchell,B.M., Granneman,S. and
            Baserga,S.J.
  TITLE     The small-subunit processome is a ribosome assembly intermediate
  JOURNAL   Eukaryot Cell 3 (6), 1619-1626 (2004)
   PUBMED   15590835
REFERENCE   7  (residues 1 to 516)
  AUTHORS   Milkereit,P., Strauss,D., Bassler,J., Gadal,O., Kuhn,H., Schutz,S.,
            Gas,N., Lechner,J., Hurt,E. and Tschochner,H.
  TITLE     A Noc complex specifically involved in the formation and nuclear
            export of ribosomal 40 S subunits
  JOURNAL   J Biol Chem 278 (6), 4072-4081 (2003)
   PUBMED   12446671
REFERENCE   8  (residues 1 to 516)
  AUTHORS   Scherl,A., Coute,Y., Deon,C., Calle,A., Kindbeiter,K.,
            Sanchez,J.C., Greco,A., Hochstrasser,D. and Diaz,J.J.
  TITLE     Functional proteomic analysis of human nucleolus
  JOURNAL   Mol Biol Cell 13 (11), 4100-4109 (2002)
   PUBMED   12429849
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY051629.1 and BC071958.1.
            
            On or before Mar 4, 2006 this sequence version replaced
            XP_951427.1, XP_947810.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.247707.1,
                                           SRR3476690.778572.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330579.6/ ENSP00000328854.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..516
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.33"
     Protein         1..516
                     /product="nucleolar complex protein 4 homolog isoform 1"
                     /note="nucleolar complex protein 4 homolog; NOC4-like
                     protein; NOC4 protein homolog; nucleolar
                     complex-associated protein 4-like protein"
                     /calculated_mol_wt=58337
     Site            297..317
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BVI4.1)"
     Region          310..452
                     /region_name="CBF"
                     /note="CBF/Mak21 family; pfam03914"
                     /db_xref="CDD:461090"
     Site            347..367
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BVI4.1)"
     Site            375..395
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BVI4.1)"
     CDS             1..516
                     /gene="NOC4L"
                     /gene_synonym="NET49; NOC4; UTP19"
                     /coded_by="NM_024078.3:33..1583"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS9277.1"
                     /db_xref="GeneID:79050"
                     /db_xref="HGNC:HGNC:28461"
                     /db_xref="MIM:612819"
ORIGIN      
        1 merepgaagv rralgrrlea vlasrseana vfdilavlqs edqeeiqeav rtcsrlfgal
       61 lergelfvgq lpseemvmtg sqgatrkykv wmrhryhscc nrlgellghp sfqvkelals
      121 allkfvqleg ahplekskwe gnylfprelf klvvggllsp eedqslllsq freyldyddt
      181 ryhtmqaavd avarvtgqhp evppafwnna ftllsavslp rreptvssfy vkraelwdtw
      241 kvahlkehrr vfqamwlsfl khklplslyk kvllivhdai lpqlaqptlm idfltracdl
      301 ggalsllaln glfilihkhn leypdfyrkl yglldpsvfh vkyrarffhl adlflssshl
      361 paylvaafak rlarlaltap peallmvlpf icnllrrhpa crvlvhrphg peldadpydp
      421 geedpaqsra lesslwelqa lqrhyhpevs kaasvinqal smpevsiapl leltayeife
      481 rdlkkkgpep vplefipaqg llgrpgelca qhftls
//
