LOCUS       NM_022451               3455 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens NOC3 like DNA replication regulator (NOC3L), mRNA.
ACCESSION   NM_022451
VERSION     NM_022451.11
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3455)
  AUTHORS   Jin,H., Kwak,S.H., Yoon,J.W., Lee,S., Park,K.S., Won,S. and
            Cho,N.H.
  TITLE     Genome-Wide Association Study on Longitudinal Change in Fasting
            Plasma Glucose in Korean Population
  JOURNAL   Diabetes Metab J 47 (2), 255-266 (2023)
   PUBMED   36653889
  REMARK    GeneRIF: Genome-Wide Association Study on Longitudinal Change in
            Fasting Plasma Glucose in Korean Population.
REFERENCE   2  (bases 1 to 3455)
  AUTHORS   Cheung,M.H., Amin,A., Wu,R., Qin,Y., Zou,L., Yu,Z. and Liang,C.
  TITLE     Human NOC3 is essential for DNA replication licensing in human
            cells
  JOURNAL   Cell Cycle 18 (5), 605-620 (2019)
   PUBMED   30741601
  REMARK    GeneRIF: Knockdown of human NOC3 in HeLa cells abrogates the
            chromatin association of other pre-RC proteins including hCDC6 and
            hMCM, leading to DNA replication defects and eventual apoptosis in
            an abortive S-phase. Human NOC3 physically interacts with multiple
            human pre-replicative complex (pre-RC) proteins and associates with
            known replication origins throughout the cell cycle.
REFERENCE   3  (bases 1 to 3455)
  AUTHORS   Duan,X., Li,X., Lou,H., Geng,T., Jin,T., Liang,P., Li,S., Long,Y.
            and Chen,C.
  TITLE     Genetic association of PLCE1, C11orf92-C11orf93, and NOC3L with
            colorectal cancer risk in the Han population
  JOURNAL   Tumour Biol 35 (3), 1813-1817 (2014)
   PUBMED   24146276
  REMARK    GeneRIF: We found PLCE1, C11orf92-C11orf93, and NOC3L associated
            with colorectal cancer susceptibility
REFERENCE   4  (bases 1 to 3455)
  AUTHORS   Yuan,L.J., Jin,T.B., Yin,J.K., Du,X.L., Wang,Q., Dong,R.,
            Wang,S.Z., Cui,Y., Chen,C. and Lu,J.G.
  TITLE     Polymorphisms of tumor-related genes IL-10, PSCA, MTRR and NOC3L
            are associated with the risk of gastric cancer in the Chinese Han
            population
  JOURNAL   Cancer Epidemiol 36 (6), e366-e372 (2012)
   PUBMED   22796266
  REMARK    GeneRIF: Results indicate the importance of four gastric cancer
            susceptibility polymorphisms of IL-10, NOC3L, PSCA and MTRR in the
            Chinese Han population.
REFERENCE   5  (bases 1 to 3455)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 3455)
  AUTHORS   Abnet,C.C., Freedman,N.D., Hu,N., Wang,Z., Yu,K., Shu,X.O.,
            Yuan,J.M., Zheng,W., Dawsey,S.M., Dong,L.M., Lee,M.P., Ding,T.,
            Qiao,Y.L., Gao,Y.T., Koh,W.P., Xiang,Y.B., Tang,Z.Z., Fan,J.H.,
            Wang,C., Wheeler,W., Gail,M.H., Yeager,M., Yuenger,J.,
            Hutchinson,A., Jacobs,K.B., Giffen,C.A., Burdett,L., Fraumeni,J.F.
            Jr., Tucker,M.A., Chow,W.H., Goldstein,A.M., Chanock,S.J. and
            Taylor,P.R.
  TITLE     A shared susceptibility locus in PLCE1 at 10q23 for gastric
            adenocarcinoma and esophageal squamous cell carcinoma
  JOURNAL   Nat Genet 42 (9), 764-767 (2010)
   PUBMED   20729852
REFERENCE   7  (bases 1 to 3455)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   8  (bases 1 to 3455)
  AUTHORS   Johmura,Y., Osada,S., Nishizuka,M. and Imagawa,M.
  TITLE     FAD24, a regulator of adipogenesis, is required for the regulation
            of DNA replication in cell proliferation
  JOURNAL   Biol Pharm Bull 31 (6), 1092-1095 (2008)
   PUBMED   18520036
REFERENCE   9  (bases 1 to 3455)
  AUTHORS   Tominaga,K., Johmura,Y., Nishizuka,M. and Imagawa,M.
  TITLE     Fad24, a mammalian homolog of Noc3p, is a positive regulator in
            adipocyte differentiation
  JOURNAL   J Cell Sci 117 (Pt 25), 6217-6226 (2004)
   PUBMED   15564382
  REMARK    GeneRIF: Fad24, a mammalian homolog of Noc3p, is a positive
            regulator in adipocyte differentiation.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX505710.1, AK091246.1, BC049850.1 and AI632144.1.
            
            On Nov 23, 2018 this sequence version replaced NM_022451.10.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049850.1, AK091246.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371361.3/ ENSP00000360412.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 BX505710.1         38-43
            7-1819              AK091246.1         1-1813
            1820-3449           BC049850.1         1807-3436
            3450-3455           AI632144.1         14-19               c
FEATURES             Location/Qualifiers
     source          1..3455
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.33"
     gene            1..3455
                     /gene="NOC3L"
                     /gene_synonym="AD24; C10orf117; FAD24"
                     /note="NOC3 like DNA replication regulator"
                     /db_xref="GeneID:64318"
                     /db_xref="HGNC:HGNC:24034"
                     /db_xref="MIM:610769"
     exon            1..110
                     /gene="NOC3L"
                     /gene_synonym="AD24; C10orf117; FAD24"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..2504
                     /gene="NOC3L"
                     /gene_synonym="AD24; C10orf117; FAD24"
                     /note="NOC3 protein homolog; factor for adipocyte
                     differentiation 24; nucleolar complex-associated protein
                     3-like protein; nucleolar complex associated 3 homolog;
                     NOC3L DNA replication regulator"
                     /codon_start=1
                     /product="nucleolar complex protein 3 homolog"
                     /protein_id="NP_071896.8"
                     /db_xref="CCDS:CCDS7433.1"
                     /db_xref="GeneID:64318"
                     /db_xref="HGNC:HGNC:24034"
                     /db_xref="MIM:610769"
                     /translation="MKARRNKKQIPSFRKLIKTSKVKLENKLKNKQFKQQSTLKKYRK
                     EQRKLRQAVKDAVSKKPIPLENPKEKRPGKRIEREEEEEEEALPLDMMDEDDLQLMKD
                     LGQRVSFLTRDLSSSEPVHAKKRKHERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSG
                     IIPQTREKPVTDSNKDEEDQEEERELEEEIIEDPIQELTIEEHLIERKKKLQEKKMHI
                     AALASAILSDPENNIKKLKELRSMLMEQDPDVAVTVRKLVIVSLMELFKDITPSYKIR
                     PLTEAEKSTKTRKETQKLREFEEGLVSQYKFYLENLEQMVKDWKQRKLKKSNVVSLKA
                     YKGLAEVAVKSLCELLVALPHFNFHNNIIVLIVPLMNDMSKLISEMCCEAVKKLFKQD
                     KLGQASLGVIKVISGFVKGRNYEVRPEMLKTFLCLRIKEVEVKKDTEDINKPKKFMTF
                     KEKRKSLSRMQRKWKKAEEKLERELREAEASESTEKKLKLHTETLNIVFVTYFRILKK
                     AQRSPLLPAVLEGLAKFAHLINVEFFDDLLVVLHTLIESGDLSYQESLHCVQTAFHIL
                     SGQGDVLNIDPLKFYTHLYKTLFKLHAGATNEGVEIVLQCLDVMLTKRRKQVSQQRAL
                     AFIKRLCTLALHVLPNSSIGILATTRILMHTFPKTDLLLDSESQGSGVFLPELDEPEY
                     CNAQNTALWELHALRRHYHPIVQRFAAHLIAGAPSEGSGALKPELSRRSATELFEAYS
                     MAEMTFNPPVESSNPKIKGKFLQGDSFLNEDLNQLIKRYSSEVATESPLDFTKYLKTS
                     LH"
     exon            111..318
                     /gene="NOC3L"
                     /gene_synonym="AD24; C10orf117; FAD24"
                     /inference="alignment:Splign:2.1.0"
     exon            319..451
                     /gene="NOC3L"
                     /gene_synonym="AD24; C10orf117; FAD24"
                     /inference="alignment:Splign:2.1.0"
     exon            452..609
                     /gene="NOC3L"
                     /gene_synonym="AD24; C10orf117; FAD24"
                     /inference="alignment:Splign:2.1.0"
     exon            610..666
                     /gene="NOC3L"
                     /gene_synonym="AD24; C10orf117; FAD24"
                     /inference="alignment:Splign:2.1.0"
     exon            667..797
                     /gene="NOC3L"
                     /gene_synonym="AD24; C10orf117; FAD24"
                     /inference="alignment:Splign:2.1.0"
     exon            798..959
                     /gene="NOC3L"
                     /gene_synonym="AD24; C10orf117; FAD24"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1053
                     /gene="NOC3L"
                     /gene_synonym="AD24; C10orf117; FAD24"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1229
                     /gene="NOC3L"
                     /gene_synonym="AD24; C10orf117; FAD24"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1358
                     /gene="NOC3L"
                     /gene_synonym="AD24; C10orf117; FAD24"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1490
                     /gene="NOC3L"
                     /gene_synonym="AD24; C10orf117; FAD24"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1571
                     /gene="NOC3L"
                     /gene_synonym="AD24; C10orf117; FAD24"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1672
                     /gene="NOC3L"
                     /gene_synonym="AD24; C10orf117; FAD24"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1745
                     /gene="NOC3L"
                     /gene_synonym="AD24; C10orf117; FAD24"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1809
                     /gene="NOC3L"
                     /gene_synonym="AD24; C10orf117; FAD24"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..1881
                     /gene="NOC3L"
                     /gene_synonym="AD24; C10orf117; FAD24"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..2063
                     /gene="NOC3L"
                     /gene_synonym="AD24; C10orf117; FAD24"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2192
                     /gene="NOC3L"
                     /gene_synonym="AD24; C10orf117; FAD24"
                     /inference="alignment:Splign:2.1.0"
     exon            2193..2290
                     /gene="NOC3L"
                     /gene_synonym="AD24; C10orf117; FAD24"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..2375
                     /gene="NOC3L"
                     /gene_synonym="AD24; C10orf117; FAD24"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..3455
                     /gene="NOC3L"
                     /gene_synonym="AD24; C10orf117; FAD24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3426..3431
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOC3L"
                     /gene_synonym="AD24; C10orf117; FAD24"
                     /note="hexamer: AATAAA"
     polyA_site      3455
                     /gene="NOC3L"
                     /gene_synonym="AD24; C10orf117; FAD24"
                     /note="major polyA site"
ORIGIN      
        1 ggtagtgtag ggacttcggc acgtgtgtca ttccccggga tttctgtagt aaccctgctt
       61 ctggtgaact tgtctggccg gcattcattt aaggcctaag gatgaaggcg agaagaaata
      121 aaaaacagat cccaagcttt cgcaagttaa taaaaactag taaagtcaaa cttgaaaaca
      181 agctaaaaaa taagcagttt aaacaacaaa gcactctcaa gaagtaccga aaagaacaga
      241 ggaaactaag gcaagctgtg aaagatgctg tgtctaagaa acccattcca ttggagaacc
      301 caaaggaaaa gcgaccaggt aaaaggattg agagggaaga agaggaagaa gaagaagccc
      361 ttcctttaga tatgatggat gaagatgact tacagttaat gaaggattta ggacaaagag
      421 tatcttttct aacaagagat ctttcttcta gtgagcctgt tcatgcgaag aaacggaagc
      481 atgaacgcat tatagataaa tatgaaaaaa taccaagaac tctgcaaact gcaccagaga
      541 aggaactgat tcatttactt cctatcaaag ataaaagtgg tataatccca cagactaggg
      601 agaagccagt tactgatagt aacaaagatg aagaggatca agaagaagag agggaacttg
      661 aggaagagat cattgaagat cctattcaag agctgaccat agaagaacat ttgattgaga
      721 gaaagaagaa attacaggag aagaagatgc atattgcagc cttggcatct gccatattat
      781 cagatccaga aaataatatt aaaaaattga aagaattacg ttctatgttg atggaacaag
      841 atcctgatgt ggctgttact gttcgaaagc tggtaattgt ttctctgatg gagttattta
      901 aagatattac tccttcatat aaaatccggc ccctcacaga agcagaaaaa tctactaaga
      961 cccgaaaaga aacccagaag ttaagagaat ttgaagaagg cctggttagc caatacaagt
     1021 tttatttgga aaatctggaa caaatggtta aagattggaa gcagaggaag ctgaagaaaa
     1081 gtaatgtagt ttccttaaag gcatacaaag gactggcaga agtcgctgtg aagagcttgt
     1141 gtgagctgtt ggtggcacta cctcatttta actttcacaa caacatcatc gtattgattg
     1201 tccctctcat gaatgacatg tcaaaattga tatctgaaat gtgttgtgaa gctgtgaaga
     1261 aactctttaa gcaagataaa ttaggccaag cttctcttgg tgtaattaaa gtgatttctg
     1321 gttttgtgaa gggcagaaat tacgaagtta ggccagagat gttaaaaaca tttttatgcc
     1381 taagaatcaa ggaagtagaa gtgaaaaaag atacagaaga cattaataaa ccaaaaaaat
     1441 ttatgacttt caaagaaaag agaaaatctc tatcaagaat gcagagaaag tggaagaaag
     1501 cagaagagaa actagagcga gagcttcgag aggcagaagc ttcagagagt actgagaaaa
     1561 aacttaaact gcacacagag actctgaata ttgtgtttgt aacctacttc agaatattga
     1621 agaaggccca gaggtcacct ctcctgccag cagttctaga aggtcttgcc aagtttgctc
     1681 accttataaa tgtggaattt tttgatgatc tgttagtagt tcttcatact ctcattgagt
     1741 ctggtgacct aagctatcaa gaaagtcttc actgtgtcca gactgctttt catattcttt
     1801 ctggacaagg tgatgttctg aatattgatc cattgaaatt ctacacacat ctctacaaaa
     1861 cactgttcaa attacatgca ggtgctacca atgaaggtgt tgagattgta ctccagtgcc
     1921 ttgatgtcat gctaactaag cgcagaaagc aagtttctca gcagcgagct cttgccttca
     1981 tcaaacgcct ttgtaccctt gctcttcatg ttcttccaaa ttcaagtatt ggcattttag
     2041 caactaccag aatattaatg catactttcc ccaaaacaga tctactgctt gacagtgaat
     2101 ctcagggaag tggagttttc cttcctgaac tggatgagcc tgagtactgc aatgctcaga
     2161 acactgctct gtgggaactg catgctctgc ggaggcatta tcatcccata gtgcagagat
     2221 ttgcagccca cctgatcgct ggagcacctt ctgaaggctc tggagcactc aaaccagagt
     2281 tgagtcgaag atctgctact gaactttttg aggcatatag catggcagaa atgacattca
     2341 atcctcctgt tgaatcttca aaccccaaaa taaagggtaa atttttacaa ggggattcat
     2401 ttttgaatga agatttaaat cagctaatca aaagatactc cagtgaagtt gctactgaat
     2461 cgcctctgga tttcacgaaa tatttgaaaa catcactaca ctagtagagg aatgaagtca
     2521 gtggactttc ttgtatattt gtgtgtgcag atgtacataa agatgagttg ttaacttagg
     2581 atcttttctt tttatacaag gaaagcttcc taagaatgtc taggaagaag aggaagaatg
     2641 accctttgca tggcacaggg ttctgcccct attctgaata tgtcattcca tcaaggagat
     2701 caaaagcctt tttttctccc cagtatttgg aaattacttt cttgatgatg ctgcctttta
     2761 aaagcttcac gtacattata gttttttaaa aaaatctttg gactggatct tactgaagtg
     2821 cagttgctat attaaaatta gggcatagag cacagaaaaa tcaagaccat gagaagacat
     2881 tttaccattt agctactttt tataactaaa tactctttaa atatttttat ttcaatactg
     2941 tggatggaaa tgagaagcat tctaaatttg agttaatata tttttatgaa gatatttgag
     3001 aaaagaaaaa aatagcttgt attcaggttc attggctttt gctggatgat ccacctaaag
     3061 aagttaccta atttggcctt ttaaaaaagg tgttagtgtt tattatagct actttcaagg
     3121 aaagtttgaa tatgattcta gtctctaaag ttcttcacgt tttctgacat tccctggagg
     3181 gtgactgggg aagaattgct ccagggtaga agaaccaggc ccaagacttt accattctga
     3241 tctagagaca aaggatactc aatgaggagc ttttttcccc tcttggaaca ggtaaaatgc
     3301 tttttcttat taatataatt ataaaacagt attttatgta acagctattc ccatattcta
     3361 ggagtggcct aagaaatgcg tgtttcagtg actagattat aaatattctc tattgtgaat
     3421 agttgaataa aacagctgtt tttttctgct tccta
//
