LOCUS       NM_015658               2757 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens NOC2 like nucleolar associated transcriptional
            repressor (NOC2L), mRNA.
ACCESSION   NM_015658
VERSION     NM_015658.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2757)
  AUTHORS   Li,Y., Wang,L., Liu,X., Zhang,C., Du,X. and Xing,B.
  TITLE     NIR promotes progression of colorectal cancer through regulating RB
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1868 (1), 118856 (2021)
   PUBMED   32931817
  REMARK    GeneRIF: NIR promotes progression of colorectal cancer through
            regulating RB.
REFERENCE   2  (bases 1 to 2757)
  AUTHORS   Wang,Q., Ding,J., Nan,G., Lyu,Y. and Ni,G.
  TITLE     LncRNA NOC2L-4.1 functions as a tumor oncogene in cervical cancer
            progression by regulating the miR-630/YAP1 pathway
  JOURNAL   J Cell Biochem 120 (10), 16913-16920 (2019)
   PUBMED   31099044
  REMARK    GeneRIF: LncRNA NOC2L-4.1 functions as a tumor oncogene in cervical
            cancer progression by regulating the miR-630/YAP1 pathway.
REFERENCE   3  (bases 1 to 2757)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 2757)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 2757)
  AUTHORS   Wu,J., Zhang,Y., Wang,Y., Kong,R., Hu,L., Schuele,R., Du,X. and
            Ke,Y.
  TITLE     Transcriptional repressor NIR functions in the ribosome RNA
            processing of both 40S and 60S subunits
  JOURNAL   PLoS One 7 (2), e31692 (2012)
   PUBMED   22363708
  REMARK    GeneRIF: A transcriptional repressor NIR functions in the rRNA
            biogenesis of both the 40S and 60S subunits.
REFERENCE   6  (bases 1 to 2757)
  AUTHORS   Nousiainen,M., Sillje,H.H., Sauer,G., Nigg,E.A. and Korner,R.
  TITLE     Phosphoproteome analysis of the human mitotic spindle
  JOURNAL   Proc Natl Acad Sci U S A 103 (14), 5391-5396 (2006)
   PUBMED   16565220
REFERENCE   7  (bases 1 to 2757)
  AUTHORS   Hublitz,P., Kunowska,N., Mayer,U.P., Muller,J.M., Heyne,K., Yin,N.,
            Fritzsche,C., Poli,C., Miguet,L., Schupp,I.W., van Grunsven,L.A.,
            Potiers,N., van Dorsselaer,A., Metzger,E., Roemer,K. and Schule,R.
  TITLE     NIR is a novel INHAT repressor that modulates the transcriptional
            activity of p53
  JOURNAL   Genes Dev 19 (23), 2912-2924 (2005)
   PUBMED   16322561
  REMARK    GeneRIF: Upon recruitment by p53, NIR represses transcription of
            both p53-dependent reporters and endogenous target genes
REFERENCE   8  (bases 1 to 2757)
  AUTHORS   Kim,J.E., Tannenbaum,S.R. and White,F.M.
  TITLE     Global phosphoproteome of HT-29 human colon adenocarcinoma cells
  JOURNAL   J Proteome Res 4 (4), 1339-1346 (2005)
   PUBMED   16083285
REFERENCE   9  (bases 1 to 2757)
  AUTHORS   Scherl,A., Coute,Y., Deon,C., Calle,A., Kindbeiter,K.,
            Sanchez,J.C., Greco,A., Hochstrasser,D. and Diaz,J.J.
  TITLE     Functional proteomic analysis of human nucleolus
  JOURNAL   Mol Biol Cell 13 (11), 4100-4109 (2002)
   PUBMED   12429849
REFERENCE   10 (bases 1 to 2757)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645608.30.
            
            On Nov 23, 2018 this sequence version replaced NM_015658.3.
            
            Summary: Histone modification by histone acetyltransferases (HAT)
            and histone deacetylases (HDAC) can control major aspects of
            transcriptional regulation. NOC2L represents a novel
            HDAC-independent inhibitor of histone acetyltransferase (INHAT)
            (Hublitz et al., 2005 [PubMed 16322561]).[supplied by OMIM, Mar
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK225239.1, AK024284.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000327044.7/ ENSP00000317992.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AL645608.30        83065-83106         c
            43-195              AL645608.30        82779-82931         c
            196-370             AL645608.30        80949-81123         c
            371-502             AL645608.30        80744-80875         c
            503-623             AL645608.30        79945-80065         c
            624-714             AL645608.30        79773-79863         c
            715-793             AL645608.30        77854-77932         c
            794-904             AL645608.30        77632-77742         c
            905-1018            AL645608.30        77025-77138         c
            1019-1207           AL645608.30        76262-76450         c
            1208-1347           AL645608.30        75850-75989         c
            1348-1459           AL645608.30        74977-75088         c
            1460-1573           AL645608.30        72340-72453         c
            1574-1675           AL645608.30        71981-72082         c
            1676-1819           AL645608.30        70252-70395         c
            1820-1933           AL645608.30        70023-70136         c
            1934-2069           AL645608.30        69368-69503         c
            2070-2159           AL645608.30        68907-68996         c
            2160-2757           AL645608.30        68053-68650         c
FEATURES             Location/Qualifiers
     source          1..2757
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.33"
     gene            1..2757
                     /gene="NOC2L"
                     /gene_synonym="NET15; NET7; NIR; PPP1R112"
                     /note="NOC2 like nucleolar associated transcriptional
                     repressor"
                     /db_xref="GeneID:26155"
                     /db_xref="HGNC:HGNC:24517"
                     /db_xref="MIM:610770"
     exon            1..42
                     /gene="NOC2L"
                     /gene_synonym="NET15; NET7; NIR; PPP1R112"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..2266
                     /gene="NOC2L"
                     /gene_synonym="NET15; NET7; NIR; PPP1R112"
                     /note="novel INHAT (inhibitor of histone
                     acetyltransferase) repressor; NOC2-like protein; protein
                     NOC2 homolog; novel INHAT repressor; protein phosphatase
                     1, regulatory subunit 12; nucleolar complex associated 2
                     homolog; NOC2L nucleolar associated transcriptional
                     repressor"
                     /codon_start=1
                     /product="nucleolar complex protein 2 homolog"
                     /protein_id="NP_056473.3"
                     /db_xref="CCDS:CCDS3.1"
                     /db_xref="GeneID:26155"
                     /db_xref="HGNC:HGNC:24517"
                     /db_xref="MIM:610770"
                     /translation="MAAAGSRKRRLAELTVDEFLASGFDSESESESENSPQAETREAR
                     EAARSPDKPGGSPSASRRKGRASEHKDQLSRLKDRDPEFYKFLQENDQSLLNFSDSDS
                     SEEEEGPFHSLPDVLEEASEEEDGAEEGEDGDRVPRGLKGKKNSVPVTVAMVERWKQA
                     AKQRLTPKLFHEVVQAFRAAVATTRGDQESAEANKFQVTDSAAFNALVTFCIRDLIGC
                     LQKLLFGKVAKDSSRMLQPSSSPLWGKLRVDIKAYLGSAIQLVSCLSETTVLAAVLRH
                     ISVLVPCFLTFPKQCRMLLKRMVIVWSTGEESLRVLAFLVLSRVCRHKKDTFLGPVLK
                     QMYITYVRNCKFTSPGALPFISFMQWTLTELLALEPGVAYQHAFLYIRQLAIHLRNAM
                     TTRKKETYQSVYNWQYVHCLFLWCRVLSTAGPSEALQPLVYPLAQVIIGCIKLIPTAR
                     FYPLRMHCIRALTLLSGSSGAFIPVLPFILEMFQQVDFNRKPGRMSSKPINFSVILKL
                     SNVNLQEKAYRDGLVEQLYDLTLEYLHSQAHCIGFPELVLPVVLQLKSFLRECKVANY
                     CRQVQQLLGKVQENSAYICSRRQRVSFGVSEQQAVEAWEKLTREEGTPLTLYYSHWRK
                     LRDREIQLEISGKERLEDLNFPEIKRRKMADRKDEDRKQFKDLFDLNSSEEDDTEGFS
                     ERGILRPLSTRHGVEDDEEDEEEGEEDSSNSEDGDPDAEAGLAPGELQQLAQGPEDEL
                     EDLQLSEDD"
     exon            43..195
                     /gene="NOC2L"
                     /gene_synonym="NET15; NET7; NIR; PPP1R112"
                     /inference="alignment:Splign:2.1.0"
     exon            196..370
                     /gene="NOC2L"
                     /gene_synonym="NET15; NET7; NIR; PPP1R112"
                     /inference="alignment:Splign:2.1.0"
     exon            371..502
                     /gene="NOC2L"
                     /gene_synonym="NET15; NET7; NIR; PPP1R112"
                     /inference="alignment:Splign:2.1.0"
     exon            503..623
                     /gene="NOC2L"
                     /gene_synonym="NET15; NET7; NIR; PPP1R112"
                     /inference="alignment:Splign:2.1.0"
     exon            624..714
                     /gene="NOC2L"
                     /gene_synonym="NET15; NET7; NIR; PPP1R112"
                     /inference="alignment:Splign:2.1.0"
     exon            715..793
                     /gene="NOC2L"
                     /gene_synonym="NET15; NET7; NIR; PPP1R112"
                     /inference="alignment:Splign:2.1.0"
     exon            794..904
                     /gene="NOC2L"
                     /gene_synonym="NET15; NET7; NIR; PPP1R112"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1018
                     /gene="NOC2L"
                     /gene_synonym="NET15; NET7; NIR; PPP1R112"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1207
                     /gene="NOC2L"
                     /gene_synonym="NET15; NET7; NIR; PPP1R112"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1347
                     /gene="NOC2L"
                     /gene_synonym="NET15; NET7; NIR; PPP1R112"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1459
                     /gene="NOC2L"
                     /gene_synonym="NET15; NET7; NIR; PPP1R112"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1573
                     /gene="NOC2L"
                     /gene_synonym="NET15; NET7; NIR; PPP1R112"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1675
                     /gene="NOC2L"
                     /gene_synonym="NET15; NET7; NIR; PPP1R112"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1819
                     /gene="NOC2L"
                     /gene_synonym="NET15; NET7; NIR; PPP1R112"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1933
                     /gene="NOC2L"
                     /gene_synonym="NET15; NET7; NIR; PPP1R112"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2069
                     /gene="NOC2L"
                     /gene_synonym="NET15; NET7; NIR; PPP1R112"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2159
                     /gene="NOC2L"
                     /gene_synonym="NET15; NET7; NIR; PPP1R112"
                     /inference="alignment:Splign:2.1.0"
     exon            2160..2757
                     /gene="NOC2L"
                     /gene_synonym="NET15; NET7; NIR; PPP1R112"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2724..2729
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOC2L"
                     /gene_synonym="NET15; NET7; NIR; PPP1R112"
                     /note="hexamer: AATAAA"
     polyA_site      2757
                     /gene="NOC2L"
                     /gene_synonym="NET15; NET7; NIR; PPP1R112"
                     /note="major polyA site"
ORIGIN      
        1 gcttcgggtt ggtgtcatgg cagctgcggg gagccgcaag aggcgcctgg cggagctgac
       61 ggtggacgag ttcctagctt cgggctttga ctccgagtcc gaatccgagt ccgaaaattc
      121 tccacaagcg gagacacggg aagcacgcga ggctgcccgg agtccggata agccgggcgg
      181 gagcccctcg gccagccggc gtaaaggccg tgcctctgag cacaaagacc agctctctcg
      241 gctgaaggac agagaccccg agttctacaa gttcctgcag gagaatgacc agagcctgct
      301 aaacttcagc gactcggaca gctctgagga ggaagagggg ccgttccact ccctgccaga
      361 tgtgctggag gaagccagtg aggaggagga tggagcggag gaaggagaag atggggacag
      421 agtccccaga gggctgaagg ggaagaagaa ttctgttcct gtgaccgtcg ccatggttga
      481 gagatggaag caggcagcaa agcaacgcct cactccaaag ctgttccatg aagtggtaca
      541 ggcgttccga gcagctgtgg ccaccacccg aggggaccag gaaagtgctg aggccaacaa
      601 attccaggtc acggacagtg ctgcattcaa tgctctggtt accttctgca tcagagacct
      661 cattggctgt ctccagaagc tgctgtttgg aaaggtggca aaggatagca gcaggatgct
      721 gcagccgtcc agcagcccgc tctgggggaa gcttcgtgtg gacatcaagg cttacctggg
      781 ctcggccata cagctggtgt cctgtctgtc ggagacgacg gtgttggcgg ccgtgctgcg
      841 gcacatcagc gtgctggtgc cctgcttcct gaccttcccc aagcagtgcc gcatgctgct
      901 caagagaatg gtgatcgtat ggagcactgg ggaagagtct ctgcgggtgc tggctttcct
      961 ggtcctcagc agagtctgcc ggcacaagaa ggacactttc cttggccccg tcctcaagca
     1021 aatgtacatc acgtatgtga ggaactgcaa gttcacctcg cctggtgccc tccccttcat
     1081 cagtttcatg cagtggacct tgacggagct gctggccctg gagccgggtg tggcctacca
     1141 gcacgccttc ctctacatcc gccagctcgc catacacctg cgcaacgcca tgaccactcg
     1201 caagaaggaa acataccagt ctgtgtacaa ctggcagtat gtgcactgcc tcttcctgtg
     1261 gtgccgggtc ctgagcactg cgggccccag cgaagccctc cagcccttgg tctaccccct
     1321 tgcccaagtc atcattggct gtatcaagct catccccact gcccgcttct acccgctgcg
     1381 aatgcactgc atccgtgccc tgacgctgct ctcggggagc tcgggggcct tcatcccggt
     1441 gctgcctttc atcctggaga tgttccagca ggtcgacttc aacaggaagc cagggcgcat
     1501 gagctccaag cccatcaact tctccgtgat cctgaagctg tccaatgtca acctgcagga
     1561 gaaggcgtac cgggacggcc tggtggagca gctgtacgac ctcaccctgg agtacctgca
     1621 cagccaggca cactgcatcg gcttcccgga gctggtgctg cctgtggtcc tgcagctgaa
     1681 gtcgttcctc cgggagtgca aggtggccaa ctactgccgg caggtgcagc agctgcttgg
     1741 gaaggttcag gagaactcgg catacatctg cagccgccgc cagagggttt ccttcggcgt
     1801 ctctgagcag caggcagtgg aagcctggga gaagctgacc cgggaagagg ggacacccct
     1861 gaccttgtac tacagccact ggcgcaagct gcgtgaccgg gagatccagc tggagatcag
     1921 tggcaaagag cggctggaag acctgaactt ccctgagatc aaacgaagga agatggctga
     1981 caggaaggat gaggacagga agcaatttaa agacctcttt gacctgaaca gctctgaaga
     2041 ggacgacacc gagggattct cggagagagg gatactgagg cccctgagca ctcggcatgg
     2101 ggtggaagac gatgaagagg acgaggagga gggcgaggag gacagcagca actcggagga
     2161 tggagaccca gacgcagagg cggggctggc ccctggggag ctgcagcagc tggcccaggg
     2221 gccggaggac gagctggagg atctgcagct ctcagaggac gactgaggca gcccatctgg
     2281 ggggcctgta ggggctgccg ggctggtggc cagtgtttcc acctccctgg cagtcaggcc
     2341 tagaggctgg cgtctgtgca gttgggggag gcagtagaca cgggacaggc tttattattt
     2401 atttttcagc atgaaagacc aaacgtatcg agagctgggc tgggctgggc tggtgtggct
     2461 gctgaagccc cacagctgtg ggctgctgaa gtcagctccg cgggggagct gaccctgacg
     2521 tcagcagacc gagaccagtc ccagttccag ggggaggcct gcaggcccct ggccccttcc
     2581 accacctctg ccctccgtct gcagacctcg tccatctgca ccaggctctg ccttcactcc
     2641 cccaagtctt tgaaaatttg ttcctttcct ttgaagtcac attttctttt aaaatttttt
     2701 gttttgcatc cgaaaccgaa agaaataaag cggtgggagg cagggccatt gtgttga
//
