LOCUS       NM_014062               1716 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens NIN1 (RPN12) binding protein 1 homolog (NOB1),
            transcript variant 1, mRNA.
ACCESSION   NM_014062
VERSION     NM_014062.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1716)
  AUTHORS   Zhou,C., Jiang,X., Liang,A., Zhu,R., Yang,Y., Zhong,L. and Wan,D.
  TITLE     LncRNA FEZF1-AS1 aggravates cell proliferation and migration in
            glioblastoma
  JOURNAL   Neurosci Lett 764, 136245 (2021)
   PUBMED   34530115
  REMARK    GeneRIF: LncRNA FEZF1-AS1 aggravates cell proliferation and
            migration in glioblastoma.
REFERENCE   2  (bases 1 to 1716)
  AUTHORS   Ren,Z., Yao,L., Liu,J., Qi,Z. and Li,J.
  TITLE     Silencing NOB1 Can Affect Cell Proliferation and Apoptosis Via the
            C-Jun N-Terminal Kinase Pathway in Colorectal Cancer
  JOURNAL   J Invest Surg 34 (8), 819-825 (2021)
   PUBMED   31906747
  REMARK    GeneRIF: Silencing NOB1 Can Affect Cell Proliferation and Apoptosis
            Via the C-Jun N-Terminal Kinase Pathway in Colorectal Cancer.
REFERENCE   3  (bases 1 to 1716)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1716)
  AUTHORS   Zhang,Y., Wang,F., Wang,L. and Zhang,Q.
  TITLE     MiR-363 suppresses cell migration, invasion, and
            epithelial-mesenchymal transition of osteosarcoma by binding to
            NOB1
  JOURNAL   World J Surg Oncol 18 (1), 83 (2020)
   PUBMED   32357945
  REMARK    GeneRIF: MiR-363 suppresses cell migration, invasion, and
            epithelial-mesenchymal transition of osteosarcoma by binding to
            NOB1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1716)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1716)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   7  (bases 1 to 1716)
  AUTHORS   Zhang,Y., Ni,J., Zhou,G., Yuan,J., Ren,W., Shan,Y., Tang,W., Yu,L.
            and Zhao,S.
  TITLE     Cloning, expression and characterization of the human NOB1 gene
  JOURNAL   Mol Biol Rep 32 (3), 185-189 (2005)
   PUBMED   16172919
  REMARK    GeneRIF: Cloning, expression and characterization of the human NOB1
            gene and its products.
REFERENCE   8  (bases 1 to 1716)
  AUTHORS   Lehner,B. and Sanderson,C.M.
  TITLE     A protein interaction framework for human mRNA degradation
  JOURNAL   Genome Res 14 (7), 1315-1323 (2004)
   PUBMED   15231747
REFERENCE   9  (bases 1 to 1716)
  AUTHORS   Fatica,A., Oeffinger,M., Dlakic,M. and Tollervey,D.
  TITLE     Nob1p is required for cleavage of the 3' end of 18S rRNA
  JOURNAL   Mol Cell Biol 23 (5), 1798-1807 (2003)
   PUBMED   12588997
REFERENCE   10 (bases 1 to 1716)
  AUTHORS   Daniele,A., Altruda,F., Ferrone,M., Silengo,L., Chiarantini,L.,
            Bianchi,M., Stocchi,V. and Magnani,M.
  TITLE     Cloning and expression of a new human polypeptide which regulates
            protein phosphorylation in Escherichia coli
  JOURNAL   Mol Cell Biochem 107 (2), 87-94 (1991)
   PUBMED   1791827
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB026125.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014062.2.
            
            Summary: In yeast, over 200 protein and RNA cofactors are required
            for ribosome assembly, and these are generally conserved in
            eukaryotes. These factors orchestrate modification and cleavage of
            the initial 35S precursor rRNA transcript into the mature 18S,
            5.8S, and 25S rRNAs, folding of the rRNA, and binding of ribosomal
            proteins and 5S RNA. Nob1 is involved in pre-rRNA processing. In a
            late cytoplasmic processing step, Nob1 cleaves a 20S rRNA
            intermediate at cleavage site D to produce the mature 18S rRNA
            (Lamanna and Karbstein, 2009 [PubMed 19706509]).[supplied by OMIM,
            Nov 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the functional protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB026125.1, SRR5189661.110726.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000268802.10/ ENSP00000268802.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1716              AB026125.1         1-1716
FEATURES             Location/Qualifiers
     source          1..1716
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..1716
                     /gene="NOB1"
                     /gene_synonym="ART-4; MST158; MSTP158; NOB1P; PSMD8BP1"
                     /note="NIN1 (RPN12) binding protein 1 homolog"
                     /db_xref="GeneID:28987"
                     /db_xref="HGNC:HGNC:29540"
                     /db_xref="MIM:613586"
     exon            1..79
                     /gene="NOB1"
                     /gene_synonym="ART-4; MST158; MSTP158; NOB1P; PSMD8BP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..1255
                     /gene="NOB1"
                     /gene_synonym="ART-4; MST158; MSTP158; NOB1P; PSMD8BP1"
                     /note="adenocarcinoma antigen recognized by T lymphocytes
                     4; PSMD8 binding protein 1; nin one binding protein;
                     protein ART-4; phosphorylation regulatory protein HP-10;
                     NIN1/PSMD8 binding protein 1 homolog"
                     /codon_start=1
                     /product="RNA-binding protein NOB1"
                     /protein_id="NP_054781.1"
                     /db_xref="CCDS:CCDS10884.1"
                     /db_xref="GeneID:28987"
                     /db_xref="HGNC:HGNC:29540"
                     /db_xref="MIM:613586"
                     /translation="MAPVEHVVADAGAFLRHAALQDIGKNIYTIREVVTEIRDKATRR
                     RLAVLPYELRFKEPLPEYVRLVTEFSKKTGDYPSLSATDIQVLALTYQLEAEFVGVSH
                     LKQEPQKVKVSSSIQHPETPLHISGFHLPYKPKPPQETEKGHSACEPENLEFSSFMFW
                     RNPLPNIDHELQELLIDRGEDVPSEEEEEEENGFEDRKDDSDDDGGGWITPSNIKQIQ
                     QELEQCDVPEDVRVGCLTTDFAMQNVLLQMGLHVLAVNGMLIREARSYILRCHGCFKT
                     TSDMSRVFCSHCGNKTLKKVSVTVSDDGTLHMHFSRNPKVLNPRGLRYSLPTPKGGKY
                     AINPHLTEDQRFPQLRLSQKARQKTNVFAPDYIAGVSPFVENDISSRSATLQVRDSTL
                     GAGRRRLNPNASRKKFVKKR"
     exon            80..212
                     /gene="NOB1"
                     /gene_synonym="ART-4; MST158; MSTP158; NOB1P; PSMD8BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            213..343
                     /gene="NOB1"
                     /gene_synonym="ART-4; MST158; MSTP158; NOB1P; PSMD8BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            344..415
                     /gene="NOB1"
                     /gene_synonym="ART-4; MST158; MSTP158; NOB1P; PSMD8BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            416..541
                     /gene="NOB1"
                     /gene_synonym="ART-4; MST158; MSTP158; NOB1P; PSMD8BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            542..742
                     /gene="NOB1"
                     /gene_synonym="ART-4; MST158; MSTP158; NOB1P; PSMD8BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            743..840
                     /gene="NOB1"
                     /gene_synonym="ART-4; MST158; MSTP158; NOB1P; PSMD8BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            841..985
                     /gene="NOB1"
                     /gene_synonym="ART-4; MST158; MSTP158; NOB1P; PSMD8BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1716
                     /gene="NOB1"
                     /gene_synonym="ART-4; MST158; MSTP158; NOB1P; PSMD8BP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1697..1702
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOB1"
                     /gene_synonym="ART-4; MST158; MSTP158; NOB1P; PSMD8BP1"
                     /note="hexamer: AATAAA"
     polyA_site      1716
                     /gene="NOB1"
                     /gene_synonym="ART-4; MST158; MSTP158; NOB1P; PSMD8BP1"
                     /note="major polyA site"
ORIGIN      
        1 ctctcacgca gccaacatgg ctccagtgga gcacgttgtg gcggatgctg gggctttcct
       61 gcggcatgcg gctctgcagg acatcgggaa gaacatttac accatccggg aggtggtcac
      121 tgagattcgg gacaaggcca cacgcaggcg gctcgctgtc ctgccctacg agctgcggtt
      181 caaggagccc ttaccggaat acgtgcggct ggtgactgag ttttcaaaga aaacaggaga
      241 ctaccccagc ctctctgcca cggacatcca agtgcttgca ctcacatacc agttggaagc
      301 agagtttgtt ggggtgtctc acctaaaaca agaaccacag aaggttaagg tgagctcatc
      361 gattcagcac ccagaaacac ctctgcacat ttctggtttc catctgccct acaagcctaa
      421 acccccacaa gaaacagaaa aaggacactc agcttgtgag cctgagaacc tggaatttag
      481 ttccttcatg ttctggagaa accctttgcc caacatcgat catgaactgc aggagctgct
      541 gattgacaga ggtgaggacg ttccaagtga ggaggaggag gaggaagaaa acgggtttga
      601 agacagaaaa gatgacagcg atgacgacgg gggtggctgg ataaccccca gtaacatcaa
      661 gcagatccag caggagctgg agcagtgtga cgtccccgag gacgtgcggg ttggctgcct
      721 gaccacagac ttcgccatgc agaatgttct gctgcagatg gggctgcacg tgctggcggt
      781 gaacggcatg ctgattcgtg aggcccggag ctacatcttg cgctgccatg gctgtttcaa
      841 gacaacgtct gacatgagcc gagtgttctg ctcacactgt gggaacaaga ccctgaagaa
      901 agtgtccgtg accgtcagcg acgacggcac cctgcacatg cacttctccc gcaaccccaa
      961 ggtgctgaac ccccgcggcc tccggtactc gcttcccact cccaaagggg gcaaatacgc
     1021 catcaacccc catctcaccg aggatcagcg cttccctcag ctgcgactct cccaaaaggc
     1081 caggcagaaa accaacgtgt tcgcccctga ctacatcgcc ggggtgtcac cctttgtcga
     1141 gaatgacatc tccagccgct cagctaccct gcaggtccgg gacagcacct tgggagctgg
     1201 gcggagacgc ttaaatccca acgcttccag aaagaagttt gtgaagaaaa ggtgaagagc
     1261 gagttcccgc aggcaaattg gatgggcgtc tggccgccgt ggagttccgg tgacccattt
     1321 ccccagccgt gtcgtctcca ggaccacccg atggaaataa caggcgggct tcacggtgcg
     1381 gctctgtccg cccatgcccc gctgggtctg cagggaactg gactgtccca tggcctgtga
     1441 gcaccggagc gcctggctgc ctgccaagga agtgcaattg cataaaaaca gaaagaacaa
     1501 cgccctggag ccaatcttca agaaaggaat ttccaaagga taatattttt ctaataaatg
     1561 cggctgcaac ctcctgtgca tttaattaaa taggccaaat ttttgctgct taggtcatct
     1621 caaggctgat acttgagctg tgtgcccaga gatcatgcat ttagatttat atttttgcca
     1681 gaaaatacaa ggttataata aaactaagaa ctacca
//
