LOCUS       NM_032313               2218 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens nitric oxide associated 1 (NOA1), mRNA.
ACCESSION   NM_032313
VERSION     NM_032313.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2218)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 2218)
  AUTHORS   Al-Furoukh,N., Kardon,J.R., Kruger,M., Szibor,M., Baker,T.A. and
            Braun,T.
  TITLE     NOA1, a novel ClpXP substrate, takes an unexpected nuclear detour
            prior to mitochondrial import
  JOURNAL   PLoS One 9 (7), e103141 (2014)
   PUBMED   25072814
  REMARK    GeneRIF: Our results uncovered an unexpected, mandatory detour of
            NOA1 through the nucleolus before uptake into mitochondria.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2218)
  AUTHORS   He,J., Cooper,H.M., Reyes,A., Di Re,M., Kazak,L., Wood,S.R.,
            Mao,C.C., Fearnley,I.M., Walker,J.E. and Holt,I.J.
  TITLE     Human C4orf14 interacts with the mitochondrial nucleoid and is
            involved in the biogenesis of the small mitochondrial ribosomal
            subunit
  JOURNAL   Nucleic Acids Res 40 (13), 6097-6108 (2012)
   PUBMED   22447445
  REMARK    GeneRIF: This study indicates rhat C4orf14 is involved in 28S
            subunit biogenesis and mtDNA maintenance.
REFERENCE   4  (bases 1 to 2218)
  AUTHORS   Heidler,J., Al-Furoukh,N., Kukat,C., Salwig,I., Ingelmann,M.E.,
            Seibel,P., Kruger,M., Holtz,J., Wittig,I., Braun,T. and Szibor,M.
  TITLE     Nitric oxide-associated protein 1 (NOA1) is necessary for
            oxygen-dependent regulation of mitochondrial respiratory complexes
  JOURNAL   J Biol Chem 286 (37), 32086-32093 (2011)
   PUBMED   21771794
REFERENCE   5  (bases 1 to 2218)
  AUTHORS   Arakawa,S., Takahashi,A., Ashikawa,K., Hosono,N., Aoi,T.,
            Yasuda,M., Oshima,Y., Yoshida,S., Enaida,H., Tsuchihashi,T.,
            Mori,K., Honda,S., Negi,A., Arakawa,A., Kadonosono,K., Kiyohara,Y.,
            Kamatani,N., Nakamura,Y., Ishibashi,T. and Kubo,M.
  TITLE     Genome-wide association study identifies two susceptibility loci
            for exudative age-related macular degeneration in the Japanese
            population
  JOURNAL   Nat Genet 43 (10), 1001-1004 (2011)
   PUBMED   21909106
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2218)
  AUTHORS   Gu,J., Ye,Y., Spitz,M.R., Lin,J., Kiemeney,L.A., Xing,J.,
            Hildebrandt,M.A., Ki Hong,W., Amos,C.I. and Wu,X.
  TITLE     A genetic variant near the PMAIP1/Noxa gene is associated with
            increased bleomycin sensitivity
  JOURNAL   Hum Mol Genet 20 (4), 820-826 (2011)
   PUBMED   21106707
REFERENCE   7  (bases 1 to 2218)
  AUTHORS   Kolanczyk,M., Pech,M., Zemojtel,T., Yamamoto,H., Mikula,I.,
            Calvaruso,M.A., van den Brand,M., Richter,R., Fischer,B., Ritz,A.,
            Kossler,N., Thurisch,B., Spoerle,R., Smeitink,J., Kornak,U.,
            Chan,D., Vingron,M., Martasek,P., Lightowlers,R.N., Nijtmans,L.,
            Schuelke,M., Nierhaus,K.H. and Mundlos,S.
  TITLE     NOA1 is an essential GTPase required for mitochondrial protein
            synthesis
  JOURNAL   Mol Biol Cell 22 (1), 1-11 (2011)
   PUBMED   21118999
REFERENCE   8  (bases 1 to 2218)
  AUTHORS   Tang,T., Zheng,B., Chen,S.H., Murphy,A.N., Kudlicka,K., Zhou,H. and
            Farquhar,M.G.
  TITLE     hNOA1 interacts with complex I and DAP3 and regulates mitochondrial
            respiration and apoptosis
  JOURNAL   J Biol Chem 284 (8), 5414-5424 (2009)
   PUBMED   19103604
REFERENCE   9  (bases 1 to 2218)
  AUTHORS   Parihar,A., Parihar,M.S., Chen,Z. and Ghafourifar,P.
  TITLE     mAtNOS1 induces apoptosis of human mammary adenocarcinoma cells
  JOURNAL   Life Sci 82 (21-22), 1077-1082 (2008)
   PUBMED   18456285
  REMARK    GeneRIF: The present study suggests a novel function for mAtNOS1 in
            regulating mitochondrial nitric oxide and calcium and inducing
            apoptosis of MCF-7 cells
REFERENCE   10 (bases 1 to 2218)
  AUTHORS   Zemojtel,T., Kolanczyk,M., Kossler,N., Stricker,S., Lurz,R.,
            Mikula,I., Duchniewicz,M., Schuelke,M., Ghafourifar,P.,
            Martasek,P., Vingron,M. and Mundlos,S.
  TITLE     Mammalian mitochondrial nitric oxide synthase: characterization of
            a novel candidate
  JOURNAL   FEBS Lett 580 (2), 455-462 (2006)
   PUBMED   16380119
  REMARK    Erratum:[FEBS Lett. 2007 May 15;581(10):2072-3]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC004894.2 and AC069307.7.
            
            On Nov 22, 2018 this sequence version replaced NM_032313.3.
            
            Summary: The protein encoded by this gene is a nuclear-encoded
            GTPase that functions in the mitochondrion. Upon translation, this
            protein is imported into the nucleus and then into the nucleolus
            before being exported to the mitochondrion. The encoded protein is
            required for oxygen-dependent regulation of mitochondrial
            respiratory complexes and for mitochondrial protein synthesis.
            [provided by RefSeq, Dec 2015].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004894.2, SRR3476690.76227.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264230.5/ ENSP00000264230.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-452               BC004894.2         55-506
            453-453             AC069307.7         91011-91011         c
            454-2218            BC004894.2         508-2272
FEATURES             Location/Qualifiers
     source          1..2218
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q12"
     gene            1..2218
                     /gene="NOA1"
                     /gene_synonym="C4orf14; hAtNOS1; hNOA1; mAtNOS1; MTG3"
                     /note="nitric oxide associated 1"
                     /db_xref="GeneID:84273"
                     /db_xref="HGNC:HGNC:28473"
                     /db_xref="MIM:614919"
     exon            1..1165
                     /gene="NOA1"
                     /gene_synonym="C4orf14; hAtNOS1; hNOA1; mAtNOS1; MTG3"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..2118
                     /gene="NOA1"
                     /gene_synonym="C4orf14; hAtNOS1; hNOA1; mAtNOS1; MTG3"
                     /note="putative ortholog of Arabidopsis mitochondrial
                     nitric oxide synthase; nitric oxide synthase,
                     mitochondrial (putative); mitochondrial GTPase 3 homolog"
                     /codon_start=1
                     /product="nitric oxide-associated protein 1"
                     /protein_id="NP_115689.1"
                     /db_xref="CCDS:CCDS3510.1"
                     /db_xref="GeneID:84273"
                     /db_xref="HGNC:HGNC:28473"
                     /db_xref="MIM:614919"
                     /translation="MLPARLPFRLLSLFLRGSAPTAARHGLREPLLERRCAAASSFQH
                     SSSLGRELPYDPVDTEGFGEGGDMQERFLFPEYILDPEPQPTREKQLQELQQQQEEEE
                     RQRQQRREERRQQNLRARSREHPVVGHPDPALPPSGVNCSGCGAELHCQDAGVPGYLP
                     REKFLRTAEADGGLARTVCQRCWLLSHHRRALRLQVSREQYLELVSAALRRPGPSLVL
                     YMVDLLDLPDALLPDLPALVGPKQLIVLGNKVDLLPQDAPGYRQRLRERLWEDCARAG
                     LLLAPGHQGPQRPVKDEPQDGENPNPPNWSRTVVRDVRLISAKTGYGVEELISALQRS
                     WRYRGDVYLVGATNAGKSTLFNTLLESDYCTAKGSEAIDRATISPWPGTTLNLLKFPI
                     CNPTPYRMFKRHQRLKKDSTQAEEDLSEQEQNQLNVLKKHGYVVGRVGRTFLYSEEQK
                     DNIPFEFDADSLAFDMENDPVMGTHKSTKQVELTAQDVKDAHWFYDTPGITKENCILN
                     LLTEKEVNIVLPTQSIVPRTFVLKPGMVLFLGAIGRIDFLQGNQSAWFTVVASNILPV
                     HITSLDRADALYQKHAGHTLLQIPMGGKERMAGFPPLVAEDIMLKEGLGASEAVADIK
                     FSSAGWVSVTPNFKDRLHLRGYTPEGTVLTVRPPLLPYIVNIKGQRIKKSVAYKTKKP
                     PSLMYNVRKKKGKINV"
     exon            1166..1330
                     /gene="NOA1"
                     /gene_synonym="C4orf14; hAtNOS1; hNOA1; mAtNOS1; MTG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1536
                     /gene="NOA1"
                     /gene_synonym="C4orf14; hAtNOS1; hNOA1; mAtNOS1; MTG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1668
                     /gene="NOA1"
                     /gene_synonym="C4orf14; hAtNOS1; hNOA1; mAtNOS1; MTG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1785
                     /gene="NOA1"
                     /gene_synonym="C4orf14; hAtNOS1; hNOA1; mAtNOS1; MTG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1906
                     /gene="NOA1"
                     /gene_synonym="C4orf14; hAtNOS1; hNOA1; mAtNOS1; MTG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..2218
                     /gene="NOA1"
                     /gene_synonym="C4orf14; hAtNOS1; hNOA1; mAtNOS1; MTG3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2200..2205
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOA1"
                     /gene_synonym="C4orf14; hAtNOS1; hNOA1; mAtNOS1; MTG3"
                     /note="hexamer: AATAAA"
     polyA_site      2218
                     /gene="NOA1"
                     /gene_synonym="C4orf14; hAtNOS1; hNOA1; mAtNOS1; MTG3"
                     /note="major polyA site"
ORIGIN      
        1 cccctttgga gctacttcct catgctgccc gctcgcctac cgttcaggct gctgagcctt
       61 ttccttcgtg gatccgctcc cacggcagcg cgccatggcc tccgggagcc gctcctggag
      121 aggaggtgcg ctgccgcctc ctccttccag cactcatcga gtctgggacg cgagcttcct
      181 tatgaccccg tggacacgga gggctttgga gaaggtggtg acatgcagga gcgttttctg
      241 ttcccggagt acatcctgga tccggagccg caacccaccc gcgaaaagca gctgcaggag
      301 ctccagcaac agcaggagga ggaggagcga cagaggcagc agcggcggga ggagcggcga
      361 cagcaaaacc tacgggccag gtcccgggag cacccggtcg tggggcaccc ggacccggca
      421 ttgccgccca gcggcgtgaa ctgctcgggc tgtggggcag agctgcactg ccaggacgcc
      481 ggagtgcccg gctacctgcc ccgagagaag ttcctccgca cggcggaggc agacggcggg
      541 ctggcacgga ccgtgtgcca gcgctgctgg ctgctgtcgc accaccggcg cgctctacgc
      601 ctgcaggtga gccgcgagca gtacctggag ctggtgagcg ccgcgttgcg gcggcccggc
      661 ccctccctgg tgctctacat ggtggacctg ctggacctgc ccgacgccct gctgcccgac
      721 ttgcccgcgc tggtgggccc caagcagctg atcgtgctgg gaaacaaagt ggacctcctg
      781 ccccaggatg ctcctggcta ccggcagagg ctgcgggagc gactgtggga ggactgtgcc
      841 cgcgccgggc tcctgctggc ccctggccac caagggccac agcgccccgt caaggacgag
      901 ccacaggacg gggagaatcc gaatccgccg aactggtccc gcacagtggt cagggacgtg
      961 cggctgatca gcgccaagac cggctatgga gtggaagagt tgatctctgc ccttcagcgc
     1021 tcctggcgct accgtgggga cgtctactta gtgggcgcca ccaacgccgg caaatccact
     1081 ctctttaaca cgctcctgga gtccgattac tgcactgcca agggctccga ggccatcgac
     1141 agagccacca tctccccttg gccaggtact acattaaacc ttctgaagtt tcctatttgc
     1201 aacccaactc cttacagaat gtttaaaagg catcaaagac ttaaaaaaga ttcaactcaa
     1261 gctgaagaag atcttagtga gcaagaacaa aatcagctta atgtcctcaa aaagcatggt
     1321 tatgtcgtag gaagagttgg aaggacattc ttgtattcag aagaacagaa ggataacatt
     1381 ccctttgagt ttgatgctga ttcacttgcc tttgacatgg aaaatgaccc tgttatgggt
     1441 acacacaaat ccaccaaaca agtagaattg actgcacaag atgtgaaaga tgcccactgg
     1501 ttttatgaca cccctggaat tacaaaagaa aattgtattt taaatcttct aacagaaaaa
     1561 gaagtaaata ttgttttgcc aacacagtcc attgttccaa gaacttttgt gcttaaacca
     1621 ggaatggttc tgtttttggg tgctataggc cgcatagatt tcctgcaggg aaatcagtca
     1681 gcttggttta cagtcgtggc ttccaacatc ctccctgtgc atatcacctc cttggacagg
     1741 gcagacgctc tgtatcagaa gcatgcaggt catacgttac tccagattcc aatgggtgga
     1801 aaagaacgaa tggcaggatt tcctcctctt gttgctgaag acattatgtt aaaagaagga
     1861 ctgggggcat ctgaagcagt ggccgacatc aagttttcct ctgcaggttg ggtttcagta
     1921 acacctaatt ttaaggacag actgcatctc cgaggctata cacctgaagg aacagttttg
     1981 accgtccggc cccctctctt gccatatatt gttaacatca aaggacagcg catcaagaaa
     2041 agtgtggcct ataaaaccaa gaagcctcct tcccttatgt acaacgtgag gaagaagaaa
     2101 ggaaagataa atgtatgaga ccgaccttgt tcactccaga tattaactgt attgaacaca
     2161 acaaaataca ttgaatttgt attaaacata taacgcataa ataaagctcc cattctta
//
