LOCUS       NM_005386               1259 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens neuronatin (NNAT), transcript variant 1, mRNA.
ACCESSION   NM_005386
VERSION     NM_005386.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1259)
  AUTHORS   Azmi,M.B., Jawed,A., Ahmed,S.D.H., Naeem,U., Feroz,N., Saleem,A.,
            Sardar,K., Qureshi,S.A. and Azim,M.K.
  TITLE     Understanding the impact of structural modifications at the NNAT
            gene's post-translational acetylation site: in silico approach for
            predicting its drug-interaction role in anorexia nervosa
  JOURNAL   Eat Weight Disord 28 (1), 97 (2023)
   PUBMED   37987927
  REMARK    GeneRIF: Understanding the impact of structural modifications at
            the NNAT gene's post-translational acetylation site: in silico
            approach for predicting its drug-interaction role in anorexia
            nervosa.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1259)
  AUTHORS   Plasterer,C., Semenikhina,M., Tsaih,S.W., Flister,M.J. and
            Palygin,O.
  TITLE     NNAT is a novel mediator of oxidative stress that suppresses ER +
            breast cancer
  JOURNAL   Mol Med 29 (1), 87 (2023)
   PUBMED   37400769
  REMARK    GeneRIF: NNAT is a novel mediator of oxidative stress that
            suppresses ER + breast cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1259)
  AUTHORS   Deng,Y., Lu,L., Liang,X., Li,J., Zhu,D., Huang,H., Zhang,Y.,
            Zhang,X., Chen,Y., Liu,X. and Fu,Y.
  TITLE     DNA methylation-mediated silencing of Neuronatin promotes
            hepatocellular carcinoma proliferation through the PI3K-Akt
            signaling pathway
  JOURNAL   Life Sci 312, 121266 (2023)
   PUBMED   36473542
  REMARK    GeneRIF: DNA methylation-mediated silencing of Neuronatin promotes
            hepatocellular carcinoma proliferation through the PI3K-Akt
            signaling pathway.
REFERENCE   4  (bases 1 to 1259)
  AUTHORS   Azmi,M.B., Naeem,U., Saleem,A., Jawed,A., Usman,H., Qureshi,S.A.
            and Azim,M.K.
  TITLE     In silico identification of the rare-coding pathogenic mutations
            and structural modeling of human NNAT gene associated with anorexia
            nervosa
  JOURNAL   Eat Weight Disord 27 (7), 2725-2744 (2022)
   PUBMED   35655118
  REMARK    GeneRIF: In silico identification of the rare-coding pathogenic
            mutations and structural modeling of human NNAT gene associated
            with anorexia nervosa.
REFERENCE   5  (bases 1 to 1259)
  AUTHORS   Pieper,W., Ignatov,A., Kalinski,T., Haybaeck,J., Czapiewski,P. and
            Nass,N.
  TITLE     The predictive potential of Neuronatin for neoadjuvant chemotherapy
            of breast cancer
  JOURNAL   Cancer Biomark 32 (2), 161-173 (2021)
   PUBMED   34092612
  REMARK    GeneRIF: The predictive potential of Neuronatin for neoadjuvant
            chemotherapy of breast cancer.
REFERENCE   6  (bases 1 to 1259)
  AUTHORS   Evans,H.K., Wylie,A.A., Murphy,S.K. and Jirtle,R.L.
  TITLE     The neuronatin gene resides in a 'micro-imprinted' domain on human
            chromosome 20q11.2
  JOURNAL   Genomics 77 (1-2), 99-104 (2001)
   PUBMED   11543638
REFERENCE   7  (bases 1 to 1259)
  AUTHORS   John,R.M., Aparicio,S.A., Ainscough,J.F., Arney,K.L., Khosla,S.,
            Hawker,K., Hilton,K.J., Barton,S.C. and Surani,M.A.
  TITLE     Imprinted expression of neuronatin from modified BAC transgenes
            reveals regulation by distinct and distant enhancers
  JOURNAL   Dev Biol 236 (2), 387-399 (2001)
   PUBMED   11476579
REFERENCE   8  (bases 1 to 1259)
  AUTHORS   Usui,H., Morii,K., Tanaka,R., Tamura,T., Washiyama,K., Ichikawa,T.
            and Kumanishi,T.
  TITLE     cDNA cloning and mRNA expression analysis of the human neuronatin.
            High level expression in human pituitary gland and pituitary
            adenomas
  JOURNAL   J Mol Neurosci 9 (1), 55-60 (1997)
   PUBMED   9356927
REFERENCE   9  (bases 1 to 1259)
  AUTHORS   Dou,D. and Joseph,R.
  TITLE     Cloning of human neuronatin gene and its localization to
            chromosome-20q 11.2-12: the deduced protein is a novel
            'proteolipid'
  JOURNAL   Brain Res 723 (1-2), 8-22 (1996)
   PUBMED   8813377
REFERENCE   10 (bases 1 to 1259)
  AUTHORS   Dou,D. and Joseph,R.
  TITLE     Structure and organization of the human neuronatin gene
  JOURNAL   Genomics 33 (2), 292-297 (1996)
   PUBMED   8660979
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY021161.1 and BC001768.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005386.3.
            
            Summary: The protein encoded by this gene is a proteolipid that may
            be involved in the regulation of ion channels during brain
            development. The encoded protein may also play a role in forming
            and maintaining the structure of the nervous system. This gene is
            found within an intron of another gene, bladder cancer associated
            protein, but on the opposite strand. This gene is imprinted and is
            expressed only from the paternal allele. [provided by RefSeq, Apr
            2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (alpha).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1160039.1,
                                           SRR3476690.374212.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000649451.1/ ENSP00000497164.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                HY021161.1         46-57
            13-1259             BC001768.1         1-1247
FEATURES             Location/Qualifiers
     source          1..1259
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.23"
     gene            1..1259
                     /gene="NNAT"
                     /gene_synonym="Peg5"
                     /note="neuronatin"
                     /db_xref="GeneID:4826"
                     /db_xref="HGNC:HGNC:7860"
                     /db_xref="MIM:603106"
     exon            1..154
                     /gene="NNAT"
                     /gene_synonym="Peg5"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..328
                     /gene="NNAT"
                     /gene_synonym="Peg5"
                     /note="isoform alpha is encoded by transcript variant 1"
                     /codon_start=1
                     /product="neuronatin isoform alpha"
                     /protein_id="NP_005377.1"
                     /db_xref="CCDS:CCDS13296.1"
                     /db_xref="GeneID:4826"
                     /db_xref="HGNC:HGNC:7860"
                     /db_xref="MIM:603106"
                     /translation="MAAVAAASAELLIIGWYIFRVLLQVFLECCIYWVGFAFRNPPGT
                     QPIARSEVFRYSLQKLAYTVSRTGRQVLGERRQRAPN"
     exon            155..235
                     /gene="NNAT"
                     /gene_synonym="Peg5"
                     /inference="alignment:Splign:2.1.0"
     exon            236..1259
                     /gene="NNAT"
                     /gene_synonym="Peg5"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1259
                     /gene="NNAT"
                     /gene_synonym="Peg5"
                     /note="major polyA site"
ORIGIN      
        1 agtgcgccca acagcggact ccgagaccag cggatctcgg caaaccctct ttctcgacca
       61 cccacctacc attcttggaa ccatggcggc agtggcggcg gcctcggctg aactgctcat
      121 catcggctgg tacatcttcc gcgtgctgct gcaggtgttc ctggaatgct gcatttactg
      181 ggtaggattc gcttttcgaa atcctccagg gacacagccc attgcgagaa gtgaggtgtt
      241 caggtactcc ctgcagaagc tggcatacac ggtgtcgcgg accgggcggc aggtgttggg
      301 ggagcgcagg cagcgagccc ccaactgagg ccccagctcc cagccctggg cggccgtatc
      361 atcaggtgct cctgtgcatc tcggccagca cgggagccag tgccgcgcag gaatgtgggg
      421 tcccctgtgt tccctcgcca gaggagcact tggcaaggtc agtgaggggc cagtagaccc
      481 ccggagaagc agtaccgaca atgacgaaga taccagatcc cttcccaacc cctttgcacc
      541 ggtcccacta aggggcaggg tcgagagagg aggggggata gggggagcag acccctgaga
      601 tctgggcata ggcaccgcat tctgatctgg acaaagtcgg gacagcacca tcccagcccc
      661 gaagccaggg ccatgccagc aggccccacc atggaaatca aaacaccgca ccagccagca
      721 gaatggacat tctgacatcg ccagccgacg ccctgaatct tggtgcagca ccaaccgcgt
      781 gcctgtgtgg cgggactgga gggcacagtt gaggaaggag ggtggttaag aaatacagtg
      841 gggccctctc gctgtccctt gcccagggca cttgcattcc agcctcgctg catttgctct
      901 ctcgattccc ctttcctcct cactgcctcc caagcccacc ctactccaaa ataatgtgtc
      961 acttgatttg gaactattca agcagtaaaa gtaaatgaat cccaccttta ctaaaacact
     1021 ttctctgaac cccccttgcc cctcactgat cttgcttttc cctggtctca tgcagttgtg
     1081 gtcaatattg tggtaatcgc taattgtact gattgtttaa gtgtgcatta gttgtgtctc
     1141 cccagctaga ttgtaagctc ctggaggaca gggaccacct ctacaaaaaa taaaaaaagt
     1201 acctcccctg tctcgcacag tgtcccagga ccctgcggtg cagtagaggc gcaccaaaa
//
