LOCUS       NM_020167               2059 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens neuromedin U receptor 2 (NMUR2), mRNA.
ACCESSION   NM_020167
VERSION     NM_020167.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2059)
  AUTHORS   Do,A.R., An,J., Jo,J., Kim,W.J., Kang,H.Y., Lee,S., Yoon,D.,
            Cho,Y.S., Adcock,I.M., Chung,K.F., Won,S. and Kim,T.B.
  TITLE     A genome-wide association study implicates the pleiotropic effect
            of NMUR2 on asthma and COPD
  JOURNAL   Sci Rep 12 (1), 22073 (2022)
   PUBMED   36543808
  REMARK    GeneRIF: A genome-wide association study implicates the pleiotropic
            effect of NMUR2 on asthma and COPD.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2059)
  AUTHORS   Alhosaini,K., Bahattab,O., Qassam,H., Challiss,R.A.J. and
            Willars,G.B.
  TITLE     Ligand-Specific Signaling Profiles and Resensitization Mechanisms
            of the Neuromedin U2 Receptor
  JOURNAL   Mol Pharmacol 94 (1), 674-688 (2018)
   PUBMED   29724789
  REMARK    GeneRIF: Activation by NMU2 is longer lasting if NmS is the ligand.
REFERENCE   3  (bases 1 to 2059)
  AUTHORS   Garczyk,S., Klotz,N., Szczepanski,S., Denecke,B., Antonopoulos,W.,
            von Stillfried,S., Knuchel,R., Rose,M. and Dahl,E.
  TITLE     Oncogenic features of neuromedin U in breast cancer are associated
            with NMUR2 expression involving crosstalk with members of the WNT
            signaling pathway
  JOURNAL   Oncotarget 8 (22), 36246-36265 (2017)
   PUBMED   28423716
  REMARK    GeneRIF: NMU might contribute to progression of NMUR2-positive
            breast cancer
REFERENCE   4  (bases 1 to 2059)
  AUTHORS   Chun,E.H., Kim,H., Suh,C.S., Kim,J.H., Kim,D.Y. and Kim,J.G.
  TITLE     Polymorphisms in neuropeptide genes and bone mineral density in
            Korean postmenopausal women
  JOURNAL   Menopause 22 (11), 1256-1263 (2015)
   PUBMED   25871004
  REMARK    GeneRIF: polymorphisms in the gene may be useful in identifying
            women at risk for osteoporosis.
REFERENCE   5  (bases 1 to 2059)
  AUTHORS   Lin,T.Y., Huang,W.L., Lee,W.Y. and Luo,C.W.
  TITLE     Identifying a Neuromedin U Receptor 2 Splice Variant and
            Determining Its Roles in the Regulation of Signaling and
            Tumorigenesis In Vitro
  JOURNAL   PLoS One 10 (8), e0136836 (2015)
   PUBMED   26317338
  REMARK    GeneRIF: Study identified a novel NMUR2 splice variant lacking the
            third exon and able to form heteromeric complexes with NMUR1 and
            NMUR2 without Neuromedin U (NMU). Its expression can block NMU
            signaling suppressing then ovarian cancer cells proliferation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2059)
  AUTHORS   Shan,L., Qiao,X., Crona,J.H., Behan,J., Wang,S., Laz,T., Bayne,M.,
            Gustafson,E.L., Monsma,F.J. Jr. and Hedrick,J.A.
  TITLE     Identification of a novel neuromedin U receptor subtype expressed
            in the central nervous system
  JOURNAL   J Biol Chem 275 (50), 39482-39486 (2000)
   PUBMED   11010960
REFERENCE   7  (bases 1 to 2059)
  AUTHORS   Raddatz,R., Wilson,A.E., Artymyshyn,R., Bonini,J.A., Borowsky,B.,
            Boteju,L.W., Zhou,S., Kouranova,E.V., Nagorny,R., Guevarra,M.S.,
            Dai,M., Lerman,G.S., Vaysse,P.J., Branchek,T.A., Gerald,C.,
            Forray,C. and Adham,N.
  TITLE     Identification and characterization of two neuromedin U receptors
            differentially expressed in peripheral tissues and the central
            nervous system
  JOURNAL   J Biol Chem 275 (42), 32452-32459 (2000)
   PUBMED   10899166
REFERENCE   8  (bases 1 to 2059)
  AUTHORS   Hosoya,M., Moriya,T., Kawamata,Y., Ohkubo,S., Fujii,R., Matsui,H.,
            Shintani,Y., Fukusumi,S., Habata,Y., Hinuma,S., Onda,H.,
            Nishimura,O. and Fujino,M.
  TITLE     Identification and functional characterization of a novel subtype
            of neuromedin U receptor
  JOURNAL   J Biol Chem 275 (38), 29528-29532 (2000)
   PUBMED   10887190
REFERENCE   9  (bases 1 to 2059)
  AUTHORS   Howard,A.D., Wang,R., Pong,S.S., Mellin,T.N., Strack,A., Guan,X.M.,
            Zeng,Z., Williams,D.L. Jr., Feighner,S.D., Nunes,C.N., Murphy,B.,
            Stair,J.N., Yu,H., Jiang,Q., Clements,M.K., Tan,C.P., McKee,K.K.,
            Hreniuk,D.L., McDonald,T.P., Lynch,K.R., Evans,J.F., Austin,C.P.,
            Caskey,C.T., Van der Ploeg,L.H. and Liu,Q.
  TITLE     Identification of receptors for neuromedin U and its role in
            feeding
  JOURNAL   Nature 406 (6791), 70-74 (2000)
   PUBMED   10894543
REFERENCE   10 (bases 1 to 2059)
  AUTHORS   Tate,C.G. and Grisshammer,R.
  TITLE     Heterologous expression of G-protein-coupled receptors
  JOURNAL   Trends Biotechnol 14 (11), 426-430 (1996)
   PUBMED   8940772
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC067776.1, AC008571.6 and
            AI023570.1.
            
            On Nov 30, 2019 this sequence version replaced NM_020167.4.
            
            Summary: This gene encodes a protein from the G-protein coupled
            receptor 1 family. This protein is a receptor for neuromedin U,
            which is a neuropeptide that is widely distributed in the gut and
            central nervous system. This receptor plays an important role in
            the regulation of food intake and body weight. [provided by RefSeq,
            Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067776.1, SRR11853564.22804.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000255262.4/ ENSP00000255262.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1348              BC067776.1         1-1348
            1349-1757           AC008571.6         91471-91879         c
            1758-2059           AI023570.1         9-310               c
FEATURES             Location/Qualifiers
     source          1..2059
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.1"
     gene            1..2059
                     /gene="NMUR2"
                     /gene_synonym="FM-4; FM4; NMU-R2; NMU2R; TGR-1; TGR1"
                     /note="neuromedin U receptor 2"
                     /db_xref="GeneID:56923"
                     /db_xref="HGNC:HGNC:16454"
                     /db_xref="MIM:605108"
     exon            1..892
                     /gene="NMUR2"
                     /gene_synonym="FM-4; FM4; NMU-R2; NMU2R; TGR-1; TGR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..1414
                     /gene="NMUR2"
                     /gene_synonym="FM-4; FM4; NMU-R2; NMU2R; TGR-1; TGR1"
                     /note="G-protein coupled receptor TGR-1; growth hormone
                     secretagogue receptor family, member 4; G-protein coupled
                     receptor FM-4"
                     /codon_start=1
                     /product="neuromedin-U receptor 2"
                     /protein_id="NP_064552.3"
                     /db_xref="CCDS:CCDS4321.1"
                     /db_xref="GeneID:56923"
                     /db_xref="HGNC:HGNC:16454"
                     /db_xref="MIM:605108"
                     /translation="MSGMEKLQNASWIYQQKLEDPFQKHLNSTEEYLAFLCGPRRSHF
                     FLPVSVVYVPIFVVGVIGNVLVCLVILQHQAMKTPTNYYLFSLAVSDLLVLLLGMPLE
                     VYEMWRNYPFLFGPVGCYFKTALFETVCFASILSITTVSVERYVAILHPFRAKLQSTR
                     RRALRILGIVWGFSVLFSLPNTSIHGIKFHYFPNGSLVPGSATCTVIKPMWIYNFIIQ
                     VTSFLFYLLPMTVISVLYYLMALRLKKDKSLEADEGNANIQRPCRKSVNKMLFVLVLV
                     FAICWAPFHIDRLFFSFVEEWSESLAAVFNLVHVVSGVFFYLSSAVNPIIYNLLSRRF
                     QAAFQNVISSFHKQWHSQHDPQLPPAQRNIFLTECHFVELTEDIGPQFPCQSSMHNSH
                     LPAALSSEQMSRTNYQSFHFNKT"
     exon            893..977
                     /gene="NMUR2"
                     /gene_synonym="FM-4; FM4; NMU-R2; NMU2R; TGR-1; TGR1"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1103
                     /gene="NMUR2"
                     /gene_synonym="FM-4; FM4; NMU-R2; NMU2R; TGR-1; TGR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..2059
                     /gene="NMUR2"
                     /gene_synonym="FM-4; FM4; NMU-R2; NMU2R; TGR-1; TGR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2038..2043
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NMUR2"
                     /gene_synonym="FM-4; FM4; NMU-R2; NMU2R; TGR-1; TGR1"
                     /note="hexamer: AATAAA"
     polyA_site      2059
                     /gene="NMUR2"
                     /gene_synonym="FM-4; FM4; NMU-R2; NMU2R; TGR-1; TGR1"
                     /note="major polyA site"
ORIGIN      
        1 aacctggagg gtgaaacact cactctctcc cagccttcct tacgaagcct gtgactttcg
       61 tgactgcttt ctcttttttg ttttcctttt ttcttttttt tttttttttc ctggctcagc
      121 ttgaaacaga gcctcgtacc aggggaggct caggccttgg attttaatgt cagggatgga
      181 aaaacttcag aatgcttcct ggatctacca gcagaaacta gaagatccat tccagaaaca
      241 cctgaacagc accgaggagt atctggcctt cctctgcgga cctcggcgca gccacttctt
      301 cctccccgtg tctgtggtgt atgtgccaat ttttgtggtg ggggtcattg gcaatgtcct
      361 ggtgtgcctg gtgattctgc agcaccaggc tatgaagacg cccaccaact actacctctt
      421 cagcctggcg gtctctgacc tcctggtcct gctccttgga atgcccctgg aggtctatga
      481 gatgtggcgc aactaccctt tcttgttcgg gcccgtgggc tgctacttca agacggccct
      541 ctttgagacc gtgtgcttcg cctccatcct cagcatcacc accgtcagcg tggagcgcta
      601 cgtggccatc ctacacccgt tccgcgccaa actgcagagc acccggcgcc gggccctcag
      661 gatcctcggc atcgtctggg gcttctccgt gctcttctcc ctgcccaaca ccagcatcca
      721 tggcatcaag ttccactact tccccaatgg gtccctggtc ccaggttcgg ccacctgtac
      781 ggtcatcaag cccatgtgga tctacaattt catcatccag gtcacctcct tcctattcta
      841 cctcctcccc atgactgtca tcagtgtcct ctactacctc atggcactca gactaaagaa
      901 agacaaatct cttgaggcag atgaagggaa tgcaaatatt caaagaccct gcagaaaatc
      961 agtcaacaag atgctgtttg tcttggtctt agtgtttgct atctgttggg ccccgttcca
     1021 cattgaccga ctcttcttca gctttgtgga ggagtggagt gaatccctgg ctgctgtgtt
     1081 caacctcgtc catgtggtgt caggtgtctt cttctacctg agctcagctg tcaaccccat
     1141 tatctataac ctactgtctc gccgcttcca ggcagcattc cagaatgtga tctcttcttt
     1201 ccacaaacag tggcactccc agcatgaccc acagttgcca cctgcccagc ggaacatctt
     1261 cctgacagaa tgccactttg tggagctgac cgaagatata ggtccccaat tcccatgtca
     1321 gtcatccatg cacaactctc acctcccagc agccctctct agtgaacaga tgtcaagaac
     1381 aaactatcaa agcttccact ttaacaaaac ctgaattctt tcagagctga ctctcctcta
     1441 tgcctcaaaa cttcagagag gaacatccca taatgtatgc cttctcatat gatattagag
     1501 aggtagaatg gctcttacaa ctcatgtacc cattgctagt tttttttttt ttaataaacg
     1561 tgaaaactga gagttagatc tggtttcaaa acccaagact gcctgatttt tagttatctt
     1621 tccactatcc taactgcctc atgccccttc actagttcat gccaagaacg tgactggaaa
     1681 ggcatggcac ctataccttg attaatttcc attaatggaa atggttcgtc ctgagtcatc
     1741 tacgttccga gtcaggctgt cactcctact accaatggcc actgtgagcc acagaaggaa
     1801 gacatgtacg tgctgttcta ctttatatga tgtgagaagc caacatcagt gtcccttggc
     1861 agcagtctac aggcataact tgttttattg tgctgaattt tattgtgctt ctcaaatatt
     1921 gcacttttaa aaaaattgaa agtttgtggc aatgctgttg agcaaatctg ctggcatctt
     1981 tcttcccaaa ggcatgtgct cacttcatgt ctctgtatca attgtcataa ttttcgcaat
     2041 aaacttgatt attattata
//
