LOCUS       NM_006056               3221 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens neuromedin U receptor 1 (NMUR1), mRNA.
ACCESSION   NM_006056
VERSION     NM_006056.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3221)
  AUTHORS   Zhao,W., An,Y., Cheng,F. and Zhao,C.
  TITLE     Expression of NMU and NMUR1 in tryptase-positive mast cells and
            PBLs in allergic rhinitis patients' nasal mucosa
  JOURNAL   Am J Rhinol Allergy 38 (3), 146-152 (2024)
   PUBMED   38378005
  REMARK    GeneRIF: Expression of NMU and NMUR1 in tryptase-positive mast
            cells and PBLs in allergic rhinitis patients' nasal mucosa.
REFERENCE   2  (bases 1 to 3221)
  AUTHORS   Zheng,R., Wang,S., Wang,J., Zhou,M., Shi,Q. and Liu,B.
  TITLE     Neuromedin U regulates the anti-tumor activity of CD8+ T cells and
            glycolysis of tumor cells in the tumor microenvironment of
            pancreatic ductal adenocarcinoma in an NMUR1-dependent manner
  JOURNAL   Cancer Sci 115 (2), 334-346 (2024)
   PUBMED   38071753
  REMARK    GeneRIF: Neuromedin U regulates the anti-tumor activity of CD8[+] T
            cells and glycolysis of tumor cells in the tumor microenvironment
            of pancreatic ductal adenocarcinoma in an NMUR1-dependent manner.
REFERENCE   3  (bases 1 to 3221)
  AUTHORS   Tsukada,A., Takata,K., Takano,S., Ohashi,Y., Mukai,M., Aikawa,J.,
            Iwase,D., Inoue,G., Takaso,M. and Uchida,K.
  TITLE     Increased NMUR1 Expression in Mast Cells in the Synovial Membrane
            of Obese Osteoarthritis Patients
  JOURNAL   Int J Mol Sci 23 (19), 11237 (2022)
   PUBMED   36232539
  REMARK    GeneRIF: Increased NMUR1 Expression in Mast Cells in the Synovial
            Membrane of Obese Osteoarthritis Patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3221)
  AUTHORS   Del-Aguila,J.L., Beitelshees,A.L., Cooper-Dehoff,R.M.,
            Chapman,A.B., Gums,J.G., Bailey,K., Gong,Y., Turner,S.T.,
            Johnson,J.A. and Boerwinkle,E.
  TITLE     Genome-wide association analyses suggest NELL1 influences adverse
            metabolic response to HCTZ in African Americans
  JOURNAL   Pharmacogenomics J 14 (1), 35-40 (2014)
   PUBMED   23400010
REFERENCE   5  (bases 1 to 3221)
  AUTHORS   Hasson,S.A., Kane,L.A., Yamano,K., Huang,C.H., Sliter,D.A.,
            Buehler,E., Wang,C., Heman-Ackah,S.M., Hessa,T., Guha,R.,
            Martin,S.E. and Youle,R.J.
  TITLE     High-content genome-wide RNAi screens identify regulators of parkin
            upstream of mitophagy
  JOURNAL   Nature 504 (7479), 291-295 (2013)
   PUBMED   24270810
REFERENCE   6  (bases 1 to 3221)
  AUTHORS   Raddatz,R., Wilson,A.E., Artymyshyn,R., Bonini,J.A., Borowsky,B.,
            Boteju,L.W., Zhou,S., Kouranova,E.V., Nagorny,R., Guevarra,M.S.,
            Dai,M., Lerman,G.S., Vaysse,P.J., Branchek,T.A., Gerald,C.,
            Forray,C. and Adham,N.
  TITLE     Identification and characterization of two neuromedin U receptors
            differentially expressed in peripheral tissues and the central
            nervous system
  JOURNAL   J Biol Chem 275 (42), 32452-32459 (2000)
   PUBMED   10899166
REFERENCE   7  (bases 1 to 3221)
  AUTHORS   Fujii,R., Hosoya,M., Fukusumi,S., Kawamata,Y., Habata,Y.,
            Hinuma,S., Onda,H., Nishimura,O. and Fujino,M.
  TITLE     Identification of neuromedin U as the cognate ligand of the orphan
            G protein-coupled receptor FM-3
  JOURNAL   J Biol Chem 275 (28), 21068-21074 (2000)
   PUBMED   10783389
REFERENCE   8  (bases 1 to 3221)
  AUTHORS   Szekeres,P.G., Muir,A.I., Spinage,L.D., Miller,J.E., Butler,S.I.,
            Smith,A., Rennie,G.I., Murdock,P.R., Fitzgerald,L.R., Wu,Hl.,
            McMillan,L.J., Guerrera,S., Vawter,L., Elshourbagy,N.A.,
            Mooney,J.L., Bergsma,D.J., Wilson,S. and Chambers,J.K.
  TITLE     Neuromedin U is a potent agonist at the orphan G protein-coupled
            receptor FM3
  JOURNAL   J Biol Chem 275 (27), 20247-20250 (2000)
   PUBMED   10811630
REFERENCE   9  (bases 1 to 3221)
  AUTHORS   Howard,A.D., Wang,R., Pong,S.S., Mellin,T.N., Strack,A., Guan,X.M.,
            Zeng,Z., Williams,D.L. Jr., Feighner,S.D., Nunes,C.N., Murphy,B.,
            Stair,J.N., Yu,H., Jiang,Q., Clements,M.K., Tan,C.P., McKee,K.K.,
            Hreniuk,D.L., McDonald,T.P., Lynch,K.R., Evans,J.F., Austin,C.P.,
            Caskey,C.T., Van der Ploeg,L.H. and Liu,Q.
  TITLE     Identification of receptors for neuromedin U and its role in
            feeding
  JOURNAL   Nature 406 (6791), 70-74 (2000)
   PUBMED   10894543
REFERENCE   10 (bases 1 to 3221)
  AUTHORS   Tan,C.P., McKee,K.K., Liu,Q., Palyha,O.C., Feighner,S.D.,
            Hreniuk,D.L., Smith,R.G. and Howard,A.D.
  TITLE     Cloning and characterization of a human and murine T-cell orphan
            G-protein-coupled receptor similar to the growth hormone
            secretagogue and neurotensin receptors
  JOURNAL   Genomics 52 (2), 223-229 (1998)
   PUBMED   9782091
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP198644.1, AF272362.1 and AC017104.8.
            
            On Nov 22, 2018 this sequence version replaced NM_006056.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036543.1, SRR1660805.80960.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA2153980,
                                           SAMEA2155770 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000305141.5/ ENSP00000305877.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                BP198644.1         27-73
            48-1365             AF272362.1         1-1318
            1366-3221           AC017104.8         131714-133569       c
FEATURES             Location/Qualifiers
     source          1..3221
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.1"
     gene            1..3221
                     /gene="NMUR1"
                     /gene_synonym="(FM-3); FM-3; FM3; GPC-R; GPR66; NMU1R"
                     /note="neuromedin U receptor 1"
                     /db_xref="GeneID:10316"
                     /db_xref="HGNC:HGNC:4518"
                     /db_xref="MIM:604153"
     exon            1..87
                     /gene="NMUR1"
                     /gene_synonym="(FM-3); FM-3; FM3; GPC-R; GPR66; NMU1R"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1365
                     /gene="NMUR1"
                     /gene_synonym="(FM-3); FM-3; FM3; GPC-R; GPR66; NMU1R"
                     /note="NMU-R1; G-protein coupled receptor 66; G-protein
                     coupled receptor FM-3"
                     /codon_start=1
                     /product="neuromedin-U receptor 1"
                     /protein_id="NP_006047.3"
                     /db_xref="CCDS:CCDS2486.1"
                     /db_xref="GeneID:10316"
                     /db_xref="HGNC:HGNC:4518"
                     /db_xref="MIM:604153"
                     /translation="MTPLCLNCSVLPGDLYPGGARNPMACNGSAARGHFDPEDLNLTD
                     EALRLKYLGPQQTELFMPICATYLLIFVVGAVGNGLTCLVILRHKAMRTPTNYYLFSL
                     AVSDLLVLLVGLPLELYEMWHNYPFLLGVGGCYFRTLLFEMVCLASVLNVTALSVERY
                     VAVVHPLQARSMVTRAHVRRVLGAVWGLAMLCSLPNTSLHGIRQLHVPCRGPVPDSAV
                     CMLVRPRALYNMVVQTTALLFFCLPMAIMSVLYLLIGLRLRRERLLLMQEAKGRGSAA
                     ARSRYTCRLQQHDRGRRQVTKMLFVLVVVFGICWAPFHADRVMWSVVSQWTDGLHLAF
                     QHVHVISGIFFYLGSAANPVLYSLMSSRFRETFQEALCLGACCHRLRPRHSSHSLSRM
                     TTGSTLCDVGSLGSWVHPLAGNDGPEAQQETDPS"
     exon            88..982
                     /gene="NMUR1"
                     /gene_synonym="(FM-3); FM-3; FM3; GPC-R; GPR66; NMU1R"
                     /inference="alignment:Splign:2.1.0"
     exon            983..3221
                     /gene="NMUR1"
                     /gene_synonym="(FM-3); FM-3; FM3; GPC-R; GPR66; NMU1R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2266..2271
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NMUR1"
                     /gene_synonym="(FM-3); FM-3; FM3; GPC-R; GPR66; NMU1R"
                     /note="hexamer: AATAAA"
     polyA_site      2295
                     /gene="NMUR1"
                     /gene_synonym="(FM-3); FM-3; FM3; GPC-R; GPR66; NMU1R"
                     /note="major polyA site"
     regulatory      3193..3198
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NMUR1"
                     /gene_synonym="(FM-3); FM-3; FM3; GPC-R; GPR66; NMU1R"
                     /note="hexamer: ATTAAA"
     polyA_site      3221
                     /gene="NMUR1"
                     /gene_synonym="(FM-3); FM-3; FM3; GPC-R; GPR66; NMU1R"
ORIGIN      
        1 gtcagtcagt ccactggctc ccgcgccgcg tctgtgtccg tcgctcggag ggtggaagcc
       61 ggggtctcgc gggccgcggg ccgcatgact cctctctgcc tcaattgctc tgtcctccct
      121 ggagacctgt acccaggggg tgcaaggaac cccatggctt gcaatggcag tgcggccagg
      181 gggcactttg accctgagga cttgaacctg actgacgagg cactgagact caagtacctg
      241 gggccccagc agacagagct gttcatgccc atctgtgcca catacctgct gatcttcgtg
      301 gtgggcgctg tgggcaatgg gctgacctgt ctggtcatcc tgcgccacaa ggccatgcgc
      361 acgcctacca actactacct cttcagcctg gccgtgtcgg acctgctggt gctgctggtg
      421 ggcctgcccc tggagctcta tgagatgtgg cacaactacc ccttcctgct gggcgttggt
      481 ggctgctatt tccgcacgct actgtttgag atggtctgcc tggcctcagt gctcaacgtc
      541 actgccctga gcgtggaacg ctatgtggcc gtggtgcacc cactccaggc caggtccatg
      601 gtgacgcggg cccatgtgcg ccgagtgctt ggggccgtct ggggtcttgc catgctctgc
      661 tccctgccca acaccagcct gcacggcatc cggcagctgc acgtgccctg ccggggccca
      721 gtgccagact cagctgtttg catgctggtc cgcccacggg ccctctacaa catggtagtg
      781 cagaccaccg cgctgctctt cttctgcctg cccatggcca tcatgagcgt gctctacctg
      841 ctcattgggc tgcgactgcg gcgggagagg ctgctgctca tgcaggaggc caagggcagg
      901 ggctctgcag cagccaggtc cagatacacc tgcaggctcc agcagcacga tcggggccgg
      961 agacaagtga ccaagatgct gtttgtcctg gtcgtggtgt ttggcatctg ctgggccccg
     1021 ttccacgccg accgcgtcat gtggagcgtc gtgtcacagt ggacagatgg cctgcacctg
     1081 gccttccagc acgtgcacgt catctccggc atcttcttct acctgggctc ggcggccaac
     1141 cccgtgctct atagcctcat gtccagccgc ttccgagaga ccttccagga ggccctgtgc
     1201 ctcggggcct gctgccatcg cctcagaccc cgccacagct cccacagcct cagcaggatg
     1261 accacaggca gcaccctgtg tgatgtgggc tccctgggca gctgggtcca ccccctggct
     1321 gggaacgatg gcccagaggc gcagcaagag accgatccat cctgagtgga gccttaaagt
     1381 ggcttcacct ggaggggcca gagggtcacc tggagctggg gagacacatc tgccttcctc
     1441 tgcagggatg ccttcacgta ctgtccctag ttcagcctag aaattctgac cagcacctca
     1501 gtttccctca gagggaaaca gcaggaggag ggatccctga ctgctgagga ctcacactga
     1561 ccagacgcca caccttgtgc ttcttatctg tccactgcca ctcccccagt tcaaatcctt
     1621 accctgcaga aatatcacag ttagctgggg ctcagcagtc ctccctctgg ggactccctg
     1681 ccaccactgc cagtttctga aacggtccca ctgggtcctc actgtccttc ccagttcctg
     1741 ttcaggttct ggcaggggcc cagggatcca ggggacctgg ttccaatctc agccctgctg
     1801 tcaccacctt gtcatgcacc atcaagcata tcagtctacc tttctttttt tctgagacag
     1861 agtctcactc tgtcgcccag gctagagtgc agtggcgcga ttttggctca ctgcaacctc
     1921 cgcctccggg gttcaagcga ttctcctgcc tcagcctccc gagtagctgg gactacaggt
     1981 gagccccagc atgcccagct aatttttttt aatttttagt agagacgggg tttcaccatg
     2041 ttggccaggc tggtctcaaa ctcttgacct caggtgatcc gccgacctcg gcctcccaaa
     2101 gtcctcggat tacaggcatg agccaccaca cccggccaat cagtccacct ttctaggcct
     2161 tggttccttg cctgaaaaat gaaagaggcg ctggctttcc acagtgtcat gctttggcac
     2221 tttagctatg gttttctttc tgtgtgtgtg taagccactg cttataataa aaccaacaat
     2281 accctcagac tgaaagggcg gaagttatta tctgcatctt tatcaacccc aagccccact
     2341 tcctccctga cctccccatg ccctccccag cctctcccag cacaagtggg gcaaagccag
     2401 catgcaagca gaccccacca ccacagccca cctccgtcct cacatacgtg caggctggct
     2461 cgggagtcca gtgagcagag cattggactt ggctggccag agggtctctg agggcaagag
     2521 acatggccaa ccaagggcaa ggagtgaccc tgtggagggt tctgccgaac tcaatgcagt
     2581 gagaagaggg acagggacaa gtagtccttg aaactgagcc ccattctgaa tccctgcagg
     2641 ccaagtcatt gctcagccag gactcagttc atggaggaaa cttgtcctgc tgcagtccct
     2701 gagtcttgtc ctcctgagag gaagccctgg cttccaaggc tgggagctgg aggatgacct
     2761 tcggtcggtc tgtctgggtt ctccctgcag acagcttcct agctcatgcc catagctcat
     2821 gctccctgcc gagaaagtgg aggacgtggt acagggttgc agatgtttag ttttaaaaat
     2881 tcaattataa aaataataaa tgctcatgat agaaaatttg gaaagtgcaa ataagcaaaa
     2941 atgaaaacaa ttttaaaaat gtaaaacctc tcttgccagg gaatggggga agggcaagtg
     3001 aggagttctt taatgggtga agagtttcag ttttgcaaaa tgaaaaagtt ctggagatca
     3061 gttgtgcaac aatatgaata tacataacaa tactgaacta tacactgaaa tggttaagat
     3121 ggtacatttt atgttatgtg tattttacca caatttttat aaaaagagga ttaaatctaa
     3181 aggaaagaaa aaattaaaac cacccataac tttactctga a
//
