LOCUS       NM_006681                816 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens neuromedin U (NMU), transcript variant 1, mRNA.
ACCESSION   NM_006681
VERSION     NM_006681.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 816)
  AUTHORS   Zhao,W., An,Y., Cheng,F. and Zhao,C.
  TITLE     Expression of NMU and NMUR1 in tryptase-positive mast cells and
            PBLs in allergic rhinitis patients' nasal mucosa
  JOURNAL   Am J Rhinol Allergy 38 (3), 146-152 (2024)
   PUBMED   38378005
  REMARK    GeneRIF: Expression of NMU and NMUR1 in tryptase-positive mast
            cells and PBLs in allergic rhinitis patients' nasal mucosa.
REFERENCE   2  (bases 1 to 816)
  AUTHORS   Zheng,R., Wang,S., Wang,J., Zhou,M., Shi,Q. and Liu,B.
  TITLE     Neuromedin U regulates the anti-tumor activity of CD8+ T cells and
            glycolysis of tumor cells in the tumor microenvironment of
            pancreatic ductal adenocarcinoma in an NMUR1-dependent manner
  JOURNAL   Cancer Sci 115 (2), 334-346 (2024)
   PUBMED   38071753
  REMARK    GeneRIF: Neuromedin U regulates the anti-tumor activity of CD8[+] T
            cells and glycolysis of tumor cells in the tumor microenvironment
            of pancreatic ductal adenocarcinoma in an NMUR1-dependent manner.
REFERENCE   3  (bases 1 to 816)
  AUTHORS   Liu,R., Shao,W., Xu,J. and Chu,C.
  TITLE     To be or not to be direct: The role of neuromedin U in
            neuro-eosinophil crosstalk
  JOURNAL   Sci Bull (Beijing) 69 (2), 148-150 (2024)
   PUBMED   38071108
  REMARK    GeneRIF: To be or not to be direct: The role of neuromedin U in
            neuro-eosinophil crosstalk.
REFERENCE   4  (bases 1 to 816)
  AUTHORS   Sim,M.K., Park,J.E., Kim,S.R., Lee,J., Kim,E.J., Kim,Y., Shin,U.S.,
            Kim,H. and Kim,K.S.
  TITLE     Neuromedin U contributes to radiation resistance in colorectal
            cancer via YAP/TAZ signaling activation
  JOURNAL   Oncol Rep 50 (4) (2023)
   PUBMED   37594135
  REMARK    GeneRIF: Neuromedin U contributes to radiation resistance in
            colorectal cancer via YAP/TAZ signaling activation.
REFERENCE   5  (bases 1 to 816)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 816)
  AUTHORS   Hosoya,M., Moriya,T., Kawamata,Y., Ohkubo,S., Fujii,R., Matsui,H.,
            Shintani,Y., Fukusumi,S., Habata,Y., Hinuma,S., Onda,H.,
            Nishimura,O. and Fujino,M.
  TITLE     Identification and functional characterization of a novel subtype
            of neuromedin U receptor
  JOURNAL   J Biol Chem 275 (38), 29528-29532 (2000)
   PUBMED   10887190
REFERENCE   7  (bases 1 to 816)
  AUTHORS   Fujii,R., Hosoya,M., Fukusumi,S., Kawamata,Y., Habata,Y.,
            Hinuma,S., Onda,H., Nishimura,O. and Fujino,M.
  TITLE     Identification of neuromedin U as the cognate ligand of the orphan
            G protein-coupled receptor FM-3
  JOURNAL   J Biol Chem 275 (28), 21068-21074 (2000)
   PUBMED   10783389
REFERENCE   8  (bases 1 to 816)
  AUTHORS   Szekeres,P.G., Muir,A.I., Spinage,L.D., Miller,J.E., Butler,S.I.,
            Smith,A., Rennie,G.I., Murdock,P.R., Fitzgerald,L.R., Wu,Hl.,
            McMillan,L.J., Guerrera,S., Vawter,L., Elshourbagy,N.A.,
            Mooney,J.L., Bergsma,D.J., Wilson,S. and Chambers,J.K.
  TITLE     Neuromedin U is a potent agonist at the orphan G protein-coupled
            receptor FM3
  JOURNAL   J Biol Chem 275 (27), 20247-20250 (2000)
   PUBMED   10811630
REFERENCE   9  (bases 1 to 816)
  AUTHORS   Howard,A.D., Wang,R., Pong,S.S., Mellin,T.N., Strack,A., Guan,X.M.,
            Zeng,Z., Williams,D.L. Jr., Feighner,S.D., Nunes,C.N., Murphy,B.,
            Stair,J.N., Yu,H., Jiang,Q., Clements,M.K., Tan,C.P., McKee,K.K.,
            Hreniuk,D.L., McDonald,T.P., Lynch,K.R., Evans,J.F., Austin,C.P.,
            Caskey,C.T., Van der Ploeg,L.H. and Liu,Q.
  TITLE     Identification of receptors for neuromedin U and its role in
            feeding
  JOURNAL   Nature 406 (6791), 70-74 (2000)
   PUBMED   10894543
REFERENCE   10 (bases 1 to 816)
  AUTHORS   Austin,C., Lo,G., Nandha,K.A., Meleagros,L. and Bloom,S.R.
  TITLE     Cloning and characterization of the cDNA encoding the human
            neuromedin U (NmU) precursor: NmU expression in the human
            gastrointestinal tract
  JOURNAL   J Mol Endocrinol 14 (2), 157-169 (1995)
   PUBMED   7619205
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI603117.1, BC012908.1 and
            X76029.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006681.3.
            
            Summary: This gene encodes a member of the neuromedin family of
            neuropeptides. The encoded protein is a precursor that is
            proteolytically processed to generate a biologically active
            neuropeptide that plays a role in pain, stress, immune-mediated
            inflammatory diseases and feeding regulation. Increased expression
            of this gene was observed in renal, pancreatic and lung cancers.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms. Some of these isoforms may undergo
            similar processing to generate the mature peptide. [provided by
            RefSeq, Jul 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X76029.1, SRR5189661.10538.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264218.7/ ENSP00000264218.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BI603117.1         6-22
            18-325              BC012908.1         1-308
            326-334             X76029.1           325-333
            335-816             BC012908.1         318-799
FEATURES             Location/Qualifiers
     source          1..816
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q12"
     gene            1..816
                     /gene="NMU"
                     /note="neuromedin U"
                     /db_xref="GeneID:10874"
                     /db_xref="HGNC:HGNC:7859"
                     /db_xref="MIM:605103"
     exon            1..218
                     /gene="NMU"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..631
                     /gene="NMU"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; prepro-NMU; neuromedin U precursor-related
                     peptide/neuromedin U preproprotein"
                     /codon_start=1
                     /product="neuromedin-U isoform 1 preproprotein"
                     /protein_id="NP_006672.1"
                     /db_xref="CCDS:CCDS3501.1"
                     /db_xref="GeneID:10874"
                     /db_xref="HGNC:HGNC:7859"
                     /db_xref="MIM:605103"
                     /translation="MLRTESCRPRSPAGQVAAASPLLLLLLLLAWCAGACRGAPILPQ
                     GLQPEQQLQLWNEIDDTCSSFLSIDSQPQASNALEELCFMIMGMLPKPQEQDEKDNTK
                     RFLFHYSKTQKLGKSNVVSSVVHPLLQLVPHLHERRMKRFRVDEEFQSPFASQSRGYF
                     LFRPRNGRRSAGFI"
     exon            219..277
                     /gene="NMU"
                     /inference="alignment:Splign:2.1.0"
     exon            278..325
                     /gene="NMU"
                     /inference="alignment:Splign:2.1.0"
     exon            326..385
                     /gene="NMU"
                     /inference="alignment:Splign:2.1.0"
     exon            386..415
                     /gene="NMU"
                     /inference="alignment:Splign:2.1.0"
     exon            416..466
                     /gene="NMU"
                     /inference="alignment:Splign:2.1.0"
     exon            467..541
                     /gene="NMU"
                     /inference="alignment:Splign:2.1.0"
     exon            542..595
                     /gene="NMU"
                     /inference="alignment:Splign:2.1.0"
     exon            596..635
                     /gene="NMU"
                     /inference="alignment:Splign:2.1.0"
     exon            636..816
                     /gene="NMU"
                     /inference="alignment:Splign:2.1.0"
     regulatory      798..803
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NMU"
                     /note="hexamer: ATTAAA"
     polyA_site      816
                     /gene="NMU"
                     /note="major polyA site"
ORIGIN      
        1 agtcctgtgt ccgggccccg aggcacagcc agggcaccag gtggagcacc agctacgcgt
       61 ggcgcagcgc agcgtcccta gcaccgagcc tcccgcagcc gccgagatgc tgcgaacaga
      121 gagctgccgc cccaggtcgc ccgccggaca ggtggccgcg gcgtccccgc tcctgctgct
      181 gctgctgctg ctcgcctggt gcgcgggcgc ctgccgaggt gctccaatat tacctcaagg
      241 attacagcct gaacaacagc tacagttgtg gaatgagata gatgatactt gttcgtcttt
      301 tctgtccatt gattctcagc ctcaggcatc caacgcactg gaggagcttt gctttatgat
      361 tatgggaatg ctaccaaagc ctcaggaaca agatgaaaaa gataatacta aaaggttctt
      421 atttcattat tcgaagacac agaagttggg caagtcaaat gttgtgtcgt cagttgtgca
      481 tccgttgctg cagctcgttc ctcacctgca tgagagaaga atgaagagat tcagagtgga
      541 cgaagaattc caaagtccct ttgcaagtca aagtcgagga tattttttat tcaggccacg
      601 gaatggaaga aggtcagcag ggttcattta aaatggatgc cagctaattt tccacagagc
      661 aatgctatgg aatacaaaat gtactgacat tttgttttct tctgaaaaaa atccttgcta
      721 aatgtactct gttgaaaatc cctgtgttgt caatgttctc agttgtaaca atgttgtaaa
      781 tgttcaattt gttgaaaatt aaaaaatcta aaaata
//
