LOCUS       NM_004808               5003 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens N-myristoyltransferase 2 (NMT2), transcript variant 1,
            mRNA.
ACCESSION   NM_004808
VERSION     NM_004808.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5003)
  AUTHORS   Zhang,T., Goel,A., Xu,X., Wu,Y., Tang,E., Zhang,F., Li,Y., Li,H.,
            Cai,Y. and Weng,W.
  TITLE     N-mytistoyltransferase 1 and 2 are potential tumor suppressors and
            novel targets of miR-182 in human non-small cell lung carcinomas
  JOURNAL   Lung Cancer 171, 70-81 (2022)
   PUBMED   35930829
  REMARK    GeneRIF: N-mytistoyltransferase 1 and 2 are potential tumor
            suppressors and novel targets of miR-182 in human non-small cell
            lung carcinomas.
REFERENCE   2  (bases 1 to 5003)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 5003)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 5003)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 5003)
  AUTHORS   Kosciuk,T., Price,I.R., Zhang,X., Zhu,C., Johnson,K.N., Zhang,S.,
            Halaby,S.L., Komaniecki,G.P., Yang,M., DeHart,C.J., Thomas,P.M.,
            Kelleher,N.L., Fromme,J.C. and Lin,H.
  TITLE     NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6
            GTPase cycle
  JOURNAL   Nat Commun 11 (1), 1067 (2020)
   PUBMED   32103017
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5003)
  AUTHORS   Seaton,K.E. and Smith,C.D.
  TITLE     N-Myristoyltransferase isozymes exhibit differential specificity
            for human immunodeficiency virus type 1 Gag and Nef
  JOURNAL   J Gen Virol 89 (Pt 1), 288-296 (2008)
   PUBMED   18089753
  REMARK    GeneRIF: Nef is preferentially myristoylated by NMT2, suggesting
            that selective inhibition of NMT2 may provide a novel means of
            blocking HIV virulence.
REFERENCE   7  (bases 1 to 5003)
  AUTHORS   Pal,R., Reitz,M.S. Jr., Tschachler,E., Gallo,R.C.,
            Sarngadharan,M.G. and Veronese,F.D.
  TITLE     Myristoylation of gag proteins of HIV-1 plays an important role in
            virus assembly
  JOURNAL   AIDS Res Hum Retroviruses 6 (6), 721-730 (1990)
   PUBMED   2194551
REFERENCE   8  (bases 1 to 5003)
  AUTHORS   Bryant,M. and Ratner,L.
  TITLE     Myristoylation-dependent replication and assembly of human
            immunodeficiency virus 1
  JOURNAL   Proc Natl Acad Sci U S A 87 (2), 523-527 (1990)
   PUBMED   2405382
REFERENCE   9  (bases 1 to 5003)
  AUTHORS   Tashiro,A., Shoji,S. and Kubota,Y.
  TITLE     Antimyristoylation of the gag proteins in the human
            immunodeficiency virus-infected cells with N-myristoyl glycinal
            diethylacetal resulted in inhibition of virus production
  JOURNAL   Biochem Biophys Res Commun 165 (3), 1145-1154 (1989)
   PUBMED   2692561
REFERENCE   10 (bases 1 to 5003)
  AUTHORS   Goddard,C., Aquino,A., Glazer,R.I. and Felsted,R.L.
  TITLE     Chemical characterization of p17gag from human immunodeficiency
            virus as an N-terminally myristoylated protein
  JOURNAL   Eur J Biochem 182 (2), 323-326 (1989)
   PUBMED   2737204
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590365.14 and AF043325.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004808.2.
            
            Summary: This gene encodes one of two N-myristoyltransferase
            proteins. N-terminal myristoylation is a lipid modification that is
            involved in regulating the function and localization of signaling
            proteins. The encoded protein catalyzes the addition of a myristoyl
            group to the N-terminal glycine residue of many signaling proteins,
            including the human immunodeficiency virus type 1 (HIV-1) proteins,
            Gag and Nef. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Apr 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF043325.1, BC006376.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378165.9/ ENSP00000367407.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-191               AL590365.14        130735-130925       c
            192-2135            AF043325.1         157-2100
            2136-5001           AL590365.14        68004-70869         c
            5002-5003           AL590365.14        68002-68003         c
FEATURES             Location/Qualifiers
     source          1..5003
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p13"
     gene            1..5003
                     /gene="NMT2"
                     /note="N-myristoyltransferase 2"
                     /db_xref="GeneID:9397"
                     /db_xref="HGNC:HGNC:7858"
                     /db_xref="MIM:603801"
     exon            1..191
                     /gene="NMT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..1578
                     /gene="NMT2"
                     /EC_number="2.3.1.97"
                     /note="isoform 1 is encoded by transcript variant 1; NMT
                     2; type II N-myristoyltransferase; peptide
                     N-myristoyltransferase 2; myristoyl-CoA:protein
                     N-myristoyltransferase 2; protein-lysine
                     myristoyltransferase NMT2"
                     /codon_start=1
                     /product="glycylpeptide N-tetradecanoyltransferase 2
                     isoform 1"
                     /protein_id="NP_004799.1"
                     /db_xref="CCDS:CCDS7109.1"
                     /db_xref="GeneID:9397"
                     /db_xref="HGNC:HGNC:7858"
                     /db_xref="MIM:603801"
                     /translation="MAEDSESAASQQSLELDDQDTCGIDGDNEEETEHAKGSPGGYLG
                     AKKKKKKQKRKKEKPNSGGTKSDSASDSQEIKIQQPSKNPSVPMQKLQDIQRAMELLS
                     ACQGPARNIDEAAKHRYQFWDTQPVPKLDEVITSHGAIEPDKDNVRQEPYSLPQGFMW
                     DTLDLSDAEVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLLQWHCGVRV
                     SSNKKLVGFISAIPANIRIYDSVKKMVEINFLCVHKKLRSKRVAPVLIREITRRVNLE
                     GIFQAVYTAGVVLPKPIATCRYWHRSLNPRKLVEVKFSHLSRNMTLQRTMKLYRLPDV
                     TKTSGLRPMEPKDIKSVRELINTYLKQFHLAPVMDEEEVAHWFLPREHIIDTFVVESP
                     NGKLTDFLSFYTLPSTVMHHPAHKSLKAAYSFYNIHTETPLLDLMSDALILAKSKGFD
                     VFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWRCPGTDSEKVGLVLQ"
     exon            192..327
                     /gene="NMT2"
                     /inference="alignment:Splign:2.1.0"
     exon            328..472
                     /gene="NMT2"
                     /inference="alignment:Splign:2.1.0"
     exon            473..591
                     /gene="NMT2"
                     /inference="alignment:Splign:2.1.0"
     exon            592..683
                     /gene="NMT2"
                     /inference="alignment:Splign:2.1.0"
     exon            684..800
                     /gene="NMT2"
                     /inference="alignment:Splign:2.1.0"
     exon            801..971
                     /gene="NMT2"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1080
                     /gene="NMT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1251
                     /gene="NMT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1419
                     /gene="NMT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1557
                     /gene="NMT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..5003
                     /gene="NMT2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2187..2192
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NMT2"
                     /note="hexamer: AATAAA"
     polyA_site      2212
                     /gene="NMT2"
                     /note="major polyA site"
     regulatory      2679..2684
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NMT2"
                     /note="hexamer: AATAAA"
     polyA_site      2701
                     /gene="NMT2"
                     /note="major polyA site"
     polyA_site      2908
                     /gene="NMT2"
     regulatory      4363..4368
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NMT2"
                     /note="hexamer: AGTAAA"
     polyA_site      4384
                     /gene="NMT2"
     regulatory      4769..4774
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NMT2"
                     /note="hexamer: AATAAA"
     polyA_site      4799
                     /gene="NMT2"
     regulatory      4987..4992
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NMT2"
                     /note="hexamer: ACTAAA"
     polyA_site      5003
                     /gene="NMT2"
ORIGIN      
        1 agtacggcgg gaggcactag agggagctgc ggccgctccg gcccggcccc gagcaccgcc
       61 tccccagcca gcgccgccgc gatggcggag gacagcgagt ctgcggccag ccagcagagc
      121 ctggaactgg acgaccagga cacgtgcggg atagacgggg acaatgagga ggagacggag
      181 cacgccaaag gaagtcctgg agggtatttg ggagccaaaa agaaaaagaa gaaacagaag
      241 agaaaaaagg agaaaccaaa ttccggaggc accaagtcag actcggcatc tgattcccag
      301 gagattaaaa ttcagcagcc ttcgaaaaat cccagtgttc caatgcagaa gttgcaggat
      361 atccagagag caatggagct gctatccgca tgccagggcc cagccaggaa cattgatgag
      421 gctgcaaagc acagatacca gttttgggac acacaaccgg taccaaaact agatgaagtc
      481 ataacatctc atggtgcaat tgaaccagat aaagacaacg tacgccaaga accgtattct
      541 ttgccacagg gttttatgtg ggacacttta gacttgagtg atgccgaagt gctcaaggag
      601 ttatacacgt tgttaaatga gaattacgta gaagatgatg acaatatgtt ccgatttgac
      661 tattcacccg agttcctgtt gtgggctctg cgtccaccag gctggctcct gcagtggcac
      721 tgtggggtca gagtgtcttc aaataaaaaa ctggtcgggt tcataagtgc catcccagca
      781 aacattcgga tttatgacag tgtgaagaag atggtagaaa tcaactttct ttgtgttcat
      841 aagaagttga gatcgaaacg ggtagcccca gtgctaatcc gagagatcac tagaagagtg
      901 aacctggaag ggatcttcca ggctgtgtac accgcgggag tggttcttcc taagcccata
      961 gccacatgca gatactggca tcgatcacta aaccccagaa aattggtaga agtgaaattt
     1021 tctcacttga gtagaaatat gactttacag agaacaatga agctatacag acttccagat
     1081 gttacaaaga cttcaggttt gagaccaatg gaaccaaaag atatcaaatc agttcgagaa
     1141 ttaatcaaca cttacctgaa gcagtttcat ctggctccag tgatggatga agaggaagta
     1201 gcccactggt tcctcccccg ggagcacatt attgacacgt ttgtagtgga gagccccaac
     1261 ggtaaactga ctgatttcct gagcttctat acgctcccct ccacggtgat gcaccaccct
     1321 gctcacaaga gcctcaaagc cgcctactca ttctacaaca tccacacaga gacgcccctg
     1381 ctggacctca tgagcgacgc gctcatcctg gctaaatcga aaggatttga tgtattcaat
     1441 gcactggatt tgatggaaaa taagacattc ttggaaaaac tcaagtttgg tataggagat
     1501 ggcaatttgc agtattacct gtacaattgg aggtgtccag gtacagattc tgaaaaggtt
     1561 ggactagtac tacaatagat ggatattttt atttctagaa ctctgacatc atcatttgtt
     1621 aatatttaat gatttctgga actgccattc caaagaagaa taaaagcaca actcaagtga
     1681 aattgaagta gtcgataatc agaaaagatg acaaaagtcc acatgtgaca tttgtacgtt
     1741 tctagctaga atgttaaact tcatcctttt tttactgttg acctatttgt gggagggatg
     1801 aaaggctaca aagagcacat tcttgtaatt ttcaaatttt tgcctgtctc ttgaagaggt
     1861 attttttcac ccttagaaaa gggactgttt ttctatggac taagtagaag ttacagagtc
     1921 atgtaagaaa atctttgcta ttgtgtggag agaaattgct gcatttctgt ttcttaagtg
     1981 atggtacatt tgtccatgta acagaacaaa agatccattt ggaaattttt tttactggta
     2041 tcaccttaca tggtatcact gggaacattt atggaatcaa cacttctgta gctcagtgac
     2101 aggtggtggt tgtttaagtg cagagcaata ttaaaatgta ctggtgacta gtacatgtat
     2161 ttctccataa gcagagttgc cgaatcaata aacatgcaag tttgtacttt gatctttacc
     2221 aggtcagtgg attgcttcaa aagcagagtt ttgtgcaagc actcactgtg ctctctgaaa
     2281 gagcctgagg ccgggcgtgg tggctcacgc ctgtaatccc agcactttgg gaggccaagg
     2341 tgggcagatc atgaggtcag gagatcgaga ccattctggc caacatagtg aaaccccatc
     2401 tctactaaaa atacaaaaat tagccgggcg tggtggcgtg tgcctgtagt cccagctgct
     2461 tgggaggctg aggcaggaga atcgcttgaa cctgagaggt gaggttgcag tgagccgaga
     2521 tcgagccact gcactccagc ctgggtgaca gagcgtgaga ctccgtctca aaaaaaaaaa
     2581 aaaagaaaga gcctgtaccc gcgactaact agacttttct gctgttgtgc aaagttcagt
     2641 ttcttctcag caacatcaag gatatatgaa gaaaaggaaa taaaaaactg taaagtcaaa
     2701 agagatgcct ggtggaactt attcgtgcta tcagggcatt gatagtttga atgtttttat
     2761 tacttatgca aaattgcaca tactcctcta tgctgatttt atcatgaaaa ctgtcatgtg
     2821 tcatgctaat ggaaaatgtc ttatttgtaa ataagtattc ataattttgt tactgatggt
     2881 gtttttaatc tagaatttga aaaactttca tggcttacag atgtgtgttt atattgccaa
     2941 taatctgcgg gaaaaataag atgctaaccg aggccacgta gcctggcctc aactcagata
     3001 ccacaaagta gatgccttgg ctgggtgtgg tggctcacgc ctgtaatccc agcactttgg
     3061 gaggccaagg cgggcgaaac atttgaggtc aggggttcga gaccagcctg gccaacatgg
     3121 tgaaacccca tctctactaa aaattcaaaa agaactagct gggtgtggtg gcgggtgcct
     3181 gtaatcccag ctgctaggag gctgaggcag gagaatcact tgaacccagg aggcggaagt
     3241 tgcagtgagc caagatcgtg ccactgcact ccagcctggg tgacagtgca agactccgtc
     3301 tcaaaaaaca aaagtagata cttttccctg cttttactgg gccagtgcct aggaagttca
     3361 gtgcagaagt taattgtttt agacatgatg gcatttcctt caagttatga gtccagtgaa
     3421 accaatcata tcttatccca ggcaggggcc accaaactat ggcctgtggg ctaaatccag
     3481 cccattgctt atttttgtgt agcccacagg ctaagaatgt ttttattttc tggaatggtt
     3541 gaggagaaaa agccaaaaaa tgacatcatt ttgtgacatg tgcaaattac acaaaattca
     3601 aattccggtg tccctcaata aggttttatt ggaacatagc catacttttt tttttttttt
     3661 ttttaggaca gggtctcact ctattgtcca ggctagaata cagtggcaca gtcaacagct
     3721 cactgcagcc ccaaactcct gggttaaaat gatcctcctg cttcagcgtc tttttgaaga
     3781 aaaagaacta gctgggcgtg cataccacca cgcctggcta agtttttcat tttttgtaga
     3841 gacaaggtct tgctatgttt cccgtgctgg tctttaactc ctggcctcaa gtgatccttc
     3901 tgccttggcc tcccaaagta ctgggattat agacatgagc caccactctt ggccacagcc
     3961 actttcattt acatattgcc tatggctgct tcacactaca aagctgagtt gagttgttgt
     4021 gacagattgt gtggcctgca aagcctaaga tattcactct ctggtctttt acagaaagtt
     4081 tgttgacctt ggtcactacg aaggagttgg aactctcctt tctataggtt gccgtgattc
     4141 taaagaccaa cccacagctg tgacatccct gagactacca ccagagggcg actgggcccc
     4201 acagtagtac ataatatagg acctctcttg gagataatgg aagacttgga atttcagatg
     4261 gttccaccct aattgcatta gcgttctttc ttaacaggag aaaggcttca agaaacaaaa
     4321 cagtcctcat tcactggaac agggtttgag ataccagcat taagtaaatg agattttgac
     4381 ttaacctgga gtcaaggctc taatttagga ctttacttcc cactcatttt catgccacaa
     4441 agtctataca aagtaggttt tcaaataatt gcagaatcag ccaggcacgg tggctcacac
     4501 ctgtaatccc tgcactttgg gaggccaagg tgagcagatc acttgaggtc aggagtcttg
     4561 agaccagcct ggccaacatg gtgaagccct atctctacta aaattacaaa aactagccgg
     4621 acatgggggt gtgcacctgt aatcccagct attcaggagg ctgaggcagg agaatcgctt
     4681 gaacccagga ggcggggttg cagtgagccg ggatcacacc actgcactcc agcctgggca
     4741 acagagtgag actctatctc gaaagtaaaa taaataactg cagcattgcc agttggaaac
     4801 tttgtcatga gcttacctca cggtgacagt tacactgctc ctttaaagag tcatttacat
     4861 aatttgttat caaattatta accactttta aatagaataa taactacatt tgcctccata
     4921 attgaagcag attactaatt aacattttcg agaattaaac tgcttgctta tgaagtagct
     4981 attaaaacta aattgaaatg caa
//
