LOCUS       NM_021079               4881 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens N-myristoyltransferase 1 (NMT1), mRNA.
ACCESSION   NM_021079
VERSION     NM_021079.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4881)
  AUTHORS   Qiu,P., Li,X., Gong,M., Wen,P., Wen,J., Xu,L. and Wang,G.
  TITLE     SPI1 Mediates N-Myristoyltransferase 1 to Advance Gastric Cancer
            Progression via PI3K/AKT/mTOR Pathway
  JOURNAL   Can J Gastroenterol Hepatol 2023, 2021515 (2023)
   PUBMED   36967718
  REMARK    GeneRIF: SPI1 Mediates N-Myristoyltransferase 1 to Advance Gastric
            Cancer Progression via PI3K/AKT/mTOR Pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4881)
  AUTHORS   Zhang,T., Goel,A., Xu,X., Wu,Y., Tang,E., Zhang,F., Li,Y., Li,H.,
            Cai,Y. and Weng,W.
  TITLE     N-mytistoyltransferase 1 and 2 are potential tumor suppressors and
            novel targets of miR-182 in human non-small cell lung carcinomas
  JOURNAL   Lung Cancer 171, 70-81 (2022)
   PUBMED   35930829
  REMARK    GeneRIF: N-mytistoyltransferase 1 and 2 are potential tumor
            suppressors and novel targets of miR-182 in human non-small cell
            lung carcinomas.
REFERENCE   3  (bases 1 to 4881)
  AUTHORS   Sun,Y., Guan,Z., Sheng,Q., Duan,W., Zhao,H., Zhou,J., Deng,Q. and
            Pei,X.
  TITLE     N-myristoyltransferase-1 deficiency blocks myristoylation of
            LAMTOR1 and inhibits bladder cancer progression
  JOURNAL   Cancer Lett 529, 126-138 (2022)
   PUBMED   34999170
  REMARK    GeneRIF: N-myristoyltransferase-1 deficiency blocks myristoylation
            of LAMTOR1 and inhibits bladder cancer progression.
REFERENCE   4  (bases 1 to 4881)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 4881)
  AUTHORS   Chen,Y.C., Navarrete,M.S., Wang,Y., McClintock,N.C., Sakurai,R.,
            Wang,F., Chen,K.T., Chou,T.F., Rehan,V.K., Lee,D.J. and Diaz,B.
  TITLE     N-myristoyltransferase-1 is necessary for lysosomal degradation and
            mTORC1 activation in cancer cells
  JOURNAL   Sci Rep 10 (1), 11952 (2020)
   PUBMED   32686708
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4881)
  AUTHORS   Duronio,R.J., Reed,S.I. and Gordon,J.I.
  TITLE     Mutations of human myristoyl-CoA:protein N-myristoyltransferase
            cause temperature-sensitive myristic acid auxotrophy in
            Saccharomyces cerevisiae
  JOURNAL   Proc Natl Acad Sci U S A 89 (9), 4129-4133 (1992)
   PUBMED   1570339
REFERENCE   7  (bases 1 to 4881)
  AUTHORS   Wice,B.M. and Gordon,J.I.
  TITLE     A strategy for isolation of cDNAs encoding proteins affecting human
            intestinal epithelial cell growth and differentiation:
            characterization of a novel gut-specific N-myristoylated annexin
  JOURNAL   J Cell Biol 116 (2), 405-422 (1992)
   PUBMED   1530946
REFERENCE   8  (bases 1 to 4881)
  AUTHORS   Pal,R., Reitz,M.S. Jr., Tschachler,E., Gallo,R.C.,
            Sarngadharan,M.G. and Veronese,F.D.
  TITLE     Myristoylation of gag proteins of HIV-1 plays an important role in
            virus assembly
  JOURNAL   AIDS Res Hum Retroviruses 6 (6), 721-730 (1990)
   PUBMED   2194551
REFERENCE   9  (bases 1 to 4881)
  AUTHORS   Bryant,M. and Ratner,L.
  TITLE     Myristoylation-dependent replication and assembly of human
            immunodeficiency virus 1
  JOURNAL   Proc Natl Acad Sci U S A 87 (2), 523-527 (1990)
   PUBMED   2405382
REFERENCE   10 (bases 1 to 4881)
  AUTHORS   Mumby,S.M., Heukeroth,R.O., Gordon,J.I. and Gilman,A.G.
  TITLE     G-protein alpha-subunit expression, myristoylation, and membrane
            association in COS cells
  JOURNAL   Proc Natl Acad Sci U S A 87 (2), 728-732 (1990)
   PUBMED   2153964
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC006569.2, AC116493.10, AC002117.2 and BC006538.2.
            
            On Nov 22, 2018 this sequence version replaced NM_021079.4.
            
            Summary: Myristate, a rare 14-carbon saturated fatty acid, is
            cotranslationally attached by an amide linkage to the N-terminal
            glycine residue of cellular and viral proteins with diverse
            functions. N-myristoyltransferase (NMT; EC 2.3.1.97) catalyzes the
            transfer of myristate from CoA to proteins. N-myristoylation
            appears to be irreversible and is required for full expression of
            the biologic activities of several N-myristoylated proteins,
            including the alpha subunit of the signal-transducing guanine
            nucleotide-binding protein (G protein) GO (GNAO1; MIM 139311)
            (Duronio et al., 1992 [PubMed 1570339]).[supplied by OMIM, Nov
            2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006538.2, SRR1660805.232373.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000258960.7/ ENSP00000258960.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-499               BC006569.2         6-504
            500-500             AC116493.10        7458-7458           c
            501-1916            BC006569.2         506-1921
            1917-3997           AC002117.2         11044-13124
            3998-4881           BC006538.2         4003-4886
FEATURES             Location/Qualifiers
     source          1..4881
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..4881
                     /gene="NMT1"
                     /gene_synonym="HsNMT1; NMT"
                     /note="N-myristoyltransferase 1"
                     /db_xref="GeneID:4836"
                     /db_xref="HGNC:HGNC:7857"
                     /db_xref="MIM:160993"
     exon            1..144
                     /gene="NMT1"
                     /gene_synonym="HsNMT1; NMT"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..1504
                     /gene="NMT1"
                     /gene_synonym="HsNMT1; NMT"
                     /EC_number="2.3.1.97"
                     /note="alternative, short form NMT-S; long form, NMT-L;
                     type I N-myristoyltransferase; myristoyl-CoA:protein
                     N-myristoyltransferase 1; protein-lysine
                     myristoyltransferase NMT1"
                     /codon_start=1
                     /product="glycylpeptide N-tetradecanoyltransferase 1"
                     /protein_id="NP_066565.1"
                     /db_xref="CCDS:CCDS11494.1"
                     /db_xref="GeneID:4836"
                     /db_xref="HGNC:HGNC:7857"
                     /db_xref="MIM:160993"
                     /translation="MADESETAVKPPAPPLPQMMEGNGNGHEHCSDCENEEDNSYNRG
                     GLSPANDTGAKKKKKKQKKKKEKGSETDSAQDQPVKMNSLPAERIQEIQKAIELFSVG
                     QGPAKTMEEASKRSYQFWDTQPVPKLGEVVNTHGPVEPDKDNIRQEPYTLPQGFTWDA
                     LDLGDRGVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLPQWHCGVRVVS
                     SRKLVGFISAIPANIHIYDTEKKMVEINFLCVHKKLRSKRVAPVLIREITRRVHLEGI
                     FQAVYTAGVVLPKPVGTCRYWHRSLNPRKLIEVKFSHLSRNMTMQRTMKLYRLPETPK
                     TAGLRPMETKDIPVVHQLLTRYLKQFHLTPVMSQEEVEHWFYPQENIIDTFVVENANG
                     EVTDFLSFYTLPSTIMNHPTHKSLKAAYSFYNVHTQTPLLDLMSDALVLAKMKGFDVF
                     NALDLMENKTFLEKLKFGIGDGNLQYYLYNWKCPSMGAEKVGLVLQ"
     exon            145..253
                     /gene="NMT1"
                     /gene_synonym="HsNMT1; NMT"
                     /inference="alignment:Splign:2.1.0"
     exon            254..398
                     /gene="NMT1"
                     /gene_synonym="HsNMT1; NMT"
                     /inference="alignment:Splign:2.1.0"
     exon            399..517
                     /gene="NMT1"
                     /gene_synonym="HsNMT1; NMT"
                     /inference="alignment:Splign:2.1.0"
     exon            518..609
                     /gene="NMT1"
                     /gene_synonym="HsNMT1; NMT"
                     /inference="alignment:Splign:2.1.0"
     exon            610..726
                     /gene="NMT1"
                     /gene_synonym="HsNMT1; NMT"
                     /inference="alignment:Splign:2.1.0"
     exon            727..897
                     /gene="NMT1"
                     /gene_synonym="HsNMT1; NMT"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1006
                     /gene="NMT1"
                     /gene_synonym="HsNMT1; NMT"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1177
                     /gene="NMT1"
                     /gene_synonym="HsNMT1; NMT"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1345
                     /gene="NMT1"
                     /gene_synonym="HsNMT1; NMT"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1483
                     /gene="NMT1"
                     /gene_synonym="HsNMT1; NMT"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..4881
                     /gene="NMT1"
                     /gene_synonym="HsNMT1; NMT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4862..4867
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NMT1"
                     /gene_synonym="HsNMT1; NMT"
                     /note="hexamer: AAGAAA"
     polyA_site      4881
                     /gene="NMT1"
                     /gene_synonym="HsNMT1; NMT"
                     /note="major polyA site"
ORIGIN      
        1 ctcgcaactc aagatggcgg acgagagtga gacagcagtg aagccgccgg cacctccgct
       61 gccgcagatg atggaaggga acgggaacgg ccatgagcac tgcagcgatt gcgagaatga
      121 ggaggacaac agctacaacc ggggtggttt gagtccagcc aatgacactg gagccaaaaa
      181 gaagaaaaag aaacaaaaaa agaagaaaga aaaaggcagt gagacagatt cagcccagga
      241 tcagcctgtg aagatgaact ctttgccagc agagaggatc caggaaatac agaaggccat
      301 tgagctgttc tcagtgggtc agggacctgc caaaaccatg gaggaggcta gcaagcgaag
      361 ctaccagttc tgggatacgc agcccgtccc caagctgggc gaagtggtga acacccatgg
      421 ccccgtggag cctgacaagg acaatatccg ccaggagccc tacaccctgc cccagggctt
      481 cacctgggat gctttggacc tgggcgatcg tggtgtgcta aaagaactgt acaccctcct
      541 gaatgagaac tatgtggaag atgatgacaa catgttccga tttgattatt ccccggagtt
      601 tcttttgtgg gctctccggc cacccggctg gctcccccag tggcactgtg gggttcgagt
      661 ggtctcaagt cggaaattgg ttgggttcat tagcgccatc ccagcaaaca tccatatcta
      721 tgacacagag aagaagatgg tagagatcaa cttcctgtgt gtccacaaga agctgcgttc
      781 caagagggtt gctccagttc tgatccgaga gatcaccagg cgggttcacc tggagggcat
      841 cttccaagca gtttacactg ccggggtggt actaccaaag cccgttggca cctgcaggta
      901 ttggcatcgg tccctaaacc cacggaagct gattgaagtg aagttctccc acctgagcag
      961 aaatatgacc atgcagcgca ccatgaagct ctaccgactg ccagagactc ccaagacagc
     1021 tgggctgcga ccaatggaaa caaaggacat tccagtagtg caccagctcc tcaccaggta
     1081 cttgaagcaa tttcacctta cgcccgtcat gagccaggag gaggtggagc actggttcta
     1141 cccccaggag aatatcatcg acactttcgt ggtggagaac gcaaacggag aggtgacaga
     1201 tttcctgagc ttttatacgc tgccctccac catcatgaac catccaaccc acaagagtct
     1261 caaagctgct tattctttct acaacgttca cacccagacc cctcttctag acctcatgag
     1321 cgacgccctt gtcctcgcca aaatgaaagg gtttgatgtg ttcaatgcac tggatctcat
     1381 ggagaacaaa accttcctgg agaagctcaa gtttggcata ggggacggca acctgcagta
     1441 ttacctttac aattggaaat gccccagcat gggggcagag aaggttggac tggtgctaca
     1501 ataaccagtc accagtgcga ttctggataa agccactgaa aattcgaacc aggaaatgga
     1561 accccaccac tgttggtcca attttcacac acgtgagaat ccctggcaaa gggagcagaa
     1621 ctgaaccggc tttaccaaac cgccagcgaa cttgacaatt gtattgcgat ggcgtgggct
     1681 gcgtgacgtc acctccggtc gtgtctctgg tctccgtgtt ttccagttaa ttacatcctc
     1741 atgcagccgt gatcaaggga atgtaactgc tgaaaactag ctcgtgattg gcatataatg
     1801 gagttaacgg gtgaataata aaagtatata tatatattat atatatataa atattttaaa
     1861 tatctttcat gttccaaatg tacaaggatg tttggtcttt aatgaaaagc tgaatccaga
     1921 tcattcctca gaatgaggac ccgaggacag tggcagacag acgcgttggc acagttcatg
     1981 gtttcctcca gaggagacat tggcttatca tggggaaaaa gaggatctgg agaacctcat
     2041 ccagctcccc ttctgaatca gctgggatga ctggctttga gaaggaaggg aagatggaac
     2101 aggctcagat ctcatgggat agcacgtgga gctcttggct ggggctgacc ctgggcaggg
     2161 actttcctgc agggccagac ctgcctgcat tctgagacaa agcaatggac ggtccgcaga
     2221 agcagacctc attgattgag tcctttcttc catccccttg gcctgctccc tgtaggaagt
     2281 catcctgcca actgatttaa aagggctctt tagccagttg ttgccaacct tatagggatg
     2341 agtcccctgt gagattttgc ttttccactg cctgggatga tgcagtttga agaggccctt
     2401 ggacctcctt gtaacatcag ggacctttgg agaccattat cagtgtaagc cctgcttagc
     2461 tcatcttaga gcaaagagcc agcaccctga tgtccctggg gtggctaggc aggagtggcg
     2521 tggggccaat acccagaccc cttcagccac cagcccctgg cctgtgcctt ccaacccatt
     2581 agccatttct tgttgtgccc ctttccaaga tacagcctgc aagtggtagc aagaagtgat
     2641 tagaggcaga tctggacttg gcaacagaag tggtttccca tctccattgt ctgagtctga
     2701 ttttcgctga tgctgttttg tggatttttg tggtagtgat ggttgtcagt gctgccagtt
     2761 tcccaaaacg taatcaagcc tctggtcaca tggctgtcga tgtaggcatt ctggagtggt
     2821 gttcagccaa gtgaccgggc aaaattgggc tgtgaaattg tacttccagg cttggatgta
     2881 atttttgctc tagagagaag caagtggtgg gaaggaggta gcatgacgtg tggtgtgcgg
     2941 gtttccttgc tgccgtcacc tctccgctca tacaggaatg aagccttagc caggaggcca
     3001 ggctcagccc tgtgccactc accgaagcca ctttctacag gccagcaggg gcttgttgca
     3061 ggctgtgggt tttggtgtgg tttgtcagag gctaattctg cagagtttcc aaaaccagaa
     3121 gacatcgtat gcttgggatg ggggccgtgc cacccgtggg aatgctgccc gctctgcaga
     3181 ctgctgctag agccagcaac tccactaagg tggattttca tcaggggcct gcagggccct
     3241 cccttttccc attgttcctg cgctgcaaat tgcaggcccc agcaatcgtg actgacgttt
     3301 gctccttgac tccaagaaac tgagaccaaa gaagctgctg ttcttagcaa gatgcgcact
     3361 gcattccaca ggtgggagga gtcggagagg caggggcttg ctttgcagcc ccacagacaa
     3421 cagttgcaca gtgcctcaag ccccagagtg gctcaccctg tccagacctt tgaggatatc
     3481 aaaggacaaa gtgcccaagt ctttcctacc ttgggggaac ctggaacttg gaaaggctcc
     3541 ctgtcctagt cttgatctgt tctgggccag gtcccagctt gagctgcctc tgagatttgg
     3601 gctgtgcgga tctctggagt gagctctgtt tcggttgacc caggtcatgg aatggaaacg
     3661 gtgaggcccc agtggctgtt ctggaagaaa cagatctcct ggcaaaggcc ccagcatctc
     3721 cctcactgaa accaggtggc cggctcctcg gactctgctt tatgttgcgg tgagaactct
     3781 gcccaggtgt gcagggtttg gcttgtgggc tgcttgctgc tcatctgatt tttgtcccag
     3841 tagtccctgc gttcttcatt caaccccttc tgggacttca gctcagagag caccatcccg
     3901 ggggtcaggg cctccccaca ggagccctgc agtgtggtag cgccatggct gtctcaaacc
     3961 aagcaaagga aggaccctga ggccttcacg ctaaccgtcc tcgagcaact gctgttggaa
     4021 ggcctccctg ggcctggccc ccaccctctg ccacccagtc ctcccagctg ccatgtttca
     4081 aagacgacct ttacctcctg cctttggatt gactctgcat ttgaccacgg actccagtct
     4141 gtgtgtaggg agagagctga gtaggaggcc tccactccgg atcgaggcct gtatagggct
     4201 cgtttcccca cacatgccta tttctgaaga ggcttctgtc ttatttgaag gccagcccac
     4261 acccagctac tttaacacca ggtttatgga aaatgtcagg ccttccccac aactcctgtc
     4321 taactgctgt cgccccccta cttgctggct ctcagaagcc taggggagtc cctgtggtcc
     4381 tgaattcttt ccccaaagac gaccagcatt taaccaacct aagggcccaa aggccttgga
     4441 caactgcatg gagctgcact ctaggagaag gaggggaacc agatgttaga tcaggggagg
     4501 gagcaggagt gtccctcccg tcagtgccta cccacctgtg aggcagcctt ctgatggcct
     4561 ggcccacctt ccccagaacc aggggaggcc tgaggcttca gttttactct gctgcaaaat
     4621 gaaggcgggc ctgcaagccg actacaccta cggaggctgt tgaggacaat ttcattccat
     4681 taaattaaaa aatactgact ggctggcagg caggtgccat gtctgggaac agggacgggg
     4741 gagcttcacc tttttgtctt ggcttttctt tgggctgtgg gggggcatcc atttccaggg
     4801 tcggggagga aataccaaat gcattgttgt tctgctcaat acatctcact tgtttctaat
     4861 aaagaaagca gctgaacaaa a
//
