LOCUS       NM_001011717             485 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens neuromedin S (NMS), mRNA.
ACCESSION   NM_001011717 XM_065278
VERSION     NM_001011717.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Mori,K., Ida,T., Fudetani,M., Mori,M., Kaiya,H., Hino,J.,
            Nakahara,K., Murakami,N., Miyazato,M. and Kangawa,K.
  TITLE     Identification of neuromedin U precursor-related peptide and its
            possible role in the regulation of prolactin release
  JOURNAL   Sci Rep 7 (1), 10468 (2017)
   PUBMED   28874765
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Lee,I.T., Chang,A.S., Manandhar,M., Shan,Y., Fan,J., Izumo,M.,
            Ikeda,Y., Motoike,T., Dixon,S., Seinfeld,J.E., Takahashi,J.S. and
            Yanagisawa,M.
  TITLE     Neuromedin s-producing neurons act as essential pacemakers in the
            suprachiasmatic nucleus to couple clock neurons and dictate
            circadian rhythms
  JOURNAL   Neuron 85 (5), 1086-1102 (2015)
   PUBMED   25741729
  REMARK    GeneRIF: Neuromedin s neurons define a subpopulation of pacemakers
            that control suprachiasmatic nucleus network synchrony.
REFERENCE   3  (bases 1 to 485)
  AUTHORS   Rietveld,C.A., Esko,T., Davies,G., Pers,T.H., Turley,P.,
            Benyamin,B., Chabris,C.F., Emilsson,V., Johnson,A.D., Lee,J.J., de
            Leeuw,C., Marioni,R.E., Medland,S.E., Miller,M.B., Rostapshova,O.,
            van der Lee,S.J., Vinkhuyzen,A.A., Amin,N., Conley,D.,
            Derringer,J., van Duijn,C.M., Fehrmann,R., Franke,L., Glaeser,E.L.,
            Hansell,N.K., Hayward,C., Iacono,W.G., Ibrahim-Verbaas,C.,
            Jaddoe,V., Karjalainen,J., Laibson,D., Lichtenstein,P.,
            Liewald,D.C., Magnusson,P.K., Martin,N.G., McGue,M., McMahon,G.,
            Pedersen,N.L., Pinker,S., Porteous,D.J., Posthuma,D.,
            Rivadeneira,F., Smith,B.H., Starr,J.M., Tiemeier,H., Timpson,N.J.,
            Trzaskowski,M., Uitterlinden,A.G., Verhulst,F.C., Ward,M.E.,
            Wright,M.J., Davey Smith,G., Deary,I.J., Johannesson,M., Plomin,R.,
            Visscher,P.M., Benjamin,D.J., Cesarini,D. and Koellinger,P.D.
  TITLE     Common genetic variants associated with cognitive performance
            identified using the proxy-phenotype method
  JOURNAL   Proc Natl Acad Sci U S A 111 (38), 13790-13794 (2014)
   PUBMED   25201988
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):E380. doi:
            10.1073/pnas.1424631112.. PMID: 25572966]
REFERENCE   4  (bases 1 to 485)
  AUTHORS   Pinheiro,A.P., Bulik,C.M., Thornton,L.M., Sullivan,P.F., Root,T.L.,
            Bloss,C.S., Berrettini,W.H., Schork,N.J., Kaye,W.H., Bergen,A.W.,
            Magistretti,P., Brandt,H., Crawford,S., Crow,S., Fichter,M.M.,
            Goldman,D., Halmi,K.A., Johnson,C., Kaplan,A.S., Keel,P.K.,
            Klump,K.L., La Via,M., Mitchell,J.E., Strober,M., Rotondo,A.,
            Treasure,J. and Woodside,D.B.
  TITLE     Association study of 182 candidate genes in anorexia nervosa
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 153B (5), 1070-1080 (2010)
   PUBMED   20468064
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 485)
  AUTHORS   Mitchell,J.D., Maguire,J.J. and Davenport,A.P.
  TITLE     Emerging pharmacology and physiology of neuromedin U and the
            structurally related peptide neuromedin S
  JOURNAL   Br J Pharmacol 158 (1), 87-103 (2009)
   PUBMED   19519756
  REMARK    GeneRIF: In man, NMS elicits vasoconstriction in isolated saphenous
            vein with comparable potency with NMU, but significantly reduces
            maximum contractile response.
            Review article
REFERENCE   6  (bases 1 to 485)
  AUTHORS   Mitchell,J.D., Maguire,J.J., Kuc,R.E. and Davenport,A.P.
  TITLE     Expression and vasoconstrictor function of anorexigenic peptides
            neuromedin U-25 and S in the human cardiovascular system
  JOURNAL   Cardiovasc Res 81 (2), 353-361 (2009)
   PUBMED   18987052
  REMARK    GeneRIF: both NMU receptor and peptide are expressed in human
            cardiovascular tissues and have shown that NMU-25 and NMS act as
            potent vasoconstrictors in human vascular beds
REFERENCE   7  (bases 1 to 485)
  AUTHORS   Miyazato,M., Mori,K., Ida,T., Kojima,M., Murakami,N. and Kangawa,K.
  TITLE     Identification and functional analysis of a novel ligand for G
            protein-coupled receptor, Neuromedin S
  JOURNAL   Regul Pept 145 (1-3), 37-41 (2008)
   PUBMED   17870195
  REMARK    GeneRIF: NMS is implicated in the regulation of circadian rhythm
            and feeding behavior
REFERENCE   8  (bases 1 to 485)
  AUTHORS   Dowal,L., Provitera,P. and Scarlata,S.
  TITLE     Stable association between G alpha(q) and phospholipase C beta 1 in
            living cells
  JOURNAL   J Biol Chem 281 (33), 23999-24014 (2006)
   PUBMED   16754659
REFERENCE   9  (bases 1 to 485)
  AUTHORS   Mori,K., Miyazato,M., Ida,T., Murakami,N., Serino,R., Ueta,Y.,
            Kojima,M. and Kangawa,K.
  TITLE     Identification of neuromedin S and its possible role in the
            mammalian circadian oscillator system
  JOURNAL   EMBO J 24 (2), 325-335 (2005)
   PUBMED   15635449
REFERENCE   10 (bases 1 to 485)
  AUTHORS   Raddatz,R., Wilson,A.E., Artymyshyn,R., Bonini,J.A., Borowsky,B.,
            Boteju,L.W., Zhou,S., Kouranova,E.V., Nagorny,R., Guevarra,M.S.,
            Dai,M., Lerman,G.S., Vaysse,P.J., Branchek,T.A., Gerald,C.,
            Forray,C. and Adham,N.
  TITLE     Identification and characterization of two neuromedin U receptors
            differentially expressed in peripheral tissues and the central
            nervous system
  JOURNAL   J Biol Chem 275 (42), 32452-32459 (2000)
   PUBMED   10899166
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB164464.1.
            
            On Feb 9, 2005 this sequence version replaced XM_065278.3.
            
            Summary: This gene encodes a member of the neuromedin family of
            neuropeptides. The encoded preproprotein is proteolytically
            processed to generate a biologically active neuropeptide that plays
            a role in the regulation of circadian rhythm, anorexigenic action,
            antidiuretic action, cardiovascular function and stimulation of
            oxytocin and vasopressin release. [provided by RefSeq, May 2016].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB164464.1, BR001411.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376865.1/ ENSP00000366061.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-485               AB164464.1         1-485
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.2"
     gene            1..485
                     /gene="NMS"
                     /note="neuromedin S"
                     /db_xref="GeneID:129521"
                     /db_xref="HGNC:HGNC:32203"
                     /db_xref="MIM:619337"
     exon            1..83
                     /gene="NMS"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..469
                     /gene="NMS"
                     /note="prepro-NMS; neuromedin S precursor-related
                     peptide/neuromedin S preproprotein"
                     /codon_start=1
                     /product="neuromedin-S preproprotein"
                     /protein_id="NP_001011717.1"
                     /db_xref="CCDS:CCDS33259.1"
                     /db_xref="GeneID:129521"
                     /db_xref="HGNC:HGNC:32203"
                     /db_xref="MIM:619337"
                     /translation="MKHLRPQFPLILAIYCFCMLQIPSSGFPQPLADPSDGLDIVQLE
                     QLAYCLSQWAPLSRQPKDNQDIYKRFLFHYSRTQEATHPVKTGFPPVHPLMHLAAKLA
                     NRRMKRILQRGSGTAAVDFTKKDHTATWGRPFFLFRPRNGRNIEDEAQIQW"
     exon            84..139
                     /gene="NMS"
                     /inference="alignment:Splign:2.1.0"
     exon            140..190
                     /gene="NMS"
                     /inference="alignment:Splign:2.1.0"
     exon            191..214
                     /gene="NMS"
                     /inference="alignment:Splign:2.1.0"
     exon            215..268
                     /gene="NMS"
                     /inference="alignment:Splign:2.1.0"
     exon            269..343
                     /gene="NMS"
                     /inference="alignment:Splign:2.1.0"
     exon            344..379
                     /gene="NMS"
                     /inference="alignment:Splign:2.1.0"
     exon            380..421
                     /gene="NMS"
                     /inference="alignment:Splign:2.1.0"
     exon            422..456
                     /gene="NMS"
                     /inference="alignment:Splign:2.1.0"
     exon            457..485
                     /gene="NMS"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctcacaatg aaacatcttc gtccccagtt ccctctcatc ttggccatct actgcttctg
       61 catgctacag attccctcct caggatttcc tcaaccttta gctgatcctt cagatggctt
      121 ggatattgtg cagcttgagc agctggcata ttgtctgagt cagtgggcac ctctttctcg
      181 ccaacctaag gataatcaag acatatacaa aaggtttttg tttcactact ccagaactca
      241 ggaggcaaca catccagtta aaactgggtt tcctccagtg catcctctaa tgcacctggc
      301 tgccaagctc gccaacaggc ggatgaagag aattctgcag cgaggctcgg ggactgctgc
      361 agtggacttc accaagaagg atcacactgc gacctgggga cgaccctttt tccttttcag
      421 gcccaggaat ggaagaaaca ttgaagatga ggcccagatt cagtggtgaa agaaagctgg
      481 atctg
//
