LOCUS       NM_170678               1160 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens nicotinamide riboside kinase 2 (NMRK2), transcript
            variant 2, mRNA.
ACCESSION   NM_170678
VERSION     NM_170678.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1160)
  AUTHORS   Chen,Y., Lu,Y., Yang,L., Ma,W., Dong,Y., Zhou,S., Liu,N., Gan,W.
            and Li,D.
  TITLE     LncRNA like NMRK2 mRNA functions as a key molecular scaffold to
            enhance mitochondrial respiration of NONO-TFE3 rearranged renal
            cell carcinoma in an NAD+ kinase-independent manner
  JOURNAL   J Exp Clin Cancer Res 42 (1), 252 (2023)
   PUBMED   37770905
  REMARK    GeneRIF: LncRNA like NMRK2 mRNA functions as a key molecular
            scaffold to enhance mitochondrial respiration of NONO-TFE3
            rearranged renal cell carcinoma in an NAD[+] kinase-independent
            manner.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1160)
  AUTHORS   Chen,Y., Yang,L., Lu,Y., Liu,N., Ma,W., Fan,H., Hu,Q., Han,X.,
            Gan,W. and Li,D.
  TITLE     Up-regulation of NMRK2 mediated by TFE3 fusions is the key for
            energy metabolism adaption of Xp11.2 translocation renal cell
            carcinoma
  JOURNAL   Cancer Lett 538, 215689 (2022)
   PUBMED   35447281
  REMARK    GeneRIF: Up-regulation of NMRK2 mediated by TFE3 fusions is the key
            for energy metabolism adaption of Xp11.2 translocation renal cell
            carcinoma.
REFERENCE   3  (bases 1 to 1160)
  AUTHORS   Tempel,W., Rabeh,W.M., Bogan,K.L., Belenky,P., Wojcik,M.,
            Seidle,H.F., Nedyalkova,L., Yang,T., Sauve,A.A., Park,H.W. and
            Brenner,C.
  TITLE     Nicotinamide riboside kinase structures reveal new pathways to NAD+
  JOURNAL   PLoS Biol 5 (10), e263 (2007)
   PUBMED   17914902
REFERENCE   4  (bases 1 to 1160)
  AUTHORS   Bieganowski,P. and Brenner,C.
  TITLE     Discoveries of nicotinamide riboside as a nutrient and conserved
            NRK genes establish a Preiss-Handler independent route to NAD+ in
            fungi and humans
  JOURNAL   Cell 117 (4), 495-502 (2004)
   PUBMED   15137942
REFERENCE   5  (bases 1 to 1160)
  AUTHORS   Li,J., Rao,H., Burkin,D., Kaufman,S.J. and Wu,C.
  TITLE     The muscle integrin binding protein (MIBP) interacts with
            alpha7beta1 integrin and regulates cell adhesion and laminin matrix
            deposition
  JOURNAL   Dev Biol 261 (1), 209-219 (2003)
   PUBMED   12941630
REFERENCE   6  (bases 1 to 1160)
  AUTHORS   Battle,M.A., Maher,V.M. and McCormick,J.J.
  TITLE     ST7 is a novel low-density lipoprotein receptor-related protein
            (LRP) with a cytoplasmic tail that interacts with proteins related
            to signal transduction pathways
  JOURNAL   Biochemistry 42 (24), 7270-7282 (2003)
   PUBMED   12809483
REFERENCE   7  (bases 1 to 1160)
  AUTHORS   Li,J., Mayne,R. and Wu,C.
  TITLE     A novel muscle-specific beta 1 integrin binding protein (MIBP) that
            modulates myogenic differentiation
  JOURNAL   J Cell Biol 147 (7), 1391-1398 (1999)
   PUBMED   10613898
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011488.7, AK001663.1 and BM669267.1.
            
            On Aug 13, 2020 this sequence version replaced NM_170678.2.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the central coding region, compared to variant 1.
            The encoded isoform (2) is shorter, compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK001663.1, DRR138527.767935.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000168977.7/ ENSP00000168977.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AC011488.7         82640-82673
            35-1158             AK001663.1         11-1134
            1159-1160           BM669267.1         17-18               c
FEATURES             Location/Qualifiers
     source          1..1160
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..1160
                     /gene="NMRK2"
                     /gene_synonym="ITGB1BP3; MIBP; NRK2"
                     /note="nicotinamide riboside kinase 2"
                     /db_xref="GeneID:27231"
                     /db_xref="HGNC:HGNC:17871"
                     /db_xref="MIM:608705"
     exon            1..110
                     /gene="NMRK2"
                     /gene_synonym="ITGB1BP3; MIBP; NRK2"
                     /inference="alignment:Splign:2.1.0"
     exon            111..350
                     /gene="NMRK2"
                     /gene_synonym="ITGB1BP3; MIBP; NRK2"
                     /inference="alignment:Splign:2.1.0"
     CDS             325..1017
                     /gene="NMRK2"
                     /gene_synonym="ITGB1BP3; MIBP; NRK2"
                     /EC_number="2.7.1.22"
                     /EC_number="2.7.1.173"
                     /note="isoform 2 is encoded by transcript variant 2;
                     muscle-specific beta 1 integrin binding protein; NRK 2;
                     RNK 2; nmR-K 2; ribosylnicotinamide kinase 2;
                     ribosylnicotinic acid kinase 2; nicotinic acid riboside
                     kinase 2; integrin beta-1-binding protein 3"
                     /codon_start=1
                     /product="nicotinamide riboside kinase 2 isoform 2"
                     /protein_id="NP_733778.1"
                     /db_xref="CCDS:CCDS12115.1"
                     /db_xref="GeneID:27231"
                     /db_xref="HGNC:HGNC:17871"
                     /db_xref="MIM:608705"
                     /translation="MKLIVGIGGMTNGGKTTLTNSLLRALPNCCVIHQDDFFKPQDQI
                     AVGEDGFKQWDVLESLDMEAMLDTVQAWLSSPQKFARAHGVSVQPEASDTHILLLEGF
                     LLYSYKPLVDLYSRRYFLTVPYEECKWRRSTRNYTVPDPPGLFDGHVWPMYQKYRQEM
                     EANGVEVVYLDGMKSREELFREVLEDIQNSLLNRSQESAPSPARPARTQGPGRGCGHR
                     TARPAASQQDSM"
     exon            351..441
                     /gene="NMRK2"
                     /gene_synonym="ITGB1BP3; MIBP; NRK2"
                     /inference="alignment:Splign:2.1.0"
     exon            442..490
                     /gene="NMRK2"
                     /gene_synonym="ITGB1BP3; MIBP; NRK2"
                     /inference="alignment:Splign:2.1.0"
     exon            491..647
                     /gene="NMRK2"
                     /gene_synonym="ITGB1BP3; MIBP; NRK2"
                     /inference="alignment:Splign:2.1.0"
     exon            648..719
                     /gene="NMRK2"
                     /gene_synonym="ITGB1BP3; MIBP; NRK2"
                     /inference="alignment:Splign:2.1.0"
     exon            720..826
                     /gene="NMRK2"
                     /gene_synonym="ITGB1BP3; MIBP; NRK2"
                     /inference="alignment:Splign:2.1.0"
     exon            827..1160
                     /gene="NMRK2"
                     /gene_synonym="ITGB1BP3; MIBP; NRK2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1136..1141
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NMRK2"
                     /gene_synonym="ITGB1BP3; MIBP; NRK2"
                     /note="hexamer: AGTAAA"
     polyA_site      1160
                     /gene="NMRK2"
                     /gene_synonym="ITGB1BP3; MIBP; NRK2"
                     /note="major polyA site"
ORIGIN      
        1 cttgtgattc actgctaagg atcttaagcc caccttggcc ctgacctcgt tggaaaacga
       61 agctccccgc agggtcccgg cctctagggc tgctgtgcgg gcgggggtgg cctggagcta
      121 tttccattcg gcggcgggaa caggtgccgg cgcctccgcc ccatccccag gggccgcctc
      181 ccccggggcg gcctccaggc tgccgagacc tataaaggcg ccaggttttc tcaatgaagc
      241 cgggacgcac tccggagcgc actgcgtggt cgcaccctac ccgggctgcc ttggaagtcg
      301 tccccgccgc ccctccgcac cggcatgaag ctcatcgtgg gcatcggagg catgaccaac
      361 ggcggcaaga ccacgctgac caacagcctg ctcagagccc tgcccaactg ctgcgtgatc
      421 catcaggatg acttcttcaa gccccaagac caaatagcag ttggggaaga cggcttcaaa
      481 cagtgggacg tgctggagtc tctggacatg gaggccatgc tggacaccgt gcaggcctgg
      541 ctgagcagcc cgcagaagtt tgcccgtgcc cacggggtca gcgtccagcc agaggcctcg
      601 gacacccaca tcctcctcct ggaaggcttc ctgctctaca gctacaagcc cctggtggac
      661 ttgtacagcc gccggtactt cctgaccgtc ccgtatgaag agtgcaagtg gaggagaagt
      721 acccgcaact acacagtccc tgatcccccc ggcctcttcg atggccacgt gtggcccatg
      781 taccagaagt ataggcagga gatggaggcc aacggtgtgg aagtggtcta cctggacggc
      841 atgaagtccc gagaggagct cttccgtgaa gtcctggaag acattcagaa ctcgctgctg
      901 aaccgctccc aggaatcagc cccctccccg gctcgcccag ccaggacaca gggacccgga
      961 cgcggatgcg gccacagaac ggccaggcct gcagcgtccc agcaggacag catgtgagcg
     1021 tttccctatg ggggtgtctg tacgtaggag agtggaggcc ccactcccag ttgggcgtcc
     1081 cggagctcag ggactgagcc ccaagacgcc tctgtaacct cgctgcagct tcagtagtaa
     1141 actgggtcct gtttttttaa
//
