LOCUS       NM_017881               1754 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens nicotinamide riboside kinase 1 (NMRK1), transcript
            variant 1, mRNA.
ACCESSION   NM_017881
VERSION     NM_017881.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1754)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1754)
  AUTHORS   Ratajczak,J., Joffraud,M., Trammell,S.A., Ras,R., Canela,N.,
            Boutant,M., Kulkarni,S.S., Rodrigues,M., Redpath,P., Migaud,M.E.,
            Auwerx,J., Yanes,O., Brenner,C. and Canto,C.
  TITLE     NRK1 controls nicotinamide mononucleotide and nicotinamide riboside
            metabolism in mammalian cells
  JOURNAL   Nat Commun 7, 13103 (2016)
   PUBMED   27725675
  REMARK    GeneRIF: nicotinamide riboside kinase 1 (NRK1) is necessary and
            rate-limiting for the use of exogenous nicotinamide riboside and
            nicotinamide mononucleotide for NAD(+) synthesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1754)
  AUTHORS   Tempel,W., Rabeh,W.M., Bogan,K.L., Belenky,P., Wojcik,M.,
            Seidle,H.F., Nedyalkova,L., Yang,T., Sauve,A.A., Park,H.W. and
            Brenner,C.
  TITLE     Nicotinamide riboside kinase structures reveal new pathways to NAD+
  JOURNAL   PLoS Biol 5 (10), e263 (2007)
   PUBMED   17914902
REFERENCE   4  (bases 1 to 1754)
  AUTHORS   Khan,J.A., Xiang,S. and Tong,L.
  TITLE     Crystal structure of human nicotinamide riboside kinase
  JOURNAL   Structure 15 (8), 1005-1013 (2007)
   PUBMED   17698003
  REMARK    GeneRIF: Crystal structure of NRK1 is reported.
REFERENCE   5  (bases 1 to 1754)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   6  (bases 1 to 1754)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   7  (bases 1 to 1754)
  AUTHORS   Bieganowski,P. and Brenner,C.
  TITLE     Discoveries of nicotinamide riboside as a nutrient and conserved
            NRK genes establish a Preiss-Handler independent route to NAD+ in
            fungi and humans
  JOURNAL   Cell 117 (4), 495-502 (2004)
   PUBMED   15137942
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK000566.1, BC036804.1 and AL133548.6.
            
            On Nov 22, 2018 this sequence version replaced NM_017881.2.
            
            Summary: Nicotinamide adenine dinucleotide (NAD+) is essential for
            life in all organisms, both as a coenzyme for oxidoreductases and
            as a source of ADP-ribosyl groups used in various reactions.
            Nicotinic acid and nicotinamide, collectively known as niacin, are
            the vitamin precursors of NAD+. Nicotinamide riboside kinases, such
            as NRK1, function to synthesize NAD+ through nicotinamide
            mononucleotide using nicotinamide riboside as the precursor
            (Bieganowski and Brenner, 2004 [PubMed 15137942]).[supplied by
            OMIM, Mar 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.850288.1,
                                           SRR1803616.134450.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361092.9/ ENSP00000354387.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               AK000566.1         28-140
            114-500             BC036804.1         176-562
            501-1131            AK000566.1         528-1158
            1132-1754           AL133548.6         31758-32380         c
FEATURES             Location/Qualifiers
     source          1..1754
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.13"
     gene            1..1754
                     /gene="NMRK1"
                     /gene_synonym="bA235O14.2; C9orf95; NRK1"
                     /note="nicotinamide riboside kinase 1"
                     /db_xref="GeneID:54981"
                     /db_xref="HGNC:HGNC:26057"
                     /db_xref="MIM:608704"
     exon            1..148
                     /gene="NMRK1"
                     /gene_synonym="bA235O14.2; C9orf95; NRK1"
                     /inference="alignment:Splign:2.1.0"
     exon            149..212
                     /gene="NMRK1"
                     /gene_synonym="bA235O14.2; C9orf95; NRK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..783
                     /gene="NMRK1"
                     /gene_synonym="bA235O14.2; C9orf95; NRK1"
                     /EC_number="2.7.1.22"
                     /EC_number="2.7.1.173"
                     /note="isoform 1 is encoded by transcript variant 1; NRK
                     1; RNK 1; nmR-K 1; ribosylnicotinamide kinase 1;
                     ribosylnicotinic acid kinase 1; nicotinic acid riboside
                     kinase 1"
                     /codon_start=1
                     /product="nicotinamide riboside kinase 1 isoform 1"
                     /protein_id="NP_060351.1"
                     /db_xref="CCDS:CCDS6650.1"
                     /db_xref="GeneID:54981"
                     /db_xref="HGNC:HGNC:26057"
                     /db_xref="MIM:608704"
                     /translation="MKTFIIGISGVTNSGKTTLAKNLQKHLPNCSVISQDDFFKPESE
                     IETDKNGFLQYDVLEALNMEKMMSAISCWMESARHSVVSTDQESAEEIPILIIEGFLL
                     FNYKPLDTIWNRSYFLTIPYEECKRRRSTRVYQPPDSPGYFDGHVWPMYLKYRQEMQD
                     ITWEVVYLDGTKSEEDLFLQVYEDLIQELAKQKCLQVTA"
     exon            213..303
                     /gene="NMRK1"
                     /gene_synonym="bA235O14.2; C9orf95; NRK1"
                     /inference="alignment:Splign:2.1.0"
     exon            304..352
                     /gene="NMRK1"
                     /gene_synonym="bA235O14.2; C9orf95; NRK1"
                     /inference="alignment:Splign:2.1.0"
     exon            353..500
                     /gene="NMRK1"
                     /gene_synonym="bA235O14.2; C9orf95; NRK1"
                     /inference="alignment:Splign:2.1.0"
     exon            501..572
                     /gene="NMRK1"
                     /gene_synonym="bA235O14.2; C9orf95; NRK1"
                     /inference="alignment:Splign:2.1.0"
     exon            573..679
                     /gene="NMRK1"
                     /gene_synonym="bA235O14.2; C9orf95; NRK1"
                     /inference="alignment:Splign:2.1.0"
     exon            680..763
                     /gene="NMRK1"
                     /gene_synonym="bA235O14.2; C9orf95; NRK1"
                     /inference="alignment:Splign:2.1.0"
     exon            764..1754
                     /gene="NMRK1"
                     /gene_synonym="bA235O14.2; C9orf95; NRK1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1115..1120
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NMRK1"
                     /gene_synonym="bA235O14.2; C9orf95; NRK1"
                     /note="hexamer: ATTACA"
     polyA_site      1131
                     /gene="NMRK1"
                     /gene_synonym="bA235O14.2; C9orf95; NRK1"
                     /note="major polyA site"
     regulatory      1735..1740
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NMRK1"
                     /gene_synonym="bA235O14.2; C9orf95; NRK1"
                     /note="hexamer: AATAAA"
     polyA_site      1754
                     /gene="NMRK1"
                     /gene_synonym="bA235O14.2; C9orf95; NRK1"
ORIGIN      
        1 ctggcatccc tctaacccag gaggagcgtg gggaaagggg ctgtgggcct ctcggggagc
       61 gagctgcggg tagcggcgca ctgggtacag gcgcgcgctt ggctgtcgcc tctgccgctg
      121 tgtttgggag gactcgaact ggcgccagga aatattagga agctgtgatt ttcaaagcta
      181 attatgaaaa catttatcat tggaatcagt ggtgtgacaa acagtggcaa aacaacactg
      241 gctaagaatt tgcagaaaca cctcccaaat tgcagtgtca tatctcagga tgatttcttc
      301 aagccagagt ctgagataga gacagataaa aatggatttt tgcagtacga tgtgcttgaa
      361 gcacttaaca tggaaaaaat gatgtcagcc atttcctgct ggatggaaag cgcaagacac
      421 tctgtggtat caacagacca ggaaagtgct gaggaaattc ccattttaat catcgaaggt
      481 tttcttcttt ttaattataa gccccttgac actatatgga atagaagcta tttcctgact
      541 attccatatg aagaatgtaa aaggaggagg agtacaaggg tctatcagcc tccagactct
      601 ccgggatact ttgatggcca tgtgtggccc atgtatctaa agtacagaca agaaatgcag
      661 gacatcacat gggaagttgt gtacctggat ggaacaaaat ctgaagagga cctctttttg
      721 caagtatatg aagatctaat acaagaacta gcaaagcaaa agtgtttgca agtgacagca
      781 taaagacgga acacaacaaa tccttcctga agtgaattag gaaactccaa ggagtaattt
      841 aagaaccttc accaagatac aatgtatact gtggtacaat gacagccatt gtttcatatg
      901 tttgattttt attgcacatg gttttcccaa catgtggaac aataaatatc catgccaatg
      961 gacaggactg taccttagca agttgctccc tctccaggga gcgcatagat acagcagagc
     1021 tcacagtgag tcagaaagtc tccactttct gaacatagct ctataacaat gattgtcaaa
     1081 cttttctaac tggagctcag agtaagaaat aaagattaca tcacaatcca atatctgtgg
     1141 aattcattgt gtatgtttat gtatttgtgt gtaggtgtgt atgtgtgtgt gtgatacata
     1201 catacatcaa gtatcacaag acattgacct tatatattat gcactgtgat gtttttccgt
     1261 ctttaattat aaaaaacata ttgatcacaa ccacaatttg gaaaatgttg ctccatacca
     1321 tcccatacca acactcacca cctgcaaata atagcattac taggagctgc agtcacaatg
     1381 aataaatcaa caattcgcta caagatctag gattatttgt gtattttgtt gagtgtgtgt
     1441 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt tggcgtgtat ctaataccat tgtatctcat
     1501 tgttgagact ttgttacaaa tagggtttct ggtttctttc tcccccctcg tggttcattt
     1561 tgtttttgtc aaaccagtgg tctaaaatca cagaaataag caattacttc aatcatgtgg
     1621 aatccagggg acctatcttt ggaaagcaca gaaggagatc tgaattgtgt gatctcttga
     1681 ggctgctttc aatgctggaa tttaaattat gtactgaaca atcttttgct tattaataaa
     1741 aagattacac acaa
//
