LOCUS       NM_020677               1092 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens NmrA like redox sensor 1 (NMRAL1), transcript variant
            1, mRNA.
ACCESSION   NM_020677
VERSION     NM_020677.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1092)
  AUTHORS   Wang,J., Li,S., Li,X., Liu,J., Yang,J., Li,Y., Li,W., Yang,Y.,
            Li,J., Chen,R., Li,K., Huang,D., Liu,Y., Lv,L., Li,M., Xiao,X. and
            Luo,X.J.
  TITLE     Functional variant rs2270363 on 16p13.3 confers schizophrenia risk
            by regulating NMRAL1
  JOURNAL   Brain 145 (7), 2569-2585 (2022)
   PUBMED   35094059
  REMARK    GeneRIF: Functional variant rs2270363 on 16p13.3 confers
            schizophrenia risk by regulating NMRAL1.
REFERENCE   2  (bases 1 to 1092)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1092)
  AUTHORS   Zang,W., Yang,C., Li,T., Liao,L. and Zheng,X.
  TITLE     Cellular redox sensor HSCARG negatively regulates the translesion
            synthesis pathway and exacerbates mammary tumorigenesis
  JOURNAL   Proc Natl Acad Sci U S A 116 (51), 25624-25633 (2019)
   PUBMED   31796584
  REMARK    GeneRIF: Investigated the role of NmrA like redox sensor 1
            (HSCARG), a cellular redox sensor. Demonstrated how HSCARG
            interacts with proliferating cell nuclear antigen (PCNA) in the
            translesion synthesis pathway, and showed that HSCARG, which is
            highly expressed in breast carcinoma, promotes accumulation of
            double stranded breaks and mutations.
REFERENCE   4  (bases 1 to 1092)
  AUTHORS   Wu,Y.H., Chiu,D.T., Lin,H.R., Tang,H.Y., Cheng,M.L. and Ho,H.Y.
  TITLE     Glucose-6-Phosphate Dehydrogenase Enhances Antiviral Response
            through Downregulation of NADPH Sensor HSCARG and Upregulation of
            NF-kappaB Signaling
  JOURNAL   Viruses 7 (12), 6689-6706 (2015)
   PUBMED   26694452
  REMARK    GeneRIF: These findings suggest that the increased susceptibility
            of the G6PD-knockdown cells to viral infection was due to impaired
            NF-kappaB signaling and antiviral response mediated by HSCARG.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1092)
  AUTHORS   Li,T., Guan,J., Li,S., Zhang,X. and Zheng,X.
  TITLE     HSCARG downregulates NF-kappaB signaling by interacting with USP7
            and inhibiting NEMO ubiquitination
  JOURNAL   Cell Death Dis 5 (5), e1229 (2014)
   PUBMED   24832601
  REMARK    GeneRIF: Data indicate that HSCARG and USP7 function in concert in
            inhibiting polyubiquination of NEMO, thus inhibiting NF-kappaB
            activity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1092)
  AUTHORS   Dai,X., Li,Y., Meng,G., Yao,S., Zhao,Y., Yu,Q., Zhang,J., Luo,M.
            and Zheng,X.
  TITLE     NADPH is an allosteric regulator of HSCARG
  JOURNAL   J Mol Biol 387 (5), 1277-1285 (2009)
   PUBMED   19254724
  REMARK    GeneRIF: In response to the changes in the NADPH/NADP(+) ratio
            within cells, HSCARG, as a redox sensor, associates and dissociates
            with NADPH to form a new dynamic equilibrium.
REFERENCE   7  (bases 1 to 1092)
  AUTHORS   Persson,B., Kallberg,Y., Bray,J.E., Bruford,E., Dellaporta,S.L.,
            Favia,A.D., Duarte,R.G., Jornvall,H., Kavanagh,K.L., Kedishvili,N.,
            Kisiela,M., Maser,E., Mindnich,R., Orchard,S., Penning,T.M.,
            Thornton,J.M., Adamski,J. and Oppermann,U.
  TITLE     The SDR (short-chain dehydrogenase/reductase and related enzymes)
            nomenclature initiative
  JOURNAL   Chem Biol Interact 178 (1-3), 94-98 (2009)
   PUBMED   19027726
REFERENCE   8  (bases 1 to 1092)
  AUTHORS   Zhao,Y., Zhang,J., Li,H., Li,Y., Ren,J., Luo,M. and Zheng,X.
  TITLE     An NADPH sensor protein (HSCARG) down-regulates nitric oxide
            synthesis by association with argininosuccinate synthetase and is
            essential for epithelial cell viability
  JOURNAL   J Biol Chem 283 (16), 11004-11013 (2008)
   PUBMED   18263583
  REMARK    GeneRIF: HSCARG regulation of argininosuccinate synthetase activity
            is crucial for maintaining the intracellular balance between redox
            state and nitric oxide levels
REFERENCE   9  (bases 1 to 1092)
  AUTHORS   Zheng,X., Dai,X., Zhao,Y., Chen,Q., Lu,F., Yao,D., Yu,Q., Liu,X.,
            Zhang,C., Gu,X. and Luo,M.
  TITLE     Restructuring of the dinucleotide-binding fold in an NADP(H) sensor
            protein
  JOURNAL   Proc Natl Acad Sci U S A 104 (21), 8809-8814 (2007)
   PUBMED   17496144
  REMARK    GeneRIF: One of the functions regulated by HSCARG may be
            argininosuccinate synthetase that is involved in NO synthesis
REFERENCE   10 (bases 1 to 1092)
  AUTHORS   Dai,X., Gu,X., Luo,M. and Zheng,X.
  TITLE     Protein expression, crystallization and preliminary X-ray
            crystallographic studies on HSCARG from Homo sapiens
  JOURNAL   Protein Pept Lett 13 (9), 955-957 (2006)
   PUBMED   17100653
  REMARK    GeneRIF: expression, crystallization and preliminary X-ray
            crystallographic studies of HSCARG at a resolution of 2.4 A;
            crystals belong to F23 space group, with unit cell parameters
            a=b=c=223.30A, alpha=beta=gamma=90 degrees
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF225419.1.
            
            On Jun 2, 2019 this sequence version replaced NM_020677.5.
            
            Summary: This gene encodes an NADPH sensor protein that
            preferentially binds to NADPH. The encoded protein also negatively
            regulates the activity of NF-kappaB in a ubiquitylation-dependent
            manner. It plays a key role in cellular antiviral response by
            negatively regulating the interferon response factor 3-mediated
            expression of interferon beta. Alternative splicing of this gene
            results in multiple transcript variants. [provided by RefSeq, Feb
            2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: GQ901038.1, BC007364.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000283429.11/ ENSP00000283429.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1092              AF225419.1         276-1367
FEATURES             Location/Qualifiers
     source          1..1092
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..1092
                     /gene="NMRAL1"
                     /gene_synonym="HSCARG; SDR48A1"
                     /note="NmrA like redox sensor 1"
                     /db_xref="GeneID:57407"
                     /db_xref="HGNC:HGNC:24987"
                     /db_xref="MIM:620004"
     exon            1..72
                     /gene="NMRAL1"
                     /gene_synonym="HSCARG; SDR48A1"
                     /inference="alignment:Splign:2.1.0"
     exon            73..146
                     /gene="NMRAL1"
                     /gene_synonym="HSCARG; SDR48A1"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..1006
                     /gene="NMRAL1"
                     /gene_synonym="HSCARG; SDR48A1"
                     /note="isoform 1 is encoded by transcript variant 1; short
                     chain dehydrogenase/reductase family 48A, member 1;
                     nmrA-like family domain-containing protein 1; NmrA-like
                     family domain containing 1; epididymis secretory sperm
                     binding protein"
                     /codon_start=1
                     /product="nmrA-like family domain-containing protein 1
                     isoform 1"
                     /protein_id="NP_065728.1"
                     /db_xref="CCDS:CCDS10516.1"
                     /db_xref="GeneID:57407"
                     /db_xref="HGNC:HGNC:24987"
                     /db_xref="MIM:620004"
                     /translation="MVDKKLVVVFGGTGAQGGSVARTLLEDGTFKVRVVTRNPRKKAA
                     KELRLQGAEVVQGDQDDQVIMELALNGAYATFIVTNYWESCSQEQEVKQGKLLADLAR
                     RLGLHYVVYSGLENIKKLTAGRLAAAHFDGKGEVEEYFRDIGVPMTSVRLPCYFENLL
                     SHFLPQKAPDGKSYLLSLPTGDVPMDGMSVSDLGPVVLSLLKMPEKYVGQNIGLSTCR
                     HTAEEYAALLTKHTRKVVHDAKMTPEDYEKLGFPGARDLANMFRFYALRPDRDIELTL
                     RLNPKALTLDQWLEQHKGDFNLL"
     exon            147..385
                     /gene="NMRAL1"
                     /gene_synonym="HSCARG; SDR48A1"
                     /inference="alignment:Splign:2.1.0"
     exon            386..635
                     /gene="NMRAL1"
                     /gene_synonym="HSCARG; SDR48A1"
                     /inference="alignment:Splign:2.1.0"
     exon            636..826
                     /gene="NMRAL1"
                     /gene_synonym="HSCARG; SDR48A1"
                     /inference="alignment:Splign:2.1.0"
     exon            827..1092
                     /gene="NMRAL1"
                     /gene_synonym="HSCARG; SDR48A1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1072..1077
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NMRAL1"
                     /gene_synonym="HSCARG; SDR48A1"
                     /note="hexamer: AATAAA"
     polyA_site      1092
                     /gene="NMRAL1"
                     /gene_synonym="HSCARG; SDR48A1"
                     /note="major polyA site"
ORIGIN      
        1 cgacacgtcg ggattggcgg ctgcagccag gggtcctccg acgctgggct tccgtgagcg
       61 gcgctctgcc agatctctgg accggattcg tcccattctc gtcctcatgg tggacaagaa
      121 actggtggtg gttttcggag gcacaggtgc ccagggtggc tccgtggccc gcacactcct
      181 ggaagatggg acattcaagg ttcgagtggt gacccgaaac cctaggaaga aggcagcaaa
      241 ggagctgagg ctgcaaggtg cagaagtagt gcagggagac caagatgacc aggtcatcat
      301 ggagctggcc ctgaatgggg cttacgccac cttcatcgtg accaattact gggagagctg
      361 cagccaggag caggaggtca agcaggggaa gctgctcgct gatctggcca ggcgcctggg
      421 cctccactat gtggtctaca gcggcctgga gaacatcaag aagctgacgg cagggagatt
      481 ggccgccgcg cactttgacg gcaaagggga ggtggaggaa tatttccggg acattggcgt
      541 tcccatgacc agtgtgcggc tgccctgcta ttttgagaac ctcctctccc acttcttgcc
      601 ccagaaagcc ccagacggaa agagctactt gctgagcttg cccacaggtg acgttcccat
      661 ggatggcatg tccgtgtctg acctgggtcc tgtggtgctc agccttttga agatgccaga
      721 aaaatacgtc ggccagaaca tcgggctgag cacttgcagg cacacggccg aggagtacgc
      781 tgccctgctc accaagcaca cccgcaaggt cgtgcacgat gccaagatga ctcctgagga
      841 ctacgaaaag cttggctttc ccggtgcccg ggacctggcc aacatgttcc gtttctatgc
      901 cctgagaccc gaccgtgaca tcgagctgac cctgagactc aaccccaagg ccctgacgct
      961 ggaccagtgg ctggaacagc acaaagggga cttcaacctg ctgtgacctg cccgcctcgc
     1021 ggccccttgt ggggatcggg ggcaccagag gggcagaggc accaacatct gaataaagcc
     1081 attgttctcc ca
//
