LOCUS       NM_004688               1229 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens N-myc and STAT interactor (NMI), mRNA.
ACCESSION   NM_004688
VERSION     NM_004688.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1229)
  AUTHORS   Park,Y., Guan,X. and Han,S.J.
  TITLE     N-Myc and STAT Interactor is an Endometriosis Suppressor
  JOURNAL   Int J Mol Sci 25 (15), 8145 (2024)
   PUBMED   39125716
  REMARK    GeneRIF: N-Myc and STAT Interactor is an Endometriosis Suppressor.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1229)
  AUTHORS   Hu,H., Li,B., Chen,H., Fan,G., Ye,Z., Ji,S., Yu,X., Xu,X. and
            Qin,Y.
  TITLE     NMI promotes tumor progression and gemcitabine resistance in
            pancreatic cancer via STAT3-IFIT3 axis
  JOURNAL   Mol Carcinog 63 (2), 195-208 (2024)
   PUBMED   37846815
  REMARK    GeneRIF: NMI promotes tumor progression and gemcitabine resistance
            in pancreatic cancer via STAT3-IFIT3 axis.
REFERENCE   3  (bases 1 to 1229)
  AUTHORS   Jing,X., Yao,Y., Wu,D., Hong,H., Feng,X., Xu,N., Liu,Y. and
            Liang,H.
  TITLE     IFP35 family proteins promote neuroinflammation and multiple
            sclerosis
  JOURNAL   Proc Natl Acad Sci U S A 118 (32) (2021)
   PUBMED   34362845
  REMARK    GeneRIF: IFP35 family proteins promote neuroinflammation and
            multiple sclerosis.
REFERENCE   4  (bases 1 to 1229)
  AUTHORS   Banday,M.M., Kumar,A., Vestal,G., Sethi,J., Patel,K.N.,
            O'Neill,E.B., Finan,J., Cheng,F., Lin,M., Davis,N.M., Goldberg,H.,
            Coppolino,A., Mallidi,H.R., Dunning,J., Visner,G., Gaggar,A.,
            Seyfang,A. and Sharma,N.S.
  TITLE     N-myc-interactor mediates microbiome induced epithelial to
            mesenchymal transition and is associated with chronic lung
            allograft dysfunction
  JOURNAL   J Heart Lung Transplant 40 (6), 447-457 (2021)
   PUBMED   33781665
  REMARK    GeneRIF: N-myc-interactor mediates microbiome induced epithelial to
            mesenchymal transition and is associated with chronic lung
            allograft dysfunction.
REFERENCE   5  (bases 1 to 1229)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1229)
  AUTHORS   Bannasch,D., Weis,I. and Schwab,M.
  TITLE     Nmi protein interacts with regions that differ between MycN and Myc
            and is localized in the cytoplasm of neuroblastoma cells in
            contrast to nuclear MycN
  JOURNAL   Oncogene 18 (48), 6810-6817 (1999)
   PUBMED   10597290
REFERENCE   7  (bases 1 to 1229)
  AUTHORS   Lee,N.D., Chen,J., Shpall,R.L. and Naumovski,L.
  TITLE     Subcellular localization of interferon-inducible
            Myc/stat-interacting protein Nmi is regulated by a novel IFP 35
            homologous domain
  JOURNAL   J Interferon Cytokine Res 19 (11), 1245-1252 (1999)
   PUBMED   10574616
REFERENCE   8  (bases 1 to 1229)
  AUTHORS   Zhu,M., John,S., Berg,M. and Leonard,W.J.
  TITLE     Functional association of Nmi with Stat5 and Stat1 in IL-2- and
            IFNgamma-mediated signaling
  JOURNAL   Cell 96 (1), 121-130 (1999)
   PUBMED   9989503
REFERENCE   9  (bases 1 to 1229)
  AUTHORS   Lebrun,S.J., Shpall,R.L. and Naumovski,L.
  TITLE     Interferon-induced upregulation and cytoplasmic localization of
            Myc-interacting protein Nmi
  JOURNAL   J Interferon Cytokine Res 18 (9), 767-771 (1998)
   PUBMED   9781816
REFERENCE   10 (bases 1 to 1229)
  AUTHORS   Bao,J. and Zervos,A.S.
  TITLE     Isolation and characterization of Nmi, a novel partner of Myc
            proteins
  JOURNAL   Oncogene 12 (10), 2171-2176 (1996)
   PUBMED   8668343
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB151555.1, BC001268.1 and
            BC021987.2.
            
            On May 17, 2019 this sequence version replaced NM_004688.2.
            
            Summary: NMYC interactor (NMI) encodes a protein that interacts
            with NMYC and CMYC (two members of the oncogene Myc family), and
            other transcription factors containing a Zip, HLH, or HLH-Zip
            motif. The NMI protein also interacts with all STATs except STAT2
            and augments STAT-mediated transcription in response to cytokines
            IL2 and IFN-gamma. The NMI mRNA has low expression levels in all
            human fetal and adult tissues tested except brain and has high
            expression in cancer cell line-myeloid leukemias. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291548.1, BC001268.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000243346.10/ ENSP00000243346.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                CB151555.1         249-280
            33-348              BC001268.1         1-316
            349-583             BC021987.2         273-507
            584-1229            BC001268.1         552-1197
FEATURES             Location/Qualifiers
     source          1..1229
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q23.3"
     gene            1..1229
                     /gene="NMI"
                     /note="N-myc and STAT interactor"
                     /db_xref="GeneID:9111"
                     /db_xref="HGNC:HGNC:7854"
                     /db_xref="MIM:603525"
     exon            1..76
                     /gene="NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            77..163
                     /gene="NMI"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1006
                     /gene="NMI"
                     /codon_start=1
                     /product="N-myc-interactor"
                     /protein_id="NP_004679.2"
                     /db_xref="CCDS:CCDS2192.1"
                     /db_xref="GeneID:9111"
                     /db_xref="HGNC:HGNC:7854"
                     /db_xref="MIM:603525"
                     /translation="MEADKDDTQQILKEHSPDEFIKDEQNKGLIDEITKKNIQLKKEI
                     QKLETELQEATKEFQIKEDIPETKMKFLSVETPENDSQLSNISCSFQVSSKVPYEIQK
                     GQALITFEKEEVAQNVVSMSKHHVQIKDVNLEVTAKPVPLNSGVRFQVYVEVSKMKIN
                     VTEIPDTLREDQMRDKLELSFSKSRNGGGEVDRVDYDRQSGSAVITFVEIGVADKILK
                     KKEYPLYINQTCHRVTVSPYTEIHLKKYQIFSGTSKRTVLLTGMEGIQMDEEIVEDLI
                     NIHFQRAKNGGGEVDVVKCSLGQPHIAYFEE"
     exon            164..259
                     /gene="NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            260..422
                     /gene="NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            423..529
                     /gene="NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            530..716
                     /gene="NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            717..823
                     /gene="NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            824..1229
                     /gene="NMI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1210..1215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NMI"
                     /note="hexamer: AATAAA"
     polyA_site      1229
                     /gene="NMI"
                     /note="major polyA site"
ORIGIN      
        1 gtttcaggcg ctgctgtttt ccgggaaggg caggcgcgct gggccttggg gagctgcgct
       61 cggcgggcgg acgcggggga tcatggaagc tgataaagat gacacacaac aaattcttaa
      121 ggagcattcg ccagatgaat ttataaaaga tgaacaaaat aagggactaa ttgatgaaat
      181 tacaaagaaa aatattcaac taaagaagga gatccaaaag cttgaaacgg agttacaaga
      241 ggctaccaaa gaattccaga ttaaagagga tattcctgaa acaaagatga aattcttatc
      301 agttgaaact cctgagaatg acagccagtt gtcaaatatc tcctgttcgt ttcaagtgag
      361 ctcgaaagtt ccttatgaga tacaaaaagg acaagcactt atcacctttg aaaaagaaga
      421 agttgctcaa aatgtggtaa gcatgagtaa acatcatgta cagataaaag atgtaaatct
      481 ggaggttacg gccaagccag ttccattaaa ttcaggagtc agattccagg tttatgtaga
      541 agtttctaaa atgaaaatca atgttactga aattcctgac acattgcgtg aagatcaaat
      601 gagagacaaa ctagagctga gcttttcaaa gtcccgaaat ggaggcggag aggtggaccg
      661 cgtggactat gacagacagt ccgggagtgc agtcatcacg tttgtggaga ttggagtggc
      721 tgacaagatt ttgaaaaaga aagaataccc tctttatata aatcaaacct gccatagagt
      781 tactgtttct ccatacacag aaatacactt gaaaaagtat cagatatttt caggaacatc
      841 taagaggaca gtgcttctga caggaatgga aggcattcaa atggatgaag aaattgtgga
      901 ggatttaatt aacattcact ttcaacgggc aaagaatgga ggtggagaag tagatgtggt
      961 caagtgttct ctaggtcaac ctcacatagc atactttgaa gaatagactt aacagaatca
     1021 tgaaaactat agctttttaa cccggattac tgtaaatgtt tgacaaaaat gaatatgctt
     1081 ttccttaaaa aatgaaaact ttaattttta ccatccattt atgtttagat acaaaactta
     1141 tttccatgtt tctgaatctt ctttgtttca aatggtgctg catgttttca actacaataa
     1201 gtgcactgta ataaaaagtt ttgtttata
//
