LOCUS       NM_001349018            2150 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens NME/NM23 family member 9 (NME9), transcript variant 1,
            mRNA.
ACCESSION   NM_001349018
VERSION     NM_001349018.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2150)
  AUTHORS   Chan,M.C., Savela,J., Ollikainen,R.K., Teppo,H.R., Miinalainen,I.,
            Pirinen,R., Kari,E.J.M., Kuitunen,H., Turpeenniemi-Hujanen,T.,
            Kuittinen,O. and Kuusisto,M.E.L.
  TITLE     Testis-Specific Thioredoxins TXNDC2, TXNDC3, and TXNDC6 Are
            Expressed in Both Testicular and Systemic DLBCL and Correlate with
            Clinical Disease Presentation
  JOURNAL   Oxid Med Cell Longev 2021, 8026941 (2021)
   PUBMED   33603952
  REMARK    GeneRIF: Testis-Specific Thioredoxins TXNDC2, TXNDC3, and TXNDC6
            Are Expressed in Both Testicular and Systemic DLBCL and Correlate
            with Clinical Disease Presentation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2150)
  AUTHORS   Lu,Y., Zhao,X., Luo,G., Shen,G., Li,K., Ren,G., Pan,Y., Wang,X. and
            Fan,D.
  TITLE     Thioredoxin-like protein 2b facilitates colon cancer cell
            proliferation and inhibits apoptosis via NF-kappaB pathway
  JOURNAL   Cancer Lett 363 (2), 119-126 (2015)
   PUBMED   25555669
  REMARK    GeneRIF: our results indicate that Txl-2b expression stimulates
            cancer cell proliferation, accelerates the cell cycle and
            contributes to apoptosis resistance in colon cancer and provides a
            potential therapeutic target for colon cancer treatment.
REFERENCE   3  (bases 1 to 2150)
  AUTHORS   Lu,Y., Zhao,X., Li,K., Luo,G., Nie,Y., Shi,Y., Zhou,Y., Ren,G.,
            Feng,B., Liu,Z., Pan,Y., Li,T., Guo,X., Wu,K., Miranda-Vizuete,A.,
            Wang,X. and Fan,D.
  TITLE     Thioredoxin-like protein 2 is overexpressed in colon cancer and
            promotes cancer cell metastasis by interaction with ran
  JOURNAL   Antioxid Redox Signal 19 (9), 899-911 (2013)
   PUBMED   23311631
  REMARK    GeneRIF: Thioredoxin-like protein 2 is overexpressed in colon
            cancer and promotes cancer cell metastasis by interaction with ran.
REFERENCE   4  (bases 1 to 2150)
  AUTHORS   Furney,S.J., Simmons,A., Breen,G., Pedroso,I., Lunnon,K.,
            Proitsi,P., Hodges,A., Powell,J., Wahlund,L.O., Kloszewska,I.,
            Mecocci,P., Soininen,H., Tsolaki,M., Vellas,B., Spenger,C.,
            Lathrop,M., Shen,L., Kim,S., Saykin,A.J., Weiner,M.W. and
            Lovestone,S.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative; AddNeuroMed Consortium
  TITLE     Genome-wide association with MRI atrophy measures as a quantitative
            trait locus for Alzheimer's disease
  JOURNAL   Mol Psychiatry 16 (11), 1130-1138 (2011)
   PUBMED   21116278
REFERENCE   5  (bases 1 to 2150)
  AUTHORS   Desvignes,T., Pontarotti,P., Fauvel,C. and Bobe,J.
  TITLE     Nme protein family evolutionary history, a vertebrate perspective
  JOURNAL   BMC Evol Biol 9, 256 (2009)
   PUBMED   19852809
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2150)
  AUTHORS   Lee,E.J., In,K.H., Kim,J.H., Lee,S.Y., Shin,C., Shim,J.J.,
            Kang,K.H., Yoo,S.H., Kim,C.H., Kim,H.K., Lee,S.H. and Uhm,C.S.
  TITLE     Proteomic analysis in lung tissue of smokers and COPD patients
  JOURNAL   Chest 135 (2), 344-352 (2009)
   PUBMED   18753468
  REMARK    GeneRIF: MMP-13 and thioredoxin-like 2 in lungs increased in
            patients with COPD. Thioredoxin-like 2 was primarily seen in the
            bronchial epithelium
REFERENCE   7  (bases 1 to 2150)
  AUTHORS   Miranda-Vizuete,A., Sadek,C.M., Jimenez,A., Krause,W.J.,
            Sutovsky,P. and Oko,R.
  TITLE     The mammalian testis-specific thioredoxin system
  JOURNAL   Antioxid Redox Signal 6 (1), 25-40 (2004)
   PUBMED   14713334
  REMARK    Review article
REFERENCE   8  (bases 1 to 2150)
  AUTHORS   Sadek,C.M., Jimenez,A., Damdimopoulos,A.E., Kieselbach,T., Nord,M.,
            Gustafsson,J.A., Spyrou,G., Davis,E.C., Oko,R., van der Hoorn,F.A.
            and Miranda-Vizuete,A.
  TITLE     Characterization of human thioredoxin-like 2. A novel
            microtubule-binding thioredoxin expressed predominantly in the
            cilia of lung airway epithelium and spermatid manchette and axoneme
  JOURNAL   J Biol Chem 278 (15), 13133-13142 (2003)
   PUBMED   12569107
  REMARK    GeneRIF: This protein is characterized. It is a microtubule-binding
            thioredoxin expressed predominantly in the cilia of lung airway
            epithelium and spermatid manchette and axoneme
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC022337.24.
            
            On Jun 2, 2019 this sequence version replaced NM_001349018.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF196568.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000333911.9/ ENSP00000335444.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-549               AC022337.24        65364-65912         c
            550-607             AC022337.24        60934-60991         c
            608-711             AC022337.24        55539-55642         c
            712-783             AC022337.24        54209-54280         c
            784-900             AC022337.24        51588-51704         c
            901-976             AC022337.24        50393-50468         c
            977-1059            AC022337.24        42459-42541         c
            1060-1152           AC022337.24        42065-42157         c
            1153-1307           AC022337.24        40934-41088         c
            1308-1444           AC022337.24        39568-39704         c
            1445-2150           AC022337.24        37060-37765         c
FEATURES             Location/Qualifiers
     source          1..2150
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q22.3"
     gene            1..2150
                     /gene="NME9"
                     /gene_synonym="NM23-H9; NXL2; TXL-2; TXL2; TXNDC6"
                     /note="NME/NM23 family member 9"
                     /db_xref="GeneID:347736"
                     /db_xref="HGNC:HGNC:21343"
                     /db_xref="MIM:618584"
     exon            1..549
                     /gene="NME9"
                     /gene_synonym="NM23-H9; NXL2; TXL-2; TXL2; TXNDC6"
                     /inference="alignment:Splign:2.1.0"
     CDS             517..1509
                     /gene="NME9"
                     /gene_synonym="NM23-H9; NXL2; TXL-2; TXL2; TXNDC6"
                     /note="isoform a is encoded by transcript variant 1;
                     thioredoxin domain-containing protein 6; thioredoxin-like
                     protein 2; NME gene family member 9"
                     /codon_start=1
                     /product="thioredoxin domain-containing protein 6 isoform
                     a"
                     /protein_id="NP_001335947.1"
                     /db_xref="CCDS:CCDS87142.1"
                     /db_xref="GeneID:347736"
                     /db_xref="HGNC:HGNC:21343"
                     /db_xref="MIM:618584"
                     /translation="MGSRKKEIALQVNISTQELWEEMLSSKGLTVVDVYQGWCGPCKP
                     VVSLFQKMRIEVGLDLLHFALAEADRLDVLEKYRGKCEPTFLFYAGGELVAVVRGANA
                     PLLQKTILDQLEAEKKVLAEGRERKVIKDEALSDEDECVSHGKNNGEDEDMVSSERTC
                     TLAIIKPDAVAHGKTDEIIMKIQEAGFEILTNEERTMTEAEVRLFYQHKAGEEAFEKL
                     VHHMCSGPSHLLILTRTEGFEDVVTTWRTVMGPRDPNVARREQPESLRAQYGTEMPFN
                     AVHGSRDREDADRELALLFPSLKFSDKDTEAPQGGEAEATAGPTEALCFPEDVD"
     exon            550..607
                     /gene="NME9"
                     /gene_synonym="NM23-H9; NXL2; TXL-2; TXL2; TXNDC6"
                     /inference="alignment:Splign:2.1.0"
     exon            608..711
                     /gene="NME9"
                     /gene_synonym="NM23-H9; NXL2; TXL-2; TXL2; TXNDC6"
                     /inference="alignment:Splign:2.1.0"
     exon            712..783
                     /gene="NME9"
                     /gene_synonym="NM23-H9; NXL2; TXL-2; TXL2; TXNDC6"
                     /inference="alignment:Splign:2.1.0"
     exon            784..900
                     /gene="NME9"
                     /gene_synonym="NM23-H9; NXL2; TXL-2; TXL2; TXNDC6"
                     /inference="alignment:Splign:2.1.0"
     exon            901..976
                     /gene="NME9"
                     /gene_synonym="NM23-H9; NXL2; TXL-2; TXL2; TXNDC6"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1059
                     /gene="NME9"
                     /gene_synonym="NM23-H9; NXL2; TXL-2; TXL2; TXNDC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1152
                     /gene="NME9"
                     /gene_synonym="NM23-H9; NXL2; TXL-2; TXL2; TXNDC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1307
                     /gene="NME9"
                     /gene_synonym="NM23-H9; NXL2; TXL-2; TXL2; TXNDC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1444
                     /gene="NME9"
                     /gene_synonym="NM23-H9; NXL2; TXL-2; TXL2; TXNDC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..2150
                     /gene="NME9"
                     /gene_synonym="NM23-H9; NXL2; TXL-2; TXL2; TXNDC6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2127..2132
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NME9"
                     /gene_synonym="NM23-H9; NXL2; TXL-2; TXL2; TXNDC6"
                     /note="hexamer: AATAAA"
     polyA_site      2150
                     /gene="NME9"
                     /gene_synonym="NM23-H9; NXL2; TXL-2; TXL2; TXNDC6"
                     /note="major polyA site"
ORIGIN      
        1 gccatgacga ccgcggctag gtcgcggcag actcggttgg tgactccggg cgcgtcgaag
       61 atcttgtacc tgtcgttcgc agtggctcac tttcccagta atccataaga acagcaggga
      121 taacagggtc ccatgtcgtt tttttgtcag aattcctcga ctggcgaccc tgtgcccgac
      181 aggctgcacc gcgcccggcg cactgactcc ggcctctgcg cgcgccccct ggccggctcc
      241 ggggtgggga gggggcttcg cagatcccca gaaaaccgcc cggcgagcca cgagcccgtg
      301 gactgcaggc tccgcttcct cgcggggtgt tcactttgta tcagtgtgct gatttgccgc
      361 cagttagaag caccttaaaa aggggccggg ggccgtagga ggggggcttg tctgaaggag
      421 gctctgggct tgctgatcca cgcagcggtt tgtcgcgagg ctgcggggga acggcccacg
      481 gccgcggtaa cagggcttcg tcttctttgc agagccatgg gcagcaggaa gaaggaaatt
      541 gccctgcagg tcaacatcag cacccaagag ctttgggagg aaatgctcag ttccaaagga
      601 ctaactgttg ttgatgtcta tcaaggctgg tgtggcccct gcaaacctgt ggtgagcctc
      661 ttccagaaga tgaggatcga ggtcggcctg gaccttctgc actttgcatt agcagaggca
      721 gatcgtcttg atgtcctcga aaagtacaga gggaagtgcg agccaacctt tctgttttat
      781 gcaggaggag aactggtggc tgtggttaga ggagcaaatg ccccactgct gcagaaaacc
      841 atcctagacc agctggaggc cgaaaagaaa gtgctggctg aaggcagaga acggaaagtg
      901 attaaagatg aggctctttc tgatgaagat gaatgtgttt cccatggaaa gaataatggt
      961 gaagatgagg acatggtttc atcagagagg acctgtacct tggccatcat taaaccagat
     1021 gcagtggccc atggaaagac tgatgagatt atcatgaaga ttcaggaagc tgggtttgaa
     1081 attctaacaa atgaagagag aaccatgaca gaggcagaag tgcgactttt ctaccaacac
     1141 aaagctggag aggaggcatt tgagaagctg gtacatcaca tgtgcagtgg accaagccac
     1201 ctcctgatcc tcaccaggac tgagggcttc gaggacgtgg tcactacctg gcgaaccgtc
     1261 atgggccccc gtgaccccaa tgtggccagg agggagcagc cagaaagtct ccgagctcag
     1321 tacggcacag aaatgccctt caatgccgtc catggaagcc gggacagaga agatgctgac
     1381 agagaactgg cattgctctt ccccagtttg aaattttcag acaaagatac agaagcccct
     1441 cagggcggtg aggctgaagc aacagcgggg cccactgagg cgctttgctt tcctgaggat
     1501 gtggattgag atggctgtgc tgctcttcca gagcacgtga ccaggggtct actgcacaaa
     1561 acagacctcc ggaatcggaa cttactcttt tgagtaccaa tactttttgg tttagctgtc
     1621 ttttgtagac aatgaaaata atatggctgg gcgcagtgac tcacacctgt aatcccagca
     1681 ctttgggagg ccgaggcagg tggatcacct gagattagga gtttgacacc agcctagcca
     1741 acatggtgaa accctgtctc tactaaaaat acaaaaaatt agccgggcgt ggtggtgtgc
     1801 acctgtcatc cagctactcg ggtggcttag gcatgagaat cgcttgaacc cgggaggtga
     1861 aggttgcagt aagccgagat catgccactg cactccagcc tgggtgacag agtgagactc
     1921 catcttaata ataataataa aaaaaaaagt aaagaaagag aatagtatat acttttctgc
     1981 cttattaaac agtatgtaga acgcagtttt ttttctctgt ctttgggatt ttacaaaata
     2041 attgaacatc agttattaca tcctgttgtg agatataagt gtcatctcag aggatactgg
     2101 gttatatgag atggtgtttc cccaacaata aatctacctt atgaattaaa
//
