LOCUS       NM_013330               1472 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens NME/NM23 family member 7 (NME7), transcript variant 1,
            mRNA.
ACCESSION   NM_013330
VERSION     NM_013330.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1472)
  AUTHORS   Andersen,J.S., Vijayakumaran,A., Godbehere,C., Lorentzen,E.,
            Mennella,V. and Schou,K.B.
  TITLE     Uncovering structural themes across cilia microtubule inner
            proteins with implications for human cilia function
  JOURNAL   Nat Commun 15 (1), 2687 (2024)
   PUBMED   38538594
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1472)
  AUTHORS   Walton,T., Gui,M., Velkova,S., Fassad,M.R., Hirst,R.A., Haarman,E.,
            O'Callaghan,C., Bottier,M., Burgoyne,T., Mitchison,H.M. and
            Brown,A.
  TITLE     Axonemal structures reveal mechanoregulatory and disease mechanisms
  JOURNAL   Nature 618 (7965), 625-633 (2023)
   PUBMED   37258679
REFERENCE   3  (bases 1 to 1472)
  AUTHORS   Gui,M., Croft,J.T., Zabeo,D., Acharya,V., Kollman,J.M.,
            Burgoyne,T., Hoog,J.L. and Brown,A.
  TITLE     SPACA9 is a lumenal protein of human ciliary singlet and doublet
            microtubules
  JOURNAL   Proc Natl Acad Sci U S A 119 (41), e2207605119 (2022)
   PUBMED   36191189
REFERENCE   4  (bases 1 to 1472)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1472)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1472)
  AUTHORS   Liu,P., Choi,Y.K. and Qi,R.Z.
  TITLE     NME7 is a functional component of the gamma-tubulin ring complex
  JOURNAL   Mol Biol Cell 25 (13), 2017-2025 (2014)
   PUBMED   24807905
  REMARK    GeneRIF: NME7 functions in the gamma-tubulin ring complex in a
            kinase-dependent manner to facilitate microtubule nucleation.
REFERENCE   7  (bases 1 to 1472)
  AUTHORS   Hippe,H.J., Luedde,M., Lutz,S., Koehler,H., Eschenhagen,T.,
            Frey,N., Katus,H.A., Wieland,T. and Niroomand,F.
  TITLE     Regulation of cardiac cAMP synthesis and contractility by
            nucleoside diphosphate kinase B/G protein beta gamma dimer
            complexes
  JOURNAL   Circ Res 100 (8), 1191-1199 (2007)
   PUBMED   17363702
  REMARK    GeneRIF: Compared with wild-type betagamma nucleoside diphosphate
            kinase overexpression of Gbeta nucleoside diphosphate kinase
            suppressed basal cAMP formation up to 55%.
REFERENCE   8  (bases 1 to 1472)
  AUTHORS   Yoon,J.H., Singh,P., Lee,D.H., Qiu,J., Cai,S., O'Connor,T.R.,
            Chen,Y., Shen,B. and Pfeifer,G.P.
  TITLE     Characterization of the 3' --> 5' exonuclease activity found in
            human nucleoside diphosphate kinase 1 (NDK1) and several of its
            homologues
  JOURNAL   Biochemistry 44 (48), 15774-15786 (2005)
   PUBMED   16313181
REFERENCE   9  (bases 1 to 1472)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
REFERENCE   10 (bases 1 to 1472)
  AUTHORS   Lacombe,M.L., Milon,L., Munier,A., Mehus,J.G. and Lambeth,D.O.
  TITLE     The human Nm23/nucleoside diphosphate kinases
  JOURNAL   J Bioenerg Biomembr 32 (3), 247-258 (2000)
   PUBMED   11768308
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF153191.2 and BG204249.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_013330.4.
            
            Summary: This gene encodes a member of the non-metastatic expressed
            family of nucleoside diphosphate kinases. Members of this family
            are enzymes that catalyzes phosphate transfer from nucleoside
            triphosphates to nucleoside diphosphates. This protein contains two
            kinase domains, one of which is involved in autophosphorylation and
            the other may be inactive. This protein localizes to the centrosome
            and functions as a component of the gamma-tubulin ring complex
            which plays a role in microtubule organization. Mutations in this
            gene may be associated with venous thromboembolism. Alternate
            splicing results in multiple transcript variants. [provided by
            RefSeq, Sep 2016].
            
            Transcript Variant: This variant (1) encodes the longer protein
            (isoform a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.141389.1,
                                           SRR1660803.17262.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367811.8/ ENSP00000356785.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1469              AF153191.2         6-1474
            1470-1472           BG204249.1         19-21               c
FEATURES             Location/Qualifiers
     source          1..1472
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q24.2"
     gene            1..1472
                     /gene="NME7"
                     /gene_synonym="CFAP67; MN23H7; NDK 7; NDK7; nm23-H7"
                     /note="NME/NM23 family member 7"
                     /db_xref="GeneID:29922"
                     /db_xref="HGNC:HGNC:20461"
                     /db_xref="MIM:613465"
     exon            1..90
                     /gene="NME7"
                     /gene_synonym="CFAP67; MN23H7; NDK 7; NDK7; nm23-H7"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1218
                     /gene="NME7"
                     /gene_synonym="CFAP67; MN23H7; NDK 7; NDK7; nm23-H7"
                     /EC_number="2.7.4.6"
                     /note="isoform a is encoded by transcript variant 1; NDP
                     kinase 7; non-metastatic cells 7, protein expressed in
                     (nucleoside-diphosphate kinase); cilia and flagella
                     associated protein 67; protein kinase NME7; NDP kinase
                     homolog 7; 3'-5' exonuclease NME7; nucleoside diphosphate
                     kinase homolog 7"
                     /codon_start=1
                     /product="nucleoside diphosphate kinase homolog 7 isoform
                     a"
                     /protein_id="NP_037462.1"
                     /db_xref="CCDS:CCDS1277.1"
                     /db_xref="GeneID:29922"
                     /db_xref="HGNC:HGNC:20461"
                     /db_xref="MIM:613465"
                     /translation="MNHSERFVFIAEWYDPNASLLRRYELLFYPGDGSVEMHDVKNHR
                     TFLKRTKYDNLHLEDLFIGNKVNVFSRQLVLIDYGDQYTARQLGSRKEKTLALIKPDA
                     ISKAGEIIEIINKAGFTITKLKMMMLSRKEALDFHVDHQSRPFFNELIQFITTGPIIA
                     MEILRDDAICEWKRLLGPANSGVARTDASESIRALFGTDGIRNAAHGPDSFASAAREM
                     ELFFPSSGGCGPANTAKFTNCTCCIVKPHAVSEGLLGKILMAIRDAGFEISAMQMFNM
                     DRVNVEEFYEVYKGVVTEYHDMVTEMYSGPCVAMEIQQNNATKTFREFCGPADPEIAR
                     HLRPGTLRAIFGKTKIQNAVHCTDLPEDGLLEVQYFFKILDN"
     exon            91..198
                     /gene="NME7"
                     /gene_synonym="CFAP67; MN23H7; NDK 7; NDK7; nm23-H7"
                     /inference="alignment:Splign:2.1.0"
     exon            199..365
                     /gene="NME7"
                     /gene_synonym="CFAP67; MN23H7; NDK 7; NDK7; nm23-H7"
                     /inference="alignment:Splign:2.1.0"
     exon            366..476
                     /gene="NME7"
                     /gene_synonym="CFAP67; MN23H7; NDK 7; NDK7; nm23-H7"
                     /inference="alignment:Splign:2.1.0"
     exon            477..527
                     /gene="NME7"
                     /gene_synonym="CFAP67; MN23H7; NDK 7; NDK7; nm23-H7"
                     /inference="alignment:Splign:2.1.0"
     exon            528..735
                     /gene="NME7"
                     /gene_synonym="CFAP67; MN23H7; NDK 7; NDK7; nm23-H7"
                     /inference="alignment:Splign:2.1.0"
     exon            736..841
                     /gene="NME7"
                     /gene_synonym="CFAP67; MN23H7; NDK 7; NDK7; nm23-H7"
                     /inference="alignment:Splign:2.1.0"
     exon            842..906
                     /gene="NME7"
                     /gene_synonym="CFAP67; MN23H7; NDK 7; NDK7; nm23-H7"
                     /inference="alignment:Splign:2.1.0"
     exon            907..975
                     /gene="NME7"
                     /gene_synonym="CFAP67; MN23H7; NDK 7; NDK7; nm23-H7"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1077
                     /gene="NME7"
                     /gene_synonym="CFAP67; MN23H7; NDK 7; NDK7; nm23-H7"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1185
                     /gene="NME7"
                     /gene_synonym="CFAP67; MN23H7; NDK 7; NDK7; nm23-H7"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1472
                     /gene="NME7"
                     /gene_synonym="CFAP67; MN23H7; NDK 7; NDK7; nm23-H7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1450..1455
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NME7"
                     /gene_synonym="CFAP67; MN23H7; NDK 7; NDK7; nm23-H7"
                     /note="hexamer: AATAAA"
     polyA_site      1472
                     /gene="NME7"
                     /gene_synonym="CFAP67; MN23H7; NDK 7; NDK7; nm23-H7"
                     /note="major polyA site"
ORIGIN      
        1 gttgcctgag taaccgtatg atggtggtgg tggtggtgtc ttcctgtctc aacgatacct
       61 attttctagt gctgagatcc tgagacaatg aatcatagtg aaagattcgt tttcattgca
      121 gagtggtatg atccaaatgc ttcacttctt cgacgttatg agcttttatt ttacccaggg
      181 gatggatctg ttgaaatgca tgatgtaaag aatcatcgca cctttttaaa gcggaccaaa
      241 tatgataacc tgcacttgga agatttattt ataggcaaca aagtgaatgt cttttctcga
      301 caactggtat taattgacta tggggatcaa tatacagctc gccagctggg cagtaggaaa
      361 gaaaaaacgc tagccctaat taaaccagat gcaatatcaa aggctggaga aataattgaa
      421 ataataaaca aagctggatt tactataacc aaactcaaaa tgatgatgct ttcaaggaaa
      481 gaagcattgg attttcatgt agatcaccag tcaagaccct ttttcaatga gctgatccag
      541 tttattacaa ctggtcctat tattgccatg gagattttaa gagatgatgc tatatgtgaa
      601 tggaaaagac tgctgggacc tgcaaactct ggagtggcac gcacagatgc ttctgaaagc
      661 attagagccc tctttggaac agatggcata agaaatgcag cgcatggccc tgattctttt
      721 gcttctgcgg ccagagaaat ggagttgttt tttccttcaa gtggaggttg tgggccggca
      781 aacactgcta aatttactaa ttgtacctgt tgcattgtta aaccccatgc tgtcagtgaa
      841 ggactgttgg gaaagatcct gatggctatc cgagatgcag gttttgaaat ctcagctatg
      901 cagatgttca atatggatcg ggttaatgtt gaggaattct atgaagttta taaaggagta
      961 gtgaccgaat atcatgacat ggtgacagaa atgtattctg gcccttgtgt agcaatggag
     1021 attcaacaga ataatgctac aaagacattt cgagaatttt gtggacctgc tgatcctgaa
     1081 attgcccggc atttacgccc tggaactctc agagcaatct ttggtaaaac taagatccag
     1141 aatgctgttc actgtactga tctgccagag gatggcctat tagaggttca atacttcttc
     1201 aagatcttgg ataattagtg gtgtggaaag taaagaagtc acaggttggg acatttagac
     1261 aagagtgaat cacacacgag gaatgtgttc attcttttat tgtccgttgt tttaacctga
     1321 ctgaatacaa gatcaacaag agcactgtac tcctggcaat tattacatat gttagaacat
     1381 ggattttgca ctgtagacaa catttaacac cagtctatgg ggtactgcat tgctttttat
     1441 aaagttcaaa ataaagattt attttcaaac aa
//
