LOCUS       NM_001308426            2903 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens NME/NM23 nucleoside diphosphate kinase 6 (NME6),
            transcript variant 2, mRNA.
ACCESSION   NM_001308426
VERSION     NM_001308426.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2903)
  AUTHORS   Proust,B., Horvat,A., Tadijan,A., Vlasic,I. and Herak Bosnar,M.
  TITLE     Mitochondrial NME6 Influences Basic Cellular Processes in Tumor
            Cells In Vitro
  JOURNAL   Int J Mol Sci 25 (17), 9580 (2024)
   PUBMED   39273527
  REMARK    GeneRIF: Mitochondrial NME6 Influences Basic Cellular Processes in
            Tumor Cells In Vitro.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2903)
  AUTHORS   Kramer,N.J., Prakash,G., Isaac,R.S., Choquet,K., Soto,I.,
            Petrova,B., Merens,H.E., Kanarek,N. and Churchman,L.S.
  TITLE     Regulators of mitonuclear balance link mitochondrial metabolism to
            mtDNA expression
  JOURNAL   Nat Cell Biol 25 (11), 1575-1589 (2023)
   PUBMED   37770567
REFERENCE   3  (bases 1 to 2903)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 2903)
  AUTHORS   Proust,B., Radic,M., Vidacek,N.S., Cottet,C., Attia,S.,
            Lamarche,F., Ackar,L., Mikulcic,V.G., Tokarska-Schlattner,M.,
            Cetkovic,H., Schlattner,U. and Bosnar,M.H.
  TITLE     NME6 is a phosphotransfer-inactive, monomeric NME/NDPK family
            member and functions in complexes at the interface of mitochondrial
            inner membrane and matrix
  JOURNAL   Cell Biosci 11 (1), 195 (2021)
   PUBMED   34789336
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2903)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 2903)
  AUTHORS   Wang,J., Huo,K., Ma,L., Tang,L., Li,D., Huang,X., Yuan,Y., Li,C.,
            Wang,W., Guan,W., Chen,H., Jin,C., Wei,J., Zhang,W., Yang,Y.,
            Liu,Q., Zhou,Y., Zhang,C., Wu,Z., Xu,W., Zhang,Y., Liu,T., Yu,D.,
            Zhang,Y., Chen,L., Zhu,D., Zhong,X., Kang,L., Gan,X., Yu,X., Ma,Q.,
            Yan,J., Zhou,L., Liu,Z., Zhu,Y., Zhou,T., He,F. and Yang,X.
  TITLE     Toward an understanding of the protein interaction network of the
            human liver
  JOURNAL   Mol Syst Biol 7, 536 (2011)
   PUBMED   21988832
  REMARK    Erratum:[Mol Syst Biol. 2017 Dec 18;13(12):965. doi:
            10.15252/msb.20178107.. PMID: 29254952]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2903)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2903)
  AUTHORS   Desvignes,T., Pontarotti,P., Fauvel,C. and Bobe,J.
  TITLE     Nme protein family evolutionary history, a vertebrate perspective
  JOURNAL   BMC Evol Biol 9, 256 (2009)
   PUBMED   19852809
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2903)
  AUTHORS   Tsuiki,H., Nitta,M., Furuya,A., Hanai,N., Fujiwara,T., Inagaki,M.,
            Kochi,M., Ushio,Y., Saya,H. and Nakamura,H.
  TITLE     A novel human nucleoside diphosphate (NDP) kinase, Nm23-H6,
            localizes in mitochondria and affects cytokinesis
  JOURNAL   J Cell Biochem 76 (2), 254-269 (1999)
   PUBMED   10618642
REFERENCE   10 (bases 1 to 2903)
  AUTHORS   Mehus,J.G., Deloukas,P. and Lambeth,D.O.
  TITLE     NME6: a new member of the nm23/nucleoside diphosphate kinase gene
            family located on human chromosome 3p21.3
  JOURNAL   Hum Genet 104 (6), 454-459 (1999)
   PUBMED   10453732
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC105267.3.
            
            On Aug 13, 2020 this sequence version replaced NM_001308426.1.
            
            Summary: Nucleoside diphosphate (NDP) kinases (EC 2.7.4.6), such as
            NME6, are ubiquitous enzymes that catalyze transfer of
            gamma-phosphates, via a phosphohistidine intermediate, between
            nucleoside and dioxynucleoside tri- and diphosphates (Mehus et al.,
            1999 [PubMed 10453732]).[supplied by OMIM, Jul 2010].
            
            Transcript Variant: This variant (2) contains a distinct 5' UTR,
            uses an alternate splice site in the 5' terminal exon, and
            initiates translation at a downstream AUG, compared to variant 1.
            The resulting isoform (2) has a shorter N-terminus, compared to
            isoform 1. Variants 2, 3 and 4 encode the same isoform (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK222555.1, SRR14478891.1459133.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000442597.6/ ENSP00000406642.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC105267.3         101539-101553       c
            16-112              AC105267.3         98613-98709         c
            113-215             AC105267.3         96913-97015         c
            216-255             AC105267.3         96305-96344         c
            256-416             AC105267.3         95261-95421         c
            417-2903            AC105267.3         92503-94989         c
FEATURES             Location/Qualifiers
     source          1..2903
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..2903
                     /gene="NME6"
                     /gene_synonym="IPIA-ALPHA; NDK 6; NM23-H6"
                     /note="NME/NM23 nucleoside diphosphate kinase 6"
                     /db_xref="GeneID:10201"
                     /db_xref="HGNC:HGNC:20567"
                     /db_xref="MIM:608294"
     exon            1..15
                     /gene="NME6"
                     /gene_synonym="IPIA-ALPHA; NDK 6; NM23-H6"
                     /inference="alignment:Splign:2.1.0"
     exon            16..112
                     /gene="NME6"
                     /gene_synonym="IPIA-ALPHA; NDK 6; NM23-H6"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..583
                     /gene="NME6"
                     /gene_synonym="IPIA-ALPHA; NDK 6; NM23-H6"
                     /EC_number="2.7.4.6"
                     /note="isoform 2 is encoded by transcript variant 2;
                     nucleoside diphosphate kinase 6; inhibitor of p53-induced
                     apoptosis-alpha; NDP kinase 6; non-metastatic cells 6,
                     protein expressed in (nucleoside-diphosphate kinase)"
                     /codon_start=1
                     /product="nucleoside diphosphate kinase 6 isoform 2"
                     /protein_id="NP_001295355.1"
                     /db_xref="CCDS:CCDS77734.1"
                     /db_xref="GeneID:10201"
                     /db_xref="HGNC:HGNC:20567"
                     /db_xref="MIM:608294"
                     /translation="MASILRSPQALQLTLALIKPDAVAHPLILEAVHQQILSNKFLIV
                     RMRELLWRKEDCQRFYREHEGRFFYQRLVEFMASGPIRAYILAHKDAIQLWRTLMGPT
                     RVFRARHVAPDSIRGSFGLTDTRNTTHGSDSVVSASREIAAFFPDFSEQRWYEEEEPQ
                     LRCGPVCYSPEGGVHYVAGTGGLGPA"
     exon            113..215
                     /gene="NME6"
                     /gene_synonym="IPIA-ALPHA; NDK 6; NM23-H6"
                     /inference="alignment:Splign:2.1.0"
     exon            216..255
                     /gene="NME6"
                     /gene_synonym="IPIA-ALPHA; NDK 6; NM23-H6"
                     /inference="alignment:Splign:2.1.0"
     exon            256..416
                     /gene="NME6"
                     /gene_synonym="IPIA-ALPHA; NDK 6; NM23-H6"
                     /inference="alignment:Splign:2.1.0"
     exon            417..2903
                     /gene="NME6"
                     /gene_synonym="IPIA-ALPHA; NDK 6; NM23-H6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1202..1207
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NME6"
                     /gene_synonym="IPIA-ALPHA; NDK 6; NM23-H6"
                     /note="hexamer: AATAAA"
     polyA_site      1225
                     /gene="NME6"
                     /gene_synonym="IPIA-ALPHA; NDK 6; NM23-H6"
                     /note="major polyA site"
     regulatory      2878..2883
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NME6"
                     /gene_synonym="IPIA-ALPHA; NDK 6; NM23-H6"
                     /note="hexamer: AATAAA"
     polyA_site      2903
                     /gene="NME6"
                     /gene_synonym="IPIA-ALPHA; NDK 6; NM23-H6"
ORIGIN      
        1 gtgccggagg acaaggagtg agatggcctc aatcttgcga agccctcagg ctctccagct
       61 cactctagcc ctgatcaagc ctgacgcagt cgcccatcca ctgattctgg aggctgttca
      121 tcagcagatt ctaagcaaca agttcctgat tgtacgaatg agagaactac tgtggagaaa
      181 ggaagattgc cagaggtttt accgagagca tgaagggcgt tttttctatc agaggctggt
      241 ggagttcatg gccagcgggc caatccgagc ctacatcctt gcccacaagg atgccatcca
      301 gctctggagg acgctcatgg gacccaccag agtgttccga gcacgccatg tggccccaga
      361 ttctatccgt gggagtttcg gcctcactga cacccgcaac accacccatg gttcggactc
      421 tgtggtttca gccagcagag agattgcagc cttcttccct gacttcagtg aacagcgctg
      481 gtatgaggag gaagagcccc agttgcgctg tggccctgtg tgctatagcc cagagggagg
      541 tgtccactat gtagctggaa caggaggcct aggaccagcc tgatgcaggt ctatgaagac
      601 cagtggtagt gcccagactt ctcctagaca tctagtctaa aacattctcc taggaccagg
      661 gaagcctggc ttacagtgcc atttctgctg ggcaccacca cctgcctgag ggcctagctc
      721 accacagcac atcctccagg atctagcctt ctatctacct cttctctgga atgtttatgg
      781 tggttcagaa gaatgatgac tcctctttgc tgagaactgt tcatccttct tcaagaagaa
      841 gcttgccagg ccgggcacgg tggctcacgc ctataatccc agcactttgg gaggccgagg
      901 caggcggatc acaaggtcag gaattcgaga ccagcctgac caacatggtg aaaccccatc
      961 tctactaaaa atacaacaat tagccaggca tggtggtgca tgcctgtaat cccagctact
     1021 cagaggctga ggcaggagaa ttgcttgaac ctgggaggca gagggtgcag tgagccgaga
     1081 tcgtgccatt gcactccagc ctgggcgaca ttctgtctca aaaaaaaaaa aaaagaagct
     1141 tgtctaattg acttgcctaa aaaatgcagt gactccaaac aacatttgac ctgtcttcct
     1201 caataaaagt cagtgttctc ctgaatcctt tatgctgcca catttagggg aaacttttca
     1261 ggcttcatca ttctgacttc tcagcagcat tcagttattg cttcattctc cagaaacact
     1321 ctcttctctt ggattttctg atcccacacc cttggttttc tccttctgtg tgtttttctt
     1381 catctccttt atcagcttat gcaaacattt attttcataa attctctatt caagacatac
     1441 tgaaaaatgc aaagatggtt aagacatgat tgggtcctca agttgctaat tatgaatttg
     1501 ggtggtcagc cagctataac gtggcagaga tggagaagtg ccctaacaga ggtataaagt
     1561 cctgtgggag aacagaggaa agaaggtttc ctttggctgg gtgaggaggt gaaggagata
     1621 gggtggaaag tcttttataa aagatatagc tggctttgga actaagcctg aaggtcaaat
     1681 agggtatcca tagcaggggt ctggggcact agacagtctg ttcattttca ggaatatatg
     1741 ggtcagtttt gtatgtgtga cctaagaaac ctgtgacact tcttacaggt cttgactttt
     1801 ctttctcagt acatgtgtat ttctcttttt ggtggccttg aaacctttga gttgaaaatt
     1861 gccttcacca tctgccactt tcactaatgg tagaccagga aatttggacc cactgaacat
     1921 agagaacaac tagaaaagct gtgcaaaata taaacagcat ctatctgaaa gcatcagctg
     1981 gcaatataga accaaaattc aggacacgaa ggaaactcaa gagaagtgag cctgggactt
     2041 agagctactt ttcccataag ggcacctgct gattctggaa gaggcagcta agaagctgag
     2101 tagaactttc aacaacttct tgtgttaggg agccagcttc atgaatgctg gcagaaaaca
     2161 caggattact tgggcagaga ctactgctca gggcacagca ggcagtgtgt tagccttggt
     2221 ctcccttgcc ctccaagtcc cacagggcaa tactggcagg cccaggaaag tgttacacac
     2281 tgcaggtttg catgacggct aaggaaccac aatcttaggg agatactatc tctgtcttct
     2341 aaggccattt gctgtacaaa aatccttgaa atacctgggc acagtggcac acctataatc
     2401 ctagcacttt gggaggctga ggcaggcgga tcacctgagg ttgggagttc cagaccagcc
     2461 tgaccaacat ggagaaatcc cgtctctact aaaaatacaa aaattagcca agcgtggtgg
     2521 cgcgagcctg taatccagct actcgggagg ctgaggcagg agaatcgctt gaacccagga
     2581 ggcggaggtt gtggtgagcc aagatcacgc cgttgcactc cagcctgggc aacaagagtg
     2641 aaactccatc tcaagaaaaa aaaaatcctt gaaatagtct ggaacaaaat ctgtcaacat
     2701 ctcagcccac aaagtatcaa caaaattgat attttgttgc atttaaaaaa tttaaatggt
     2761 ggtcaaagcg tacaaaatct gacaattaag acacccacaa gagacacaga attatctccc
     2821 aataaaattg tctcataaaa acctggctcc cacaaatatg gaaagggaga aaactagaat
     2881 aaaccctgtg gtgtcgaatt gga
//
