LOCUS       NM_003551               1208 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens NME/NM23 family member 5 (NME5), mRNA.
ACCESSION   NM_003551
VERSION     NM_003551.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1208)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1208)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1208)
  AUTHORS   Cho,E.H., Huh,H.J., Jeong,I., Lee,N.Y., Koh,W.J., Park,H.C. and
            Ki,C.S.
  TITLE     A nonsense variant in NME5 causes human primary ciliary dyskinesia
            with radial spoke defects
  JOURNAL   Clin Genet 98 (1), 64-68 (2020)
   PUBMED   32185794
  REMARK    GeneRIF: A nonsense variant in NME5 causes human primary ciliary
            dyskinesia with radial spoke defects.
REFERENCE   4  (bases 1 to 1208)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1208)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1208)
  AUTHORS   Desvignes,T., Pontarotti,P., Fauvel,C. and Bobe,J.
  TITLE     Nme protein family evolutionary history, a vertebrate perspective
  JOURNAL   BMC Evol Biol 9, 256 (2009)
   PUBMED   19852809
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1208)
  AUTHORS   Xin,X., Rual,J.F., Hirozane-Kishikawa,T., Hill,D.E., Vidal,M.,
            Boone,C. and Thierry-Mieg,N.
  TITLE     Shifted Transversal Design smart-pooling for high coverage
            interactome mapping
  JOURNAL   Genome Res 19 (7), 1262-1269 (2009)
   PUBMED   19447967
REFERENCE   8  (bases 1 to 1208)
  AUTHORS   Yoon,J.H., Singh,P., Lee,D.H., Qiu,J., Cai,S., O'Connor,T.R.,
            Chen,Y., Shen,B. and Pfeifer,G.P.
  TITLE     Characterization of the 3' --> 5' exonuclease activity found in
            human nucleoside diphosphate kinase 1 (NDK1) and several of its
            homologues
  JOURNAL   Biochemistry 44 (48), 15774-15786 (2005)
   PUBMED   16313181
REFERENCE   9  (bases 1 to 1208)
  AUTHORS   Munier,A., Serres,C., Kann,M.L., Boissan,M., Lesaffre,C.,
            Capeau,J., Fouquet,J.P. and Lacombe,M.L.
  TITLE     Nm23/NDP kinases in human male germ cells: role in spermiogenesis
            and sperm motility?
  JOURNAL   Exp Cell Res 289 (2), 295-306 (2003)
   PUBMED   14499630
  REMARK    GeneRIF: found that Nm23-H5 and NDP kinases A and B are differently
            distributed in spermatids and mature spermatozoa and could
            therefore be involved at various levels of sperm differentiation
            and function
REFERENCE   10 (bases 1 to 1208)
  AUTHORS   Munier,A., Feral,C., Milon,L., Pinon,V.P., Gyapay,G., Capeau,J.,
            Guellaen,G. and Lacombe,M.L.
  TITLE     A new human nm23 homologue (nm23-H5) specifically expressed in
            testis germinal cells
  JOURNAL   FEBS Lett 434 (3), 289-294 (1998)
   PUBMED   9742940
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX490554.1, BC026182.2, AF067724.1 and BM979998.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003551.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.94630.1,
                                           SRR5189667.238363.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265191.4/ ENSP00000265191.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                BX490554.1         17-29
            14-827              BC026182.2         1-814
            828-1206            AF067724.1         813-1191
            1207-1208           BM979998.1         21-22               c
FEATURES             Location/Qualifiers
     source          1..1208
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.2"
     gene            1..1208
                     /gene="NME5"
                     /gene_synonym="CILD48; NM23-H5; NM23H5; RSPH23"
                     /note="NME/NM23 family member 5"
                     /db_xref="GeneID:8382"
                     /db_xref="HGNC:HGNC:7853"
                     /db_xref="MIM:603575"
     exon            1..58
                     /gene="NME5"
                     /gene_synonym="CILD48; NM23-H5; NM23H5; RSPH23"
                     /inference="alignment:Splign:2.1.0"
     exon            59..192
                     /gene="NME5"
                     /gene_synonym="CILD48; NM23-H5; NM23H5; RSPH23"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..702
                     /gene="NME5"
                     /gene_synonym="CILD48; NM23-H5; NM23H5; RSPH23"
                     /EC_number="2.7.4.6"
                     /note="radial spoke 23 homolog; NDK-H 5; IPIA-beta; NDP
                     kinase homolog 5; testis-specific nm23 homolog; inhibitor
                     of p53-induced apoptosis-beta; non-metastatic cells 5,
                     protein expressed in (nucleoside-diphosphate kinase);
                     non-metastatic cells 5 protein expressed in; 3'-5'
                     exonuclease NME5"
                     /codon_start=1
                     /product="nucleoside diphosphate kinase homolog 5"
                     /protein_id="NP_003542.1"
                     /db_xref="CCDS:CCDS4197.1"
                     /db_xref="GeneID:8382"
                     /db_xref="HGNC:HGNC:7853"
                     /db_xref="MIM:603575"
                     /translation="MEISMPPPQIYVEKTLAIIKPDIVDKEEEIQDIILRSGFTIVQR
                     RKLRLSPEQCSNFYVEKYGKMFFPNLTAYMSSGPLVAMILARHKAISYWLELLGPNNS
                     LVAKETHPDSLRAIYGTDDLRNALHGSNDFAAAEREIRFMFPEVIVEPIPIGQAAKDY
                     LNLHIMPTLLEGLTELCKQKPADPLIWLADWLLKNNPNKPKLCHHPIVEEPY"
     exon            193..398
                     /gene="NME5"
                     /gene_synonym="CILD48; NM23-H5; NM23H5; RSPH23"
                     /inference="alignment:Splign:2.1.0"
     exon            399..499
                     /gene="NME5"
                     /gene_synonym="CILD48; NM23-H5; NM23H5; RSPH23"
                     /inference="alignment:Splign:2.1.0"
     exon            500..618
                     /gene="NME5"
                     /gene_synonym="CILD48; NM23-H5; NM23H5; RSPH23"
                     /inference="alignment:Splign:2.1.0"
     exon            619..1208
                     /gene="NME5"
                     /gene_synonym="CILD48; NM23-H5; NM23H5; RSPH23"
                     /inference="alignment:Splign:2.1.0"
     regulatory      807..812
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NME5"
                     /gene_synonym="CILD48; NM23-H5; NM23H5; RSPH23"
                     /note="hexamer: AATAAA"
     polyA_site      830
                     /gene="NME5"
                     /gene_synonym="CILD48; NM23-H5; NM23H5; RSPH23"
                     /note="major polyA site"
     regulatory      1187..1192
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NME5"
                     /gene_synonym="CILD48; NM23-H5; NM23H5; RSPH23"
                     /note="hexamer: AATAAA"
     polyA_site      1208
                     /gene="NME5"
                     /gene_synonym="CILD48; NM23-H5; NM23H5; RSPH23"
ORIGIN      
        1 acgctggggc ttcaggtctc ctagcaacaa gttgtaccat atgaggacgg ccgctgagcc
       61 ataatggaga tatcaatgcc tccacctcag atatatgtag aaaaaactct ggccattatc
      121 aaaccagata ttgttgacaa agaggaggag atacaagata ttattcttag atccggattc
      181 accattgttc agagaagaaa actacgcctc agccctgagc aatgtagtaa cttttatgtg
      241 gaaaagtatg gaaaaatgtt tttccccaac ttaacagctt acatgagttc tggaccactt
      301 gtcgccatga tattagctag acataaagcc atctcttatt ggttagaact tttgggacca
      361 aataatagct tagtagcgaa ggagacacat ccagacagtc tgagggcaat ttatggcaca
      421 gatgacctaa ggaatgcact tcatgggagt aatgactttg ctgctgcgga aagagaaata
      481 cgttttatgt ttcctgaagt gattgttgag cccattccaa ttggacaagc tgctaaggac
      541 tatttaaatt tacatataat gccaactctg cttgaaggac tcacagagct ttgtaagcaa
      601 aaaccagcag atcctttgat ttggctagct gattggctgc tgaaaaataa tcctaacaaa
      661 cccaaacttt gtcaccatcc aattgtagaa gaaccttatt aaaaaaaaaa tcctcgaaag
      721 aacaaatcat gaactatctt attataaaag gctgtacttc tactgtttga aaaaattatt
      781 tctagggttt aagtaactac aagtaaaata aatttatttc ttaaaaataa gtgttaaagg
      841 aataactatt ctatgaagca gataacatta aggtaaaata taggcttaga gtatgatttt
      901 aacaatgatg taacactagg taatggaaaa ctcatgtaag atgttgctag atgtttttgt
      961 ttttcttaag tttgagaagt aagacataaa gtttagttat acattttccc aagcacatat
     1021 cctatatcta aatacataat taatgcacag ttgagacagt ctagtttaaa aggcttaggt
     1081 ccttttgtag tccataagca tggtgatttg gtttcatgct catgtgtcag atatgcttcc
     1141 ctcaaacctt gttacagcat catcacatta cctgtttgat gtaaaaaata aaaaatagaa
     1201 aggtgtaa
//
