LOCUS       NM_005009               1000 bp    mRNA    linear   PRI 13-DEC-2024
DEFINITION  Homo sapiens NME/NM23 nucleoside diphosphate kinase 4 (NME4),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_005009
VERSION     NM_005009.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1000)
  AUTHORS   Zheng,S., He,S., Liang,Y., Liu,Q., Liu,T., Tan,Y., Peng,T.,
            Huang,C., Gao,H. and Lu,X.
  TITLE     NME4 suppresses NFkappaB2-CCL5 axis, restricting CD8+ T cell tumour
            infiltration in oesophageal squamous cell carcinoma
  JOURNAL   Immunology 173 (2), 408-421 (2024)
   PUBMED   39016535
  REMARK    GeneRIF: NME4 suppresses NFkappaB2-CCL5 axis, restricting CD8+ T
            cell tumour infiltration in oesophageal squamous cell carcinoma.
REFERENCE   2  (bases 1 to 1000)
  AUTHORS   Yu,J.H., Jung,Y.J., Kim,M.S., Cho,S.R. and Kim,Y.H.
  TITLE     Differential Expression of NME4 in Trophoblast Stem-Like Cells and
            Peripheral Blood Mononuclear Cells of Normal Pregnancy and
            Preeclampsia
  JOURNAL   J Korean Med Sci 38 (16), e128 (2023)
   PUBMED   37096311
  REMARK    GeneRIF: Differential Expression of NME4 in Trophoblast Stem-Like
            Cells and Peripheral Blood Mononuclear Cells of Normal Pregnancy
            and Preeclampsia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1000)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 1000)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1000)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 1000)
  AUTHORS   Martin,J., Han,C., Gordon,L.A., Terry,A., Prabhakar,S., She,X.,
            Xie,G., Hellsten,U., Chan,Y.M., Altherr,M., Couronne,O., Aerts,A.,
            Bajorek,E., Black,S., Blumer,H., Branscomb,E., Brown,N.C.,
            Bruno,W.J., Buckingham,J.M., Callen,D.F., Campbell,C.S.,
            Campbell,M.L., Campbell,E.W., Caoile,C., Challacombe,J.F.,
            Chasteen,L.A., Chertkov,O., Chi,H.C., Christensen,M., Clark,L.M.,
            Cohn,J.D., Denys,M., Detter,J.C., Dickson,M.,
            Dimitrijevic-Bussod,M., Escobar,J., Fawcett,J.J., Flowers,D.,
            Fotopulos,D., Glavina,T., Gomez,M., Gonzales,E., Goodstein,D.,
            Goodwin,L.A., Grady,D.L., Grigoriev,I., Groza,M., Hammon,N.,
            Hawkins,T., Haydu,L., Hildebrand,C.E., Huang,W., Israni,S.,
            Jett,J., Jewett,P.B., Kadner,K., Kimball,H., Kobayashi,A.,
            Krawczyk,M.C., Leyba,T., Longmire,J.L., Lopez,F., Lou,Y., Lowry,S.,
            Ludeman,T., Manohar,C.F., Mark,G.A., McMurray,K.L., Meincke,L.J.,
            Morgan,J., Moyzis,R.K., Mundt,M.O., Munk,A.C., Nandkeshwar,R.D.,
            Pitluck,S., Pollard,M., Predki,P., Parson-Quintana,B., Ramirez,L.,
            Rash,S., Retterer,J., Ricke,D.O., Robinson,D.L., Rodriguez,A.,
            Salamov,A., Saunders,E.H., Scott,D., Shough,T., Stallings,R.L.,
            Stalvey,M., Sutherland,R.D., Tapia,R., Tesmer,J.G., Thayer,N.,
            Thompson,L.S., Tice,H., Torney,D.C., Tran-Gyamfi,M., Tsai,M.,
            Ulanovsky,L.E., Ustaszewska,A., Vo,N., White,P.S., Williams,A.L.,
            Wills,P.L., Wu,J.R., Wu,K., Yang,J., Dejong,P., Bruce,D.,
            Doggett,N.A., Deaven,L., Schmutz,J., Grimwood,J., Richardson,P.,
            Rokhsar,D.S., Eichler,E.E., Gilna,P., Lucas,S.M., Myers,R.M.,
            Rubin,E.M. and Pennacchio,L.A.
  TITLE     The sequence and analysis of duplication-rich human chromosome 16
  JOURNAL   Nature 432 (7020), 988-994 (2004)
   PUBMED   15616553
REFERENCE   7  (bases 1 to 1000)
  AUTHORS   Kowluru,A., Tannous,M. and Chen,H.Q.
  TITLE     Localization and characterization of the mitochondrial isoform of
            the nucleoside diphosphate kinase in the pancreatic beta cell:
            evidence for its complexation with mitochondrial succinyl-CoA
            synthetase
  JOURNAL   Arch Biochem Biophys 398 (2), 160-169 (2002)
   PUBMED   11831846
REFERENCE   8  (bases 1 to 1000)
  AUTHORS   Daniels,R.J., Peden,J.F., Lloyd,C., Horsley,S.W., Clark,K.,
            Tufarelli,C., Kearney,L., Buckle,V.J., Doggett,N.A., Flint,J. and
            Higgs,D.R.
  TITLE     Sequence, structure and pathology of the fully annotated terminal 2
            Mb of the short arm of human chromosome 16
  JOURNAL   Hum Mol Genet 10 (4), 339-352 (2001)
   PUBMED   11157797
REFERENCE   9  (bases 1 to 1000)
  AUTHORS   Milon,L., Meyer,P., Chiadmi,M., Munier,A., Johansson,M.,
            Karlsson,A., Lascu,I., Capeau,J., Janin,J. and Lacombe,M.L.
  TITLE     The human nm23-H4 gene product is a mitochondrial nucleoside
            diphosphate kinase
  JOURNAL   J Biol Chem 275 (19), 14264-14272 (2000)
   PUBMED   10799505
REFERENCE   10 (bases 1 to 1000)
  AUTHORS   Milon,L., Rousseau-Merck,M.F., Munier,A., Erent,M., Lascu,I.,
            Capeau,J. and Lacombe,M.L.
  TITLE     nm23-H4, a new member of the family of human nm23/nucleoside
            diphosphate kinase genes localised on chromosome 16p13
  JOURNAL   Hum Genet 99 (4), 550-557 (1997)
   PUBMED   9099850
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC017067.1 and BC004880.2.
            
            On Nov 23, 2018 this sequence version replaced NM_005009.2.
            
            Summary: The nucleoside diphosphate (NDP) kinases (EC 2.7.4.6) are
            ubiquitous enzymes that catalyze transfer of gamma-phosphates, via
            a phosphohistidine intermediate, between nucleoside and
            dioxynucleoside tri- and diphosphates. The enzymes are products of
            the nm23 gene family, which includes NME4 (Milon et al., 1997
            [PubMed 9099850]).[supplied by OMIM, May 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.534310.1,
                                           SRR1163657.246549.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000219479.7/
                                                  ENSP00000219479.2
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BC017067.1         8-17
            11-1000             BC004880.2         1-990
FEATURES             Location/Qualifiers
     source          1..1000
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..1000
                     /gene="NME4"
                     /gene_synonym="NDK; NDPK-D; NDPKD; nm23-H4; NM23H4"
                     /note="NME/NM23 nucleoside diphosphate kinase 4"
                     /db_xref="GeneID:4833"
                     /db_xref="HGNC:HGNC:7852"
                     /db_xref="MIM:601818"
     exon            1..115
                     /gene="NME4"
                     /gene_synonym="NDK; NDPK-D; NDPKD; nm23-H4; NM23H4"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..588
                     /gene="NME4"
                     /gene_synonym="NDK; NDPK-D; NDPKD; nm23-H4; NM23H4"
                     /EC_number="2.7.4.6"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; NDP kinase D; nucleoside diphosphate kinase,
                     mitochondrial; NDP kinase, mitochondrial; nucleoside
                     diphosphate kinase D; non-metastatic cells 4, protein
                     expressed in"
                     /codon_start=1
                     /product="nucleoside diphosphate kinase, mitochondrial
                     isoform a precursor"
                     /protein_id="NP_005000.1"
                     /db_xref="CCDS:CCDS10408.1"
                     /db_xref="GeneID:4833"
                     /db_xref="HGNC:HGNC:7852"
                     /db_xref="MIM:601818"
                     /translation="MGGLFWRSALRGLRCGPRAPGPSLLVRHGSGGPSWTRERTLVAV
                     KPDGVQRRLVGDVIQRFERRGFTLVGMKMLQAPESVLAEHYQDLRRKPFYPALIRYMS
                     SGPVVAMVWEGYNVVRASRAMIGHTDSAEAAPGTIRGDFSVHISRNVIHASDSVEGAQ
                     REIQLWFQSSELVSWADGGQHSSIHPA"
     exon            116..249
                     /gene="NME4"
                     /gene_synonym="NDK; NDPK-D; NDPKD; nm23-H4; NM23H4"
                     /inference="alignment:Splign:2.1.0"
     exon            250..351
                     /gene="NME4"
                     /gene_synonym="NDK; NDPK-D; NDPKD; nm23-H4; NM23H4"
                     /inference="alignment:Splign:2.1.0"
     exon            352..464
                     /gene="NME4"
                     /gene_synonym="NDK; NDPK-D; NDPKD; nm23-H4; NM23H4"
                     /inference="alignment:Splign:2.1.0"
     exon            465..1000
                     /gene="NME4"
                     /gene_synonym="NDK; NDPK-D; NDPKD; nm23-H4; NM23H4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      872..877
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NME4"
                     /gene_synonym="NDK; NDPK-D; NDPKD; nm23-H4; NM23H4"
                     /note="hexamer: ATTAAA"
     polyA_site      894
                     /gene="NME4"
                     /gene_synonym="NDK; NDPK-D; NDPKD; nm23-H4; NM23H4"
                     /note="major polyA site"
     regulatory      975..980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NME4"
                     /gene_synonym="NDK; NDPK-D; NDPKD; nm23-H4; NM23H4"
                     /note="hexamer: AGTAAA"
     polyA_site      1000
                     /gene="NME4"
                     /gene_synonym="NDK; NDPK-D; NDPKD; nm23-H4; NM23H4"
                     /note="major polyA site"
ORIGIN      
        1 acagcggccc gcgggccggg cgtcatgggc ggcctcttct ggcgctccgc gctgcggggg
       61 ctgcgctgcg gcccgcgggc cccgggcccg agcctgctag tgcgccacgg ctcgggaggg
      121 ccctcctgga cccgggagcg gaccctggtg gcggtgaagc ccgatggcgt gcaacggcgg
      181 ctcgttgggg acgtgatcca gcgctttgag aggcggggct tcacgctggt ggggatgaag
      241 atgctgcagg caccagagag cgtccttgcc gagcactacc aggacctgcg gaggaagccc
      301 ttctaccctg ccctcatccg ctacatgagc tctgggcctg tggtggccat ggtctgggaa
      361 gggtacaatg tcgtccgcgc ctcgagggcc atgattggac acaccgactc ggctgaggct
      421 gccccaggaa ccataagggg tgacttcagc gtccacatca gcaggaatgt catccacgcc
      481 agcgactccg tggagggggc ccagcgggag atccagctgt ggttccagag cagtgagctg
      541 gtgagctggg cagacggggg ccagcacagc agcatccacc cagcctgagg ctcaagctgc
      601 ccttaccacc ccatccccca cgcaggacca actacctccg tcagcaagaa cccaagccca
      661 catccaaacc tgcctgtccc aaaccactta cttccctgtt cacctctgcc ccaccccagc
      721 ccagaggagt ttgagccacc aacttcagtg cctttctgta ccccaagcca gcacaagatt
      781 ggaccaatcc tttttgcacc aaagtgccgg acaacctttg tggtgggggg gggtcttcac
      841 attatcataa cctctcctct aaaggggagg cattaaaatt cactgtgccc agcacatggg
      901 tggtacacta attatgactt cccccagctc tgaggtagaa atgacgcctt tatgcaagtt
      961 gtaaggagtt gaacagtaaa gaggaagttt tgcacaccca
//
