LOCUS       NM_002513                848 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens NME/NM23 nucleoside diphosphate kinase 3 (NME3), mRNA.
ACCESSION   NM_002513
VERSION     NM_002513.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 848)
  AUTHORS   Amjadi,R., Werten,S., Lomada,S.K., Baldin,C., Scheffzek,K.,
            Dunzendorfer-Matt,T. and Wieland,T.
  TITLE     Mechanistic Insights into Substrate Recognition of Human Nucleoside
            Diphosphate Kinase C Based on Nucleotide-Induced Structural Changes
  JOURNAL   Int J Mol Sci 25 (18), 9768 (2024)
   PUBMED   39337255
  REMARK    GeneRIF: Mechanistic Insights into Substrate Recognition of Human
            Nucleoside Diphosphate Kinase C Based on Nucleotide-Induced
            Structural Changes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 848)
  AUTHORS   Su,Y.A., Chiu,H.Y., Chang,Y.C., Sung,C.J., Chen,C.W., Tei,R.,
            Huang,X.R., Hsu,S.C., Lin,S.S., Wang,H.C., Lin,Y.C., Hsu,J.C.,
            Bauer,H., Feng,Y., Baskin,J.M., Chang,Z.F. and Liu,Y.W.
  TITLE     NME3 binds to phosphatidic acid and mediates PLD6-induced
            mitochondrial tethering
  JOURNAL   J Cell Biol 222 (10) (2023)
   PUBMED   37584589
  REMARK    GeneRIF: NME3 binds to phosphatidic acid and mediates PLD6-induced
            mitochondrial tethering.
REFERENCE   3  (bases 1 to 848)
  AUTHORS   Abe,Y., Wanders,R.J.A., Waterham,H.R., Mandel,H.,
            Falik-Zaccai,T.C., Ishihara,N. and Fujiki,Y.
  TITLE     Genetic defects in peroxisome morphogenesis (Pex11beta,
            dynamin-like protein 1, and nucleoside diphosphate kinase 3) affect
            docosahexaenoic acid-phospholipid metabolism
  JOURNAL   J Inherit Metab Dis 46 (2), 273-285 (2023)
   PUBMED   36522796
  REMARK    GeneRIF: Genetic defects in peroxisome morphogenesis (Pex11beta,
            dynamin-like protein 1, and nucleoside diphosphate kinase 3) affect
            docosahexaenoic acid-phospholipid metabolism.
REFERENCE   4  (bases 1 to 848)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   5  (bases 1 to 848)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 848)
  AUTHORS   Erent,M., Gonin,P., Cherfils,J., Tissier,P., Raschella,G.,
            Giartosio,A., Agou,F., Sarger,C., Lacombe,M.L., Konrad,M. and
            Lascu,I.
  TITLE     Structural and catalytic properties and homology modelling of the
            human nucleoside diphosphate kinase C, product of the DRnm23 gene
  JOURNAL   Eur J Biochem 268 (7), 1972-1981 (2001)
   PUBMED   11277919
REFERENCE   7  (bases 1 to 848)
  AUTHORS   Daniels,R.J., Peden,J.F., Lloyd,C., Horsley,S.W., Clark,K.,
            Tufarelli,C., Kearney,L., Buckle,V.J., Doggett,N.A., Flint,J. and
            Higgs,D.R.
  TITLE     Sequence, structure and pathology of the fully annotated terminal 2
            Mb of the short arm of human chromosome 16
  JOURNAL   Hum Mol Genet 10 (4), 339-352 (2001)
   PUBMED   11157797
REFERENCE   8  (bases 1 to 848)
  AUTHORS   Negroni,A., Venturelli,D., Tanno,B., Amendola,R., Ransac,S.,
            Cesi,V., Calabretta,B. and Raschella,G.
  TITLE     Neuroblastoma specific effects of DR-nm23 and its mutant forms on
            differentiation and apoptosis
  JOURNAL   Cell Death Differ 7 (9), 843-850 (2000)
   PUBMED   11042679
REFERENCE   9  (bases 1 to 848)
  AUTHORS   Martinez,R., Venturelli,D., Perrotti,D., Veronese,M.L., Kastury,K.,
            Druck,T., Huebner,K. and Calabretta,B.
  TITLE     Gene structure, promoter activity, and chromosomal location of the
            DR-nm23 gene, a related member of the nm23 gene family
  JOURNAL   Cancer Res 57 (6), 1180-1187 (1997)
   PUBMED   9067290
REFERENCE   10 (bases 1 to 848)
  AUTHORS   Venturelli,D., Martinez,R., Melotti,P., Casella,I., Peschle,C.,
            Cucco,C., Spampinato,G., Darzynkiewicz,Z. and Calabretta,B.
  TITLE     Overexpression of DR-nm23, a protein encoded by a member of the
            nm23 gene family, inhibits granulocyte differentiation and induces
            apoptosis in 32Dc13 myeloid cells
  JOURNAL   Proc Natl Acad Sci U S A 92 (16), 7435-7439 (1995)
   PUBMED   7638209
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC012180.6.
            
            On Nov 18, 2020 this sequence version replaced NM_002513.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC000250.1, BG774902.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2142670
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000219302.8/ ENSP00000219302.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                AC012180.6         8500-8554           c
            56-186              AC012180.6         8291-8421           c
            187-288             AC012180.6         8081-8182           c
            289-401             AC012180.6         7892-8004           c
            402-848             AC012180.6         7331-7777           c
FEATURES             Location/Qualifiers
     source          1..848
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..848
                     /gene="NME3"
                     /gene_synonym="c371H6.2; DR-nm23; NDPK-C; NDPKC; NM23-H3;
                     NM23H3"
                     /note="NME/NM23 nucleoside diphosphate kinase 3"
                     /db_xref="GeneID:4832"
                     /db_xref="HGNC:HGNC:7851"
                     /db_xref="MIM:601817"
     exon            1..55
                     /gene="NME3"
                     /gene_synonym="c371H6.2; DR-nm23; NDPK-C; NDPKC; NM23-H3;
                     NM23H3"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..519
                     /gene="NME3"
                     /gene_synonym="c371H6.2; DR-nm23; NDPK-C; NDPKC; NM23-H3;
                     NM23H3"
                     /EC_number="2.7.4.6"
                     /note="NDP kinase C; nucleoside diphosphate kinase 3; NDK
                     3; NDP kinase 3; nucleoside diphosphate kinase C;
                     non-metastatic cells 3, protein expressed in"
                     /codon_start=1
                     /product="nucleoside diphosphate kinase 3 precursor"
                     /protein_id="NP_002504.2"
                     /db_xref="CCDS:CCDS10443.1"
                     /db_xref="GeneID:4832"
                     /db_xref="HGNC:HGNC:7851"
                     /db_xref="MIM:601817"
                     /translation="MICLVLTIFANLFPAACTGAHERTFLAVKPDGVQRRLVGEIVRR
                     FERKGFKLVALKLVQASEELLREHYAELRERPFYGRLVKYMASGPVVAMVWQGLDVVR
                     TSRALIGATNPADAPPGTIRGDFCIEVGKNLIHGSDSVESARREIALWFRADELLCWE
                     DSAGHWLYE"
     exon            56..186
                     /gene="NME3"
                     /gene_synonym="c371H6.2; DR-nm23; NDPK-C; NDPKC; NM23-H3;
                     NM23H3"
                     /inference="alignment:Splign:2.1.0"
     exon            187..288
                     /gene="NME3"
                     /gene_synonym="c371H6.2; DR-nm23; NDPK-C; NDPKC; NM23-H3;
                     NM23H3"
                     /inference="alignment:Splign:2.1.0"
     exon            289..401
                     /gene="NME3"
                     /gene_synonym="c371H6.2; DR-nm23; NDPK-C; NDPKC; NM23-H3;
                     NM23H3"
                     /inference="alignment:Splign:2.1.0"
     exon            402..848
                     /gene="NME3"
                     /gene_synonym="c371H6.2; DR-nm23; NDPK-C; NDPKC; NM23-H3;
                     NM23H3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      804..809
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NME3"
                     /gene_synonym="c371H6.2; DR-nm23; NDPK-C; NDPKC; NM23-H3;
                     NM23H3"
                     /note="hexamer: AATAAA"
     polyA_site      848
                     /gene="NME3"
                     /gene_synonym="c371H6.2; DR-nm23; NDPK-C; NDPKC; NM23-H3;
                     NM23H3"
                     /note="major polyA site"
ORIGIN      
        1 accgccatca tgatctgcct ggtgctgacc atcttcgcta acctcttccc cgcggcctgc
       61 accggcgcac acgaacgcac cttcctggcc gtgaagccgg acggcgtgca gcggcggctg
      121 gtgggcgaga ttgtgcggcg cttcgagagg aagggcttca agttggtggc gctgaagctg
      181 gtgcaggcct ccgaggagct gctgcgtgag cactacgccg agctgcgtga acgcccgttc
      241 tacggccgcc ttgtcaagta tatggcctcc gggccggtgg tggccatggt atggcagggg
      301 ctggacgtgg tgcgcacctc gcgggcgctc atcggagcca cgaacccggc cgacgccccg
      361 cccggcacca tccgcgggga tttctgcatc gaggttggca agaacctgat tcacggcagc
      421 gactcggtgg agagtgcccg ccgcgagatc gctctctggt tccgcgcaga cgagctcctc
      481 tgctgggagg acagcgctgg gcactggctg tatgagtagc ccggcagatg cgcgtcacag
      541 aggctctcac actccagcct cctccagggc ccaggtgggc gggcttctgg ccccacccca
      601 cagcgcttgg agcatccctt tggacgggct gctgaacatc cacctgtctg gacgttgcat
      661 ggagggtggc gcaggcctct ccaatccctg gcgtacaggg tttcctgccc gaggagctgc
      721 tccaggagcc tgcgcggctc gcctggaaac gtgccaggac actgtcctgg tgcccagccc
      781 aacgtggtcc aacgtttttt tataataaag tcctcgtttt cgtttcgatt tgggcccagg
      841 aacaggca
//
