LOCUS       NM_000269                890 bp    mRNA    linear   PRI 13-APR-2024
DEFINITION  Homo sapiens NME/NM23 nucleoside diphosphate kinase 1 (NME1),
            transcript variant 2, mRNA.
ACCESSION   NM_000269
VERSION     NM_000269.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 890)
  AUTHORS   Marquez-Gonzalez,R.M., Saucedo-Sarinana,A.M., de Jesus
            Tovar-Jacome,C., Barros-Nunez,P., Gallegos-Arreola,M.P.,
            Orozco-Gutierrez,M.H., Mariscal-Ramirez,I., Pineda-Razo,T.D.,
            Alcaraz-Wong,A.A., Marin-Contreras,M.E. and Rosales-Reynoso,M.A.
  TITLE     NME1 and DCC variants are associated with susceptibility and tumor
            characteristics in Mexican patients with colorectal cancer
  JOURNAL   J Egypt Natl Canc Inst 36 (1), 10 (2024)
   PUBMED   38556604
  REMARK    GeneRIF: NME1 and DCC variants are associated with susceptibility
            and tumor characteristics in Mexican patients with colorectal
            cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 890)
  AUTHORS   Lu,Z., Liu,B., Kong,D., Zhou,X., Pei,D. and Liu,D.
  TITLE     NSUN6 Regulates NM23-H1 Expression in an m5C Manner to Affect
            Epithelial-Mesenchymal Transition in Lung Cancer
  JOURNAL   Med Princ Pract 33 (1), 56-65 (2024)
   PUBMED   38029727
  REMARK    GeneRIF: NSUN6 Regulates NM23-H1 Expression in an m5C Manner to
            Affect Epithelial-Mesenchymal Transition in Lung Cancer.
REFERENCE   3  (bases 1 to 890)
  AUTHORS   Quentin,D., Schuhmacher,J.S., Klink,B.U., Lauer,J., Shaikh,T.R.,
            Huis In 't Veld,P.J., Welp,L.M., Urlaub,H., Zerial,M. and
            Raunser,S.
  TITLE     Structural basis of mRNA binding by the human FERRY Rab5 effector
            complex
  JOURNAL   Mol Cell 83 (11), 1856-1871 (2023)
   PUBMED   37267906
REFERENCE   4  (bases 1 to 890)
  AUTHORS   Tossounian,M.A., Hristov,S.D., Semelak,J.A., Yu,B.Y.K.,
            Baczynska,M., Zhao,Y., Estrin,D.A., Trujillo,M., Filonenko,V.,
            Gouge,J. and Gout,I.
  TITLE     A Unique Mode of Coenzyme A Binding to the Nucleotide Binding
            Pocket of Human Metastasis Suppressor NME1
  JOURNAL   Int J Mol Sci 24 (11), 9359 (2023)
   PUBMED   37298313
  REMARK    GeneRIF: A Unique Mode of Coenzyme A Binding to the Nucleotide
            Binding Pocket of Human Metastasis Suppressor NME1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 890)
  AUTHORS   Misan,N., Michalak,S., Kapska,K., Osztynowicz,K., Ropacka-Lesiak,M.
            and Kawka-Paciorkowska,K.
  TITLE     Does the Blood-Brain Barrier Integrity Change in Regard to the
            Onset of Fetal Growth Restriction?
  JOURNAL   Int J Mol Sci 24 (3), 1965 (2023)
   PUBMED   36768287
  REMARK    GeneRIF: Does the Blood-Brain Barrier Integrity Change in Regard to
            the Onset of Fetal Growth Restriction?
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 890)
  AUTHORS   Hailat,N., Keim,D.R., Melhem,R.F., Zhu,X.X., Eckerskorn,C.,
            Brodeur,G.M., Reynolds,C.P., Seeger,R.C., Lottspeich,F.,
            Strahler,J.R. et al.
  TITLE     High levels of p19/nm23 protein in neuroblastoma are associated
            with advanced stage disease and with N-myc gene amplification
  JOURNAL   J Clin Invest 88 (1), 341-345 (1991)
   PUBMED   2056128
REFERENCE   7  (bases 1 to 890)
  AUTHORS   Gilles,A.M., Presecan,E., Vonica,A. and Lascu,I.
  TITLE     Nucleoside diphosphate kinase from human erythrocytes. Structural
            characterization of the two polypeptide chains responsible for
            heterogeneity of the hexameric enzyme
  JOURNAL   J Biol Chem 266 (14), 8784-8789 (1991)
   PUBMED   1851158
REFERENCE   8  (bases 1 to 890)
  AUTHORS   Leone,A., McBride,O.W., Weston,A., Wang,M.G., Anglard,P.,
            Cropp,C.S., Goepel,J.R., Lidereau,R., Callahan,R., Linehan,W.M. et
            al.
  TITLE     Somatic allelic deletion of nm23 in human cancer
  JOURNAL   Cancer Res 51 (9), 2490-2493 (1991)
   PUBMED   2015608
REFERENCE   9  (bases 1 to 890)
  AUTHORS   Rosengard,A.M., Krutzsch,H.C., Shearn,A., Biggs,J.R., Barker,E.,
            Margulies,I.M., King,C.R., Liotta,L.A. and Steeg,P.S.
  TITLE     Reduced Nm23/Awd protein in tumour metastasis and aberrant
            Drosophila development
  JOURNAL   Nature 342 (6246), 177-180 (1989)
   PUBMED   2509941
REFERENCE   10 (bases 1 to 890)
  AUTHORS   Fong,C.T., Dracopoli,N.C., White,P.S., Merrill,P.T., Griffith,R.C.,
            Housman,D.E. and Brodeur,G.M.
  TITLE     Loss of heterozygosity for the short arm of chromosome 1 in human
            neuroblastomas: correlation with N-myc amplification
  JOURNAL   Proc Natl Acad Sci U S A 86 (10), 3753-3757 (1989)
   PUBMED   2566996
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BU600979.1, AF487339.1,
            BG715560.1, BF965472.1, BM479520.1, BI666785.1, BE727815.1 and
            AC005839.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 27, 2020 this sequence version replaced NM_000269.2.
            
            Summary: This gene (NME1) was identified because of its reduced
            mRNA transcript levels in highly metastatic cells. Nucleoside
            diphosphate kinase (NDK) exists as a hexamer composed of 'A'
            (encoded by this gene) and 'B' (encoded by NME2) isoforms.
            Mutations in this gene have been identified in aggressive
            neuroblastomas. Two transcript variants encoding different isoforms
            have been found for this gene. Co-transcription of this gene and
            the neighboring downstream gene (NME2) generates
            naturally-occurring transcripts (NME1-NME2), which encodes a fusion
            protein comprised of sequence sharing identity with each individual
            gene product. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) lacks an alternate exon
            compared to variant 1. The resulting isoform (b) has a shorter
            N-terminus compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291105.1, BG531372.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393196.8/ ENSP00000376892.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-612               BU600979.1         27-638
            613-783             AF487339.1         817-987
            784-789             BG715560.1         777-782
            790-791             BF965472.1         739-740
            792-793             BM479520.1         728-729
            794-804             BI666785.1         782-792
            805-806             BE727815.1         768-769
            807-811             BI666785.1         795-799
            812-890             AC005839.1         88573-88651
FEATURES             Location/Qualifiers
     source          1..890
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.33"
     gene            1..890
                     /gene="NME1"
                     /gene_synonym="AWD; GAAD; NB; NBS; NDKA; NDPK-A; NDPKA;
                     NM23; NM23-H1"
                     /note="NME/NM23 nucleoside diphosphate kinase 1"
                     /db_xref="GeneID:4830"
                     /db_xref="HGNC:HGNC:7849"
                     /db_xref="MIM:156490"
     exon            1..104
                     /gene="NME1"
                     /gene_synonym="AWD; GAAD; NB; NBS; NDKA; NDPK-A; NDPKA;
                     NM23; NM23-H1"
                     /inference="alignment:Splign:2.1.0"
     exon            105..234
                     /gene="NME1"
                     /gene_synonym="AWD; GAAD; NB; NBS; NDKA; NDPK-A; NDPKA;
                     NM23; NM23-H1"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..567
                     /gene="NME1"
                     /gene_synonym="AWD; GAAD; NB; NBS; NDKA; NDPK-A; NDPKA;
                     NM23; NM23-H1"
                     /EC_number="2.7.4.6"
                     /note="isoform b is encoded by transcript variant 2; NDP
                     kinase A; non-metastatic cells 1, protein (NM23A)
                     expressed in; nucleoside diphosphate kinase A; tumor
                     metastatic process-associated protein; granzyme
                     A-activated DNase; metastasis inhibition factor nm23;
                     epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="nucleoside diphosphate kinase A isoform b"
                     /protein_id="NP_000260.1"
                     /db_xref="CCDS:CCDS11579.1"
                     /db_xref="GeneID:4830"
                     /db_xref="HGNC:HGNC:7849"
                     /db_xref="MIM:156490"
                     /translation="MANCERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQAS
                     EDLLKEHYVDLKDRPFFAGLVKYMHSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPG
                     TIRGDFCIQVGRNIIHGSDSVESAEKEIGLWFHPEELVDYTSCAQNWIYE"
     exon            235..336
                     /gene="NME1"
                     /gene_synonym="AWD; GAAD; NB; NBS; NDKA; NDPK-A; NDPKA;
                     NM23; NM23-H1"
                     /inference="alignment:Splign:2.1.0"
     exon            337..449
                     /gene="NME1"
                     /gene_synonym="AWD; GAAD; NB; NBS; NDKA; NDPK-A; NDPKA;
                     NM23; NM23-H1"
                     /inference="alignment:Splign:2.1.0"
     exon            450..890
                     /gene="NME1"
                     /gene_synonym="AWD; GAAD; NB; NBS; NDKA; NDPK-A; NDPKA;
                     NM23; NM23-H1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      736..741
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NME1"
                     /gene_synonym="AWD; GAAD; NB; NBS; NDKA; NDPK-A; NDPKA;
                     NM23; NM23-H1"
                     /note="hexamer: ATTAAA"
     polyA_site      762
                     /gene="NME1"
                     /gene_synonym="AWD; GAAD; NB; NBS; NDKA; NDPK-A; NDPKA;
                     NM23; NM23-H1"
                     /note="major polyA site"
     regulatory      839..844
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NME1"
                     /gene_synonym="AWD; GAAD; NB; NBS; NDKA; NDPK-A; NDPKA;
                     NM23; NM23-H1"
                     /note="hexamer: AATAGA"
     regulatory      857..862
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NME1"
                     /gene_synonym="AWD; GAAD; NB; NBS; NDKA; NDPK-A; NDPKA;
                     NM23; NM23-H1"
                     /note="hexamer: TATAAA"
     polyA_site      864
                     /gene="NME1"
                     /gene_synonym="AWD; GAAD; NB; NBS; NDKA; NDPK-A; NDPKA;
                     NM23; NM23-H1"
     polyA_site      890
                     /gene="NME1"
                     /gene_synonym="AWD; GAAD; NB; NBS; NDKA; NDPK-A; NDPKA;
                     NM23; NM23-H1"
ORIGIN      
        1 gcagaagcgt tccgtgcgtg caagtgctgc gaaccacgtg ggtcccgggc gcgtttcggg
       61 tgctggcggc tgcagccgga gttcaaacct aagcagctgg aaggaaccat ggccaactgt
      121 gagcgtacct tcattgcgat caaaccagat ggggtccagc ggggtcttgt gggagagatt
      181 atcaagcgtt ttgagcagaa aggattccgc cttgttggtc tgaaattcat gcaagcttcc
      241 gaagatcttc tcaaggaaca ctacgttgac ctgaaggacc gtccattctt tgccggcctg
      301 gtgaaataca tgcactcagg gccggtagtt gccatggtct gggaggggct gaatgtggtg
      361 aagacgggcc gagtcatgct cggggagacc aaccctgcag actccaagcc tgggaccatc
      421 cgtggagact tctgcataca agttggcagg aacattatac atggcagtga ttctgtggag
      481 agtgcagaga aggagatcgg cttgtggttt caccctgagg aactggtaga ttacacgagc
      541 tgtgctcaga actggatcta tgaatgacag gagggcagac cacattgctt ttcacatcca
      601 tttcccctcc ttcccatggg cagaggacca ggctgtagga aatctagtta tttacaggaa
      661 cttcatcata atttggaggg aagctcttgg agctgtgagt tctccctgta cagtgttacc
      721 atccccgacc atctgattaa aatgcttcct cccagcatag gattcattga gttggttact
      781 tcatattgtt gcattgcttt tttttccttc ttttcatgta cactgaataa cctgacctaa
      841 tagagagtgt aaatactata aaaatgattt attttgaggt ctcacataca
//
