LOCUS       NM_001018136            1052 bp    mRNA    linear   PRI 10-JUL-2022
DEFINITION  Homo sapiens NME1-NME2 readthrough (NME1-NME2), transcript variant
            1, mRNA.
ACCESSION   NM_001018136
VERSION     NM_001018136.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1052)
  AUTHORS   Lango Allen H, Estrada K, Lettre G, Berndt SI, Weedon MN,
            Rivadeneira F, Willer CJ, Jackson AU, Vedantam S, Raychaudhuri S,
            Ferreira T, Wood AR, Weyant RJ, Segre AV, Speliotes EK, Wheeler E,
            Soranzo N, Park JH, Yang J, Gudbjartsson D, Heard-Costa NL, Randall
            JC, Qi L, Vernon Smith A, Magi R, Pastinen T, Liang L, Heid IM,
            Luan J, Thorleifsson G, Winkler TW, Goddard ME, Sin Lo K, Palmer C,
            Workalemahu T, Aulchenko YS, Johansson A, Zillikens MC, Feitosa MF,
            Esko T, Johnson T, Ketkar S, Kraft P, Mangino M, Prokopenko I,
            Absher D, Albrecht E, Ernst F, Glazer NL, Hayward C, Hottenga JJ,
            Jacobs KB, Knowles JW, Kutalik Z, Monda KL, Polasek O, Preuss M,
            Rayner NW, Robertson NR, Steinthorsdottir V, Tyrer JP, Voight BF,
            Wiklund F, Xu J, Zhao JH, Nyholt DR, Pellikka N, Perola M, Perry
            JR, Surakka I, Tammesoo ML, Altmaier EL, Amin N, Aspelund T,
            Bhangale T, Boucher G, Chasman DI, Chen C, Coin L, Cooper MN, Dixon
            AL, Gibson Q, Grundberg E, Hao K, Juhani Junttila M, Kaplan LM,
            Kettunen J, Konig IR, Kwan T, Lawrence RW, Levinson DF, Lorentzon
            M, McKnight B, Morris AP, Muller M, Suh Ngwa J, Purcell S, Rafelt
            S, Salem RM, Salvi E, Sanna S, Shi J, Sovio U, Thompson JR, Turchin
            MC, Vandenput L, Verlaan DJ, Vitart V, White CC, Ziegler A, Almgren
            P, Balmforth AJ, Campbell H, Citterio L, De Grandi A, Dominiczak A,
            Duan J, Elliott P, Elosua R, Eriksson JG, Freimer NB, Geus EJ,
            Glorioso N, Haiqing S, Hartikainen AL, Havulinna AS, Hicks AA, Hui
            J, Igl W, Illig T, Jula A, Kajantie E, Kilpelainen TO, Koiranen M,
            Kolcic I, Koskinen S, Kovacs P, Laitinen J, Liu J, Lokki ML,
            Marusic A, Maschio A, Meitinger T, Mulas A, Pare G, Parker AN,
            Peden JF, Petersmann A, Pichler I, Pietilainen KH, Pouta A,
            Ridderstrale M, Rotter JI, Sambrook JG, Sanders AR, Schmidt CO,
            Sinisalo J, Smit JH, Stringham HM, Bragi Walters G, Widen E, Wild
            SH, Willemsen G, Zagato L, Zgaga L, Zitting P, Alavere H, Farrall
            M, McArdle WL, Nelis M, Peters MJ, Ripatti S, van Meurs JB, Aben
            KK, Ardlie KG, Beckmann JS, Beilby JP, Bergman RN, Bergmann S,
            Collins FS, Cusi D, den Heijer M, Eiriksdottir G, Gejman PV, Hall
            AS, Hamsten A, Huikuri HV, Iribarren C, Kahonen M, Kaprio J,
            Kathiresan S, Kiemeney L, Kocher T, Launer LJ, Lehtimaki T,
            Melander O, Mosley TH Jr, Musk AW, Nieminen MS, O'Donnell CJ,
            Ohlsson C, Oostra B, Palmer LJ, Raitakari O, Ridker PM, Rioux JD,
            Rissanen A, Rivolta C, Schunkert H, Shuldiner AR, Siscovick DS,
            Stumvoll M, Tonjes A, Tuomilehto J, van Ommen GJ, Viikari J, Heath
            AC, Martin NG, Montgomery GW, Province MA, Kayser M, Arnold AM,
            Atwood LD, Boerwinkle E, Chanock SJ, Deloukas P, Gieger C, Gronberg
            H, Hall P, Hattersley AT, Hengstenberg C, Hoffman W, Lathrop GM,
            Salomaa V, Schreiber S, Uda M, Waterworth D, Wright AF, Assimes TL,
            Barroso I, Hofman A, Mohlke KL, Boomsma DI, Caulfield MJ, Cupples
            LA, Erdmann J, Fox CS, Gudnason V, Gyllensten U, Harris TB, Hayes
            RB, Jarvelin MR, Mooser V, Munroe PB, Ouwehand WH, Penninx BW,
            Pramstaller PP, Quertermous T, Rudan I, Samani NJ, Spector TD,
            Volzke H, Watkins H, Wilson JF, Groop LC, Haritunians T, Hu FB,
            Kaplan RC, Metspalu A, North KE, Schlessinger D, Wareham NJ, Hunter
            DJ, O'Connell JR, Strachan DP, Wichmann HE, Borecki IB, van Duijn
            CM, Schadt EE, Thorsteinsdottir U, Peltonen L, Uitterlinden AG,
            Visscher PM, Chatterjee N, Loos RJ, Boehnke M, McCarthy MI,
            Ingelsson E, Lindgren CM, Abecasis GR, Stefansson K, Frayling TM
            and Hirschhorn JN.
  TITLE     Hundreds of variants clustered in genomic loci and biological
            pathways affect human height
  JOURNAL   Nature 467 (7317), 832-838 (2010)
   PUBMED   20881960
REFERENCE   2  (bases 1 to 1052)
  AUTHORS   Prakash T, Sharma VK, Adati N, Ozawa R, Kumar N, Nishida Y,
            Fujikake T, Takeda T and Taylor TD.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS One 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1052)
  AUTHORS   Aktary Z, Chapman K, Lam L, Lo A, Ji C, Graham K, Cook L, Li L,
            Mackey JR and Pasdar M.
  TITLE     Plakoglobin interacts with and increases the protein levels of
            metastasis suppressor Nm23-H2 and regulates the expression of
            Nm23-H1
  JOURNAL   Oncogene 29 (14), 2118-2129 (2010)
   PUBMED   20101217
  REMARK    GeneRIF: Plakoglobin has a role in regulating the metastasis
            suppressor activity of Nm23.
REFERENCE   4  (bases 1 to 1052)
  AUTHORS   Seong HA, Jung H and Ha H.
  TITLE     NM23-H1 tumor suppressor physically interacts with serine-threonine
            kinase receptor-associated protein, a transforming growth
            factor-beta (TGF-beta) receptor-interacting protein, and negatively
            regulates TGF-beta signaling
  JOURNAL   J Biol Chem 282 (16), 12075-12096 (2007)
   PUBMED   17314099
REFERENCE   5  (bases 1 to 1052)
  AUTHORS   Braun S, Mauch C, Boukamp P and Werner S.
  TITLE     Novel roles of NM23 proteins in skin homeostasis, repair and
            disease
  JOURNAL   Oncogene 26 (4), 532-542 (2007)
   PUBMED   16862176
REFERENCE   6  (bases 1 to 1052)
  AUTHORS   Valentijn LJ, Koster J and Versteeg R.
  TITLE     Read-through transcript from NM23-H1 into the neighboring NM23-H2
            gene encodes a novel protein, NM23-LV
  JOURNAL   Genomics 87 (4), 483-489 (2006)
   PUBMED   16442775
REFERENCE   7  (bases 1 to 1052)
  AUTHORS   Fournier HN, Dupe-Manet S, Bouvard D, Lacombe ML, Marie C, Block MR
            and Albiges-Rizo C.
  TITLE     Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha)
            interacts directly with the metastasis suppressor nm23-H2, and both
            proteins are targeted to newly formed cell adhesion sites upon
            integrin engagement
  JOURNAL   J Biol Chem 277 (23), 20895-20902 (2002)
   PUBMED   11919189
REFERENCE   8  (bases 1 to 1052)
  AUTHORS   Postel EH, Berberich SJ, Flint SJ and Ferrone CA.
  TITLE     Human c-myc transcription factor PuF identified as nm23-H2
            nucleoside diphosphate kinase, a candidate suppressor of tumor
            metastasis
  JOURNAL   Science 261 (5120), 478-480 (1993)
   PUBMED   8392752
REFERENCE   9  (bases 1 to 1052)
  AUTHORS   Gilles AM, Presecan E, Vonica A and Lascu I.
  TITLE     Nucleoside diphosphate kinase from human erythrocytes. Structural
            characterization of the two polypeptide chains responsible for
            heterogeneity of the hexameric enzyme
  JOURNAL   J Biol Chem 266 (14), 8784-8789 (1991)
   PUBMED   1851158
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005839.1, BC133029.1 and DQ109675.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001018136.2.
            
            Summary: This locus represents naturally occurring read-through
            transcription between the neighboring NME1 and NME2 genes. The
            significance of this read-through transcription and the function of
            the resulting protein product have not yet been determined.
            Alternative splicing of this gene results in multiple transcript
            variants. [provided by RefSeq, Nov 2010].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript but encodes the supported protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7410570.634538.1, DQ109675.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 4830, 4831
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                AC005839.1         80042-80115
            75-949              BC133029.1         1-875
            950-1052            DQ109675.1         893-995
FEATURES             Location/Qualifiers
     source          1..1052
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.33"
     gene            1..1052
                     /gene="NME1-NME2"
                     /gene_synonym="NM23-LV; NMELV"
                     /note="NME1-NME2 readthrough"
                     /db_xref="GeneID:654364"
                     /db_xref="HGNC:HGNC:33531"
     exon            1..104
                     /gene="NME1-NME2"
                     /gene_synonym="NM23-LV; NMELV"
                     /inference="alignment:Splign:2.1.0"
     exon            105..234
                     /gene="NME1-NME2"
                     /gene_synonym="NM23-LV; NMELV"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..912
                     /gene="NME1-NME2"
                     /gene_synonym="NM23-LV; NMELV"
                     /EC_number="2.7.4.6"
                     /note="NME1-NME2 readthrough transcript"
                     /codon_start=1
                     /product="NME1-NME2 protein"
                     /protein_id="NP_001018146.1"
                     /db_xref="GeneID:654364"
                     /db_xref="HGNC:HGNC:33531"
                     /translation="MANCERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQAS
                     EDLLKEHYVDLKDRPFFAGLVKYMHSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPG
                     TIRGDFCIQVGRTMANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASE
                     EHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGT
                     IRGDFCIQVGRNIIHGSDSVKSAEKEISLWFKPEELVDYKSCAHDWVYE"
     exon            235..336
                     /gene="NME1-NME2"
                     /gene_synonym="NM23-LV; NMELV"
                     /inference="alignment:Splign:2.1.0"
     exon            337..449
                     /gene="NME1-NME2"
                     /gene_synonym="NM23-LV; NMELV"
                     /inference="alignment:Splign:2.1.0"
     exon            450..579
                     /gene="NME1-NME2"
                     /gene_synonym="NM23-LV; NMELV"
                     /inference="alignment:Splign:2.1.0"
     exon            580..681
                     /gene="NME1-NME2"
                     /gene_synonym="NM23-LV; NMELV"
                     /inference="alignment:Splign:2.1.0"
     exon            682..794
                     /gene="NME1-NME2"
                     /gene_synonym="NM23-LV; NMELV"
                     /inference="alignment:Splign:2.1.0"
     exon            795..1052
                     /gene="NME1-NME2"
                     /gene_synonym="NM23-LV; NMELV"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1031..1036
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NME1-NME2"
                     /gene_synonym="NM23-LV; NMELV"
                     /note="hexamer: AATAAA"
     polyA_site      1052
                     /gene="NME1-NME2"
                     /gene_synonym="NM23-LV; NMELV"
                     /note="major polyA site"
ORIGIN      
        1 gcagaagcgt tccgtgcgtg caagtgctgc gaaccacgtg ggtcccgggc gcgtttcggg
       61 tgctggcggc tgcagccgga gttcaaacct aagcagctgg aaggaaccat ggccaactgt
      121 gagcgtacct tcattgcgat caaaccagat ggggtccagc ggggtcttgt gggagagatt
      181 atcaagcgtt ttgagcagaa aggattccgc cttgttggtc tgaaattcat gcaagcttcc
      241 gaagatcttc tcaaggaaca ctacgttgac ctgaaggacc gtccattctt tgccggcctg
      301 gtgaaataca tgcactcagg gccggtagtt gccatggtct gggaggggct gaatgtggtg
      361 aagacgggcc gagtcatgct cggggagacc aaccctgcag actccaagcc tgggaccatc
      421 cgtggagact tctgcataca agttggcagg accatggcca acctggagcg caccttcatc
      481 gccatcaagc cggacggcgt gcagcgcggc ctggtgggcg agatcatcaa gcgcttcgag
      541 cagaagggat tccgcctcgt ggccatgaag ttcctccggg cctctgaaga acacctgaag
      601 cagcactaca ttgacctgaa agaccgacca ttcttccctg ggctggtgaa gtacatgaac
      661 tcagggccgg ttgtggccat ggtctgggag gggctgaacg tggtgaagac aggccgagtg
      721 atgcttgggg agaccaatcc agcagattca aagccaggca ccattcgtgg ggacttctgc
      781 attcaggttg gcaggaacat cattcatggc agtgattcag taaaaagtgc tgaaaaagaa
      841 atcagcctat ggtttaagcc tgaagaactg gttgactaca agtcttgtgc tcatgactgg
      901 gtctatgaat aagaggtgga cacaacagca gtctccttca gcacggcgtg gtgtgtccct
      961 ggacacagct cttcattcca ttgacttaga ggcaacagga ttgatcattc ttttatagag
     1021 catatttgcc aataaagctt ttggaagccg ga
//
