LOCUS       NM_015938               3028 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens NMD3 ribosome export adaptor (NMD3), transcript
            variant 2, mRNA.
ACCESSION   NM_015938
VERSION     NM_015938.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3028)
  AUTHORS   Wu,H., Li,H., Shi,Z., Tang,J., Mei,S., Ai,T. and He,Z.
  TITLE     Association between NMD3 and symptoms of Parkinson's disease in
            Chinese patients
  JOURNAL   BMC Neurol 20 (1), 19 (2020)
   PUBMED   31937261
  REMARK    GeneRIF: The recessive and overdominant model of NMD3 rs34016896
            was associated with cognitive impairment in Parkinson's disease
            patients.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3028)
  AUTHORS   Chen,Y., Cao,B., Ou,R., Wei,Q., Chen,X., Zhao,B., Wu,Y., Song,W.
            and Shang,H.F.
  TITLE     Determining the Effect of the HNMT, STK39, and NMD3 Polymorphisms
            on the Incidence of Parkinson's Disease, Amyotrophic Lateral
            Sclerosis, and Multiple System Atrophy in Chinese Populations
  JOURNAL   J Mol Neurosci 64 (4), 574-580 (2018)
   PUBMED   29564728
  REMARK    GeneRIF: The presence of the rs34016896 allele in the NMD3 gene may
            contribute to the development of synucleinopathies.
REFERENCE   3  (bases 1 to 3028)
  AUTHORS   Bai,B., Moore,H.M. and Laiho,M.
  TITLE     CRM1 and its ribosome export adaptor NMD3 localize to the nucleolus
            and affect rRNA synthesis
  JOURNAL   Nucleus 4 (4), 315-325 (2013)
   PUBMED   23782956
  REMARK    GeneRIF: The CRM1 and NMD3 have complex functions in pathways that
            couple rRNA synthetic and processing engines and that the rRNA
            synthesis rate may be adjusted according to proficiency in rRNA
            processing and export.
REFERENCE   4  (bases 1 to 3028)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 3028)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 3028)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   7  (bases 1 to 3028)
  AUTHORS   Thomas,F. and Kutay,U.
  TITLE     Biogenesis and nuclear export of ribosomal subunits in higher
            eukaryotes depend on the CRM1 export pathway
  JOURNAL   J Cell Sci 116 (Pt 12), 2409-2419 (2003)
   PUBMED   12724356
REFERENCE   8  (bases 1 to 3028)
  AUTHORS   Trotta,C.R., Lund,E., Kahan,L., Johnson,A.W. and Dahlberg,J.E.
  TITLE     Coordinated nuclear export of 60S ribosomal subunits and NMD3 in
            vertebrates
  JOURNAL   EMBO J 22 (11), 2841-2851 (2003)
   PUBMED   12773398
  REMARK    GeneRIF: contains a CRM-1-dependent leucine-rich nuclear export
            signal and a complex, dispersed nuclear localization signal (NMD3)
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC013317.1 and AC108738.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 27, 2020 this sequence version replaced NM_015938.4.
            
            Summary: Ribosomal 40S and 60S subunits associate in the nucleolus
            and are exported to the cytoplasm. The protein encoded by this gene
            is involved in the passage of the 60S subunit through the nuclear
            pore complex and into the cytoplasm. Several transcript variants
            exist for this gene, but the full-length natures of only two have
            been described to date. [provided by RefSeq, Feb 2016].
            
            Transcript Variant: This variant (2) differs in the 3' UTR and
            coding sequence compared to variant 1. The resulting  isoform (2)
            has a shorter and distinct C-terminus compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013317.1, SRR11853565.21219.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000351193.7/ ENSP00000307525.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2728              BC013317.1         5-2732
            2729-3028           AC108738.6         28529-28828         c
FEATURES             Location/Qualifiers
     source          1..3028
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q26.1"
     gene            1..3028
                     /gene="NMD3"
                     /gene_synonym="CGI-07"
                     /note="NMD3 ribosome export adaptor"
                     /db_xref="GeneID:51068"
                     /db_xref="HGNC:HGNC:24250"
                     /db_xref="MIM:611021"
     exon            1..99
                     /gene="NMD3"
                     /gene_synonym="CGI-07"
                     /inference="alignment:Splign:2.1.0"
     exon            100..163
                     /gene="NMD3"
                     /gene_synonym="CGI-07"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..1631
                     /gene="NMD3"
                     /gene_synonym="CGI-07"
                     /note="isoform 2 is encoded by transcript variant 2; 60S
                     ribosomal export protein NMD3; hNMD3; NMD3 homolog"
                     /codon_start=1
                     /product="60S ribosomal export protein NMD3 isoform 2"
                     /protein_id="NP_057022.2"
                     /db_xref="CCDS:CCDS3194.1"
                     /db_xref="GeneID:51068"
                     /db_xref="HGNC:HGNC:24250"
                     /db_xref="MIM:611021"
                     /translation="MEYMAESTDRSPGHILCCECGVPISPNPANICVACLRSKVDISQ
                     GIPKQVSISFCKQCQRYFQPPGTWIQCALESRELLALCLKKIKAPLSKVRLVDAGFVW
                     TEPHSKRLKVKLTIQKEVMNGAILQQVFVVDYVVQSQMCGDCHRVEAKDFWKAVIQVR
                     QKTLHKKTFYYLEQLILKYGMHQNTLRIKEIHDGLDFYYSSKQHAQKMVEFLQCTVPC
                     RYKASQRLISQDIHSNTYNYKSTFSVEIVPICKDNVVCLSPKLAQSLGNMNQICVCIR
                     VTSAIHLIDPNTLQVADIDGSTFWSHPFNSLCHPKQLEEFIVMECSIVQDIKRAAGAG
                     MISKKHTLGEVWVQKTSEMNTDKQYFCRTHLGHLLNPGDLVLGFDLANCNLNDEHVNK
                     MNSDRVPDVVLIKKSYDRTKRQRRRNWKLKELARERENMDTDDERQYQDFLEDLEEDE
                     AIRKNVNIYRDSAIPVESDTDDEGAPRISLAEMLEDLHISQDATGEEGASMLT"
     exon            164..298
                     /gene="NMD3"
                     /gene_synonym="CGI-07"
                     /inference="alignment:Splign:2.1.0"
     exon            299..395
                     /gene="NMD3"
                     /gene_synonym="CGI-07"
                     /inference="alignment:Splign:2.1.0"
     exon            396..476
                     /gene="NMD3"
                     /gene_synonym="CGI-07"
                     /inference="alignment:Splign:2.1.0"
     exon            477..605
                     /gene="NMD3"
                     /gene_synonym="CGI-07"
                     /inference="alignment:Splign:2.1.0"
     exon            606..696
                     /gene="NMD3"
                     /gene_synonym="CGI-07"
                     /inference="alignment:Splign:2.1.0"
     exon            697..775
                     /gene="NMD3"
                     /gene_synonym="CGI-07"
                     /inference="alignment:Splign:2.1.0"
     exon            776..872
                     /gene="NMD3"
                     /gene_synonym="CGI-07"
                     /inference="alignment:Splign:2.1.0"
     exon            873..990
                     /gene="NMD3"
                     /gene_synonym="CGI-07"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1136
                     /gene="NMD3"
                     /gene_synonym="CGI-07"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1249
                     /gene="NMD3"
                     /gene_synonym="CGI-07"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1322
                     /gene="NMD3"
                     /gene_synonym="CGI-07"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1429
                     /gene="NMD3"
                     /gene_synonym="CGI-07"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1500
                     /gene="NMD3"
                     /gene_synonym="CGI-07"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..3028
                     /gene="NMD3"
                     /gene_synonym="CGI-07"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2992..2997
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NMD3"
                     /gene_synonym="CGI-07"
                     /note="hexamer: AATAAA"
     polyA_site      3028
                     /gene="NMD3"
                     /gene_synonym="CGI-07"
                     /note="major polyA site"
ORIGIN      
        1 ctctgtggcg gagacagcca ggttggcagc tgacgggaca gccggggtct attttgttgc
       61 gggttttcag caaatccagg gctggtctgg aggcgcgaaa acttaaggca tacagaacga
      121 tggagtatat ggcagaatcc accgaccgca gccctggaca catcttgtgc tgtgagtgtg
      181 gtgttccgat aagtccaaat cctgccaata tttgtgtggc ctgtttgcga agtaaagtgg
      241 acatcagcca aggtattccg aaacaagtct cgatttcgtt ctgcaaacaa tgtcaaaggt
      301 attttcaacc accaggaact tggatacagt gtgctttaga atccagggaa cttcttgctt
      361 tgtgcttgaa aaaaatcaaa gcccctctga gtaaggtacg gcttgtagat gcaggctttg
      421 tttggactga gcctcattct aagagactta aagttaaact gactattcag aaagaggtga
      481 tgaatggtgc tatccttcaa caagtgtttg tggtggatta tgttgttcag tcccaaatgt
      541 gtggagattg ccatagagta gaagctaagg atttctggaa ggctgtgatt caagtgaggc
      601 aaaagacttt gcataaaaaa actttctact atctggaaca gttaattctg aaatatggaa
      661 tgcatcagaa tacacttcgt atcaaagaga ttcatgatgg tctggatttt tattattcct
      721 caaaacaaca tgctcagaag atggtcgaat ttcttcagtg tacagttccc tgtagataca
      781 aagcatcaca aagactgatc tctcaagata tccatagtaa cacatacaat tacaaaagca
      841 ctttttctgt ggaaattgtt ccaatatgca aggataatgt tgtctgtctg tctccaaaac
      901 tggcacaaag cctgggaaat atgaaccaga tttgtgtgtg tattcgagta accagtgcca
      961 ttcacctcat tgatccaaac accctacaag tggcagatat tgatgggagc actttctgga
     1021 gtcacccttt caatagttta tgtcatccca aacagctaga ggagtttatt gtgatggaat
     1081 gcagcatagt ccaagatata aaacgtgctg caggtgctgg aatgatatca aaaaagcata
     1141 ccctcgggga agtctgggta cagaagacat ctgaaatgaa tacagataaa cagtattttt
     1201 gtcgtactca tttgggacat cttctaaatc ccggagacct ggtgttaggg tttgatttgg
     1261 ccaactgtaa cttaaatgat gagcatgtca acaaaatgaa ctcagataga gttccagatg
     1321 tggtattaat caagaagagc tatgaccgga ccaaacgtca gcgtcgtaga aactggaaat
     1381 tgaaagagct tgcaagagag agagaaaaca tggatacaga tgatgaaagg caataccaag
     1441 attttcttga agatcttgaa gaagatgagg caattcgaaa aaatgtcaac atttacagag
     1501 attcagccat ccctgtggaa agtgacaccg atgatgaagg agcacctcga attagtctgg
     1561 ctgagatgct tgaagacctt catatttccc aagatgccac tggtgaagaa ggtgcatcaa
     1621 tgctgacata atgagatgtt gtagactgtt tccatacatg ggcttaagaa gttggacaga
     1681 gttaccttaa gtgtctctac tatctttgcc tccagatttc aagaggagaa atttagtttt
     1741 aaacctgaat aaacatgttt gttttcagtg ctcactcaaa ccactaaaac agatggatag
     1801 ctttgaggtt ttagataagg aaagattatg gagaatgtag ttgttattga tttttggcaa
     1861 ttttacattt ggaattttat cactgtgctt ttttatatga ggcactgtag tattttcaca
     1921 tagtatagta ctctggatgt aaaagctcaa aaattgtgat tccttgaacg ttcactaaat
     1981 cttcaagcaa aaacacattt ttacattatt tttacgttga ttattttagt gaaagaccat
     2041 atgaagaagc atttttaata ttaacttgtt acatactttg atccacttta catcattttt
     2101 atgttgttga ggtagggaaa ttagggttca gtttatcact ggacattcag gaggcaagtc
     2161 aatctttttt atttccttat aaaattaact cttcaaaagc cgttaaacag agagttatct
     2221 taatttttat tgcagtagga ggaaatatat ttaaaatatt tgtagattta tagcaaatag
     2281 agactcgtta tttaaaggtt aaataacaat ttgttctttt gttgtttttg ccagtttagg
     2341 gcagtagctg cttttgtcat aaatatcttc ctaccacatc aaaaatgctg cttttaaaat
     2401 ttttgtttat aaattgagaa ggaattttct ctctataagt ttctgtcatt gaacagatca
     2461 ccattaaaaa gaatattaga atccagcatg aagataatgg ctaataaaaa tgaggtacat
     2521 actttataaa accattaatc agatttgaat gaggaatgct tcccacatcc ttgaaagaaa
     2581 aactgtggct tacgttttga agtattctga gaatgaagta ttaagatcca atttctataa
     2641 gcaagatcag acttgttaag tatgccgcaa gtaagagcta attcattcat tccatgtgtg
     2701 ccactaaata aagagattga gcaagtgcca ctgtgtggaa catttttctt ttttttaata
     2761 ttggactttc caattttgaa attatggata aagtcctaaa ttttctatag tggcttcttt
     2821 tctgtctgca tattttgtta aaattgtgga tctaaaagcc atatcctgtc tttggtggtg
     2881 gcctggtagg aatggcttgt cctagttctt caaaggtaag attgaccaaa gcaagttctc
     2941 attggtggtc tgtgtttaca tcttccgtgt caagatattt taaagcatga aaataaagcc
     3001 attcttgccc tttttcgtgt gtttgaaa
//
