LOCUS       NM_002511               3079 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens neuromedin B receptor (NMBR), transcript variant 1,
            mRNA.
ACCESSION   NM_002511
VERSION     NM_002511.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3079)
  AUTHORS   Rametta,R., Dongiovanni,P., Baselli,G.A., Pelusi,S., Meroni,M.,
            Fracanzani,A.L., Busti,F., Castagna,A., Scarlini,S., Corradini,E.,
            Pietrangelo,A., Girelli,D., Fargion,S. and Valenti,L.
  TITLE     Impact of natural neuromedin-B receptor variants on iron metabolism
  JOURNAL   Am J Hematol 95 (2), 167-177 (2020)
   PUBMED   31724192
  REMARK    GeneRIF: NMBR natural variants were enriched in patients with iron
            overload, and associated with facilitated iron absorption, possibly
            related to a defect of iron-induced hepcidin release.
REFERENCE   2  (bases 1 to 3079)
  AUTHORS   Yang,G., Huang,H., Tang,M., Cai,Z., Huang,C., Qi,B. and Chen,J.L.
  TITLE     Role of neuromedin B and its receptor in the innate immune
            responses against influenza A virus infection in vitro and in vivo
  JOURNAL   Vet Res 50 (1), 80 (2019)
   PUBMED   31601264
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3079)
  AUTHORS   Jaeger,M., Ghisleni,E.C., Fratini,L., Brunetto,A.L.,
            Gregianin,L.J., Brunetto,A.T., Schwartsmann,G., de Farias,C.B. and
            Roesler,R.
  TITLE     Viability of D283 medulloblastoma cells treated with a histone
            deacetylase inhibitor combined with bombesin receptor antagonists
  JOURNAL   Childs Nerv Syst 32 (1), 61-64 (2016)
   PUBMED   26590027
REFERENCE   4  (bases 1 to 3079)
  AUTHORS   Porcelli,S., Balzarro,B., Lee,S.J., Han,C., Patkar,A.A., Pae,C.U.
            and Serretti,A.
  TITLE     PDE7B, NMBR and EPM2A Variants and Schizophrenia: A Case-Control
            and Pharmacogenetics Study
  JOURNAL   Neuropsychobiology 73 (3), 160-168 (2016)
   PUBMED   27092952
  REMARK    GeneRIF: The rs2717 and rs6926279 within the NMBR gene were
            associated with schizophrenia liability.
REFERENCE   5  (bases 1 to 3079)
  AUTHORS   Li,J., Liu,F., Wang,H., Liu,X., Liu,J., Li,N., Wan,F., Wang,W.,
            Zhang,C., Jin,S., Liu,J., Zhu,P. and Liu,Y.
  TITLE     Systematic mapping and functional analysis of a family of human
            epididymal secretory sperm-located proteins
  JOURNAL   Mol Cell Proteomics 9 (11), 2517-2528 (2010)
   PUBMED   20736409
REFERENCE   6  (bases 1 to 3079)
  AUTHORS   Wu,J.M., Hoang,D.O. and Feldman,R.I.
  TITLE     Differential activation of human gastrin-releasing peptide
            receptor-mediated responses by bombesin analogs
  JOURNAL   Mol Pharmacol 47 (4), 871-881 (1995)
   PUBMED   7723750
REFERENCE   7  (bases 1 to 3079)
  AUTHORS   Benya,R.V., Kusui,T., Pradhan,T.K., Battey,J.F. and Jensen,R.T.
  TITLE     Expression and characterization of cloned human bombesin receptors
  JOURNAL   Mol Pharmacol 47 (1), 10-20 (1995)
   PUBMED   7838118
REFERENCE   8  (bases 1 to 3079)
  AUTHORS   DeMichele,M.A., Davis,A.L., Hunt,J.D., Landreneau,R.J. and
            Siegfried,J.M.
  TITLE     Expression of mRNA for three bombesin receptor subtypes in human
            bronchial epithelial cells
  JOURNAL   Am J Respir Cell Mol Biol 11 (1), 66-74 (1994)
   PUBMED   8018339
REFERENCE   9  (bases 1 to 3079)
  AUTHORS   Bitar,K.N. and Zhu,X.X.
  TITLE     Expression of bombesin-receptor subtypes and their differential
            regulation of colonic smooth muscle contraction
  JOURNAL   Gastroenterology 105 (6), 1672-1680 (1993)
   PUBMED   8253343
REFERENCE   10 (bases 1 to 3079)
  AUTHORS   Corjay,M.H., Dobrzanski,D.J., Way,J.M., Viallet,J., Shapira,H.,
            Worland,P., Sausville,E.A. and Battey,J.F.
  TITLE     Two distinct bombesin receptor subtypes are expressed and
            functional in human lung carcinoma cells
  JOURNAL   J Biol Chem 266 (28), 18771-18779 (1991)
   PUBMED   1655761
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL033522.1 and AL589674.9.
            
            On Jun 16, 2020 this sequence version replaced NM_002511.3.
            
            Summary: This gene encodes a 7-transmembrane G protein-coupled
            receptor that binds neuromedin B, which is a growth factor and
            mitogen for gastrointestinal epithelial tissue and for normal and
            neoplastic lung. This receptor may play a role in smooth muscle
            contraction, neuronal responses, and the regulation of cell growth.
            Antagonists of this receptor have a potential therapeutic use in
            inhibiting tumor cell growth. Polymorphisms in this gene may be
            associated with a susceptibility for schizophrenia. Alternative
            splicing of this gene results in multiple transcript variants.
            [provided by RefSeq, Apr 2016].
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: M73482.1, GU727635.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1968189,
                                    SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000258042.2/ ENSP00000258042.1
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                AL033522.1         37858-37936         c
            80-1164             AL589674.9         89715-90799         c
            1165-1513           AL589674.9         80033-80381         c
            1514-3079           AL589674.9         75962-77527         c
FEATURES             Location/Qualifiers
     source          1..3079
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q24.1"
     gene            1..3079
                     /gene="NMBR"
                     /gene_synonym="BB1; BB1R; BRS1; NMB-R"
                     /note="neuromedin B receptor"
                     /db_xref="GeneID:4829"
                     /db_xref="HGNC:HGNC:7843"
                     /db_xref="MIM:162341"
     exon            1..79
                     /gene="NMBR"
                     /gene_synonym="BB1; BB1R; BRS1; NMB-R"
                     /inference="alignment:Splign:2.1.0"
     exon            80..1164
                     /gene="NMBR"
                     /gene_synonym="BB1; BB1R; BRS1; NMB-R"
                     /inference="alignment:Splign:2.1.0"
     CDS             743..1915
                     /gene="NMBR"
                     /gene_synonym="BB1; BB1R; BRS1; NMB-R"
                     /note="isoform a is encoded by transcript variant 1;
                     neuromedin-B-preferring bombesin receptor; epididymis
                     tissue protein Li 185a; bombesin receptor 1; epididymis
                     secretory sperm binding protein Li 185a"
                     /codon_start=1
                     /product="neuromedin-B receptor isoform a"
                     /protein_id="NP_002502.2"
                     /db_xref="CCDS:CCDS5196.1"
                     /db_xref="GeneID:4829"
                     /db_xref="HGNC:HGNC:7843"
                     /db_xref="MIM:162341"
                     /translation="MPSKSLSNLSVTTGANESGSVPEGWERDFLPASDGTTTELVIRC
                     VIPSLYLLIITVGLLGNIMLVKIFITNSAMRSVPNIFISNLAAGDLLLLLTCVPVDAS
                     RYFFDEWMFGKVGCKLIPVIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGALLRT
                     CVKAMGIWVVSVLLAVPEAVFSEVARISSLDNSSFTACIPYPQTDELHPKIHSVLIFL
                     VYFLIPLAIISIYYYHIAKTLIKSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFI
                     FCWFPNHILYMYRSFNYNEIDPSLGHMIVTLVARVLSFGNSCVNPFALYLLSESFRRH
                     FNSQLCCGRKSYQERGTSYLLSSSAVRMTSLKSNAKNMVTNSVLLNGHSMKQEMAL"
     exon            1165..1513
                     /gene="NMBR"
                     /gene_synonym="BB1; BB1R; BRS1; NMB-R"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..3079
                     /gene="NMBR"
                     /gene_synonym="BB1; BB1R; BRS1; NMB-R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3057..3062
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NMBR"
                     /gene_synonym="BB1; BB1R; BRS1; NMB-R"
                     /note="hexamer: AATAAA"
     polyA_site      3079
                     /gene="NMBR"
                     /gene_synonym="BB1; BB1R; BRS1; NMB-R"
                     /note="major polyA site"
ORIGIN      
        1 ggctctcggc ggttagaacc cacagaagac ccgagcattt tggcgcttat gccgcgcatg
       61 gcgctagcgc tctctgctgc attagggact tgccaactca gccctttaat cctcagagat
      121 tccaaagttc ttgcctggag ctcctcctgc ttggaggcgg gtaaggatgg atgtatatag
      181 gggcacacac acatgcatgg aggactgacc tcccctccag ttccacacaa tacaacagga
      241 acttcacaaa caagagcaaa gctgtgggaa aagcaggttg caggtggccc cgcctagttc
      301 ccgggatttc agctgcggcc cgctggacag cgccaggatg acttctgctt ctctgggcga
      361 agagtccggc aggtgcttct actgatcccc aagggacagc tccttgttcc tgaaaggctg
      421 ttttccgcta gataaccgcg agaacaaacc actgaatacg gaacaaagac gcaaccgctt
      481 tgcttttttt ttttttttaa tttaaattca gagttagccg gagccatttc ccccctctag
      541 aagcggagcg cccgagtgtg tggacagacc cctccccagg tcctgaactc ttagggacgt
      601 ggtgctgtga ggcttgcccc gcggacagta aacttgcagg ggcgagaggg agggacatcg
      661 attaaaccta aatcgtgggc gttcagtcct cagggcaccg gagcgcgtga aaactccagc
      721 ggactctgct ggaaaggaga tcatgccctc taagtctctt tccaacctct cggtgaccac
      781 cggcgcgaat gagagcggtt ccgttcccga ggggtgggaa agggatttcc tgccggcctc
      841 ggacgggacc accacggagt tggtgatccg ctgtgtgatc ccgtccctct acctgctcat
      901 catcaccgtg ggcttgctgg gcaacatcat gctggtgaag atcttcatca ccaacagcgc
      961 catgaggagc gtccccaaca tcttcatctc taacctggcg gccggggact tgctgctgct
     1021 gctcacctgc gtcccggtgg acgcctcgcg ctacttcttc gacgagtgga tgtttggcaa
     1081 ggtgggctgc aaactgatcc ctgtcatcca gctcacttcc gtgggggttt ccgtgttcac
     1141 tctcactgcc ctcagcgccg acaggtacag agccatcgtt aaccccatgg acatgcagac
     1201 gtcaggggca ttgctgcgga cctgtgtgaa ggccatgggt atctgggtgg tctccgtgtt
     1261 gctggcagtt cccgaagcgg tgttttcaga agtggctcgc atcagtagct tggataatag
     1321 cagcttcaca gcatgtatcc cataccctca aacagatgaa ttacatccaa agattcattc
     1381 agtgctcatt ttcttggtct atttcctcat accacttgct attattagca tttattatta
     1441 tcatattgca aagaccttaa ttaaaagcgc acacaatctt cctggagaat acaatgaaca
     1501 taccaaaaaa cagatggaaa cacggaaacg cctggctaaa attgtgcttg tctttgtggg
     1561 ctgtttcatc ttctgttggt ttccaaacca catcctttac atgtatcggt ctttcaacta
     1621 taatgagatt gatccatctc taggccacat gattgtcacc ttagttgccc gggttctcag
     1681 ttttggcaat tcttgtgtca acccatttgc tctttaccta ctcagtgaaa gcttcaggag
     1741 gcatttcaac agccaactct gctgtgggag gaagtcctat caagagagag gaaccagcta
     1801 cctactcagc tcttcagcgg tgcgtatgac atctctgaaa agcaatgcta agaacatggt
     1861 gaccaattct gttttactaa atgggcacag catgaagcag gaaatggcac tgtgattttg
     1921 gccattcaac tcactacctg gagagaactt agtaactgtt aaaattccta ttcggcagat
     1981 cagaacttgc tgttgcttag ctaatttatt aggcaattgc atgattgact cagaaaatgc
     2041 aagacatttt ttctctacac tagactttat tttttctctt ttcatttcct aataattaga
     2101 atatgagaaa agactttaaa tcactacata taatacatat atgtatatat atgtatttgc
     2161 acacacacat gtacacacat gtacattata tatatttcac atttaagatg atccccaaac
     2221 caatgcaata tgtataattt aacattgctt tagtatttag gctgttgcta aagccagttc
     2281 tagcatattt gtcttaggtt ttgttttatc ttgaagcatg aaataaattt ctatattgac
     2341 tcaatgattc agtgagggta atattcaaac tcctattatt tgaaatacaa gtcagattgt
     2401 cctggtgaat ttcattcaat tcacaactat tgcatgagtg tgtgtgtgtg tgtatatata
     2461 tatgtatatg tatatatgta cacacacaca cgtccttcat tttaagaaaa taagaaaaaa
     2521 ttcaaaggtg gagcttaatc aaattggtat ttattgtgat tctgtgatta atcataattt
     2581 atagaaataa ttcatatctg taattctaag tatgtgatta acagatataa tgaaattaat
     2641 attatgaatt ataaaataga tatgatatga atataattta tattatgaat gtaaaatagg
     2701 tatcatatga atatgattta cattatgaat gtaaaatagg tatcatatgt cccaaattgc
     2761 aaagctacaa ctcacaagtt tgcatggcca tcttagtata cattgctaaa tcctcgaata
     2821 tttggatgat tgtgtataga tgtgataaga tttgtgtaat tccagtgagt tcaaccattt
     2881 actcatcctc tcttgcaata cccaactgac aagtatgtgg gatcacactt aggcaatttt
     2941 tttctgcttt tcctgcatga taccacagtt ttctctgaac aaatgtcttc tttttttagg
     3001 aaaatgcaaa tgtattgatt acagtttaaa agctaccatt tttaaaagca tgtatcaata
     3061 aatctaacat ttaaatcaa
//
