LOCUS       NM_021077                655 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens neuromedin B (NMB), transcript variant 1, mRNA.
ACCESSION   NM_021077
VERSION     NM_021077.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 655)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 655)
  AUTHORS   Chen,C., Okita,Y., Watanabe,Y., Abe,F., Fikry,M.A., Ichikawa,Y.,
            Suzuki,H., Shibuya,A. and Kato,M.
  TITLE     Glycoprotein nmb Is Exposed on the Surface of Dormant Breast Cancer
            Cells and Induces Stem Cell-like Properties
  JOURNAL   Cancer Res 78 (22), 6424-6435 (2018)
   PUBMED   30224376
  REMARK    GeneRIF: GPNMB is exposed on the surface of dormant breast cancer
            cells and its activity contributes to the acquisition of stem
            cell-like properties
REFERENCE   3  (bases 1 to 655)
  AUTHORS   Kirac,D., Kasimay Cakir,O., Avcilar,T., Deyneli,O., Kurtel,H.,
            Yazici,D., Kaspar,E.C., Celik,N. and Guney,A.I.
  TITLE     Effects of MC4R, FTO, and NMB gene variants to obesity, physical
            activity, and eating behavior phenotypes
  JOURNAL   IUBMB Life 68 (10), 806-816 (2016)
   PUBMED   27634552
  REMARK    GeneRIF: Genetic clues to the mechanism by which MC4R, FTO, and NMB
            influences changes in BMI and obesity.
REFERENCE   4  (bases 1 to 655)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   5  (bases 1 to 655)
  AUTHORS   Goswami,S.C., Thierry-Mieg,D., Thierry-Mieg,J., Mishra,S.,
            Hoon,M.A., Mannes,A.J. and Iadarola,M.J.
  TITLE     Itch-associated peptides: RNA-Seq and bioinformatic analysis of
            natriuretic precursor peptide B and gastrin releasing peptide in
            dorsal root and trigeminal ganglia, and the spinal cord
  JOURNAL   Mol Pain 10, 44 (2014)
   PUBMED   25123163
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 655)
  AUTHORS   Hearn,S.C., Jones,P.M., Ghatei,M.A., Byrne,J., Hill,S.F. and
            Bloom,S.R.
  TITLE     The presence, characterisation and synthesis of neuromedin B in the
            human pituitary gland
  JOURNAL   Neuroendocrinology 56 (5), 729-734 (1992)
   PUBMED   1488105
REFERENCE   7  (bases 1 to 655)
  AUTHORS   Sekar,M.C., Uemura,N., Coy,D.H., Hirschowitz,B.I. and
            Dickinson,K.E.
  TITLE     Bombesin, neuromedin B and neuromedin C interact with a common rat
            pancreatic phosphoinositide-coupled receptor, but are
            differentially regulated by guanine nucleotides
  JOURNAL   Biochem J 280 (Pt 1) (Pt 1), 163-169 (1991)
   PUBMED   1720612
REFERENCE   8  (bases 1 to 655)
  AUTHORS   Cardona,C., Rabbitts,P.H., Spindel,E.R., Ghatei,M.A., Bleehen,N.M.,
            Bloom,S.R. and Reeve,J.G.
  TITLE     Production of neuromedin B and neuromedin B gene expression in
            human lung tumor cell lines
  JOURNAL   Cancer Res 51 (19), 5205-5211 (1991)
   PUBMED   1717141
REFERENCE   9  (bases 1 to 655)
  AUTHORS   Krane,I.M., Naylor,S.L., Helin-Davis,D., Chin,W.W. and Spindel,E.R.
  TITLE     Molecular cloning of cDNAs encoding the human bombesin-like peptide
            neuromedin B. Chromosomal localization and comparison to cDNAs
            encoding its amphibian homolog ranatensin
  JOURNAL   J Biol Chem 263 (26), 13317-13323 (1988)
   PUBMED   2458345
  REMARK    Erratum:[J Biol Chem 1990 Apr 25;265(12):7091]
REFERENCE   10 (bases 1 to 655)
  AUTHORS   Namba,M., Ghatei,M.A., Anand,P. and Bloom,S.R.
  TITLE     Distribution and chromatographic characterization of neuromedin
            B-like immunoreactivity in the human spinal cord
  JOURNAL   Brain Res 342 (1), 183-186 (1985)
   PUBMED   4041812
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI858080.1, BC008603.1 and
            BC007431.2.
            
            On Nov 23, 2018 this sequence version replaced NM_021077.3.
            
            Summary: This gene encodes a member of the bombesin-like family of
            neuropeptides, which negatively regulate eating behavior. The
            encoded protein may regulate colonic smooth muscle contraction
            through binding to its cognate receptor, the neuromedin B receptor
            (NMBR). Polymorphisms of this gene may be associated with hunger,
            weight gain and obesity. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Jul 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript but encodes the shorter isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: W46216.1, SRR1163655.354772.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2157437 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360476.8/ ENSP00000353664.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-363               BI858080.1         326-688
            364-651             BC008603.1         356-643
            652-655             BC007431.2         1012-1015
FEATURES             Location/Qualifiers
     source          1..655
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q25.2"
     gene            1..655
                     /gene="NMB"
                     /note="neuromedin B"
                     /db_xref="GeneID:4828"
                     /db_xref="HGNC:HGNC:7842"
                     /db_xref="MIM:162340"
     exon            1..204
                     /gene="NMB"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..413
                     /gene="NMB"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; Neuromedin-B-32; neuromedin-beta"
                     /codon_start=1
                     /product="neuromedin-B isoform 1 preproprotein"
                     /protein_id="NP_066563.2"
                     /db_xref="CCDS:CCDS10332.1"
                     /db_xref="GeneID:4828"
                     /db_xref="HGNC:HGNC:7842"
                     /db_xref="MIM:162340"
                     /translation="MARRAGGARMFGSLLLFALLAAGVAPLSWDLPEPRSRASKIRVH
                     SRGNLWATGHFMGKKSLEPSSPSPLGTAPHTSLRDQRLQLSHDLLGILLLKKALGVSL
                     SRPAPQIQYRRLLVQILQK"
     exon            205..377
                     /gene="NMB"
                     /inference="alignment:Splign:2.1.0"
     exon            378..655
                     /gene="NMB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      633..638
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NMB"
                     /note="hexamer: AATAAA"
     polyA_site      655
                     /gene="NMB"
                     /note="major polyA site"
ORIGIN      
        1 agcggccggg aagcgcgccc gaacgaagcc gcggcccggg cacagccatg gcccggcggg
       61 cggggggcgc tcggatgttc ggcagcctcc tgctcttcgc cctgctcgct gccggcgtcg
      121 ccccgctcag ctgggatctc ccggagcccc gcagccgagc cagcaagatc cgagtgcact
      181 cgcgaggcaa cctctgggcc accggtcact tcatgggcaa gaagagtctg gagccttcca
      241 gcccatcccc attggggaca gctccccaca cctccctgag ggaccagcga ctgcagctga
      301 gtcatgatct gctcggaatc ctcctgctaa agaaggctct gggcgtgagc ctcagccgcc
      361 ccgcacccca aatccagtac aggaggctgc tggtacaaat actgcagaaa tgacaccaat
      421 aatggggcag acacaacagc gtggcttaga ttgtgcccac ccagggaagg tgctgaatgg
      481 gaccctgttg atggccccat ctggatgtaa atcctgagct caaatctctg ttactccatt
      541 actgtgattt ctggctgggt caccagaaat atcgctgatg cagacacaga ttatgttcct
      601 gctgtatttc ctgcttccct gttgaattgg tgaataaaac cttgctcttt acata
//
