LOCUS       NM_001282144            4131 bp    mRNA    linear   PRI 09-JUL-2024
DEFINITION  Homo sapiens NLR family member X1 (NLRX1), transcript variant 4,
            mRNA.
ACCESSION   NM_001282144 XM_005271668
VERSION     NM_001282144.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4131)
  AUTHORS   Tao,J., Cheng,J., Shi,Y., Li,B., Tang,P., Jiao,J. and Liu,H.
  TITLE     NLRX1 Mediates the Disruption of Intestinal Mucosal Function Caused
            by Porcine Astrovirus Infection via the Extracellular Regulated
            Protein Kinases/Myosin Light-Chain Kinase (ERK/MLCK) Pathway
  JOURNAL   Cells 13 (11), 913 (2024)
   PUBMED   38891045
  REMARK    GeneRIF: NLRX1 Mediates the Disruption of Intestinal Mucosal
            Function Caused by Porcine Astrovirus Infection via the
            Extracellular Regulated Protein Kinases/Myosin Light-Chain Kinase
            (ERK/MLCK) Pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4131)
  AUTHORS   Ding,Y., Sun,W., Han,M., Liu,Z., Kang,H., Ma,X., Wang,J., Mu,H.,
            Huang,Y., Hou,S., Sun,D., Shen,X., Wu,X. and Liu,R.
  TITLE     NLRX1: a key regulator in mitochondrial respiration and colorectal
            cancer progression
  JOURNAL   Med Oncol 41 (6), 131 (2024)
   PUBMED   38683455
  REMARK    GeneRIF: NLRX1: a key regulator in mitochondrial respiration and
            colorectal cancer progression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4131)
  AUTHORS   Bi,P.Y., Killackey,S.A., Schweizer,L. and Girardin,S.E.
  TITLE     NLRX1: Versatile functions of a mitochondrial NLR protein that
            controls mitophagy
  JOURNAL   Biomed J 47 (1), 100635 (2024)
   PUBMED   37574163
  REMARK    GeneRIF: NLRX1: Versatile functions of a mitochondrial NLR protein
            that controls mitophagy.
            Review article
REFERENCE   4  (bases 1 to 4131)
  AUTHORS   Wang,Q., He,F. and Wu,L.
  TITLE     NLRX1 increases human retinal pigment epithelial autophagy and
            reduces H2O2-induced oxidative stress and inflammation by
            suppressing FUNDC1 phosphorylation and NLRP3 activation
  JOURNAL   Allergol Immunopathol (Madr) 51 (1), 177-186 (2023)
   PUBMED   36617838
  REMARK    GeneRIF: NLRX1 increases human retinal pigment epithelial autophagy
            and reduces H2O2-induced oxidative stress and inflammation by
            suppressing FUNDC1 phosphorylation and NLRP3 activation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4131)
  AUTHORS   Arnoult,D., Soares,F., Tattoli,I., Castanier,C., Philpott,D.J. and
            Girardin,S.E.
  TITLE     An N-terminal addressing sequence targets NLRX1 to the
            mitochondrial matrix
  JOURNAL   J Cell Sci 122 (Pt 17), 3161-3168 (2009)
   PUBMED   19692591
  REMARK    GeneRIF: NLRX1 has a functional leader sequence and fully
            translocates to the mitochondrial matrix.
REFERENCE   6  (bases 1 to 4131)
  AUTHORS   Pietras,E.M. and Cheng,G.
  TITLE     New tricks for old NODs
  JOURNAL   Genome Biol 9 (4), 217 (2008)
   PUBMED   18466630
  REMARK    GeneRIF: function of NOD-like receptors in the antiviral response
            [REVIEW]
            Review article
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4131)
  AUTHORS   O'Neill,L.A.
  TITLE     Innate immunity: squelching anti-viral signalling with NLRX1
  JOURNAL   Curr Biol 18 (7), R302-R304 (2008)
   PUBMED   18397740
  REMARK    GeneRIF: sequesters MAVS away from RIG-I and thereby prevents
            mitochondrial anti-viral immunity
REFERENCE   8  (bases 1 to 4131)
  AUTHORS   Tattoli,I., Carneiro,L.A., Jehanno,M., Magalhaes,J.G., Shu,Y.,
            Philpott,D.J., Arnoult,D. and Girardin,S.E.
  TITLE     NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-kappaB
            and JNK pathways by inducing reactive oxygen species production
  JOURNAL   EMBO Rep 9 (3), 293-300 (2008)
   PUBMED   18219313
  REMARK    GeneRIF: These results identify NLRX1 as a NLR that contributes to
            the link between reactive oxygen species generation at the
            mitochondria and innate immune responses.
REFERENCE   9  (bases 1 to 4131)
  AUTHORS   Moore,C.B., Bergstralh,D.T., Duncan,J.A., Lei,Y., Morrison,T.E.,
            Zimmermann,A.G., Accavitti-Loper,M.A., Madden,V.J., Sun,L., Ye,Z.,
            Lich,J.D., Heise,M.T., Chen,Z. and Ting,J.P.
  TITLE     NLRX1 is a regulator of mitochondrial antiviral immunity
  JOURNAL   Nature 451 (7178), 573-577 (2008)
   PUBMED   18200010
  REMARK    GeneRIF: identification of NLRX1 as a check against mitochondrial
            antiviral responses--an intersection of three ancient cellular
            processes: NLR signalling, intracellular virus detection and the
            use of mitochondria as a platform for anti-pathogen signalling
REFERENCE   10 (bases 1 to 4131)
  AUTHORS   Inohara,N. and Nunez,G.
  TITLE     NODs: intracellular proteins involved in inflammation and apoptosis
  JOURNAL   Nat Rev Immunol 3 (5), 371-382 (2003)
   PUBMED   12766759
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA107044.1, BC110890.2 and
            AB094095.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001282144.1.
            
            Summary: The protein encoded by this gene is a member of the NLR
            family and localizes to the outer mitochondrial membrane. The
            encoded protein is a regulator of mitochondrial antivirus
            responses. Three transcript variants encoding the same protein have
            been found for this gene. [provided by RefSeq, Aug 2013].
            
            Transcript Variant: This variant (4) represents the longest
            transcript. All three variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC110890.2, SRR1163658.241374.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 19692591; reported by
                                                  MitoCarta
            MANE Ensembl match                 :: ENST00000409109.6/
                                                  ENSP00000387334.1
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                DA107044.1         13-59
            48-4023             BC110890.2         1-3976
            4024-4131           AB094095.1         3639-3746
FEATURES             Location/Qualifiers
     source          1..4131
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.3"
     gene            1..4131
                     /gene="NLRX1"
                     /gene_synonym="CLR11.3; DLNB26; NOD26; NOD5; NOD9"
                     /note="NLR family member X1"
                     /db_xref="GeneID:79671"
                     /db_xref="HGNC:HGNC:29890"
                     /db_xref="MIM:611947"
     exon            1..578
                     /gene="NLRX1"
                     /gene_synonym="CLR11.3; DLNB26; NOD26; NOD5; NOD9"
                     /inference="alignment:Splign:2.1.0"
     exon            579..696
                     /gene="NLRX1"
                     /gene_synonym="CLR11.3; DLNB26; NOD26; NOD5; NOD9"
                     /inference="alignment:Splign:2.1.0"
     CDS             627..3554
                     /gene="NLRX1"
                     /gene_synonym="CLR11.3; DLNB26; NOD26; NOD5; NOD9"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 4; NOD-like receptor X1; nucleotide-binding
                     oligomerization domain, leucine rich repeat containing X1;
                     caterpiller protein 11.3; nucleotide-binding
                     oligomerization domain protein 5; nucleotide-binding
                     oligomerization domain protein 9; nucleotide-binding
                     oligomerization domain protein 26"
                     /codon_start=1
                     /product="NLR family member X1 isoform 1 precursor"
                     /protein_id="NP_001269073.1"
                     /db_xref="CCDS:CCDS8416.1"
                     /db_xref="GeneID:79671"
                     /db_xref="HGNC:HGNC:29890"
                     /db_xref="MIM:611947"
                     /translation="MRWGHHLPRASWGSGFRRALQRPDDRIPFLIHWSWPLQGERPFG
                     PPRAFIRHHGSSVDSAPPPGRHGRLFPSASATEAIQRHRRNLAEWFSRLPREERQFGP
                     TFALDTVHVDPVIRESTPDELLRPPAELALEHQPPQAGLPPLALSQLFNPDACGRRVQ
                     TVVLYGTVGTGKSTLVRKMVLDWCYGRLPAFELLIPFSCEDLSSLGPAPASLCQLVAQ
                     RYTPLKEVLPLMAAAGSHLLFVLHGLEHLNLDFRLAGTGLCSDPEEPQEPAAIIVNLL
                     RKYMLPQASILVTTRPSAIGRIPSKYVGRYGEICGFSDTNLQKLYFQLRLNQPYCGYA
                     VGGSGVSATPAQRDHLVQMLSRNLEGHHQIAAACFLPSYCWLVCATLHFLHAPTPAGQ
                     TLTSIYTSFLRLNFSGETLDSTDPSNLSLMAYAARTMGKLAYEGVSSRKTYFSEEDVC
                     GCLEAGIRTEEEFQLLHIFRRDALRFFLAPCVEPGRAGTFVFTVPAMQEYLAALYIVL
                     GLRKTTLQKVGKEVAELVGRVGEDVSLVLGIMAKLLPLRALPLLFNLIKVVPRVFGRM
                     VGKSREAVAQAMVLEMFREEDYYNDDVLDQMGASILGVEGPRRHPDEPPEDEVFELFP
                     MFMGGLLSAHNRAVLAQLGCPIKNLDALENAQAIKKKLGKLGRQVLPPSELLDHLFFH
                     YEFQNQRFSAEVLSSLRQLNLAGVRMTPVKCTVVAAVLGSGRHALDEVNLASCQLDPA
                     GLRTLLPVFLRARKLGLQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAV
                     LMEGLAGNTSVTHLSLLHTGLGDEGLELLAAQLDRNRQLQELNVAYNGAGDTAALALA
                     RAAREHPSLELLHLYFNELSSEGRQVLRDLGGAAEGGARVVVSLTEGTAVSEYWSVIL
                     SEVQRNLNSWDRARVQRHLELLLRDLEDSRGATLNPWRKAQLLRVEGEVRALLEQLGS
                     SGS"
     exon            697..766
                     /gene="NLRX1"
                     /gene_synonym="CLR11.3; DLNB26; NOD26; NOD5; NOD9"
                     /inference="alignment:Splign:2.1.0"
     exon            767..855
                     /gene="NLRX1"
                     /gene_synonym="CLR11.3; DLNB26; NOD26; NOD5; NOD9"
                     /inference="alignment:Splign:2.1.0"
     exon            856..1475
                     /gene="NLRX1"
                     /gene_synonym="CLR11.3; DLNB26; NOD26; NOD5; NOD9"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..2297
                     /gene="NLRX1"
                     /gene_synonym="CLR11.3; DLNB26; NOD26; NOD5; NOD9"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..2893
                     /gene="NLRX1"
                     /gene_synonym="CLR11.3; DLNB26; NOD26; NOD5; NOD9"
                     /inference="alignment:Splign:2.1.0"
     exon            2894..2980
                     /gene="NLRX1"
                     /gene_synonym="CLR11.3; DLNB26; NOD26; NOD5; NOD9"
                     /inference="alignment:Splign:2.1.0"
     exon            2981..3232
                     /gene="NLRX1"
                     /gene_synonym="CLR11.3; DLNB26; NOD26; NOD5; NOD9"
                     /inference="alignment:Splign:2.1.0"
     exon            3233..4131
                     /gene="NLRX1"
                     /gene_synonym="CLR11.3; DLNB26; NOD26; NOD5; NOD9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4105..4110
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NLRX1"
                     /gene_synonym="CLR11.3; DLNB26; NOD26; NOD5; NOD9"
                     /note="hexamer: ATTAAA"
     polyA_site      4131
                     /gene="NLRX1"
                     /gene_synonym="CLR11.3; DLNB26; NOD26; NOD5; NOD9"
                     /note="major polyA site"
ORIGIN      
        1 agtgcccgcg gggatggagg cagggagggg ggacgatggc gggacgggtg gcgccggggt
       61 tccagccctg cgcctgctcc ggagcaccgg gcccctctcg ctgaccccct cgtcccagga
      121 ccccgcaggc ccgagtgcct gggctcgtcc tctttcgcgc ccgctgccag gtgccagggc
      181 cgcgcaggcg ggcggaggtg ggcaggaagc gccacgccga ggagccgggg actctgggag
      241 ctagcgggag acgccggcgt ccgcccagcc gacccctctg ggccgcggcc gacggctccc
      301 ggaactgggc agccgcgggt aaaggcctag cgggcttgat aacccctgcg ccctggctgg
      361 gaggccgcgc tgagcggggg gcagggcggg ccgggggagg aggctgtgca agggccgcgg
      421 ggagatcccg gccgagaacg agagggacgg agctgggcgc tgaatggcgg gcgttctggc
      481 aagtctcccc ctgcgttccc gaggccaccc gaaagtagga gagctgtttg ggacccagtt
      541 tggtggagga gctctggacc tgtaggaaca ccgcccctga cagaagtcgg tcctaggccc
      601 cccaggctct gaccttcttt cccaggatga ggtggggcca ccatttgccc agggcctctt
      661 ggggctctgg ttttagaaga gcactccagc gaccagatga tcgtatcccc ttcctgatcc
      721 actggagttg gccccttcaa ggggagcgtc cctttgggcc ccctagggcc tttatacgcc
      781 accacggaag ctcggtagat agcgctcccc cacccgggag gcatggacgg ctgttcccca
      841 gcgcctctgc aactgaagct atacagcggc accgccggaa cctggctgag tggttcagcc
      901 ggctgcccag ggaggagcgc cagtttggcc caacctttgc cctagacacg gtccacgttg
      961 accctgtgat ccgcgagagt acccctgatg agctacttcg cccacccgcg gagctggccc
     1021 tggagcatca gccaccccag gccgggctcc ccccactggc cttgtctcag ctctttaacc
     1081 cggatgcctg tgggcgccgg gtgcagacag tggtgctgta tgggacagtg ggcacaggca
     1141 agagcacgct ggtgcgcaag atggttctgg actggtgtta tgggcggctg ccggccttcg
     1201 agctgctcat ccccttctcc tgtgaggacc tgtcatccct gggccctgcc ccagcctccc
     1261 tgtgccaact tgtggcccag cgctacacgc ccctgaagga ggttctgccc ctgatggctg
     1321 ctgctgggtc ccacctcctc tttgtgctcc atggcttaga gcatctcaac ctcgacttcc
     1381 ggctggcagg cacgggactt tgtagtgacc cggaggaacc gcaggaacca gctgctatca
     1441 tcgtcaacct gctgcgcaaa tacatgctgc ctcaggccag cattctggtg accactcggc
     1501 cctctgccat tggccgtatc cccagcaagt acgtgggccg ctatggtgag atctgcggtt
     1561 tctctgatac caacctgcag aagctctact tccagctccg cctcaaccag ccgtactgcg
     1621 ggtatgccgt tggcggttca ggtgtctctg ccacaccagc tcagcgtgac cacctggtgc
     1681 agatgctctc ccggaacctg gaggggcacc accagatagc cgctgcctgc ttcctgccgt
     1741 cctattgctg gctcgtttgt gccaccttgc acttcctgca tgcccccacg cctgctgggc
     1801 agacccttac aagcatctat accagcttcc tgcgcctcaa cttcagcggg gaaaccctgg
     1861 acagcactga cccctccaat ttgtccctga tggcctatgc agcccgaacc atgggcaagt
     1921 tggcctatga gggggtgtcc tcccgcaaga cctacttctc tgaagaggat gtctgtggct
     1981 gcctggaggc tggcatcagg acggaggagg agtttcagct gctgcacatc ttccgtcggg
     2041 atgccctgag gtttttcctg gccccatgtg tggagccagg gcgtgcaggc accttcgtgt
     2101 tcaccgtgcc cgccatgcag gaatacctgg ctgccctcta cattgtgctg ggtttgcgca
     2161 agacgaccct gcaaaaggtg ggcaaggaag tggctgagct cgtgggccgt gttggggagg
     2221 acgtcagcct ggtactgggc atcatggcca agctgctgcc tctgcgggct ctgcctctgc
     2281 tcttcaacct gatcaaggtg gttccacgag tgtttgggcg catggtgggt aaaagccggg
     2341 aggcggtggc tcaggccatg gtgctggaga tgtttcgaga ggaggactac tacaacgatg
     2401 atgttctgga ccagatgggc gccagtatcc tgggcgtgga gggcccccgg cgccacccag
     2461 atgagccccc tgaggatgaa gtcttcgagc tcttccccat gttcatgggg gggcttctct
     2521 ctgcccacaa ccgagctgtg ctagctcagc ttggctgccc catcaagaac ctggatgccc
     2581 tggagaatgc ccaggccatc aagaagaagc tgggcaagct gggccggcag gtgctgcccc
     2641 catcagagct ccttgaccac ctcttcttcc actatgagtt ccagaaccag cgcttctccg
     2701 ctgaggtgct cagctccctg cgtcagctca acctggcagg tgtgcgcatg acaccagtca
     2761 agtgcacagt ggtggcagct gtgctgggca gcggaaggca tgccctggat gaggtgaact
     2821 tggcctcctg ccagctagat cctgctgggc tgcgcacact cctgcctgtc ttcctgcgtg
     2881 cccggaagct gggcttgcaa ctcaacagcc tgggccctga ggcctgcaag gacctccgag
     2941 acctgttgct gcatgaccag tgccaaatta ccacactgcg gctgtccaac aacccgctga
     3001 cggcggcagg tgttgccgtg ctaatggagg ggctggcagg aaacacctca gtgacgcacc
     3061 tgtccctgct gcacacgggc cttggggacg aaggcctgga gctgctggct gcccagctgg
     3121 accgcaaccg gcagctgcag gagctgaacg tggcgtacaa cggtgctggt gacacagcgg
     3181 ccctggccct ggccagagct gcccgggagc acccttccct ggaactgcta cacctctact
     3241 tcaatgagct gagctcagag ggccgccagg tcttgcgaga cttggggggt gctgctgaag
     3301 gtggtgcccg ggtggtggtg tcactgacag aggggacggc ggtgtcagaa tactggtcag
     3361 tgatcctcag tgaagtccag cggaacctca atagctggga tcgggcccgg gttcagcgac
     3421 accttgagct cctactgcgg gatctggaag atagccgggg tgccaccctt aatccttggc
     3481 gcaaggccca gctgctgcga gtggagggcg aggtcagggc cctcctggag cagctgggaa
     3541 gctctggaag ctgagacact ggcggcaggc acctagctat gtgaccactg gccctaaacc
     3601 ttttccctct gtggcctcct ggcttgcact gctccctcta gaaagattcc ttcaggtctg
     3661 gaggcagagg aatgggcata gctgagccag ttgccctcct agggcatgtt tgaccaggac
     3721 tgagtctgga atctccaagt taaagatggt gaatcaatgc ttcgggcttg gagatggaac
     3781 atgcctcctc tccattcagc tagaaggacc aaagcatgtg gcatttggat ggccagagtg
     3841 ccctgaagca ccactaccaa ccttgcctcc ccctcctctc aaagagcctc tgactgtgtc
     3901 accaaggggc tcacatctta tgtctgccat gccaggggtg tcgccatcca gatgtgttgg
     3961 aagcttcccc tcctgcctta tgctcacctg tggacaccga ggatgccctc acattggtgc
     4021 tttctcctca tcctcatgcc ccctttgcca caatggtatg atggcttggt agcccctcga
     4081 ggcagatgca cctgacttgc tgctattaaa aagccgtgtg ccttctacca a
//
