LOCUS       XM_047443578            3845 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens NLR family pyrin domain containing 3
            (NLRP3), transcript variant X12, mRNA.
ACCESSION   XM_047443578
VERSION     XM_047443578.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000001.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3845
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
     gene            1..3845
                     /gene="NLRP3"
                     /gene_synonym="AGTAVPRL; AII; AVP; C1orf7; CIAS1; CLR1.1;
                     DFNA34; FCAS; FCAS1; FCU; KEFH; MWS; NALP3; PYPAF1"
                     /note="NLR family pyrin domain containing 3; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 11 ESTs, 13 long SRA reads, 2 Proteins, and 95%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 4 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:114548"
                     /db_xref="HGNC:HGNC:16400"
                     /db_xref="MIM:606416"
     CDS             764..3532
                     /gene="NLRP3"
                     /gene_synonym="AGTAVPRL; AII; AVP; C1orf7; CIAS1; CLR1.1;
                     DFNA34; FCAS; FCAS1; FCU; KEFH; MWS; NALP3; PYPAF1"
                     /codon_start=1
                     /product="NACHT, LRR and PYD domains-containing protein 3
                     isoform X4"
                     /protein_id="XP_047299534.1"
                     /db_xref="GeneID:114548"
                     /db_xref="HGNC:HGNC:16400"
                     /db_xref="MIM:606416"
                     /translation="MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRG
                     QTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVS
                     NPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGE
                     SVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEP
                     VHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLI
                     MSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSS
                     LIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQA
                     RAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSL
                     LQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLF
                     QKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYG
                     KFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQ
                     PSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLG
                     FLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTS
                     QSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLVNSGLTSVCCSALSSVLSTNQ
                     NLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQS
                     LRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPEL
                     TVVFEPSW"
ORIGIN      
        1 gttcctgagg ctggcatctg gatgaggaaa ctgaagttga ggaatagtga agagtttgtc
       61 caatgtcata gccccgtaat caacgggaca aaaattttct tgctgatggg tcaagatggc
      121 atcgtgaagt ggttgttcac cgtaaactgt aatacaatcc tgtttatgga tttgtttgca
      181 tatttttccc tccataggga aacctttctt ccatggctca ggacacactc ctggatcgag
      241 ccaacaggag aactttctgg taagcatttg gctaactttt ttttttttga gatggagtct
      301 tgctgtgtcg cctaggctgg agtgcagtgg cgtgatcttg gctcactgca gcctccactt
      361 cccgggttca atcaattctc ctacctcaac ttcctgagta gctgggatta caggcgcccg
      421 ccaccacacc cggctcattt ttgtactttt agtagagaca cagttttgcc atgttggcca
      481 ggctggtctt gaattcctca gctcaggtga tctgcctgcc ttggcctctc aaagtgctgg
      541 gattacaggc gtgagccact gtgcccggcc ttggctaact tttcaaaatt aaagattttg
      601 acttgttaca gtcatgtgac atttttttct ttctgtttgc tgagtttttg ataatttata
      661 tctctcaaag tggagacttt aaaaaagact catccgtgtg ccgtgttcac tgcctggtat
      721 cttagtgtgg accgaagcct aaggaccctg aaaacagctg cagatgaaga tggcaagcac
      781 ccgctgcaag ctggccaggt acctggagga cctggaggat gtggacttga agaaatttaa
      841 gatgcactta gaggactatc ctccccagaa gggctgcatc cccctcccga ggggtcagac
      901 agagaaggca gaccatgtgg atctagccac gctaatgatc gacttcaatg gggaggagaa
      961 ggcgtgggcc atggccgtgt ggatcttcgc tgcgatcaac aggagagacc tttatgagaa
     1021 agcaaaaaga gatgagccga agtggggttc agataatgca cgtgtttcga atcccactgt
     1081 gatatgccag gaagacagca ttgaagagga gtggatgggt ttactggagt acctttcgag
     1141 aatctctatt tgtaaaatga agaaagatta ccgtaagaag tacagaaagt acgtgagaag
     1201 cagattccag tgcattgaag acaggaatgc ccgtctgggt gagagtgtga gcctcaacaa
     1261 acgctacaca cgactgcgtc tcatcaagga gcaccggagc cagcaggaga gggagcagga
     1321 gcttctggcc atcggcaaga ccaagacgtg tgagagcccc gtgagtccca ttaagatgga
     1381 gttgctgttt gaccccgatg atgagcattc tgagcctgtg cacaccgtgg tgttccaggg
     1441 ggcggcaggg attgggaaaa caatcctggc caggaagatg atgttggact gggcgtcggg
     1501 gacactctac caagacaggt ttgactatct gttctatatc cactgtcgag aggtgagcct
     1561 tgtgacacag aggagcctgg gggacctgat catgagctgc tgccccgacc caaacccacc
     1621 catccacaag atcgtgagaa aaccctccag aatcctcttc ctcatggacg gcttcgatga
     1681 gctgcaaggt gcctttgacg agcacatagg accgctctgc actgactggc agaaggccga
     1741 gcggggagac attctcctga gcagcctcat cagaaagaag ctgcttcccg aggcctctct
     1801 gctcatcacc acgagacctg tggccctgga gaaactgcag cacttgctgg accatcctcg
     1861 gcatgtggag atcctgggtt tctccgaggc caaaaggaaa gagtacttct tcaagtactt
     1921 ctctgatgag gcccaagcca gggcagcctt cagtctgatt caggagaacg aggtcctctt
     1981 caccatgtgc ttcatccccc tggtctgctg gatcgtgtgc actggactga aacagcagat
     2041 ggagagtggc aagagccttg cccagacatc caagaccacc accgcggtgt acgtcttctt
     2101 cctttccagt ttgctgcagc cccggggagg gagccaggag cacggcctct gcgcccacct
     2161 ctgggggctc tgctctttgg ctgcagatgg aatctggaac cagaaaatcc tgtttgagga
     2221 gtccgacctc aggaatcatg gactgcagaa ggcggatgtg tctgctttcc tgaggatgaa
     2281 cctgttccaa aaggaagtgg actgcgagaa gttctacagc ttcatccaca tgactttcca
     2341 ggagttcttt gccgccatgt actacctgct ggaagaggaa aaggaaggaa ggacgaacgt
     2401 tccagggagt cgtttgaagc ttcccagccg agacgtgaca gtccttctgg aaaactatgg
     2461 caaattcgaa aaggggtatt tgatttttgt tgtacgtttc ctctttggcc tggtaaacca
     2521 ggagaggacc tcctacttgg agaagaaatt aagttgcaag atctctcagc aaatcaggct
     2581 ggagctgctg aaatggattg aagtgaaagc caaagctaaa aagctgcaga tccagcccag
     2641 ccagctggaa ttgttctact gtttgtacga gatgcaggag gaggacttcg tgcaaagggc
     2701 catggactat ttccccaaga ttgagatcaa tctctccacc agaatggacc acatggtttc
     2761 ttccttttgc attgagaact gtcatcgggt ggagtcactg tccctggggt ttctccataa
     2821 catgcccaag gaggaagagg aggaggaaaa ggaaggccga caccttgata tggtgcagtg
     2881 tgtcctccca agctcctctc atgctgcctg ttctcatgga ttggtgaaca gccacctcac
     2941 ttccagtttt tgccggggcc tcttttcagt tctgagcacc agccagagtc taactgaatt
     3001 ggacctcagt gacaattctc tgggggaccc agggatgaga gtgttgtgtg aaacgctcca
     3061 gcatcctggc tgtaacattc ggagattgtg gttggtgaat tctggcctta cgtcagtctg
     3121 ttgttcagct ttgtcctcgg tactcagcac taatcagaat ctcacgcacc tttacctgcg
     3181 aggcaacact ctcggagaca aggggatcaa actactctgt gagggactct tgcaccccga
     3241 ctgcaagctt caggtgttgg aattagacaa ctgcaacctc acgtcacact gctgctggga
     3301 tctttccaca cttctgacct ccagccagag cctgcgaaag ctgagcctgg gcaacaatga
     3361 cctgggcgac ctgggggtca tgatgttctg tgaagtgctg aaacagcaga gctgcctcct
     3421 gcagaacctg gggttgtctg aaatgtattt caattatgag acaaaaagtg cgttagaaac
     3481 acttcaagaa gaaaagcctg agctgaccgt cgtctttgag ccttcttggt aggagtggaa
     3541 acggggctgc cagacgccag tgttctccgg tccctccagc tgggggccct caggtggaga
     3601 gagctgcgat ccatccaggc caagaccaca gctctgtgat ccttccggtg gagtgtcgga
     3661 gaagagagct tgccgacgat gccttcctgt gcagagcttg ggcatctcct ttacgccagg
     3721 gtgaggaaga caccaggaca atgacagcat cgggtgttgt tgtcatcaca gcgcctcagt
     3781 tagaggatgt tcctcttggt gacctcatgt aattagctca ttcaataaag cactttcttt
     3841 atttt
//
