LOCUS       XM_047443562            3550 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens NLR family pyrin domain containing 3
            (NLRP3), transcript variant X9, mRNA.
ACCESSION   XM_047443562
VERSION     XM_047443562.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000001.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3550
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
     gene            1..3550
                     /gene="NLRP3"
                     /gene_synonym="AGTAVPRL; AII; AVP; C1orf7; CIAS1; CLR1.1;
                     DFNA34; FCAS; FCAS1; FCU; KEFH; MWS; NALP3; PYPAF1"
                     /note="NLR family pyrin domain containing 3; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 1 mRNA, 10 ESTs, 13 long SRA reads, 3 Proteins, and
                     98% coverage of the annotated genomic feature by RNAseq
                     alignments, including 8 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:114548"
                     /db_xref="HGNC:HGNC:16400"
                     /db_xref="MIM:606416"
     CDS             298..3237
                     /gene="NLRP3"
                     /gene_synonym="AGTAVPRL; AII; AVP; C1orf7; CIAS1; CLR1.1;
                     DFNA34; FCAS; FCAS1; FCU; KEFH; MWS; NALP3; PYPAF1"
                     /codon_start=1
                     /product="NACHT, LRR and PYD domains-containing protein 3
                     isoform X2"
                     /protein_id="XP_047299518.1"
                     /db_xref="GeneID:114548"
                     /db_xref="HGNC:HGNC:16400"
                     /db_xref="MIM:606416"
                     /translation="MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRG
                     QTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVS
                     NPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGE
                     SVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEP
                     VHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLI
                     MSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSS
                     LIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQA
                     RAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSL
                     LQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLF
                     QKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYG
                     KFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQ
                     PSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLG
                     FLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLGRCGLSHECCFDISLVLSSN
                     QKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSH
                     SLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQN
                     LTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSL
                     RKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELT
                     VVFEPSW"
ORIGIN      
        1 gttcctgagg ctggcatctg gatgaggaaa ctgaagttga ggaatagtga agagtttgtc
       61 caatgtcata gccccgtaat caacgggaca aaaattttct tgctgatggg tcaagatggc
      121 atcgtgaagt ggttgttcac cgtaaactgt aatacaatcc tgtttatgga tttgtttgca
      181 tatttttccc tccataggga aacctttctt ccatggctca ggacacactc ctggatcgag
      241 ccaacaggag aactttctgt gtggaccgaa gcctaaggac cctgaaaaca gctgcagatg
      301 aagatggcaa gcacccgctg caagctggcc aggtacctgg aggacctgga ggatgtggac
      361 ttgaagaaat ttaagatgca cttagaggac tatcctcccc agaagggctg catccccctc
      421 ccgaggggtc agacagagaa ggcagaccat gtggatctag ccacgctaat gatcgacttc
      481 aatggggagg agaaggcgtg ggccatggcc gtgtggatct tcgctgcgat caacaggaga
      541 gacctttatg agaaagcaaa aagagatgag ccgaagtggg gttcagataa tgcacgtgtt
      601 tcgaatccca ctgtgatatg ccaggaagac agcattgaag aggagtggat gggtttactg
      661 gagtaccttt cgagaatctc tatttgtaaa atgaagaaag attaccgtaa gaagtacaga
      721 aagtacgtga gaagcagatt ccagtgcatt gaagacagga atgcccgtct gggtgagagt
      781 gtgagcctca acaaacgcta cacacgactg cgtctcatca aggagcaccg gagccagcag
      841 gagagggagc aggagcttct ggccatcggc aagaccaaga cgtgtgagag ccccgtgagt
      901 cccattaaga tggagttgct gtttgacccc gatgatgagc attctgagcc tgtgcacacc
      961 gtggtgttcc agggggcggc agggattggg aaaacaatcc tggccaggaa gatgatgttg
     1021 gactgggcgt cggggacact ctaccaagac aggtttgact atctgttcta tatccactgt
     1081 cgagaggtga gccttgtgac acagaggagc ctgggggacc tgatcatgag ctgctgcccc
     1141 gacccaaacc cacccatcca caagatcgtg agaaaaccct ccagaatcct cttcctcatg
     1201 gacggcttcg atgagctgca aggtgccttt gacgagcaca taggaccgct ctgcactgac
     1261 tggcagaagg ccgagcgggg agacattctc ctgagcagcc tcatcagaaa gaagctgctt
     1321 cccgaggcct ctctgctcat caccacgaga cctgtggccc tggagaaact gcagcacttg
     1381 ctggaccatc ctcggcatgt ggagatcctg ggtttctccg aggccaaaag gaaagagtac
     1441 ttcttcaagt acttctctga tgaggcccaa gccagggcag ccttcagtct gattcaggag
     1501 aacgaggtcc tcttcaccat gtgcttcatc cccctggtct gctggatcgt gtgcactgga
     1561 ctgaaacagc agatggagag tggcaagagc cttgcccaga catccaagac caccaccgcg
     1621 gtgtacgtct tcttcctttc cagtttgctg cagccccggg gagggagcca ggagcacggc
     1681 ctctgcgccc acctctgggg gctctgctct ttggctgcag atggaatctg gaaccagaaa
     1741 atcctgtttg aggagtccga cctcaggaat catggactgc agaaggcgga tgtgtctgct
     1801 ttcctgagga tgaacctgtt ccaaaaggaa gtggactgcg agaagttcta cagcttcatc
     1861 cacatgactt tccaggagtt ctttgccgcc atgtactacc tgctggaaga ggaaaaggaa
     1921 ggaaggacga acgttccagg gagtcgtttg aagcttccca gccgagacgt gacagtcctt
     1981 ctggaaaact atggcaaatt cgaaaagggg tatttgattt ttgttgtacg tttcctcttt
     2041 ggcctggtaa accaggagag gacctcctac ttggagaaga aattaagttg caagatctct
     2101 cagcaaatca ggctggagct gctgaaatgg attgaagtga aagccaaagc taaaaagctg
     2161 cagatccagc ccagccagct ggaattgttc tactgtttgt acgagatgca ggaggaggac
     2221 ttcgtgcaaa gggccatgga ctatttcccc aagattgaga tcaatctctc caccagaatg
     2281 gaccacatgg tttcttcctt ttgcattgag aactgtcatc gggtggagtc actgtccctg
     2341 gggtttctcc ataacatgcc caaggaggaa gaggaggagg aaaaggaagg ccgacacctt
     2401 gatatggtgc agtgtgtcct cccaagctcc tctcatgctg cctgttctca tgggttgggg
     2461 cgctgtggcc tctcgcatga gtgctgcttc gacatctcct tggtcctcag cagcaaccag
     2521 aagctggtgg agctggacct gagtgacaac gccctcggtg acttcggaat cagacttctg
     2581 tgtgtgggac tgaagcacct gttgtgcaat ctgaagaagc tctggttggt cagctgctgc
     2641 ctcacatcag catgttgtca ggatcttgca tcagtattga gcaccagcca ttccctgacc
     2701 agactctatg tgggggagaa tgccttggga gactcaggag tcgcaatttt atgtgaaaaa
     2761 gccaagaatc cacagtgtaa cctgcagaaa ctggggttgg tgaattctgg ccttacgtca
     2821 gtctgttgtt cagctttgtc ctcggtactc agcactaatc agaatctcac gcacctttac
     2881 ctgcgaggca acactctcgg agacaagggg atcaaactac tctgtgaggg actcttgcac
     2941 cccgactgca agcttcaggt gttggaatta gacaactgca acctcacgtc acactgctgc
     3001 tgggatcttt ccacacttct gacctccagc cagagcctgc gaaagctgag cctgggcaac
     3061 aatgacctgg gcgacctggg ggtcatgatg ttctgtgaag tgctgaaaca gcagagctgc
     3121 ctcctgcaga acctggggtt gtctgaaatg tatttcaatt atgagacaaa aagtgcgtta
     3181 gaaacacttc aagaagaaaa gcctgagctg accgtcgtct ttgagccttc ttggtaggag
     3241 tggaaacggg gctgccagac gccagtgttc tccggtccct ccagctgggg gccctcaggt
     3301 ggagagagct gcgatccatc caggccaaga ccacagctct gtgatccttc cggtggagtg
     3361 tcggagaaga gagcttgccg acgatgcctt cctgtgcaga gcttgggcat ctcctttacg
     3421 ccagggtgag gaagacacca ggacaatgac agcatcgggt gttgttgtca tcacagcgcc
     3481 tcagttagag gatgttcctc ttggtgacct catgtaatta gctcattcaa taaagcactt
     3541 tctttatttt
//
