LOCUS       XM_024452862            3967 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens NLR family pyrin domain containing 3
            (NLRP3), transcript variant X10, mRNA.
ACCESSION   XM_024452862
VERSION     XM_024452862.2
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000001.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_024452862.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3967
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
     gene            1..3967
                     /gene="NLRP3"
                     /gene_synonym="AGTAVPRL; AII; AVP; C1orf7; CIAS1; CLR1.1;
                     DFNA34; FCAS; FCAS1; FCU; KEFH; MWS; NALP3; PYPAF1"
                     /note="NLR family pyrin domain containing 3; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 1 mRNA, 9 ESTs, 6 long SRA reads, 2 Proteins, and 95%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 5 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:114548"
                     /db_xref="HGNC:HGNC:16400"
                     /db_xref="MIM:606416"
     CDS             886..3654
                     /gene="NLRP3"
                     /gene_synonym="AGTAVPRL; AII; AVP; C1orf7; CIAS1; CLR1.1;
                     DFNA34; FCAS; FCAS1; FCU; KEFH; MWS; NALP3; PYPAF1"
                     /codon_start=1
                     /product="NACHT, LRR and PYD domains-containing protein 3
                     isoform X4"
                     /protein_id="XP_024308630.1"
                     /db_xref="GeneID:114548"
                     /db_xref="HGNC:HGNC:16400"
                     /db_xref="MIM:606416"
                     /translation="MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRG
                     QTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVS
                     NPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGE
                     SVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEP
                     VHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLI
                     MSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSS
                     LIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQA
                     RAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSL
                     LQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLF
                     QKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYG
                     KFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQ
                     PSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLG
                     FLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTS
                     QSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLVNSGLTSVCCSALSSVLSTNQ
                     NLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQS
                     LRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPEL
                     TVVFEPSW"
ORIGIN      
        1 gttcctgagg ctggcatctg ggtaagtcca gctccgcggg gcagtgtggg cgacaggacc
       61 gggagagcag tgggggagat tgtgttcaga gggcagaact tgtcctggtt aatgcactag
      121 gaatttcttc tggcgtctcc aagatgagga aactgaagtt gaggaatagt gaagagtttg
      181 tccaatgtca tagccccgta atcaacggga caaaaatttt cttgctgatg ggtcaagatg
      241 gcatcgtgaa gtggttgttc accgtaaact gtaatacaat cctgtttatg gatttgtttg
      301 catatttttc cctccatagg gaaacctttc ttccatggct caggacacac tcctggatcg
      361 agccaacagg agaactttct ggtaagcatt tggctaactt tttttttttt gagatggagt
      421 cttgctgtgt cgcctaggct ggagtgcagt ggcgtgatct tggctcactg cagcctccac
      481 ttcccgggtt caatcaattc tcctacctca acttcctgag tagctgggat tacaggcgcc
      541 cgccaccaca cccggctcat ttttgtactt ttagtagaga cacagttttg ccatgttggc
      601 caggctggtc ttgaattcct cagctcaggt gatctgcctg ccttggcctc tcaaagtgct
      661 gggattacag gcgtgagcca ctgtgcccgg ccttggctaa cttttcaaaa ttaaagattt
      721 tgacttgtta cagtcatgtg acattttttt ctttctgttt gctgagtttt tgataattta
      781 tatctctcaa agtggagact ttaaaaaaga ctcatccgtg tgccgtgttc actgcctggt
      841 atcttagtgt ggaccgaagc ctaaggaccc tgaaaacagc tgcagatgaa gatggcaagc
      901 acccgctgca agctggccag gtacctggag gacctggagg atgtggactt gaagaaattt
      961 aagatgcact tagaggacta tcctccccag aagggctgca tccccctccc gaggggtcag
     1021 acagagaagg cagaccatgt ggatctagcc acgctaatga tcgacttcaa tggggaggag
     1081 aaggcgtggg ccatggccgt gtggatcttc gctgcgatca acaggagaga cctttatgag
     1141 aaagcaaaaa gagatgagcc gaagtggggt tcagataatg cacgtgtttc gaatcccact
     1201 gtgatatgcc aggaagacag cattgaagag gagtggatgg gtttactgga gtacctttcg
     1261 agaatctcta tttgtaaaat gaagaaagat taccgtaaga agtacagaaa gtacgtgaga
     1321 agcagattcc agtgcattga agacaggaat gcccgtctgg gtgagagtgt gagcctcaac
     1381 aaacgctaca cacgactgcg tctcatcaag gagcaccgga gccagcagga gagggagcag
     1441 gagcttctgg ccatcggcaa gaccaagacg tgtgagagcc ccgtgagtcc cattaagatg
     1501 gagttgctgt ttgaccccga tgatgagcat tctgagcctg tgcacaccgt ggtgttccag
     1561 ggggcggcag ggattgggaa aacaatcctg gccaggaaga tgatgttgga ctgggcgtcg
     1621 gggacactct accaagacag gtttgactat ctgttctata tccactgtcg agaggtgagc
     1681 cttgtgacac agaggagcct gggggacctg atcatgagct gctgccccga cccaaaccca
     1741 cccatccaca agatcgtgag aaaaccctcc agaatcctct tcctcatgga cggcttcgat
     1801 gagctgcaag gtgcctttga cgagcacata ggaccgctct gcactgactg gcagaaggcc
     1861 gagcggggag acattctcct gagcagcctc atcagaaaga agctgcttcc cgaggcctct
     1921 ctgctcatca ccacgagacc tgtggccctg gagaaactgc agcacttgct ggaccatcct
     1981 cggcatgtgg agatcctggg tttctccgag gccaaaagga aagagtactt cttcaagtac
     2041 ttctctgatg aggcccaagc cagggcagcc ttcagtctga ttcaggagaa cgaggtcctc
     2101 ttcaccatgt gcttcatccc cctggtctgc tggatcgtgt gcactggact gaaacagcag
     2161 atggagagtg gcaagagcct tgcccagaca tccaagacca ccaccgcggt gtacgtcttc
     2221 ttcctttcca gtttgctgca gccccgggga gggagccagg agcacggcct ctgcgcccac
     2281 ctctgggggc tctgctcttt ggctgcagat ggaatctgga accagaaaat cctgtttgag
     2341 gagtccgacc tcaggaatca tggactgcag aaggcggatg tgtctgcttt cctgaggatg
     2401 aacctgttcc aaaaggaagt ggactgcgag aagttctaca gcttcatcca catgactttc
     2461 caggagttct ttgccgccat gtactacctg ctggaagagg aaaaggaagg aaggacgaac
     2521 gttccaggga gtcgtttgaa gcttcccagc cgagacgtga cagtccttct ggaaaactat
     2581 ggcaaattcg aaaaggggta tttgattttt gttgtacgtt tcctctttgg cctggtaaac
     2641 caggagagga cctcctactt ggagaagaaa ttaagttgca agatctctca gcaaatcagg
     2701 ctggagctgc tgaaatggat tgaagtgaaa gccaaagcta aaaagctgca gatccagccc
     2761 agccagctgg aattgttcta ctgtttgtac gagatgcagg aggaggactt cgtgcaaagg
     2821 gccatggact atttccccaa gattgagatc aatctctcca ccagaatgga ccacatggtt
     2881 tcttcctttt gcattgagaa ctgtcatcgg gtggagtcac tgtccctggg gtttctccat
     2941 aacatgccca aggaggaaga ggaggaggaa aaggaaggcc gacaccttga tatggtgcag
     3001 tgtgtcctcc caagctcctc tcatgctgcc tgttctcatg gattggtgaa cagccacctc
     3061 acttccagtt tttgccgggg cctcttttca gttctgagca ccagccagag tctaactgaa
     3121 ttggacctca gtgacaattc tctgggggac ccagggatga gagtgttgtg tgaaacgctc
     3181 cagcatcctg gctgtaacat tcggagattg tggttggtga attctggcct tacgtcagtc
     3241 tgttgttcag ctttgtcctc ggtactcagc actaatcaga atctcacgca cctttacctg
     3301 cgaggcaaca ctctcggaga caaggggatc aaactactct gtgagggact cttgcacccc
     3361 gactgcaagc ttcaggtgtt ggaattagac aactgcaacc tcacgtcaca ctgctgctgg
     3421 gatctttcca cacttctgac ctccagccag agcctgcgaa agctgagcct gggcaacaat
     3481 gacctgggcg acctgggggt catgatgttc tgtgaagtgc tgaaacagca gagctgcctc
     3541 ctgcagaacc tggggttgtc tgaaatgtat ttcaattatg agacaaaaag tgcgttagaa
     3601 acacttcaag aagaaaagcc tgagctgacc gtcgtctttg agccttcttg gtaggagtgg
     3661 aaacggggct gccagacgcc agtgttctcc ggtccctcca gctgggggcc ctcaggtgga
     3721 gagagctgcg atccatccag gccaagacca cagctctgtg atccttccgg tggagtgtcg
     3781 gagaagagag cttgccgacg atgccttcct gtgcagagct tgggcatctc ctttacgcca
     3841 gggtgaggaa gacaccagga caatgacagc atcgggtgtt gttgtcatca cagcgcctca
     3901 gttagaggat gttcctcttg gtgacctcat gtaattagct cattcaataa agcactttct
     3961 ttatttt
//
