LOCUS       NM_001319967            3194 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens NLR family pyrin domain containing 2B (NLRP2B), mRNA.
ACCESSION   NM_001319967
VERSION     NM_001319967.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3194)
  AUTHORS   Porter,K.A., Duffy,E.B., Nyland,P., Atianand,M.K., Sharifi,H. and
            Harton,J.A.
  TITLE     The CLRX.1/NOD24 (NLRP2P) pseudogene codes a functional negative
            regulator of NF-kappaB, pyrin-only protein 4
  JOURNAL   Genes Immun 15 (6), 392-403 (2014)
   PUBMED   24871464
REFERENCE   2  (bases 1 to 3194)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   3  (bases 1 to 3194)
  AUTHORS   Inohara,N. and Nunez,G.
  TITLE     NODs: intracellular proteins involved in inflammation and apoptosis
  JOURNAL   Nat Rev Immunol 3 (5), 371-382 (2003)
   PUBMED   12766759
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL807813.6.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000434992.1/ ENSP00000488995.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3194              AL807813.6         71128-74321         c
FEATURES             Location/Qualifiers
     source          1..3194
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.21"
     gene            1..3194
                     /gene="NLRP2B"
                     /gene_synonym="CLRX.1; NALP2P; NLRP2P; NOD24; POP4"
                     /note="NLR family pyrin domain containing 2B"
                     /db_xref="GeneID:286430"
                     /db_xref="HGNC:HGNC:29887"
     exon            1..3194
                     /gene="NLRP2B"
                     /gene_synonym="CLRX.1; NALP2P; NLRP2P; NOD24; POP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             1..138
                     /gene="NLRP2B"
                     /gene_synonym="CLRX.1; NALP2P; NLRP2P; NOD24; POP4"
                     /note="NOD24 pseudogene; Pyrin-only protein 4; NLR family,
                     pyrin domain containing 2 pseudogene; NLR family and pyrin
                     domain-containing 2 pseudogene; Pyrin domain-containing
                     protein 2-like protein POP4"
                     /codon_start=1
                     /product="NLR family pyrin domain-containing protein 2B"
                     /protein_id="NP_001306896.1"
                     /db_xref="CCDS:CCDS83476.1"
                     /db_xref="GeneID:286430"
                     /db_xref="HGNC:HGNC:29887"
                     /translation="MVSSAQLDFNLQALLGQLSQDDLCKFKSLIRTVSLGNELQKIPQ
                     T"
ORIGIN      
        1 atggtgtctt ctgcacagct ggacttcaac ctgcaggctc ttctgggaca gctcagccag
       61 gatgacttgt gcaagttcaa gtctctgatc aggaccgtct ccctgggaaa tgagctgcaa
      121 aagatccccc agacataggt agacaaggct gatgggaagc aactggcaga aatcatcacc
      181 agccattgcc acagctactg gatgaagata gagaccatcc aggtctttga aaagatgcac
      241 cgagcggatc tgtctgagaa agtaaaggat gaactcagag aagacacttt gaaatcaagc
      301 ctgtatcatt agggaaaaca gggaaagaag agccaaaacc tatagacctg aaacaaatgc
      361 tggggcgttt cgaagcagaa gcactagagt ttatagaaac ggaggaagat gtcaccagcc
      421 taagagaagc taaagaagtc ttgaaaggag aaaagccagg taaagaggat aggtacagga
      481 gtatattgaa gacgaagttc tggcaaatgt ggaaaacctg gcctggagac ctcaaagtgg
      541 tccatattat ggctcagaga tacaagatgc tgatcccgtt cagcaacccc agggtgcttc
      601 ccgggccctg cccacacacg gtggtgctgc atggtcctgc gggccttggg aaaaccacgc
      661 tggccaagaa attaatgctg gactgggcag aggacaacct cagccagaaa tttagatagg
      721 ctttctacct cacctgcaag gagctcatct gcctgggccc gtgcagtttt gcagagctgg
      781 tcttcaggaa ctggcctgaa ttgcaggatg acattccaaa catcctagcc caagcacaga
      841 aaatcctgtt cgtggtcgac ggctttgatg agctgggagc cccacctggg gcactgatct
      901 aggacatctg tggggactgg gagaagcaga agccggtgcc ggtcttcttg gggaggttac
      961 tgaagaggaa gattttaccc agggccgccg tgctggtcac cacgtggcct gcgggccctg
     1021 agagacctcc ggctgttggt ggagcggccg atctatgtaa gggtggagga gttcctggag
     1081 aaggacagga gggcatattt cctgagacac tttggagacg aggaccaagc catgtgtgcc
     1141 tttgagctga tgagaagaaa cgcggccctg ttccagcctg tctcggcacc catggtgtgc
     1201 tggatcatgt gcatgagtct gaagctgcag aggttagaag gggaaggacc cgccccaccc
     1261 gcacggggct gttcctgcgc ttcctttgcg gccggttccc gcagggcgca cagctctggg
     1321 gcgtgctgcg ggcgctgagc ctcctggcgg cacagggcct gtgggcgcag atgtcagtgt
     1381 tccgtggaga ggacttggcg aggctcgggg tgcaggagtt caacatccgc ccgtccctgg
     1441 acagagacat cctccgccag gacatagtct ctaaaggctg ctattcctac atccacctca
     1501 gcttccagca gtttttcact gtgctgttcc acgccctgga gaaggaggag gaggaggagg
     1561 aggaggacaa ggacggccac gcctgggaca atggagacgt gcagaagctg ttttctagag
     1621 aagaaagact caagaacccc gacctgatcc aagcaagaca cttcttattc ggcttcgcca
     1681 acgagaagaa agccaaggag ttggagacca ctttgggctg cctgatgtca ccggagatca
     1741 aaaaggaatt actgtgatga gagataaatt gtgaaaaggt tggacactca acaatgatga
     1801 acccgaagga gctcttgtgc tgtctgtacg agtctcagga ggaggagctg gtgaagggag
     1861 tgatggctcc gttcaaagaa atatccctgc acttaaatgc agtagacatt atgctgtttt
     1921 caatctgcct caagcattgt cgaaacttgc agaaaatgcc actgcaggca gcaaaggcaa
     1981 agctcccaga gaatgtcact gtgtctgaat cagatgctga agttgagaga tcccaggatg
     2041 atcaacacat gcttcctttc tggaccgacc tttgttccat atttggctca aataaggatc
     2101 tgatcattct agaaatcaat aatagctttc ttggtgccac attagtaagg atcctgtgtg
     2161 aacaaatagc ttctgacacc tgtcgtctcc agagagtgat gttcaaaaac atttcaccag
     2221 ctgatgctta tcggaacctc tgcctagctc tttgaggtca caagactgta agatatctga
     2281 cccttcaagg caatgaccag aatgatatgc ttcctgcatt gtgtaaggtc ttgagacact
     2341 caaaatgtaa cctgcaatat ctcgggttgg tgtctttttc caccaccact tagcaatggg
     2401 ctgatctctc cttggccctt gaagtcaacc agtccctgac atgtgtaaac ctctctcaca
     2461 atgagctctt ggatgagggt gccaagttgc tgtacacaac tttgagacac ccaaaatgct
     2521 tcctgccgag gttgttgttg gaaaactgtc actttataga aggcaattgc aagaactttg
     2581 ctgctgtttt ggttgtcagc ggggagctga cacacctgtg cttggccaag aaccccccac
     2641 tcggggatac atgggtgatg tttctgtgta agggtttgag ttacccccat tgtaaactac
     2701 agaccctggt gctgtgggac tgcgacataa ctagcaatgg ctgctgttat ctcgcagagc
     2761 ttctccaaga aaaatcaagc ctaatgtgct tggatctggg actgaatcac ataggagtta
     2821 ctggagtgaa gctcctatgt gaggctttga agaaaccact gtgtaacttg agatgtctgt
     2881 ggttgtgggg gtgttccatc cctctgttca gttgtgagga cctctgctct gtgctcagct
     2941 gcaaccacag cctcgtcgtt ctggacctga gccagaatcc cttggggtct agtggagtaa
     3001 agatgctgtt tgaaaccttg acacatccaa attgcaccct ccagacactc aggttgaaaa
     3061 tagatgactt taatgttgaa ctcgataagc tgctggaaga aatagaagaa aacaacccac
     3121 aactgcctgc tgataactga gaaacatgat cctttggggg ggaaaaaagg ctttcttttc
     3181 attacttcat tatc
//
